Riscos ocupacionais, danos no material genético e estresse oxidativo frente à exposição aos resíduos de gases anestésicos
Autor(a) principal: | |
---|---|
Data de Publicação: | 2018 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng por |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.bjan.2017.05.001 http://hdl.handle.net/11449/174797 |
Resumo: | Background and objectives The waste anesthetic gases (WAGs) present in the ambient air of operating rooms (OR), are associated with various occupational hazards. This paper intends to discuss occupational exposure to WAGs and its impact on exposed professionals, with emphasis on genetic damage and oxidative stress. Content Despite the emergence of safer inhaled anesthetics, occupational exposure to WAGs remains a current concern. Factors related to anesthetic techniques and anesthesia workstations, in addition to the absence of a scavenging system in the OR, contribute to anesthetic pollution. In order to minimize the health risks of exposed professionals, several countries have recommended legislation with maximum exposure limits. However, developing countries still require measurement of WAGs and regulation for occupational exposure to WAGs. WAGs are capable of inducing damage to the genetic material, such as DNA damage assessed using the comet assay and increased frequency of micronucleus in professionals with long‐term exposure. Oxidative stress is also associated with WAGs exposure, as it induces lipid peroxidation, oxidative damage in DNA, and impairment of the antioxidant defense system in exposed professionals. Conclusions The occupational hazards related to WAGs including genotoxicity, mutagenicity and oxidative stress, stand as a public health issue and must be acknowledged by exposed personnel and responsible authorities, especially in developing countries. Thus, it is urgent to stablish maximum safe limits of concentration of WAGs in ORs and educational practices and protocols for exposed professionals. |
id |
UNSP_9a6c8ce98edced32f0d3f1561f32934a |
---|---|
oai_identifier_str |
oai:repositorio.unesp.br:11449/174797 |
network_acronym_str |
UNSP |
network_name_str |
Repositório Institucional da UNESP |
repository_id_str |
2946 |
spelling |
Riscos ocupacionais, danos no material genético e estresse oxidativo frente à exposição aos resíduos de gases anestésicosOccupational hazards, DNA damage, and oxidative stress on exposure to waste anesthetic gasesEnvironment pollutionGenomic instabilityGenotoxicity testingInhaled anestheticsOccupational exposureOxidative stressBackground and objectives The waste anesthetic gases (WAGs) present in the ambient air of operating rooms (OR), are associated with various occupational hazards. This paper intends to discuss occupational exposure to WAGs and its impact on exposed professionals, with emphasis on genetic damage and oxidative stress. Content Despite the emergence of safer inhaled anesthetics, occupational exposure to WAGs remains a current concern. Factors related to anesthetic techniques and anesthesia workstations, in addition to the absence of a scavenging system in the OR, contribute to anesthetic pollution. In order to minimize the health risks of exposed professionals, several countries have recommended legislation with maximum exposure limits. However, developing countries still require measurement of WAGs and regulation for occupational exposure to WAGs. WAGs are capable of inducing damage to the genetic material, such as DNA damage assessed using the comet assay and increased frequency of micronucleus in professionals with long‐term exposure. Oxidative stress is also associated with WAGs exposure, as it induces lipid peroxidation, oxidative damage in DNA, and impairment of the antioxidant defense system in exposed professionals. Conclusions The occupational hazards related to WAGs including genotoxicity, mutagenicity and oxidative stress, stand as a public health issue and must be acknowledged by exposed personnel and responsible authorities, especially in developing countries. Thus, it is urgent to stablish maximum safe limits of concentration of WAGs in ORs and educational practices and protocols for exposed professionals.Universidade Estadual Paulista (Unesp) Faculdade de Medicina de Botucatu Departamento de AnestesiologiaUniversidade Estadual Paulista (Unesp) Faculdade de Medicina de Botucatu Departamento de AnestesiologiaUniversidade Estadual Paulista (Unesp)Lucio, Lorena M.C. [UNESP]Braz, Mariana G. [UNESP]do Nascimento Junior, Paulo [UNESP]Braz, José Reinaldo C. [UNESP]Braz, Leandro G. [UNESP]2018-12-11T17:12:54Z2018-12-11T17:12:54Z2018-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article33-41application/pdfhttp://dx.doi.org/10.1016/j.bjan.2017.05.001Brazilian Journal of Anesthesiology, v. 68, n. 1, p. 33-41, 2018.1806-907X0034-7094http://hdl.handle.net/11449/17479710.1016/j.bjan.2017.05.0012-s2.0-850212456812-s2.0-85021245681.pdf87453589896806000000-0002-2323-9159Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengporBrazilian Journal of Anesthesiology0,320info:eu-repo/semantics/openAccess2024-08-14T13:20:52Zoai:repositorio.unesp.br:11449/174797Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-14T13:20:52Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Riscos ocupacionais, danos no material genético e estresse oxidativo frente à exposição aos resíduos de gases anestésicos Occupational hazards, DNA damage, and oxidative stress on exposure to waste anesthetic gases |
title |
Riscos ocupacionais, danos no material genético e estresse oxidativo frente à exposição aos resíduos de gases anestésicos |
spellingShingle |
Riscos ocupacionais, danos no material genético e estresse oxidativo frente à exposição aos resíduos de gases anestésicos Lucio, Lorena M.C. [UNESP] Environment pollution Genomic instability Genotoxicity testing Inhaled anesthetics Occupational exposure Oxidative stress |
title_short |
Riscos ocupacionais, danos no material genético e estresse oxidativo frente à exposição aos resíduos de gases anestésicos |
title_full |
Riscos ocupacionais, danos no material genético e estresse oxidativo frente à exposição aos resíduos de gases anestésicos |
title_fullStr |
Riscos ocupacionais, danos no material genético e estresse oxidativo frente à exposição aos resíduos de gases anestésicos |
title_full_unstemmed |
Riscos ocupacionais, danos no material genético e estresse oxidativo frente à exposição aos resíduos de gases anestésicos |
title_sort |
Riscos ocupacionais, danos no material genético e estresse oxidativo frente à exposição aos resíduos de gases anestésicos |
author |
Lucio, Lorena M.C. [UNESP] |
author_facet |
Lucio, Lorena M.C. [UNESP] Braz, Mariana G. [UNESP] do Nascimento Junior, Paulo [UNESP] Braz, José Reinaldo C. [UNESP] Braz, Leandro G. [UNESP] |
author_role |
author |
author2 |
Braz, Mariana G. [UNESP] do Nascimento Junior, Paulo [UNESP] Braz, José Reinaldo C. [UNESP] Braz, Leandro G. [UNESP] |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Lucio, Lorena M.C. [UNESP] Braz, Mariana G. [UNESP] do Nascimento Junior, Paulo [UNESP] Braz, José Reinaldo C. [UNESP] Braz, Leandro G. [UNESP] |
dc.subject.por.fl_str_mv |
Environment pollution Genomic instability Genotoxicity testing Inhaled anesthetics Occupational exposure Oxidative stress |
topic |
Environment pollution Genomic instability Genotoxicity testing Inhaled anesthetics Occupational exposure Oxidative stress |
description |
Background and objectives The waste anesthetic gases (WAGs) present in the ambient air of operating rooms (OR), are associated with various occupational hazards. This paper intends to discuss occupational exposure to WAGs and its impact on exposed professionals, with emphasis on genetic damage and oxidative stress. Content Despite the emergence of safer inhaled anesthetics, occupational exposure to WAGs remains a current concern. Factors related to anesthetic techniques and anesthesia workstations, in addition to the absence of a scavenging system in the OR, contribute to anesthetic pollution. In order to minimize the health risks of exposed professionals, several countries have recommended legislation with maximum exposure limits. However, developing countries still require measurement of WAGs and regulation for occupational exposure to WAGs. WAGs are capable of inducing damage to the genetic material, such as DNA damage assessed using the comet assay and increased frequency of micronucleus in professionals with long‐term exposure. Oxidative stress is also associated with WAGs exposure, as it induces lipid peroxidation, oxidative damage in DNA, and impairment of the antioxidant defense system in exposed professionals. Conclusions The occupational hazards related to WAGs including genotoxicity, mutagenicity and oxidative stress, stand as a public health issue and must be acknowledged by exposed personnel and responsible authorities, especially in developing countries. Thus, it is urgent to stablish maximum safe limits of concentration of WAGs in ORs and educational practices and protocols for exposed professionals. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-12-11T17:12:54Z 2018-12-11T17:12:54Z 2018-01-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.bjan.2017.05.001 Brazilian Journal of Anesthesiology, v. 68, n. 1, p. 33-41, 2018. 1806-907X 0034-7094 http://hdl.handle.net/11449/174797 10.1016/j.bjan.2017.05.001 2-s2.0-85021245681 2-s2.0-85021245681.pdf 8745358989680600 0000-0002-2323-9159 |
url |
http://dx.doi.org/10.1016/j.bjan.2017.05.001 http://hdl.handle.net/11449/174797 |
identifier_str_mv |
Brazilian Journal of Anesthesiology, v. 68, n. 1, p. 33-41, 2018. 1806-907X 0034-7094 10.1016/j.bjan.2017.05.001 2-s2.0-85021245681 2-s2.0-85021245681.pdf 8745358989680600 0000-0002-2323-9159 |
dc.language.iso.fl_str_mv |
eng por |
language |
eng por |
dc.relation.none.fl_str_mv |
Brazilian Journal of Anesthesiology 0,320 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
33-41 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128198125289472 |