Replication of overmolded orthopedic implants with a functionalized thin layer of biodegradable polymer
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.3390/polym10070707 http://hdl.handle.net/11449/171148 |
Resumo: | The present paper reports on the development of a biodegradable overmolded orthopedic implant: a metal bone fixing screw, which has been overmolded with a functionalized thin layer of biodegradable polymer to enhance cell adhesion during the healing process. The main challenges were to integrate precise, high-throughput and repeatable solutions to achieve a thin, defect-free structured polymer layer and to ensure a high and consistent implant quality. The work carried out entailed determining proper materials (Purasorb PDLG 5010) for the biodegradable overmolding layer and its economical substitute (NaKu PLA 100HF) to be used during initial tool and process development, designing the surface structure of the overmolded polymer layer, development of injection molding tools, as well as feeding and handling procedures. The injection overmolding process of Purasorb PDLG 5010 polymer was controlled, and the process parameters were optimized. In particular, the dominant process parameters for the overmolding, namely injection pressure, barrel temperature and mold temperature, were experimentally examined using a circumscribed three-factor central composite design and two quality marks; overmolding roughness and mass of polymer. The analysis of the experimental results shows that the mass of the overmolding is not feasible for use as the quality mark. However, the optimal parameters for the overmolding of a metallic implant screw with a thin, micro-structured polymer layer with a predefined roughness of the surface texture have been identified successfully. |
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Replication of overmolded orthopedic implants with a functionalized thin layer of biodegradable polymerBiodegradable polymerFunctionalized surfaceMicro injection moldingOrthopedic implantsProcess optimizationThe present paper reports on the development of a biodegradable overmolded orthopedic implant: a metal bone fixing screw, which has been overmolded with a functionalized thin layer of biodegradable polymer to enhance cell adhesion during the healing process. The main challenges were to integrate precise, high-throughput and repeatable solutions to achieve a thin, defect-free structured polymer layer and to ensure a high and consistent implant quality. The work carried out entailed determining proper materials (Purasorb PDLG 5010) for the biodegradable overmolding layer and its economical substitute (NaKu PLA 100HF) to be used during initial tool and process development, designing the surface structure of the overmolded polymer layer, development of injection molding tools, as well as feeding and handling procedures. The injection overmolding process of Purasorb PDLG 5010 polymer was controlled, and the process parameters were optimized. In particular, the dominant process parameters for the overmolding, namely injection pressure, barrel temperature and mold temperature, were experimentally examined using a circumscribed three-factor central composite design and two quality marks; overmolding roughness and mass of polymer. The analysis of the experimental results shows that the mass of the overmolding is not feasible for use as the quality mark. However, the optimal parameters for the overmolding of a metallic implant screw with a thin, micro-structured polymer layer with a predefined roughness of the surface texture have been identified successfully.Institute for Automation and Applied Informatics Karlsruhe Institute of TechnologyFaculty of Engineering Port Said UniversityIK4-TEKNIKER, c/Iñaki Goenaga 5Wittmann Battenfeld GmbHRHP Technology GmbHErnst Wittner Ges. m. b. H.Alicona Imaging GmbHFaculdade de Engenharia Universidade Estadual Paulista (Unesp)Faculdade de Engenharia Universidade Estadual Paulista (Unesp)Karlsruhe Institute of TechnologyPort Said UniversityIK4-TEKNIKERWittmann Battenfeld GmbHRHP Technology GmbHErnst Wittner Ges. m. b. H.Alicona Imaging GmbHUniversidade Estadual Paulista (Unesp)Elkaseer, AhmedMueller, TobiasAzcarate, SabinoPhilipp-Pichler, MartinWilfinger, ThomasWittner, WolfgangPrantl, ManfredSampaio, Daniel [UNESP]Hagenmeyer, VeitScholz, Steffen2018-12-11T16:54:06Z2018-12-11T16:54:06Z2018-06-26info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://dx.doi.org/10.3390/polym10070707Polymers, v. 10, n. 7, 2018.2073-4360http://hdl.handle.net/11449/17114810.3390/polym100707072-s2.0-850491574252-s2.0-85049157425.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengPolymers0,852info:eu-repo/semantics/openAccess2023-12-29T06:15:16Zoai:repositorio.unesp.br:11449/171148Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T21:33:40.907336Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Replication of overmolded orthopedic implants with a functionalized thin layer of biodegradable polymer |
title |
Replication of overmolded orthopedic implants with a functionalized thin layer of biodegradable polymer |
spellingShingle |
Replication of overmolded orthopedic implants with a functionalized thin layer of biodegradable polymer Elkaseer, Ahmed Biodegradable polymer Functionalized surface Micro injection molding Orthopedic implants Process optimization |
title_short |
Replication of overmolded orthopedic implants with a functionalized thin layer of biodegradable polymer |
title_full |
Replication of overmolded orthopedic implants with a functionalized thin layer of biodegradable polymer |
title_fullStr |
Replication of overmolded orthopedic implants with a functionalized thin layer of biodegradable polymer |
title_full_unstemmed |
Replication of overmolded orthopedic implants with a functionalized thin layer of biodegradable polymer |
title_sort |
Replication of overmolded orthopedic implants with a functionalized thin layer of biodegradable polymer |
author |
Elkaseer, Ahmed |
author_facet |
Elkaseer, Ahmed Mueller, Tobias Azcarate, Sabino Philipp-Pichler, Martin Wilfinger, Thomas Wittner, Wolfgang Prantl, Manfred Sampaio, Daniel [UNESP] Hagenmeyer, Veit Scholz, Steffen |
author_role |
author |
author2 |
Mueller, Tobias Azcarate, Sabino Philipp-Pichler, Martin Wilfinger, Thomas Wittner, Wolfgang Prantl, Manfred Sampaio, Daniel [UNESP] Hagenmeyer, Veit Scholz, Steffen |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Karlsruhe Institute of Technology Port Said University IK4-TEKNIKER Wittmann Battenfeld GmbH RHP Technology GmbH Ernst Wittner Ges. m. b. H. Alicona Imaging GmbH Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Elkaseer, Ahmed Mueller, Tobias Azcarate, Sabino Philipp-Pichler, Martin Wilfinger, Thomas Wittner, Wolfgang Prantl, Manfred Sampaio, Daniel [UNESP] Hagenmeyer, Veit Scholz, Steffen |
dc.subject.por.fl_str_mv |
Biodegradable polymer Functionalized surface Micro injection molding Orthopedic implants Process optimization |
topic |
Biodegradable polymer Functionalized surface Micro injection molding Orthopedic implants Process optimization |
description |
The present paper reports on the development of a biodegradable overmolded orthopedic implant: a metal bone fixing screw, which has been overmolded with a functionalized thin layer of biodegradable polymer to enhance cell adhesion during the healing process. The main challenges were to integrate precise, high-throughput and repeatable solutions to achieve a thin, defect-free structured polymer layer and to ensure a high and consistent implant quality. The work carried out entailed determining proper materials (Purasorb PDLG 5010) for the biodegradable overmolding layer and its economical substitute (NaKu PLA 100HF) to be used during initial tool and process development, designing the surface structure of the overmolded polymer layer, development of injection molding tools, as well as feeding and handling procedures. The injection overmolding process of Purasorb PDLG 5010 polymer was controlled, and the process parameters were optimized. In particular, the dominant process parameters for the overmolding, namely injection pressure, barrel temperature and mold temperature, were experimentally examined using a circumscribed three-factor central composite design and two quality marks; overmolding roughness and mass of polymer. The analysis of the experimental results shows that the mass of the overmolding is not feasible for use as the quality mark. However, the optimal parameters for the overmolding of a metallic implant screw with a thin, micro-structured polymer layer with a predefined roughness of the surface texture have been identified successfully. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-12-11T16:54:06Z 2018-12-11T16:54:06Z 2018-06-26 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.3390/polym10070707 Polymers, v. 10, n. 7, 2018. 2073-4360 http://hdl.handle.net/11449/171148 10.3390/polym10070707 2-s2.0-85049157425 2-s2.0-85049157425.pdf |
url |
http://dx.doi.org/10.3390/polym10070707 http://hdl.handle.net/11449/171148 |
identifier_str_mv |
Polymers, v. 10, n. 7, 2018. 2073-4360 10.3390/polym10070707 2-s2.0-85049157425 2-s2.0-85049157425.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Polymers 0,852 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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1808129335602708480 |