Gene flow networks among American Aedes aegypti populations

Detalhes bibliográficos
Autor(a) principal: da Silva, Anders Goncalves
Data de Publicação: 2012
Outros Autores: Cunha, Ivana C. L., Santos, Walter S., Luz, Sergio L. B., Ribolla, Paulo E. M. [UNESP], Abad-Franch, Fernando
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1111/j.1752-4571.2012.00244.x
http://hdl.handle.net/11449/18770
Resumo: The mosquito Aedes aegypti, the dengue virus vector, has spread throughout the tropics in historical times. While this suggests man-mediated dispersal, estimating contemporary connectivity among populations has remained elusive. Here, we use a large mtDNA dataset and a Bayesian coalescent framework to test a set of hypotheses about gene flow among American Ae. aegypti populations. We assessed gene flow patterns at the continental and subregional (Amazon basin) scales. For the Americas, our data favor a stepping-stone model in which gene flow is higher among adjacent populations but in which, at the same time, North American and southeastern Brazilian populations are directly connected, likely via sea trade. Within Amazonia, the model with highest support suggests extensive gene flow among major cities; Manaus, located at the center of the subregional transport network, emerges as a potentially important connecting hub. Our results suggest substantial connectivity across Ae. aegypti populations in the Americas. As long-distance active dispersal has not been observed in this species, our data support man-mediated dispersal as a major determinant of the genetic structure of American Ae. aegypti populations. The inferred topology of interpopulation connectivity can inform network models of Ae. aegypti and dengue spread.
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spelling Gene flow networks among American Aedes aegypti populationsAmazoniacoalescentdenguedisease spreadMigrate-NND4networksThe mosquito Aedes aegypti, the dengue virus vector, has spread throughout the tropics in historical times. While this suggests man-mediated dispersal, estimating contemporary connectivity among populations has remained elusive. Here, we use a large mtDNA dataset and a Bayesian coalescent framework to test a set of hypotheses about gene flow among American Ae. aegypti populations. We assessed gene flow patterns at the continental and subregional (Amazon basin) scales. For the Americas, our data favor a stepping-stone model in which gene flow is higher among adjacent populations but in which, at the same time, North American and southeastern Brazilian populations are directly connected, likely via sea trade. Within Amazonia, the model with highest support suggests extensive gene flow among major cities; Manaus, located at the center of the subregional transport network, emerges as a potentially important connecting hub. Our results suggest substantial connectivity across Ae. aegypti populations in the Americas. As long-distance active dispersal has not been observed in this species, our data support man-mediated dispersal as a major determinant of the genetic structure of American Ae. aegypti populations. The inferred topology of interpopulation connectivity can inform network models of Ae. aegypti and dengue spread.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado do Amazonas (FAPEAM)CSIRO, Div Marine & Atmospher Res, Hobart, Tas 7000, AustraliaFiocruz Amazonia, ILMD, Manaus, Amazonas, BrazilUniv Estadual Paulista UNESP, São Paulo, BrazilUniv Estadual Paulista UNESP, São Paulo, BrazilWiley-BlackwellCSIROFiocruz AmazoniaUniversidade Estadual Paulista (Unesp)da Silva, Anders GoncalvesCunha, Ivana C. L.Santos, Walter S.Luz, Sergio L. B.Ribolla, Paulo E. M. [UNESP]Abad-Franch, Fernando2014-05-20T13:52:35Z2014-05-20T13:52:35Z2012-11-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article664-676application/pdfhttp://dx.doi.org/10.1111/j.1752-4571.2012.00244.xEvolutionary Applications. Hoboken: Wiley-blackwell, v. 5, n. 7, p. 664-676, 2012.1752-4571http://hdl.handle.net/11449/1877010.1111/j.1752-4571.2012.00244.xWOS:000310543800002WOS000310543800002.pdf35771497484568800000-0001-8735-6090Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengEvolutionary Applications4.6942,676info:eu-repo/semantics/openAccess2023-12-31T06:20:19Zoai:repositorio.unesp.br:11449/18770Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T21:47:28.818563Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Gene flow networks among American Aedes aegypti populations
title Gene flow networks among American Aedes aegypti populations
spellingShingle Gene flow networks among American Aedes aegypti populations
da Silva, Anders Goncalves
Amazonia
coalescent
dengue
disease spread
Migrate-N
ND4
networks
title_short Gene flow networks among American Aedes aegypti populations
title_full Gene flow networks among American Aedes aegypti populations
title_fullStr Gene flow networks among American Aedes aegypti populations
title_full_unstemmed Gene flow networks among American Aedes aegypti populations
title_sort Gene flow networks among American Aedes aegypti populations
author da Silva, Anders Goncalves
author_facet da Silva, Anders Goncalves
Cunha, Ivana C. L.
Santos, Walter S.
Luz, Sergio L. B.
Ribolla, Paulo E. M. [UNESP]
Abad-Franch, Fernando
author_role author
author2 Cunha, Ivana C. L.
Santos, Walter S.
Luz, Sergio L. B.
Ribolla, Paulo E. M. [UNESP]
Abad-Franch, Fernando
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv CSIRO
Fiocruz Amazonia
Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv da Silva, Anders Goncalves
Cunha, Ivana C. L.
Santos, Walter S.
Luz, Sergio L. B.
Ribolla, Paulo E. M. [UNESP]
Abad-Franch, Fernando
dc.subject.por.fl_str_mv Amazonia
coalescent
dengue
disease spread
Migrate-N
ND4
networks
topic Amazonia
coalescent
dengue
disease spread
Migrate-N
ND4
networks
description The mosquito Aedes aegypti, the dengue virus vector, has spread throughout the tropics in historical times. While this suggests man-mediated dispersal, estimating contemporary connectivity among populations has remained elusive. Here, we use a large mtDNA dataset and a Bayesian coalescent framework to test a set of hypotheses about gene flow among American Ae. aegypti populations. We assessed gene flow patterns at the continental and subregional (Amazon basin) scales. For the Americas, our data favor a stepping-stone model in which gene flow is higher among adjacent populations but in which, at the same time, North American and southeastern Brazilian populations are directly connected, likely via sea trade. Within Amazonia, the model with highest support suggests extensive gene flow among major cities; Manaus, located at the center of the subregional transport network, emerges as a potentially important connecting hub. Our results suggest substantial connectivity across Ae. aegypti populations in the Americas. As long-distance active dispersal has not been observed in this species, our data support man-mediated dispersal as a major determinant of the genetic structure of American Ae. aegypti populations. The inferred topology of interpopulation connectivity can inform network models of Ae. aegypti and dengue spread.
publishDate 2012
dc.date.none.fl_str_mv 2012-11-01
2014-05-20T13:52:35Z
2014-05-20T13:52:35Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1111/j.1752-4571.2012.00244.x
Evolutionary Applications. Hoboken: Wiley-blackwell, v. 5, n. 7, p. 664-676, 2012.
1752-4571
http://hdl.handle.net/11449/18770
10.1111/j.1752-4571.2012.00244.x
WOS:000310543800002
WOS000310543800002.pdf
3577149748456880
0000-0001-8735-6090
url http://dx.doi.org/10.1111/j.1752-4571.2012.00244.x
http://hdl.handle.net/11449/18770
identifier_str_mv Evolutionary Applications. Hoboken: Wiley-blackwell, v. 5, n. 7, p. 664-676, 2012.
1752-4571
10.1111/j.1752-4571.2012.00244.x
WOS:000310543800002
WOS000310543800002.pdf
3577149748456880
0000-0001-8735-6090
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Evolutionary Applications
4.694
2,676
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dc.format.none.fl_str_mv 664-676
application/pdf
dc.publisher.none.fl_str_mv Wiley-Blackwell
publisher.none.fl_str_mv Wiley-Blackwell
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
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