Metformin anticipates peak of lactate during high-intensity interval training but no changes performance or neuromuscular response in amateur swimmers
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.clnesp.2021.09.739 http://hdl.handle.net/11449/222659 |
Resumo: | Background & aims: Metformin demonstrated potential to improve metabolic efficiency in short-intense and prolonged-continuous efforts. The present study investigates the acute effects of metformin intake on performance, rating of perceived exertion (RPE), blood lactate, blood glucose and neuromuscular parameters related to swimming high-intensity interval series. Methods: A double-blind, crossover, randomized and placebo-controlled study was carried out. Seven healthy swimmers ingested metformin (500 mg) or placebo capsules on different days and performed a typical high-intensity training series (10 bouts of 50 m with a 3-min interval). Performance, RPE, neuromuscular parameters (lower and upper limbs), blood lactate and glucose were analyzed by the Wilcoxon Signed-Rank and Friedman's tests between supplementation situations and moments, respectively (p > 0.05), the moment where glucose and blood lactate peak were found were analyzed by a Student t-test (p > 0.05) and a Bayesian repeated-measures ANOVA for effects analysis (BFincl). Results: The anticipation of blood glucose and peak lactate was signaling by the interaction effect (metformin increased and placebo decreased) between the eighth and the last bout (BFincl: 4.230 and 5.188 respectively). The second interaction effect of blood glucose and lactate (metformin maintained and placebo increased) during recoveries between 5 min and 7 min (BFincl: 3.825 and 3.806 respectively) also signaling the anticipatory behavior of both physiological parameters. The anticipation of blood lactate peak concentration after metformin intake confirms the anticipatory behavior of blood lactate (p: 0.015). Conclusions: The anticipatory behavior of glucose was not confirmed. Although the anticipatory peak of blood lactate, metformin does not affect neuromuscular responses, RPE and performance. Registration of clinical trial: RBR-67wxdw8 Effects of metformin during swimmer training performance. |
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Repositório Institucional da UNESP |
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Metformin anticipates peak of lactate during high-intensity interval training but no changes performance or neuromuscular response in amateur swimmersBlood glucoseBlood lactateNeuromuscular fatigueSwimmingTypical series performanceBackground & aims: Metformin demonstrated potential to improve metabolic efficiency in short-intense and prolonged-continuous efforts. The present study investigates the acute effects of metformin intake on performance, rating of perceived exertion (RPE), blood lactate, blood glucose and neuromuscular parameters related to swimming high-intensity interval series. Methods: A double-blind, crossover, randomized and placebo-controlled study was carried out. Seven healthy swimmers ingested metformin (500 mg) or placebo capsules on different days and performed a typical high-intensity training series (10 bouts of 50 m with a 3-min interval). Performance, RPE, neuromuscular parameters (lower and upper limbs), blood lactate and glucose were analyzed by the Wilcoxon Signed-Rank and Friedman's tests between supplementation situations and moments, respectively (p > 0.05), the moment where glucose and blood lactate peak were found were analyzed by a Student t-test (p > 0.05) and a Bayesian repeated-measures ANOVA for effects analysis (BFincl). Results: The anticipation of blood glucose and peak lactate was signaling by the interaction effect (metformin increased and placebo decreased) between the eighth and the last bout (BFincl: 4.230 and 5.188 respectively). The second interaction effect of blood glucose and lactate (metformin maintained and placebo increased) during recoveries between 5 min and 7 min (BFincl: 3.825 and 3.806 respectively) also signaling the anticipatory behavior of both physiological parameters. The anticipation of blood lactate peak concentration after metformin intake confirms the anticipatory behavior of blood lactate (p: 0.015). Conclusions: The anticipatory behavior of glucose was not confirmed. Although the anticipatory peak of blood lactate, metformin does not affect neuromuscular responses, RPE and performance. Registration of clinical trial: RBR-67wxdw8 Effects of metformin during swimmer training performance.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)University of São Paulo Medical School of Ribeirão Preto (FMRP)University of São Paulo School of Physical Education and Sport of Ribeirão Preto (EEFERP-USP)Sao Paulo State University (UNESP) Institute of Biosciences and Postgraduate Program in Movement SciencesApplied Sport Science Research Group and Experimental Nutrition Laboratory Federal University of Alagoas (PPGNUT/PPGCS)Sao Paulo State University (UNESP) Institute of Biosciences and Postgraduate Program in Movement SciencesFAPESP: 2015/24833-7FAPESP: 2016/10029-4Universidade de São Paulo (USP)Universidade Estadual Paulista (UNESP)Federal University of Alagoas (PPGNUT/PPGCS)Norberto, Matheus SilvaDe Arruda, Tarine BottaCursiol, Jonatas AugustoDe Andrade, Vitor Luiz [UNESP]De Araujo, Gustavo GomesPapoti, Marcelo2022-04-28T19:45:59Z2022-04-28T19:45:59Z2021-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.clnesp.2021.09.739Clinical Nutrition ESPEN.2405-4577http://hdl.handle.net/11449/22265910.1016/j.clnesp.2021.09.7392-s2.0-85117221308Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengClinical Nutrition ESPENinfo:eu-repo/semantics/openAccess2022-04-28T19:45:59Zoai:repositorio.unesp.br:11449/222659Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462022-04-28T19:45:59Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Metformin anticipates peak of lactate during high-intensity interval training but no changes performance or neuromuscular response in amateur swimmers |
title |
Metformin anticipates peak of lactate during high-intensity interval training but no changes performance or neuromuscular response in amateur swimmers |
spellingShingle |
Metformin anticipates peak of lactate during high-intensity interval training but no changes performance or neuromuscular response in amateur swimmers Norberto, Matheus Silva Blood glucose Blood lactate Neuromuscular fatigue Swimming Typical series performance |
title_short |
Metformin anticipates peak of lactate during high-intensity interval training but no changes performance or neuromuscular response in amateur swimmers |
title_full |
Metformin anticipates peak of lactate during high-intensity interval training but no changes performance or neuromuscular response in amateur swimmers |
title_fullStr |
Metformin anticipates peak of lactate during high-intensity interval training but no changes performance or neuromuscular response in amateur swimmers |
title_full_unstemmed |
Metformin anticipates peak of lactate during high-intensity interval training but no changes performance or neuromuscular response in amateur swimmers |
title_sort |
Metformin anticipates peak of lactate during high-intensity interval training but no changes performance or neuromuscular response in amateur swimmers |
author |
Norberto, Matheus Silva |
author_facet |
Norberto, Matheus Silva De Arruda, Tarine Botta Cursiol, Jonatas Augusto De Andrade, Vitor Luiz [UNESP] De Araujo, Gustavo Gomes Papoti, Marcelo |
author_role |
author |
author2 |
De Arruda, Tarine Botta Cursiol, Jonatas Augusto De Andrade, Vitor Luiz [UNESP] De Araujo, Gustavo Gomes Papoti, Marcelo |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade de São Paulo (USP) Universidade Estadual Paulista (UNESP) Federal University of Alagoas (PPGNUT/PPGCS) |
dc.contributor.author.fl_str_mv |
Norberto, Matheus Silva De Arruda, Tarine Botta Cursiol, Jonatas Augusto De Andrade, Vitor Luiz [UNESP] De Araujo, Gustavo Gomes Papoti, Marcelo |
dc.subject.por.fl_str_mv |
Blood glucose Blood lactate Neuromuscular fatigue Swimming Typical series performance |
topic |
Blood glucose Blood lactate Neuromuscular fatigue Swimming Typical series performance |
description |
Background & aims: Metformin demonstrated potential to improve metabolic efficiency in short-intense and prolonged-continuous efforts. The present study investigates the acute effects of metformin intake on performance, rating of perceived exertion (RPE), blood lactate, blood glucose and neuromuscular parameters related to swimming high-intensity interval series. Methods: A double-blind, crossover, randomized and placebo-controlled study was carried out. Seven healthy swimmers ingested metformin (500 mg) or placebo capsules on different days and performed a typical high-intensity training series (10 bouts of 50 m with a 3-min interval). Performance, RPE, neuromuscular parameters (lower and upper limbs), blood lactate and glucose were analyzed by the Wilcoxon Signed-Rank and Friedman's tests between supplementation situations and moments, respectively (p > 0.05), the moment where glucose and blood lactate peak were found were analyzed by a Student t-test (p > 0.05) and a Bayesian repeated-measures ANOVA for effects analysis (BFincl). Results: The anticipation of blood glucose and peak lactate was signaling by the interaction effect (metformin increased and placebo decreased) between the eighth and the last bout (BFincl: 4.230 and 5.188 respectively). The second interaction effect of blood glucose and lactate (metformin maintained and placebo increased) during recoveries between 5 min and 7 min (BFincl: 3.825 and 3.806 respectively) also signaling the anticipatory behavior of both physiological parameters. The anticipation of blood lactate peak concentration after metformin intake confirms the anticipatory behavior of blood lactate (p: 0.015). Conclusions: The anticipatory behavior of glucose was not confirmed. Although the anticipatory peak of blood lactate, metformin does not affect neuromuscular responses, RPE and performance. Registration of clinical trial: RBR-67wxdw8 Effects of metformin during swimmer training performance. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-01-01 2022-04-28T19:45:59Z 2022-04-28T19:45:59Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.clnesp.2021.09.739 Clinical Nutrition ESPEN. 2405-4577 http://hdl.handle.net/11449/222659 10.1016/j.clnesp.2021.09.739 2-s2.0-85117221308 |
url |
http://dx.doi.org/10.1016/j.clnesp.2021.09.739 http://hdl.handle.net/11449/222659 |
identifier_str_mv |
Clinical Nutrition ESPEN. 2405-4577 10.1016/j.clnesp.2021.09.739 2-s2.0-85117221308 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Clinical Nutrition ESPEN |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
repositoriounesp@unesp.br |
_version_ |
1826304285305995264 |