Metformin anticipates peak of lactate during high-intensity interval training but no changes performance or neuromuscular response in amateur swimmers

Detalhes bibliográficos
Autor(a) principal: Norberto, Matheus Silva
Data de Publicação: 2021
Outros Autores: De Arruda, Tarine Botta, Cursiol, Jonatas Augusto, De Andrade, Vitor Luiz [UNESP], De Araujo, Gustavo Gomes, Papoti, Marcelo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1016/j.clnesp.2021.09.739
http://hdl.handle.net/11449/222659
Resumo: Background & aims: Metformin demonstrated potential to improve metabolic efficiency in short-intense and prolonged-continuous efforts. The present study investigates the acute effects of metformin intake on performance, rating of perceived exertion (RPE), blood lactate, blood glucose and neuromuscular parameters related to swimming high-intensity interval series. Methods: A double-blind, crossover, randomized and placebo-controlled study was carried out. Seven healthy swimmers ingested metformin (500 mg) or placebo capsules on different days and performed a typical high-intensity training series (10 bouts of 50 m with a 3-min interval). Performance, RPE, neuromuscular parameters (lower and upper limbs), blood lactate and glucose were analyzed by the Wilcoxon Signed-Rank and Friedman's tests between supplementation situations and moments, respectively (p > 0.05), the moment where glucose and blood lactate peak were found were analyzed by a Student t-test (p > 0.05) and a Bayesian repeated-measures ANOVA for effects analysis (BFincl). Results: The anticipation of blood glucose and peak lactate was signaling by the interaction effect (metformin increased and placebo decreased) between the eighth and the last bout (BFincl: 4.230 and 5.188 respectively). The second interaction effect of blood glucose and lactate (metformin maintained and placebo increased) during recoveries between 5 min and 7 min (BFincl: 3.825 and 3.806 respectively) also signaling the anticipatory behavior of both physiological parameters. The anticipation of blood lactate peak concentration after metformin intake confirms the anticipatory behavior of blood lactate (p: 0.015). Conclusions: The anticipatory behavior of glucose was not confirmed. Although the anticipatory peak of blood lactate, metformin does not affect neuromuscular responses, RPE and performance. Registration of clinical trial: RBR-67wxdw8 Effects of metformin during swimmer training performance.
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spelling Metformin anticipates peak of lactate during high-intensity interval training but no changes performance or neuromuscular response in amateur swimmersBlood glucoseBlood lactateNeuromuscular fatigueSwimmingTypical series performanceBackground & aims: Metformin demonstrated potential to improve metabolic efficiency in short-intense and prolonged-continuous efforts. The present study investigates the acute effects of metformin intake on performance, rating of perceived exertion (RPE), blood lactate, blood glucose and neuromuscular parameters related to swimming high-intensity interval series. Methods: A double-blind, crossover, randomized and placebo-controlled study was carried out. Seven healthy swimmers ingested metformin (500 mg) or placebo capsules on different days and performed a typical high-intensity training series (10 bouts of 50 m with a 3-min interval). Performance, RPE, neuromuscular parameters (lower and upper limbs), blood lactate and glucose were analyzed by the Wilcoxon Signed-Rank and Friedman's tests between supplementation situations and moments, respectively (p > 0.05), the moment where glucose and blood lactate peak were found were analyzed by a Student t-test (p > 0.05) and a Bayesian repeated-measures ANOVA for effects analysis (BFincl). Results: The anticipation of blood glucose and peak lactate was signaling by the interaction effect (metformin increased and placebo decreased) between the eighth and the last bout (BFincl: 4.230 and 5.188 respectively). The second interaction effect of blood glucose and lactate (metformin maintained and placebo increased) during recoveries between 5 min and 7 min (BFincl: 3.825 and 3.806 respectively) also signaling the anticipatory behavior of both physiological parameters. The anticipation of blood lactate peak concentration after metformin intake confirms the anticipatory behavior of blood lactate (p: 0.015). Conclusions: The anticipatory behavior of glucose was not confirmed. Although the anticipatory peak of blood lactate, metformin does not affect neuromuscular responses, RPE and performance. Registration of clinical trial: RBR-67wxdw8 Effects of metformin during swimmer training performance.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)University of São Paulo Medical School of Ribeirão Preto (FMRP)University of São Paulo School of Physical Education and Sport of Ribeirão Preto (EEFERP-USP)Sao Paulo State University (UNESP) Institute of Biosciences and Postgraduate Program in Movement SciencesApplied Sport Science Research Group and Experimental Nutrition Laboratory Federal University of Alagoas (PPGNUT/PPGCS)Sao Paulo State University (UNESP) Institute of Biosciences and Postgraduate Program in Movement SciencesFAPESP: 2015/24833-7FAPESP: 2016/10029-4Universidade de São Paulo (USP)Universidade Estadual Paulista (UNESP)Federal University of Alagoas (PPGNUT/PPGCS)Norberto, Matheus SilvaDe Arruda, Tarine BottaCursiol, Jonatas AugustoDe Andrade, Vitor Luiz [UNESP]De Araujo, Gustavo GomesPapoti, Marcelo2022-04-28T19:45:59Z2022-04-28T19:45:59Z2021-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.clnesp.2021.09.739Clinical Nutrition ESPEN.2405-4577http://hdl.handle.net/11449/22265910.1016/j.clnesp.2021.09.7392-s2.0-85117221308Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengClinical Nutrition ESPENinfo:eu-repo/semantics/openAccess2022-04-28T19:45:59Zoai:repositorio.unesp.br:11449/222659Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462022-04-28T19:45:59Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Metformin anticipates peak of lactate during high-intensity interval training but no changes performance or neuromuscular response in amateur swimmers
title Metformin anticipates peak of lactate during high-intensity interval training but no changes performance or neuromuscular response in amateur swimmers
spellingShingle Metformin anticipates peak of lactate during high-intensity interval training but no changes performance or neuromuscular response in amateur swimmers
Norberto, Matheus Silva
Blood glucose
Blood lactate
Neuromuscular fatigue
Swimming
Typical series performance
title_short Metformin anticipates peak of lactate during high-intensity interval training but no changes performance or neuromuscular response in amateur swimmers
title_full Metformin anticipates peak of lactate during high-intensity interval training but no changes performance or neuromuscular response in amateur swimmers
title_fullStr Metformin anticipates peak of lactate during high-intensity interval training but no changes performance or neuromuscular response in amateur swimmers
title_full_unstemmed Metformin anticipates peak of lactate during high-intensity interval training but no changes performance or neuromuscular response in amateur swimmers
title_sort Metformin anticipates peak of lactate during high-intensity interval training but no changes performance or neuromuscular response in amateur swimmers
author Norberto, Matheus Silva
author_facet Norberto, Matheus Silva
De Arruda, Tarine Botta
Cursiol, Jonatas Augusto
De Andrade, Vitor Luiz [UNESP]
De Araujo, Gustavo Gomes
Papoti, Marcelo
author_role author
author2 De Arruda, Tarine Botta
Cursiol, Jonatas Augusto
De Andrade, Vitor Luiz [UNESP]
De Araujo, Gustavo Gomes
Papoti, Marcelo
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade de São Paulo (USP)
Universidade Estadual Paulista (UNESP)
Federal University of Alagoas (PPGNUT/PPGCS)
dc.contributor.author.fl_str_mv Norberto, Matheus Silva
De Arruda, Tarine Botta
Cursiol, Jonatas Augusto
De Andrade, Vitor Luiz [UNESP]
De Araujo, Gustavo Gomes
Papoti, Marcelo
dc.subject.por.fl_str_mv Blood glucose
Blood lactate
Neuromuscular fatigue
Swimming
Typical series performance
topic Blood glucose
Blood lactate
Neuromuscular fatigue
Swimming
Typical series performance
description Background & aims: Metformin demonstrated potential to improve metabolic efficiency in short-intense and prolonged-continuous efforts. The present study investigates the acute effects of metformin intake on performance, rating of perceived exertion (RPE), blood lactate, blood glucose and neuromuscular parameters related to swimming high-intensity interval series. Methods: A double-blind, crossover, randomized and placebo-controlled study was carried out. Seven healthy swimmers ingested metformin (500 mg) or placebo capsules on different days and performed a typical high-intensity training series (10 bouts of 50 m with a 3-min interval). Performance, RPE, neuromuscular parameters (lower and upper limbs), blood lactate and glucose were analyzed by the Wilcoxon Signed-Rank and Friedman's tests between supplementation situations and moments, respectively (p > 0.05), the moment where glucose and blood lactate peak were found were analyzed by a Student t-test (p > 0.05) and a Bayesian repeated-measures ANOVA for effects analysis (BFincl). Results: The anticipation of blood glucose and peak lactate was signaling by the interaction effect (metformin increased and placebo decreased) between the eighth and the last bout (BFincl: 4.230 and 5.188 respectively). The second interaction effect of blood glucose and lactate (metformin maintained and placebo increased) during recoveries between 5 min and 7 min (BFincl: 3.825 and 3.806 respectively) also signaling the anticipatory behavior of both physiological parameters. The anticipation of blood lactate peak concentration after metformin intake confirms the anticipatory behavior of blood lactate (p: 0.015). Conclusions: The anticipatory behavior of glucose was not confirmed. Although the anticipatory peak of blood lactate, metformin does not affect neuromuscular responses, RPE and performance. Registration of clinical trial: RBR-67wxdw8 Effects of metformin during swimmer training performance.
publishDate 2021
dc.date.none.fl_str_mv 2021-01-01
2022-04-28T19:45:59Z
2022-04-28T19:45:59Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/j.clnesp.2021.09.739
Clinical Nutrition ESPEN.
2405-4577
http://hdl.handle.net/11449/222659
10.1016/j.clnesp.2021.09.739
2-s2.0-85117221308
url http://dx.doi.org/10.1016/j.clnesp.2021.09.739
http://hdl.handle.net/11449/222659
identifier_str_mv Clinical Nutrition ESPEN.
2405-4577
10.1016/j.clnesp.2021.09.739
2-s2.0-85117221308
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Clinical Nutrition ESPEN
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv repositoriounesp@unesp.br
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