Evaluation of argyrophilic nucleolar organizer regions in oral tumor progression

Detalhes bibliográficos
Autor(a) principal: Spolidorio, L. C.
Data de Publicação: 2002
Outros Autores: Neves, K. A., Soares, C. P., Spolidorio, D. M.P., Basso, M. F.M., Malavazzi, I., Almeida, O. P.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1016/S0968-4328(02)00031-8
http://hdl.handle.net/11449/230921
Resumo: The aim of this study was to compare the presence of nucleolar organizer regions (NORs) in normal oral mucosa, dysplasia and microinvasive carcinoma. All histological specimens were reviewed according to the modified classification and staging system for oral leukoplakia described by van-der-Waal et al. [Oral Oncol. 36 (2000) 264]. NOR quantification was performed with an image analyzer after staining by the argyrophilic nucleolar region technique. The morphometric results were statistically different for normal mucosa, dysplasia and microinvasive carcinoma. It was concluded that an increase of NOR activity follows the disease progression and may reflect the degree of cellular proliferation and malignancy. © 2002 Elsevier Science Ltd. All rights reserved.
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spelling Evaluation of argyrophilic nucleolar organizer regions in oral tumor progressionArgyrophilic nucleolar regionsDysplasiaOral carcinomaOral mucosaTumor progressionThe aim of this study was to compare the presence of nucleolar organizer regions (NORs) in normal oral mucosa, dysplasia and microinvasive carcinoma. All histological specimens were reviewed according to the modified classification and staging system for oral leukoplakia described by van-der-Waal et al. [Oral Oncol. 36 (2000) 264]. NOR quantification was performed with an image analyzer after staining by the argyrophilic nucleolar region technique. The morphometric results were statistically different for normal mucosa, dysplasia and microinvasive carcinoma. It was concluded that an increase of NOR activity follows the disease progression and may reflect the degree of cellular proliferation and malignancy. © 2002 Elsevier Science Ltd. All rights reserved.Department of Oral Pathology Araraquara Dental School University of São Paulo State, Rua Humaitá, 1680 CEP, 14801-903 AraraquaraDepartment of Clinical Analysis Faculty of Pharmaceutical Sciences University of São Paulo State, Rua Expedicionários do Brasil, 1621 CEP, 14801-902 AraraquaraDepartment of Oral Pathology Piracicaba Dental School UNICAMP, Av Limeira s/n, PiracicabaUniversidade de São Paulo (USP)Universidade Estadual de Campinas (UNICAMP)Spolidorio, L. C.Neves, K. A.Soares, C. P.Spolidorio, D. M.P.Basso, M. F.M.Malavazzi, I.Almeida, O. P.2022-04-29T08:42:46Z2022-04-29T08:42:46Z2002-12-18info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article605-608http://dx.doi.org/10.1016/S0968-4328(02)00031-8Micron, v. 33, n. 7-8, p. 605-608, 2002.0968-4328http://hdl.handle.net/11449/23092110.1016/S0968-4328(02)00031-82-s2.0-0036446038Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengMicroninfo:eu-repo/semantics/openAccess2022-04-29T08:42:46Zoai:repositorio.unesp.br:11449/230921Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462022-04-29T08:42:46Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Evaluation of argyrophilic nucleolar organizer regions in oral tumor progression
title Evaluation of argyrophilic nucleolar organizer regions in oral tumor progression
spellingShingle Evaluation of argyrophilic nucleolar organizer regions in oral tumor progression
Spolidorio, L. C.
Argyrophilic nucleolar regions
Dysplasia
Oral carcinoma
Oral mucosa
Tumor progression
title_short Evaluation of argyrophilic nucleolar organizer regions in oral tumor progression
title_full Evaluation of argyrophilic nucleolar organizer regions in oral tumor progression
title_fullStr Evaluation of argyrophilic nucleolar organizer regions in oral tumor progression
title_full_unstemmed Evaluation of argyrophilic nucleolar organizer regions in oral tumor progression
title_sort Evaluation of argyrophilic nucleolar organizer regions in oral tumor progression
author Spolidorio, L. C.
author_facet Spolidorio, L. C.
Neves, K. A.
Soares, C. P.
Spolidorio, D. M.P.
Basso, M. F.M.
Malavazzi, I.
Almeida, O. P.
author_role author
author2 Neves, K. A.
Soares, C. P.
Spolidorio, D. M.P.
Basso, M. F.M.
Malavazzi, I.
Almeida, O. P.
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade de São Paulo (USP)
Universidade Estadual de Campinas (UNICAMP)
dc.contributor.author.fl_str_mv Spolidorio, L. C.
Neves, K. A.
Soares, C. P.
Spolidorio, D. M.P.
Basso, M. F.M.
Malavazzi, I.
Almeida, O. P.
dc.subject.por.fl_str_mv Argyrophilic nucleolar regions
Dysplasia
Oral carcinoma
Oral mucosa
Tumor progression
topic Argyrophilic nucleolar regions
Dysplasia
Oral carcinoma
Oral mucosa
Tumor progression
description The aim of this study was to compare the presence of nucleolar organizer regions (NORs) in normal oral mucosa, dysplasia and microinvasive carcinoma. All histological specimens were reviewed according to the modified classification and staging system for oral leukoplakia described by van-der-Waal et al. [Oral Oncol. 36 (2000) 264]. NOR quantification was performed with an image analyzer after staining by the argyrophilic nucleolar region technique. The morphometric results were statistically different for normal mucosa, dysplasia and microinvasive carcinoma. It was concluded that an increase of NOR activity follows the disease progression and may reflect the degree of cellular proliferation and malignancy. © 2002 Elsevier Science Ltd. All rights reserved.
publishDate 2002
dc.date.none.fl_str_mv 2002-12-18
2022-04-29T08:42:46Z
2022-04-29T08:42:46Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/S0968-4328(02)00031-8
Micron, v. 33, n. 7-8, p. 605-608, 2002.
0968-4328
http://hdl.handle.net/11449/230921
10.1016/S0968-4328(02)00031-8
2-s2.0-0036446038
url http://dx.doi.org/10.1016/S0968-4328(02)00031-8
http://hdl.handle.net/11449/230921
identifier_str_mv Micron, v. 33, n. 7-8, p. 605-608, 2002.
0968-4328
10.1016/S0968-4328(02)00031-8
2-s2.0-0036446038
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Micron
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 605-608
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1799964771421782016

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