Pharmacokinetics and Biodistribution of Eriocitrin in Rats
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1021/acs.jafc.0c04553 http://hdl.handle.net/11449/207274 |
Resumo: | Eriocitrin plays a role in the reduction of oxidative stress and inflammation linked to the development of diabetes mellitus and atherosclerosis. We investigated the pharmacokinetics and distribution of eriocitrin metabolites in rats orally administered with eriocitrin. Plasma, urine, and organs were collected at 12 different time points from 0 to 24 h and analyzed by HPLC-PDA-MS. For the first time, the metabolism and distribution of orally administered eriocitrin were shown. Nine metabolites of eriocitrin were identified in rat urine, and seven in various tissues (eriodictyol, homoeriodictyol, hesperetin, and glucuronidated metabolites), and preliminary identifications of these metabolites are suggested. Overall, eriocitrin metabolites were widely distributed in the rat tissues, where homoeriodictyol and homoeriodictyol-7-O-glucuronide were the major metabolites. The half-lives of the metabolites in plasma were between 3 and 3.2 h, and the total bioavailability of eriocitrin was less than 1%. |
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Pharmacokinetics and Biodistribution of Eriocitrin in RatsbiodistributioneriocitrinidentificationmetabolitespharmacokineticsEriocitrin plays a role in the reduction of oxidative stress and inflammation linked to the development of diabetes mellitus and atherosclerosis. We investigated the pharmacokinetics and distribution of eriocitrin metabolites in rats orally administered with eriocitrin. Plasma, urine, and organs were collected at 12 different time points from 0 to 24 h and analyzed by HPLC-PDA-MS. For the first time, the metabolism and distribution of orally administered eriocitrin were shown. Nine metabolites of eriocitrin were identified in rat urine, and seven in various tissues (eriodictyol, homoeriodictyol, hesperetin, and glucuronidated metabolites), and preliminary identifications of these metabolites are suggested. Overall, eriocitrin metabolites were widely distributed in the rat tissues, where homoeriodictyol and homoeriodictyol-7-O-glucuronide were the major metabolites. The half-lives of the metabolites in plasma were between 3 and 3.2 h, and the total bioavailability of eriocitrin was less than 1%.Universidade Estadual Paulista (UNESP) Faculdade de Ciências Farmacêuticas Araraquara Departamento de Alimentos e Nutrição, Rodovia Araraquara - Jau, km 1U.S. Horticultural Research Laboratory Agricultural Research Service USDA, 2001 South Rock RoadUniversidade Estadual Paulista (UNESP) Faculdade de Ciências Farmacêuticas Araraquara Departamento de Alimentos e Nutrição, Rodovia Araraquara - Jau, km 1Universidade Estadual Paulista (Unesp)USDAFerreira, Paula S. [UNESP]Manthey, John A.Nery, Marina S. [UNESP]Cesar, Thais B. [UNESP]2021-06-25T10:52:18Z2021-06-25T10:52:18Z2021-02-17info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1796-1805http://dx.doi.org/10.1021/acs.jafc.0c04553Journal of Agricultural and Food Chemistry, v. 69, n. 6, p. 1796-1805, 2021.1520-51180021-8561http://hdl.handle.net/11449/20727410.1021/acs.jafc.0c045532-s2.0-85100797463Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Agricultural and Food Chemistryinfo:eu-repo/semantics/openAccess2024-06-21T12:47:23Zoai:repositorio.unesp.br:11449/207274Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T23:23:38.465114Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Pharmacokinetics and Biodistribution of Eriocitrin in Rats |
title |
Pharmacokinetics and Biodistribution of Eriocitrin in Rats |
spellingShingle |
Pharmacokinetics and Biodistribution of Eriocitrin in Rats Ferreira, Paula S. [UNESP] biodistribution eriocitrin identification metabolites pharmacokinetics |
title_short |
Pharmacokinetics and Biodistribution of Eriocitrin in Rats |
title_full |
Pharmacokinetics and Biodistribution of Eriocitrin in Rats |
title_fullStr |
Pharmacokinetics and Biodistribution of Eriocitrin in Rats |
title_full_unstemmed |
Pharmacokinetics and Biodistribution of Eriocitrin in Rats |
title_sort |
Pharmacokinetics and Biodistribution of Eriocitrin in Rats |
author |
Ferreira, Paula S. [UNESP] |
author_facet |
Ferreira, Paula S. [UNESP] Manthey, John A. Nery, Marina S. [UNESP] Cesar, Thais B. [UNESP] |
author_role |
author |
author2 |
Manthey, John A. Nery, Marina S. [UNESP] Cesar, Thais B. [UNESP] |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) USDA |
dc.contributor.author.fl_str_mv |
Ferreira, Paula S. [UNESP] Manthey, John A. Nery, Marina S. [UNESP] Cesar, Thais B. [UNESP] |
dc.subject.por.fl_str_mv |
biodistribution eriocitrin identification metabolites pharmacokinetics |
topic |
biodistribution eriocitrin identification metabolites pharmacokinetics |
description |
Eriocitrin plays a role in the reduction of oxidative stress and inflammation linked to the development of diabetes mellitus and atherosclerosis. We investigated the pharmacokinetics and distribution of eriocitrin metabolites in rats orally administered with eriocitrin. Plasma, urine, and organs were collected at 12 different time points from 0 to 24 h and analyzed by HPLC-PDA-MS. For the first time, the metabolism and distribution of orally administered eriocitrin were shown. Nine metabolites of eriocitrin were identified in rat urine, and seven in various tissues (eriodictyol, homoeriodictyol, hesperetin, and glucuronidated metabolites), and preliminary identifications of these metabolites are suggested. Overall, eriocitrin metabolites were widely distributed in the rat tissues, where homoeriodictyol and homoeriodictyol-7-O-glucuronide were the major metabolites. The half-lives of the metabolites in plasma were between 3 and 3.2 h, and the total bioavailability of eriocitrin was less than 1%. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-06-25T10:52:18Z 2021-06-25T10:52:18Z 2021-02-17 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1021/acs.jafc.0c04553 Journal of Agricultural and Food Chemistry, v. 69, n. 6, p. 1796-1805, 2021. 1520-5118 0021-8561 http://hdl.handle.net/11449/207274 10.1021/acs.jafc.0c04553 2-s2.0-85100797463 |
url |
http://dx.doi.org/10.1021/acs.jafc.0c04553 http://hdl.handle.net/11449/207274 |
identifier_str_mv |
Journal of Agricultural and Food Chemistry, v. 69, n. 6, p. 1796-1805, 2021. 1520-5118 0021-8561 10.1021/acs.jafc.0c04553 2-s2.0-85100797463 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of Agricultural and Food Chemistry |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
1796-1805 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129515448172544 |