The oldest unvaccinated Covid-19 survivors in South America

• Autor(a) principal: de Castro, Mateus V.
• Data de Publicação: 2022
• Outros Autores: Silva, Monize V. R., Naslavsky, Michel S., Scliar, Marilia O., Nunes, Kelly, Passos-Bueno, Maria Rita, Castelli, Erick C. [UNESP], Magawa, Jhosiene Y., Adami, Flávia L., Moretti, Ana I. S., de Oliveira, Vivian L., Boscardin, Silvia B., Cunha-Neto, Edecio, Kalil, Jorge, Jouanguy, Emmanuelle, Bastard, Paul, Casanova, Jean-Laurent, Quiñones-Vega, Mauricio, Sosa-Acosta, Patricia, de Guedes, Jéssica S., de Almeida, Natália P., Nogueira, Fábio C. S., Domont, Gilberto B., Santos, Keity S., Zatz, Mayana
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://dx.doi.org/10.1186/s12979-022-00310-y; http://hdl.handle.net/11449/249002
• topic: Covid-19; Elderly; SARS-CoV-2; Supercentenarians

Background: Although older adults are at a high risk of severe or critical Covid-19, there are many cases of unvaccinated centenarians who had a silent infection or recovered from mild or moderate Covid-19. We studied three Brazilian supercentenarians, older than 110 years, who survived Covid-19 in 2020 before being vaccinated. Results: Despite their advanced age, humoral immune response analysis showed that these individuals displayed robust levels of IgG and neutralizing antibodies (NAbs) against SARS-CoV-2. Enrichment of plasma proteins and metabolites related to innate immune response and host defense was also observed. None presented autoantibodies (auto-Abs) to type I interferon (IFN). Furthermore, these supercentenarians do not carry rare variants in genes underlying the known inborn errors of immunity, including particular inborn errors of type I IFN. Conclusion: These observations suggest that their Covid-19 resilience might be a combination of their genetic background and their innate and adaptive immunity.