Cholesterol-lowering effect of whole lupin (Lupinus albus) seed and its protein isolate

Detalhes bibliográficos
Autor(a) principal: Fontanari, Gustavo Guadagnucci [UNESP]
Data de Publicação: 2012
Outros Autores: Batistuti, José Paschoal [UNESP], da Cruz, Robison Jose, Nascimento Saldiva, Paulo Hilario, Gomes Areas, Jose Alfredo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1016/j.foodchem.2011.11.145
http://hdl.handle.net/11449/7212
Resumo: This study describes the hypocholesterolaemic effect of whole lupin and its protein in hamsters. The diets were: casein (control group HC), lupin protein isolate (group HPI) and whole lupin seed (group HWS). Diets from HPI and HWS promoted a significant reduction of total cholesterol and non-HDL cholesterol in the hamsters' plasma as compared with HC. The true digestibility of HPI and HC groups were similar and differed significantly from the HWS one, which in turn showed a significant difference in total sterol excretion as compared to the former groups. Histological analysis of the liver revealed that animals fed on HPI and HWS diets presented a low level of steatosis (level 1) as compared to the ones fed on HC diet (level 4). Our findings demonstrate that protein isolate from Lupinus albus from Brazil has a metabolic effect on endogenous cholesterol metabolism and a protector effect on development of hepatic steatosis. (C) 2011 Elsevier Ltd. All rights reserved.
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spelling Cholesterol-lowering effect of whole lupin (Lupinus albus) seed and its protein isolateLupinus albusProtein isolateCholesterolHypocholesterolemiaSteatosisHamstersThis study describes the hypocholesterolaemic effect of whole lupin and its protein in hamsters. The diets were: casein (control group HC), lupin protein isolate (group HPI) and whole lupin seed (group HWS). Diets from HPI and HWS promoted a significant reduction of total cholesterol and non-HDL cholesterol in the hamsters' plasma as compared with HC. The true digestibility of HPI and HC groups were similar and differed significantly from the HWS one, which in turn showed a significant difference in total sterol excretion as compared to the former groups. Histological analysis of the liver revealed that animals fed on HPI and HWS diets presented a low level of steatosis (level 1) as compared to the ones fed on HC diet (level 4). Our findings demonstrate that protein isolate from Lupinus albus from Brazil has a metabolic effect on endogenous cholesterol metabolism and a protector effect on development of hepatic steatosis. (C) 2011 Elsevier Ltd. All rights reserved.Predilecta Foods (Sao Lourenco do Turvo, SP, Brazil)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Programa de Apoio ao Desenvolvimento Científico da Faculdade de Ciências Farmacêuticas da UNESP (PADC)Univ São Paulo, Fac Saúde Publ, Dept Nutr, BR-01246904 São Paulo, BrazilUNESP, Fac Ciencias Farmaceut, Dept Alimentos & Nutr, BR-14801902 Araraquara, SP, BrazilUniv São Paulo, Fac Med, Ctr Bioterismo, BR-01246903 São Paulo, BrazilUniv São Paulo, Fac Med, Dept Patol, BR-01246903 São Paulo, BrazilUNESP, Fac Ciencias Farmaceut, Dept Alimentos & Nutr, BR-14801902 Araraquara, SP, BrazilElsevier B.V.Universidade de São Paulo (USP)Universidade Estadual Paulista (Unesp)Fontanari, Gustavo Guadagnucci [UNESP]Batistuti, José Paschoal [UNESP]da Cruz, Robison JoseNascimento Saldiva, Paulo HilarioGomes Areas, Jose Alfredo2014-05-20T13:23:44Z2014-05-20T13:23:44Z2012-06-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1521-1526application/pdfhttp://dx.doi.org/10.1016/j.foodchem.2011.11.145Food Chemistry. Oxford: Elsevier B.V., v. 132, n. 3, p. 1521-1526, 2012.0308-8146http://hdl.handle.net/11449/721210.1016/j.foodchem.2011.11.145WOS:000301022400055WOS000301022400055.pdf6406973152069497Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengFood Chemistry4.9461,793info:eu-repo/semantics/openAccess2024-06-21T12:46:32Zoai:repositorio.unesp.br:11449/7212Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T13:54:46.767379Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Cholesterol-lowering effect of whole lupin (Lupinus albus) seed and its protein isolate
title Cholesterol-lowering effect of whole lupin (Lupinus albus) seed and its protein isolate
spellingShingle Cholesterol-lowering effect of whole lupin (Lupinus albus) seed and its protein isolate
Fontanari, Gustavo Guadagnucci [UNESP]
Lupinus albus
Protein isolate
Cholesterol
Hypocholesterolemia
Steatosis
Hamsters
title_short Cholesterol-lowering effect of whole lupin (Lupinus albus) seed and its protein isolate
title_full Cholesterol-lowering effect of whole lupin (Lupinus albus) seed and its protein isolate
title_fullStr Cholesterol-lowering effect of whole lupin (Lupinus albus) seed and its protein isolate
title_full_unstemmed Cholesterol-lowering effect of whole lupin (Lupinus albus) seed and its protein isolate
title_sort Cholesterol-lowering effect of whole lupin (Lupinus albus) seed and its protein isolate
author Fontanari, Gustavo Guadagnucci [UNESP]
author_facet Fontanari, Gustavo Guadagnucci [UNESP]
Batistuti, José Paschoal [UNESP]
da Cruz, Robison Jose
Nascimento Saldiva, Paulo Hilario
Gomes Areas, Jose Alfredo
author_role author
author2 Batistuti, José Paschoal [UNESP]
da Cruz, Robison Jose
Nascimento Saldiva, Paulo Hilario
Gomes Areas, Jose Alfredo
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade de São Paulo (USP)
Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Fontanari, Gustavo Guadagnucci [UNESP]
Batistuti, José Paschoal [UNESP]
da Cruz, Robison Jose
Nascimento Saldiva, Paulo Hilario
Gomes Areas, Jose Alfredo
dc.subject.por.fl_str_mv Lupinus albus
Protein isolate
Cholesterol
Hypocholesterolemia
Steatosis
Hamsters
topic Lupinus albus
Protein isolate
Cholesterol
Hypocholesterolemia
Steatosis
Hamsters
description This study describes the hypocholesterolaemic effect of whole lupin and its protein in hamsters. The diets were: casein (control group HC), lupin protein isolate (group HPI) and whole lupin seed (group HWS). Diets from HPI and HWS promoted a significant reduction of total cholesterol and non-HDL cholesterol in the hamsters' plasma as compared with HC. The true digestibility of HPI and HC groups were similar and differed significantly from the HWS one, which in turn showed a significant difference in total sterol excretion as compared to the former groups. Histological analysis of the liver revealed that animals fed on HPI and HWS diets presented a low level of steatosis (level 1) as compared to the ones fed on HC diet (level 4). Our findings demonstrate that protein isolate from Lupinus albus from Brazil has a metabolic effect on endogenous cholesterol metabolism and a protector effect on development of hepatic steatosis. (C) 2011 Elsevier Ltd. All rights reserved.
publishDate 2012
dc.date.none.fl_str_mv 2012-06-01
2014-05-20T13:23:44Z
2014-05-20T13:23:44Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/j.foodchem.2011.11.145
Food Chemistry. Oxford: Elsevier B.V., v. 132, n. 3, p. 1521-1526, 2012.
0308-8146
http://hdl.handle.net/11449/7212
10.1016/j.foodchem.2011.11.145
WOS:000301022400055
WOS000301022400055.pdf
6406973152069497
url http://dx.doi.org/10.1016/j.foodchem.2011.11.145
http://hdl.handle.net/11449/7212
identifier_str_mv Food Chemistry. Oxford: Elsevier B.V., v. 132, n. 3, p. 1521-1526, 2012.
0308-8146
10.1016/j.foodchem.2011.11.145
WOS:000301022400055
WOS000301022400055.pdf
6406973152069497
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Food Chemistry
4.946
1,793
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 1521-1526
application/pdf
dc.publisher.none.fl_str_mv Elsevier B.V.
publisher.none.fl_str_mv Elsevier B.V.
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1808128289278001152

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