Gene flow networks among American Aedes aegypti populations
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1111/j.1752-4571.2012.00244.x http://hdl.handle.net/11449/18770 |
Resumo: | The mosquito Aedes aegypti, the dengue virus vector, has spread throughout the tropics in historical times. While this suggests man-mediated dispersal, estimating contemporary connectivity among populations has remained elusive. Here, we use a large mtDNA dataset and a Bayesian coalescent framework to test a set of hypotheses about gene flow among American Ae. aegypti populations. We assessed gene flow patterns at the continental and subregional (Amazon basin) scales. For the Americas, our data favor a stepping-stone model in which gene flow is higher among adjacent populations but in which, at the same time, North American and southeastern Brazilian populations are directly connected, likely via sea trade. Within Amazonia, the model with highest support suggests extensive gene flow among major cities; Manaus, located at the center of the subregional transport network, emerges as a potentially important connecting hub. Our results suggest substantial connectivity across Ae. aegypti populations in the Americas. As long-distance active dispersal has not been observed in this species, our data support man-mediated dispersal as a major determinant of the genetic structure of American Ae. aegypti populations. The inferred topology of interpopulation connectivity can inform network models of Ae. aegypti and dengue spread. |
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Gene flow networks among American Aedes aegypti populationsAmazoniacoalescentdenguedisease spreadMigrate-NND4networksThe mosquito Aedes aegypti, the dengue virus vector, has spread throughout the tropics in historical times. While this suggests man-mediated dispersal, estimating contemporary connectivity among populations has remained elusive. Here, we use a large mtDNA dataset and a Bayesian coalescent framework to test a set of hypotheses about gene flow among American Ae. aegypti populations. We assessed gene flow patterns at the continental and subregional (Amazon basin) scales. For the Americas, our data favor a stepping-stone model in which gene flow is higher among adjacent populations but in which, at the same time, North American and southeastern Brazilian populations are directly connected, likely via sea trade. Within Amazonia, the model with highest support suggests extensive gene flow among major cities; Manaus, located at the center of the subregional transport network, emerges as a potentially important connecting hub. Our results suggest substantial connectivity across Ae. aegypti populations in the Americas. As long-distance active dispersal has not been observed in this species, our data support man-mediated dispersal as a major determinant of the genetic structure of American Ae. aegypti populations. The inferred topology of interpopulation connectivity can inform network models of Ae. aegypti and dengue spread.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado do Amazonas (FAPEAM)CSIRO, Div Marine & Atmospher Res, Hobart, Tas 7000, AustraliaFiocruz Amazonia, ILMD, Manaus, Amazonas, BrazilUniv Estadual Paulista UNESP, São Paulo, BrazilUniv Estadual Paulista UNESP, São Paulo, BrazilWiley-BlackwellCSIROFiocruz AmazoniaUniversidade Estadual Paulista (Unesp)da Silva, Anders GoncalvesCunha, Ivana C. L.Santos, Walter S.Luz, Sergio L. B.Ribolla, Paulo E. M. [UNESP]Abad-Franch, Fernando2014-05-20T13:52:35Z2014-05-20T13:52:35Z2012-11-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article664-676application/pdfhttp://dx.doi.org/10.1111/j.1752-4571.2012.00244.xEvolutionary Applications. Hoboken: Wiley-blackwell, v. 5, n. 7, p. 664-676, 2012.1752-4571http://hdl.handle.net/11449/1877010.1111/j.1752-4571.2012.00244.xWOS:000310543800002WOS000310543800002.pdf35771497484568800000-0001-8735-6090Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengEvolutionary Applications4.6942,676info:eu-repo/semantics/openAccess2023-12-31T06:20:19Zoai:repositorio.unesp.br:11449/18770Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T21:47:28.818563Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Gene flow networks among American Aedes aegypti populations |
title |
Gene flow networks among American Aedes aegypti populations |
spellingShingle |
Gene flow networks among American Aedes aegypti populations da Silva, Anders Goncalves Amazonia coalescent dengue disease spread Migrate-N ND4 networks |
title_short |
Gene flow networks among American Aedes aegypti populations |
title_full |
Gene flow networks among American Aedes aegypti populations |
title_fullStr |
Gene flow networks among American Aedes aegypti populations |
title_full_unstemmed |
Gene flow networks among American Aedes aegypti populations |
title_sort |
Gene flow networks among American Aedes aegypti populations |
author |
da Silva, Anders Goncalves |
author_facet |
da Silva, Anders Goncalves Cunha, Ivana C. L. Santos, Walter S. Luz, Sergio L. B. Ribolla, Paulo E. M. [UNESP] Abad-Franch, Fernando |
author_role |
author |
author2 |
Cunha, Ivana C. L. Santos, Walter S. Luz, Sergio L. B. Ribolla, Paulo E. M. [UNESP] Abad-Franch, Fernando |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
CSIRO Fiocruz Amazonia Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
da Silva, Anders Goncalves Cunha, Ivana C. L. Santos, Walter S. Luz, Sergio L. B. Ribolla, Paulo E. M. [UNESP] Abad-Franch, Fernando |
dc.subject.por.fl_str_mv |
Amazonia coalescent dengue disease spread Migrate-N ND4 networks |
topic |
Amazonia coalescent dengue disease spread Migrate-N ND4 networks |
description |
The mosquito Aedes aegypti, the dengue virus vector, has spread throughout the tropics in historical times. While this suggests man-mediated dispersal, estimating contemporary connectivity among populations has remained elusive. Here, we use a large mtDNA dataset and a Bayesian coalescent framework to test a set of hypotheses about gene flow among American Ae. aegypti populations. We assessed gene flow patterns at the continental and subregional (Amazon basin) scales. For the Americas, our data favor a stepping-stone model in which gene flow is higher among adjacent populations but in which, at the same time, North American and southeastern Brazilian populations are directly connected, likely via sea trade. Within Amazonia, the model with highest support suggests extensive gene flow among major cities; Manaus, located at the center of the subregional transport network, emerges as a potentially important connecting hub. Our results suggest substantial connectivity across Ae. aegypti populations in the Americas. As long-distance active dispersal has not been observed in this species, our data support man-mediated dispersal as a major determinant of the genetic structure of American Ae. aegypti populations. The inferred topology of interpopulation connectivity can inform network models of Ae. aegypti and dengue spread. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-11-01 2014-05-20T13:52:35Z 2014-05-20T13:52:35Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1111/j.1752-4571.2012.00244.x Evolutionary Applications. Hoboken: Wiley-blackwell, v. 5, n. 7, p. 664-676, 2012. 1752-4571 http://hdl.handle.net/11449/18770 10.1111/j.1752-4571.2012.00244.x WOS:000310543800002 WOS000310543800002.pdf 3577149748456880 0000-0001-8735-6090 |
url |
http://dx.doi.org/10.1111/j.1752-4571.2012.00244.x http://hdl.handle.net/11449/18770 |
identifier_str_mv |
Evolutionary Applications. Hoboken: Wiley-blackwell, v. 5, n. 7, p. 664-676, 2012. 1752-4571 10.1111/j.1752-4571.2012.00244.x WOS:000310543800002 WOS000310543800002.pdf 3577149748456880 0000-0001-8735-6090 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Evolutionary Applications 4.694 2,676 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
664-676 application/pdf |
dc.publisher.none.fl_str_mv |
Wiley-Blackwell |
publisher.none.fl_str_mv |
Wiley-Blackwell |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129358499414016 |