Herpetic brainstem encephalitis: report of a post-mortem case studied electron microscopically and immunohisiochemically
Autor(a) principal: | |
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Data de Publicação: | 1987 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/S0004-282X1987000100006 http://hdl.handle.net/11449/211055 |
Resumo: | A post-mortem examined case of herpetic brainstem encephalitis is presented. Clinically, the patient had cephalea followed by ataxia, drowsiness and multiple palsies of some cranial nerves, developing into death in eight days. The pathologic examination of the brain showed necrotizing encephalitis in multiple foci limited to the brainstem, more distinctly in the pons and medula oblongata. The technique of immunoperoxidase revealed rare glial cells with intranuclear immunoreactivity for herpes antigen. Rare viral particles with the morphological characteristics of the herpesvirus were identified in the nuclei of neurons in 10% formol fixed material. This is the second reported case of herpetic brainstem encephalitis confirmed by post-mortem examination. The pathway used by the virus to reach the central nervous system and its posterior dissemination to the oral cavity, the orbitofrontal region and the temporal lobes as well as to the brainstem, after a period of latency and reactivation, are discussed. |
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Herpetic brainstem encephalitis: report of a post-mortem case studied electron microscopically and immunohisiochemicallyEncefalite herpetica do tronco encefálico: relato de um caso autopsiado com estudo imuno-histoquímico e ao microscópio eletrônicoA post-mortem examined case of herpetic brainstem encephalitis is presented. Clinically, the patient had cephalea followed by ataxia, drowsiness and multiple palsies of some cranial nerves, developing into death in eight days. The pathologic examination of the brain showed necrotizing encephalitis in multiple foci limited to the brainstem, more distinctly in the pons and medula oblongata. The technique of immunoperoxidase revealed rare glial cells with intranuclear immunoreactivity for herpes antigen. Rare viral particles with the morphological characteristics of the herpesvirus were identified in the nuclei of neurons in 10% formol fixed material. This is the second reported case of herpetic brainstem encephalitis confirmed by post-mortem examination. The pathway used by the virus to reach the central nervous system and its posterior dissemination to the oral cavity, the orbitofrontal region and the temporal lobes as well as to the brainstem, after a period of latency and reactivation, are discussed.É apresentado um caso autopsiado de encefalite herpética do tronco encefalico. Clinicamente o paciente apresentou de início cefaléia, seguida de ataxia, sonolência e paralisias múltiplas de alguns nervos cranianos, evoluindo para a morte em 8 dias. O exame anatomopatológico do encéfalo mostrou encefalite necrosante em focos múltiplos limitada ao tronco encefálico, mais acentuada na ponte e bulbo. A técnica da imunoperoxidase revelou raras células gliais com imunorreatividade intranuclear para antígeno do herpes. Raras partículas virais com as características morfológicas do herpesvírus foram identificadas nos núcleos de células nervosas em material fixado em formol a 10%. Este caso é o segundo relatado de encefalite herpética do tronco do encéfalo confirmado pelo exame anatomopatológico. Comentam-se as vias de chegada do herpesvírus ao sistema nervoso central e sua posterior disseminação, após período de latência e reativação, para a cavidade oral, região órbito-frontal, lobos temporais e tronco encefálico.Universidade Federal de Minas Gerais, Faculdade de MedicinaUniversidade Estadual Paulista, Faculdade de MedicinaUniversidade Estadual Paulista, Faculdade de MedicinaAcademia Brasileira de Neurologia - ABNEUROUniversidade Federal de Minas GeraisUniversidade Estadual Paulista (Unesp)Pitella, José Eymard HomemLeite, Virgínia Hora RiosLana-peixoto, Marco AurélioBacchi, Carlos Eduardo [UNESP]2021-07-14T10:18:33Z2021-07-14T10:18:33Z1987-03info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article44-52application/pdfhttp://dx.doi.org/10.1590/S0004-282X1987000100006Arquivos de Neuro-Psiquiatria. São Paulo, SP, Brazil: Academia Brasileira de Neurologia - ABNEURO, v. 45, n. 1, p. 44-52, 1987.0004-282X1678-4227http://hdl.handle.net/11449/21105510.1590/S0004-282X1987000100006S0004-282X1987000100006S0004-282X1987000100006.pdfSciELOreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengArquivos de Neuro-Psiquiatriainfo:eu-repo/semantics/openAccess2023-12-11T06:19:24Zoai:repositorio.unesp.br:11449/211055Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-12-11T06:19:24Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Herpetic brainstem encephalitis: report of a post-mortem case studied electron microscopically and immunohisiochemically Encefalite herpetica do tronco encefálico: relato de um caso autopsiado com estudo imuno-histoquímico e ao microscópio eletrônico |
title |
Herpetic brainstem encephalitis: report of a post-mortem case studied electron microscopically and immunohisiochemically |
spellingShingle |
Herpetic brainstem encephalitis: report of a post-mortem case studied electron microscopically and immunohisiochemically Pitella, José Eymard Homem |
title_short |
Herpetic brainstem encephalitis: report of a post-mortem case studied electron microscopically and immunohisiochemically |
title_full |
Herpetic brainstem encephalitis: report of a post-mortem case studied electron microscopically and immunohisiochemically |
title_fullStr |
Herpetic brainstem encephalitis: report of a post-mortem case studied electron microscopically and immunohisiochemically |
title_full_unstemmed |
Herpetic brainstem encephalitis: report of a post-mortem case studied electron microscopically and immunohisiochemically |
title_sort |
Herpetic brainstem encephalitis: report of a post-mortem case studied electron microscopically and immunohisiochemically |
author |
Pitella, José Eymard Homem |
author_facet |
Pitella, José Eymard Homem Leite, Virgínia Hora Rios Lana-peixoto, Marco Aurélio Bacchi, Carlos Eduardo [UNESP] |
author_role |
author |
author2 |
Leite, Virgínia Hora Rios Lana-peixoto, Marco Aurélio Bacchi, Carlos Eduardo [UNESP] |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal de Minas Gerais Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Pitella, José Eymard Homem Leite, Virgínia Hora Rios Lana-peixoto, Marco Aurélio Bacchi, Carlos Eduardo [UNESP] |
description |
A post-mortem examined case of herpetic brainstem encephalitis is presented. Clinically, the patient had cephalea followed by ataxia, drowsiness and multiple palsies of some cranial nerves, developing into death in eight days. The pathologic examination of the brain showed necrotizing encephalitis in multiple foci limited to the brainstem, more distinctly in the pons and medula oblongata. The technique of immunoperoxidase revealed rare glial cells with intranuclear immunoreactivity for herpes antigen. Rare viral particles with the morphological characteristics of the herpesvirus were identified in the nuclei of neurons in 10% formol fixed material. This is the second reported case of herpetic brainstem encephalitis confirmed by post-mortem examination. The pathway used by the virus to reach the central nervous system and its posterior dissemination to the oral cavity, the orbitofrontal region and the temporal lobes as well as to the brainstem, after a period of latency and reactivation, are discussed. |
publishDate |
1987 |
dc.date.none.fl_str_mv |
1987-03 2021-07-14T10:18:33Z 2021-07-14T10:18:33Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S0004-282X1987000100006 Arquivos de Neuro-Psiquiatria. São Paulo, SP, Brazil: Academia Brasileira de Neurologia - ABNEURO, v. 45, n. 1, p. 44-52, 1987. 0004-282X 1678-4227 http://hdl.handle.net/11449/211055 10.1590/S0004-282X1987000100006 S0004-282X1987000100006 S0004-282X1987000100006.pdf |
url |
http://dx.doi.org/10.1590/S0004-282X1987000100006 http://hdl.handle.net/11449/211055 |
identifier_str_mv |
Arquivos de Neuro-Psiquiatria. São Paulo, SP, Brazil: Academia Brasileira de Neurologia - ABNEURO, v. 45, n. 1, p. 44-52, 1987. 0004-282X 1678-4227 10.1590/S0004-282X1987000100006 S0004-282X1987000100006 S0004-282X1987000100006.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Arquivos de Neuro-Psiquiatria |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
44-52 application/pdf |
dc.publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
dc.source.none.fl_str_mv |
SciELO reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799965253120819200 |