Análise da regeneração óssea alveolar de ratas ovariectomizadas tratadas com Raloxifeno e água fluoretada

• Autor(a) principal: Rossi, Ana Cláudia [UNESP]
• Data de Publicação: 2009
• Tipo de documento: Trabalho de conclusão de curso
• Idioma: por
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://hdl.handle.net/11449/156332; http://www.athena.biblioteca.unesp.br/exlibris/bd/capelo/2018-03-06/000896557.pdf
• topic: Osteoporose; Cloridrato de raloxifeno; Ovariectomia; Menopausa; Regeneração óssea; Osteoporosis

Decreased plasma concentration of estrogen (E2) alters the function of systems and results in significant loss of bone mass. The hormone replacement seems to be able to prevent bone resorption and reduce the risk of fractures. Furthermore, studies indicate the importance of fluoride in the composition and incorporation of the calcium present in bone, giving it greater resistance. This research established whether the combination of fluoride and raloxifene (selective modulator of estrogen receptors) improve bone quality in ovariectomized rats. Seven days after ovariectomy (OVX), Wistar rats (6 m) received raloxifene (1 mg / kg bw / day) to gavage for 6 months. During this period the rats drunks distilled water and distilled water + NaF/20 or 40 ppm. Twenty eight days before the specified period, the tooth extraction was performed to analyze the process of alveolar bone regeneration in animals subjected to different treatments. After six months of treatment, animals were anesthetized for blood collection. Femurs and the jaws were removed for analysis during biomechanics and the process of alveolar bone regeneration, respectively. With plasm, there was total serum calcium, phosphorus and alkaline phosphatase. The combination of these therapies didn't result in improvement in mechanical strength of experimental groups. The results suggest that the association of anabolic therapy and antireabsorptive triggered changes in the metabolism of phosphorus and alkaline phosphatase, but didn't alter the plasm calcium concentration between experimental groups. Alveolar bone regeneration was found qualitative and quantitative improvements to administrative RLX is associated with NaF 20 ppm