Pharmacokinetics and Biodistribution of Eriocitrin in Rats

Detalhes bibliográficos
Autor(a) principal: Ferreira, Paula S. [UNESP]
Data de Publicação: 2021
Outros Autores: Manthey, John A., Nery, Marina S. [UNESP], Cesar, Thais B. [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1021/acs.jafc.0c04553
http://hdl.handle.net/11449/207274
Resumo: Eriocitrin plays a role in the reduction of oxidative stress and inflammation linked to the development of diabetes mellitus and atherosclerosis. We investigated the pharmacokinetics and distribution of eriocitrin metabolites in rats orally administered with eriocitrin. Plasma, urine, and organs were collected at 12 different time points from 0 to 24 h and analyzed by HPLC-PDA-MS. For the first time, the metabolism and distribution of orally administered eriocitrin were shown. Nine metabolites of eriocitrin were identified in rat urine, and seven in various tissues (eriodictyol, homoeriodictyol, hesperetin, and glucuronidated metabolites), and preliminary identifications of these metabolites are suggested. Overall, eriocitrin metabolites were widely distributed in the rat tissues, where homoeriodictyol and homoeriodictyol-7-O-glucuronide were the major metabolites. The half-lives of the metabolites in plasma were between 3 and 3.2 h, and the total bioavailability of eriocitrin was less than 1%.
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spelling Pharmacokinetics and Biodistribution of Eriocitrin in RatsbiodistributioneriocitrinidentificationmetabolitespharmacokineticsEriocitrin plays a role in the reduction of oxidative stress and inflammation linked to the development of diabetes mellitus and atherosclerosis. We investigated the pharmacokinetics and distribution of eriocitrin metabolites in rats orally administered with eriocitrin. Plasma, urine, and organs were collected at 12 different time points from 0 to 24 h and analyzed by HPLC-PDA-MS. For the first time, the metabolism and distribution of orally administered eriocitrin were shown. Nine metabolites of eriocitrin were identified in rat urine, and seven in various tissues (eriodictyol, homoeriodictyol, hesperetin, and glucuronidated metabolites), and preliminary identifications of these metabolites are suggested. Overall, eriocitrin metabolites were widely distributed in the rat tissues, where homoeriodictyol and homoeriodictyol-7-O-glucuronide were the major metabolites. The half-lives of the metabolites in plasma were between 3 and 3.2 h, and the total bioavailability of eriocitrin was less than 1%.Universidade Estadual Paulista (UNESP) Faculdade de Ciências Farmacêuticas Araraquara Departamento de Alimentos e Nutrição, Rodovia Araraquara - Jau, km 1U.S. Horticultural Research Laboratory Agricultural Research Service USDA, 2001 South Rock RoadUniversidade Estadual Paulista (UNESP) Faculdade de Ciências Farmacêuticas Araraquara Departamento de Alimentos e Nutrição, Rodovia Araraquara - Jau, km 1Universidade Estadual Paulista (Unesp)USDAFerreira, Paula S. [UNESP]Manthey, John A.Nery, Marina S. [UNESP]Cesar, Thais B. [UNESP]2021-06-25T10:52:18Z2021-06-25T10:52:18Z2021-02-17info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1796-1805http://dx.doi.org/10.1021/acs.jafc.0c04553Journal of Agricultural and Food Chemistry, v. 69, n. 6, p. 1796-1805, 2021.1520-51180021-8561http://hdl.handle.net/11449/20727410.1021/acs.jafc.0c045532-s2.0-85100797463Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Agricultural and Food Chemistryinfo:eu-repo/semantics/openAccess2024-06-21T12:47:23Zoai:repositorio.unesp.br:11449/207274Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T23:23:38.465114Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Pharmacokinetics and Biodistribution of Eriocitrin in Rats
title Pharmacokinetics and Biodistribution of Eriocitrin in Rats
spellingShingle Pharmacokinetics and Biodistribution of Eriocitrin in Rats
Ferreira, Paula S. [UNESP]
biodistribution
eriocitrin
identification
metabolites
pharmacokinetics
title_short Pharmacokinetics and Biodistribution of Eriocitrin in Rats
title_full Pharmacokinetics and Biodistribution of Eriocitrin in Rats
title_fullStr Pharmacokinetics and Biodistribution of Eriocitrin in Rats
title_full_unstemmed Pharmacokinetics and Biodistribution of Eriocitrin in Rats
title_sort Pharmacokinetics and Biodistribution of Eriocitrin in Rats
author Ferreira, Paula S. [UNESP]
author_facet Ferreira, Paula S. [UNESP]
Manthey, John A.
Nery, Marina S. [UNESP]
Cesar, Thais B. [UNESP]
author_role author
author2 Manthey, John A.
Nery, Marina S. [UNESP]
Cesar, Thais B. [UNESP]
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
USDA
dc.contributor.author.fl_str_mv Ferreira, Paula S. [UNESP]
Manthey, John A.
Nery, Marina S. [UNESP]
Cesar, Thais B. [UNESP]
dc.subject.por.fl_str_mv biodistribution
eriocitrin
identification
metabolites
pharmacokinetics
topic biodistribution
eriocitrin
identification
metabolites
pharmacokinetics
description Eriocitrin plays a role in the reduction of oxidative stress and inflammation linked to the development of diabetes mellitus and atherosclerosis. We investigated the pharmacokinetics and distribution of eriocitrin metabolites in rats orally administered with eriocitrin. Plasma, urine, and organs were collected at 12 different time points from 0 to 24 h and analyzed by HPLC-PDA-MS. For the first time, the metabolism and distribution of orally administered eriocitrin were shown. Nine metabolites of eriocitrin were identified in rat urine, and seven in various tissues (eriodictyol, homoeriodictyol, hesperetin, and glucuronidated metabolites), and preliminary identifications of these metabolites are suggested. Overall, eriocitrin metabolites were widely distributed in the rat tissues, where homoeriodictyol and homoeriodictyol-7-O-glucuronide were the major metabolites. The half-lives of the metabolites in plasma were between 3 and 3.2 h, and the total bioavailability of eriocitrin was less than 1%.
publishDate 2021
dc.date.none.fl_str_mv 2021-06-25T10:52:18Z
2021-06-25T10:52:18Z
2021-02-17
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1021/acs.jafc.0c04553
Journal of Agricultural and Food Chemistry, v. 69, n. 6, p. 1796-1805, 2021.
1520-5118
0021-8561
http://hdl.handle.net/11449/207274
10.1021/acs.jafc.0c04553
2-s2.0-85100797463
url http://dx.doi.org/10.1021/acs.jafc.0c04553
http://hdl.handle.net/11449/207274
identifier_str_mv Journal of Agricultural and Food Chemistry, v. 69, n. 6, p. 1796-1805, 2021.
1520-5118
0021-8561
10.1021/acs.jafc.0c04553
2-s2.0-85100797463
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Journal of Agricultural and Food Chemistry
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 1796-1805
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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