Lornoxicam drug—A new study of thermal degradation under oxidative and pyrolysis conditions using the thermoanalytical techniques, DRX and LC-MS/MS
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.tca.2019.178353 http://hdl.handle.net/11449/190593 |
Resumo: | In the present work, the thermal behavior of Lornoxicam drug was studied under oxidizing (air) and pyrolysis (N2) atmospheres using simultaneous thermogravimetry and differential scanning calorimetry (TG-DSC), differential scanning calorimetry (DSC), Hot Stage Microscopy (HSM) and Evolved Gas Analysis (EGA) in the form of thermogravimetry coupled to infrared spectroscopy (TG-FTIR) and mass spectrometry (TG-MS). The thermal degradation product formed at different temperatures were examined using liquid chromatography coupled to mass spectrometry (LC–MS) and Powder X-Ray Diffraction (PXRD). The thermal study showed that the drug does not melt, partially amorphized on heating, it is thermally stable to 205 °C and undergoes thermal decomposition in two overlapping mass loss steps. Furthermore, the DSC and MS techniques suggest that thermal degradation processes are very complex, which occur with the release of gaseous products HCN, SO2, COS, CO2, N2O and CO and formation of three intermediate in the thermal residue. |
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Lornoxicam drug—A new study of thermal degradation under oxidative and pyrolysis conditions using the thermoanalytical techniques, DRX and LC-MS/MSEGAHSMLC–MS/MSLornoxicamThermal degradationIn the present work, the thermal behavior of Lornoxicam drug was studied under oxidizing (air) and pyrolysis (N2) atmospheres using simultaneous thermogravimetry and differential scanning calorimetry (TG-DSC), differential scanning calorimetry (DSC), Hot Stage Microscopy (HSM) and Evolved Gas Analysis (EGA) in the form of thermogravimetry coupled to infrared spectroscopy (TG-FTIR) and mass spectrometry (TG-MS). The thermal degradation product formed at different temperatures were examined using liquid chromatography coupled to mass spectrometry (LC–MS) and Powder X-Ray Diffraction (PXRD). The thermal study showed that the drug does not melt, partially amorphized on heating, it is thermally stable to 205 °C and undergoes thermal decomposition in two overlapping mass loss steps. Furthermore, the DSC and MS techniques suggest that thermal degradation processes are very complex, which occur with the release of gaseous products HCN, SO2, COS, CO2, N2O and CO and formation of three intermediate in the thermal residue.Universidade Estadual Paulista (Unesp) Instituto de QuímicaThermal Methods Research Unit Department of Chemistry University of Huddersfield, QueensgateUniversidade Estadual Paulista (Unesp) Faculdade de CiênciasUniversidade Estadual Paulista (Unesp) Instituto de QuímicaUniversidade Estadual Paulista (Unesp) Faculdade de CiênciasUniversidade Estadual Paulista (Unesp)University of HuddersfieldCarvalho, A. C.S. [UNESP]Zangaro, G. A.C. [UNESP]Fernandes, R. P. [UNESP]Ekawa, B. [UNESP]Nascimento, A. L.C.S. [UNESP]Silva, B. F. [UNESP]Ashton, G. P.Parkes, G. M.B.Ionashiro, M. [UNESP]Caires, F. J. [UNESP]2019-10-06T17:18:25Z2019-10-06T17:18:25Z2019-10-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.tca.2019.178353Thermochimica Acta, v. 680.0040-6031http://hdl.handle.net/11449/19059310.1016/j.tca.2019.1783532-s2.0-85071019311Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengThermochimica Actainfo:eu-repo/semantics/openAccess2021-10-23T20:19:32Zoai:repositorio.unesp.br:11449/190593Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462021-10-23T20:19:32Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Lornoxicam drug—A new study of thermal degradation under oxidative and pyrolysis conditions using the thermoanalytical techniques, DRX and LC-MS/MS |
title |
Lornoxicam drug—A new study of thermal degradation under oxidative and pyrolysis conditions using the thermoanalytical techniques, DRX and LC-MS/MS |
spellingShingle |
Lornoxicam drug—A new study of thermal degradation under oxidative and pyrolysis conditions using the thermoanalytical techniques, DRX and LC-MS/MS Carvalho, A. C.S. [UNESP] EGA HSM LC–MS/MS Lornoxicam Thermal degradation |
title_short |
Lornoxicam drug—A new study of thermal degradation under oxidative and pyrolysis conditions using the thermoanalytical techniques, DRX and LC-MS/MS |
title_full |
Lornoxicam drug—A new study of thermal degradation under oxidative and pyrolysis conditions using the thermoanalytical techniques, DRX and LC-MS/MS |
title_fullStr |
Lornoxicam drug—A new study of thermal degradation under oxidative and pyrolysis conditions using the thermoanalytical techniques, DRX and LC-MS/MS |
title_full_unstemmed |
Lornoxicam drug—A new study of thermal degradation under oxidative and pyrolysis conditions using the thermoanalytical techniques, DRX and LC-MS/MS |
title_sort |
Lornoxicam drug—A new study of thermal degradation under oxidative and pyrolysis conditions using the thermoanalytical techniques, DRX and LC-MS/MS |
author |
Carvalho, A. C.S. [UNESP] |
author_facet |
Carvalho, A. C.S. [UNESP] Zangaro, G. A.C. [UNESP] Fernandes, R. P. [UNESP] Ekawa, B. [UNESP] Nascimento, A. L.C.S. [UNESP] Silva, B. F. [UNESP] Ashton, G. P. Parkes, G. M.B. Ionashiro, M. [UNESP] Caires, F. J. [UNESP] |
author_role |
author |
author2 |
Zangaro, G. A.C. [UNESP] Fernandes, R. P. [UNESP] Ekawa, B. [UNESP] Nascimento, A. L.C.S. [UNESP] Silva, B. F. [UNESP] Ashton, G. P. Parkes, G. M.B. Ionashiro, M. [UNESP] Caires, F. J. [UNESP] |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) University of Huddersfield |
dc.contributor.author.fl_str_mv |
Carvalho, A. C.S. [UNESP] Zangaro, G. A.C. [UNESP] Fernandes, R. P. [UNESP] Ekawa, B. [UNESP] Nascimento, A. L.C.S. [UNESP] Silva, B. F. [UNESP] Ashton, G. P. Parkes, G. M.B. Ionashiro, M. [UNESP] Caires, F. J. [UNESP] |
dc.subject.por.fl_str_mv |
EGA HSM LC–MS/MS Lornoxicam Thermal degradation |
topic |
EGA HSM LC–MS/MS Lornoxicam Thermal degradation |
description |
In the present work, the thermal behavior of Lornoxicam drug was studied under oxidizing (air) and pyrolysis (N2) atmospheres using simultaneous thermogravimetry and differential scanning calorimetry (TG-DSC), differential scanning calorimetry (DSC), Hot Stage Microscopy (HSM) and Evolved Gas Analysis (EGA) in the form of thermogravimetry coupled to infrared spectroscopy (TG-FTIR) and mass spectrometry (TG-MS). The thermal degradation product formed at different temperatures were examined using liquid chromatography coupled to mass spectrometry (LC–MS) and Powder X-Ray Diffraction (PXRD). The thermal study showed that the drug does not melt, partially amorphized on heating, it is thermally stable to 205 °C and undergoes thermal decomposition in two overlapping mass loss steps. Furthermore, the DSC and MS techniques suggest that thermal degradation processes are very complex, which occur with the release of gaseous products HCN, SO2, COS, CO2, N2O and CO and formation of three intermediate in the thermal residue. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-10-06T17:18:25Z 2019-10-06T17:18:25Z 2019-10-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.tca.2019.178353 Thermochimica Acta, v. 680. 0040-6031 http://hdl.handle.net/11449/190593 10.1016/j.tca.2019.178353 2-s2.0-85071019311 |
url |
http://dx.doi.org/10.1016/j.tca.2019.178353 http://hdl.handle.net/11449/190593 |
identifier_str_mv |
Thermochimica Acta, v. 680. 0040-6031 10.1016/j.tca.2019.178353 2-s2.0-85071019311 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Thermochimica Acta |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799965618158436352 |