Antitumor effect of snake venoms
Autor(a) principal: | |
---|---|
Data de Publicação: | 1996 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/S0104-79301996000200002 http://hdl.handle.net/11449/64714 |
Resumo: | The search for biological antitumor agents has been pursued for over half a century. Snake venom has been shown to possess a wide spectrum of biological activities. The objectives of the present review are to evaluate the existing controversies on this subject published in a number of papers and to propose probable explanations for the phenomena observed. We reported our results obtained in a study, in which we evaluated the action of the venoms of Crotalus durissus terrificus and Bothrops jararaca on Ehrlich ascites tumor cells. We noticed an important antitumor effect, mainly with Bothrops jararaca venom, as well as an increase in the functional activity of macrophages. We also observed an increase in the number of mononuclear and polymorphonuclear cells with Bothrops jararaca venom. Considering these findings, we postulate that both Borhrops jararaca and Crotalus durissus terrificus venoms can act directly on tumor cells. In addition, we propose an indirect mechanism, based on the stimulation of the inflammatory response, to inhibit tumor growth and to promote its rejection. |
id |
UNSP_9a20b510b1d4ab9d9cf3ca1df34bf912 |
---|---|
oai_identifier_str |
oai:repositorio.unesp.br:11449/64714 |
network_acronym_str |
UNSP |
network_name_str |
Repositório Institucional da UNESP |
repository_id_str |
2946 |
spelling |
Antitumor effect of snake venomsBothrops jararacaCancerCrotalus durissus terrificusInflammationSnakesVenomantineoplastic agentbatroxobininterleukin 6snake venomantineoplastic activitycancer inhibitioncytolysisdrug mechanismehrlich ascites tumor cellhumaninflammationleukocyte countlymphokine activated killer cellmacrophagemononuclear cellnonhumanpolymorphonuclear cellreviewsarcomasnakebitetumor cellThe search for biological antitumor agents has been pursued for over half a century. Snake venom has been shown to possess a wide spectrum of biological activities. The objectives of the present review are to evaluate the existing controversies on this subject published in a number of papers and to propose probable explanations for the phenomena observed. We reported our results obtained in a study, in which we evaluated the action of the venoms of Crotalus durissus terrificus and Bothrops jararaca on Ehrlich ascites tumor cells. We noticed an important antitumor effect, mainly with Bothrops jararaca venom, as well as an increase in the functional activity of macrophages. We also observed an increase in the number of mononuclear and polymorphonuclear cells with Bothrops jararaca venom. Considering these findings, we postulate that both Borhrops jararaca and Crotalus durissus terrificus venoms can act directly on tumor cells. In addition, we propose an indirect mechanism, based on the stimulation of the inflammatory response, to inhibit tumor growth and to promote its rejection.Ctr. Study Venoms Venomous Animals CEVAP-UNESP, Sao PauloCtr. Study Venoms Venomous Animals CEVAP-UNESP, Sao PauloUniversidade Estadual Paulista (Unesp)Da Silva, R. J. [UNESP]Fecchio, D. [UNESP]Barraviera, B. [UNESP]2014-05-27T11:18:03Z2014-05-27T11:18:03Z1996-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article79-90http://dx.doi.org/10.1590/S0104-79301996000200002Journal of Venomous Animals and Toxins, v. 2, n. 2, p. 79-90, 1996.0104-7930http://hdl.handle.net/11449/6471410.1590/S0104-79301996000200002S0104-793019960002000022-s2.0-0029830157Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Venomous Animals and Toxinsinfo:eu-repo/semantics/openAccess2024-04-11T15:28:16Zoai:repositorio.unesp.br:11449/64714Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-04-11T15:28:16Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Antitumor effect of snake venoms |
title |
Antitumor effect of snake venoms |
spellingShingle |
Antitumor effect of snake venoms Da Silva, R. J. [UNESP] Bothrops jararaca Cancer Crotalus durissus terrificus Inflammation Snakes Venom antineoplastic agent batroxobin interleukin 6 snake venom antineoplastic activity cancer inhibition cytolysis drug mechanism ehrlich ascites tumor cell human inflammation leukocyte count lymphokine activated killer cell macrophage mononuclear cell nonhuman polymorphonuclear cell review sarcoma snakebite tumor cell |
title_short |
Antitumor effect of snake venoms |
title_full |
Antitumor effect of snake venoms |
title_fullStr |
Antitumor effect of snake venoms |
title_full_unstemmed |
Antitumor effect of snake venoms |
title_sort |
Antitumor effect of snake venoms |
author |
Da Silva, R. J. [UNESP] |
author_facet |
Da Silva, R. J. [UNESP] Fecchio, D. [UNESP] Barraviera, B. [UNESP] |
author_role |
author |
author2 |
Fecchio, D. [UNESP] Barraviera, B. [UNESP] |
author2_role |
author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Da Silva, R. J. [UNESP] Fecchio, D. [UNESP] Barraviera, B. [UNESP] |
dc.subject.por.fl_str_mv |
Bothrops jararaca Cancer Crotalus durissus terrificus Inflammation Snakes Venom antineoplastic agent batroxobin interleukin 6 snake venom antineoplastic activity cancer inhibition cytolysis drug mechanism ehrlich ascites tumor cell human inflammation leukocyte count lymphokine activated killer cell macrophage mononuclear cell nonhuman polymorphonuclear cell review sarcoma snakebite tumor cell |
topic |
Bothrops jararaca Cancer Crotalus durissus terrificus Inflammation Snakes Venom antineoplastic agent batroxobin interleukin 6 snake venom antineoplastic activity cancer inhibition cytolysis drug mechanism ehrlich ascites tumor cell human inflammation leukocyte count lymphokine activated killer cell macrophage mononuclear cell nonhuman polymorphonuclear cell review sarcoma snakebite tumor cell |
description |
The search for biological antitumor agents has been pursued for over half a century. Snake venom has been shown to possess a wide spectrum of biological activities. The objectives of the present review are to evaluate the existing controversies on this subject published in a number of papers and to propose probable explanations for the phenomena observed. We reported our results obtained in a study, in which we evaluated the action of the venoms of Crotalus durissus terrificus and Bothrops jararaca on Ehrlich ascites tumor cells. We noticed an important antitumor effect, mainly with Bothrops jararaca venom, as well as an increase in the functional activity of macrophages. We also observed an increase in the number of mononuclear and polymorphonuclear cells with Bothrops jararaca venom. Considering these findings, we postulate that both Borhrops jararaca and Crotalus durissus terrificus venoms can act directly on tumor cells. In addition, we propose an indirect mechanism, based on the stimulation of the inflammatory response, to inhibit tumor growth and to promote its rejection. |
publishDate |
1996 |
dc.date.none.fl_str_mv |
1996-01-01 2014-05-27T11:18:03Z 2014-05-27T11:18:03Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S0104-79301996000200002 Journal of Venomous Animals and Toxins, v. 2, n. 2, p. 79-90, 1996. 0104-7930 http://hdl.handle.net/11449/64714 10.1590/S0104-79301996000200002 S0104-79301996000200002 2-s2.0-0029830157 |
url |
http://dx.doi.org/10.1590/S0104-79301996000200002 http://hdl.handle.net/11449/64714 |
identifier_str_mv |
Journal of Venomous Animals and Toxins, v. 2, n. 2, p. 79-90, 1996. 0104-7930 10.1590/S0104-79301996000200002 S0104-79301996000200002 2-s2.0-0029830157 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of Venomous Animals and Toxins |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
79-90 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799964435399311360 |