Comparison of pulse pressure variation and plethysmographic variability index to predict fluid responsiveness in anesthetized cats
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Tipo de documento: | Tese |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://hdl.handle.net/11449/242750 |
Resumo: | Objective To compare the ability/accuracy of pulse pressure variation (PPV) and plethysmographic variability index (PVI) to predict fluid responsiveness (FR) in anesthetized cats. Study design Prospective, experimental study. Animal population Thirty-one healthy cats (2.7–5.0 kg). Methods During isoflurane anesthesia and volume-controlled ventilation [tidal volume (VT): 12 mL kg-1, 30% of inspiratory pause] a femoral artery catheter was used to measure transpulmonary thermodilution stroke volume (SVTPTD) and PPV. A pulse oximeter probe placed on the tongue measured PVI. Variables were recorded before and after a fluid challenge (FC) with 10 mL kg-1 of lactated Ringer´s over 10 minutes. Based on percent changes in SVTPTD induced by the FC, cats were grouped into responders (SVTPTD ≥15%) or nonresponders (SVTPTD <15%) to volume expansion. Results Four animals were excluded from analysis because of unstable hemodynamic conditions. The FC increased SVTPTD by 21.7 (17.5–38.1)% [median (range)] in responders (n = 15) and by 8.8 (-10.6–14.3)% in nonresponders (n = 12). In two cats, the monitor failed to provide PVI values. The area under the receiver operating characteristics curve (95% confidence intervals) was 0.853 (0.664–0.959) for PPV and 0.702 (0.490–0.914) for PVI. PPV values >17% predicted responders to volume expansion with 75% specificity and 86.7% sensitivity (p <0.0001); PVI did not show predictive ability (p = 0.062). The range of PPV values associated with higher probability of false positives (18–23%) was larger and included more animals (11/27 cats) than the range associated with higher probability of false negatives (14–17% and 4/27 cats, respectively). Conclusions and clinical relevance PPV >17% predicted responders to volume expansion with an increased probability of false positive results, suggesting that a VT of 12 mL kg-1 is excessively large for accurate prediction of FR in feline species. PVI showed limited clinical application in cats. |
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Comparison of pulse pressure variation and plethysmographic variability index to predict fluid responsiveness in anesthetized catsComparação da variação da pressão de pulso e do índice de variabilidade pletismográfica para predição da fluido responsividade em gatos anestesiados com isofluranoDomestic catsGatosHidrataçãoPressão arterialPletismografiaGoal-directed fluid therapyFluid responsivenessPulse pressure variationPlethysmographic variability indexObjective To compare the ability/accuracy of pulse pressure variation (PPV) and plethysmographic variability index (PVI) to predict fluid responsiveness (FR) in anesthetized cats. Study design Prospective, experimental study. Animal population Thirty-one healthy cats (2.7–5.0 kg). Methods During isoflurane anesthesia and volume-controlled ventilation [tidal volume (VT): 12 mL kg-1, 30% of inspiratory pause] a femoral artery catheter was used to measure transpulmonary thermodilution stroke volume (SVTPTD) and PPV. A pulse oximeter probe placed on the tongue measured PVI. Variables were recorded before and after a fluid challenge (FC) with 10 mL kg-1 of lactated Ringer´s over 10 minutes. Based on percent changes in SVTPTD induced by the FC, cats were grouped into responders (SVTPTD ≥15%) or nonresponders (SVTPTD <15%) to volume expansion. Results Four animals were excluded from analysis because of unstable hemodynamic conditions. The FC increased SVTPTD by 21.7 (17.5–38.1)% [median (range)] in responders (n = 15) and by 8.8 (-10.6–14.3)% in nonresponders (n = 12). In two cats, the monitor failed to provide PVI values. The area under the receiver operating characteristics curve (95% confidence intervals) was 0.853 (0.664–0.959) for PPV and 0.702 (0.490–0.914) for PVI. PPV values >17% predicted responders to volume expansion with 75% specificity and 86.7% sensitivity (p <0.0001); PVI did not show predictive ability (p = 0.062). The range of PPV values associated with higher probability of false positives (18–23%) was larger and included more animals (11/27 cats) than the range associated with higher probability of false negatives (14–17% and 4/27 cats, respectively). Conclusions and clinical relevance PPV >17% predicted responders to volume expansion with an increased probability of false positive results, suggesting that a VT of 12 mL kg-1 is excessively large for accurate prediction of FR in feline species. PVI showed limited clinical application in cats.Objetivo– Comparar a habilidade e acurácia da variação da pressão de pulso (VPP) e do índice de variabilidade pletismográfica (IVP) para predizer a fluido responsividade (FR) em gatos anestesiados. Delineamente experimental– Estudo experimental prospectivo. Animais– Trinta e um gatos hígidos (2,7–5,0 kg). Material e Método– Durante anestesia com isoflurano sob ventilação mecânica controlada a volume [volume corrente (VT): 12 mL/kg, pausa inspiratória de 30%], um cateter na artéria femoral foi utilizado para mensurar o volume sistólico por termodiluição transpulmonar (VSTDTP) e a VPP. Um oxímetro de pulso posicionado na língua mensurou o IVP. As variáveis foram registradas antes e após o desafio volêmico (DV) com 10 mL/kg de Ringer Lactato administrados em 10 minutos. Com base no aumento percentual do VS induzido pelo DV, os gatos foram classificados como respondedores (VSTDTP ≥15%) ou não respondedores (VSTDTP <15%) à expansão volêmica. Resultados– Quatro gatos foram excluídos da análise estatística por instabilidade hemodinâmica. O DV aumentou o VSTDTP em 21,7 (17,5–38,1)% [mediana (intervalos)] nos respondedores (n = 15) e em 8.8 (-10,6–14,3)% nos não respondedores (n = 12). Em dois gatos, o monitor falhou em fornecer os valores do IVP. A área sob a curva “receiver operating characteristics” (ROC) e intervalos de confiança de 95% foi de 0,853 (0,664–0,959) para a VPP e 0,702 (0,490–0,914) para o IVP. A VPP >17% predisse respondedores à expansão volêmica com especificidade de 75% e sensibilidade de 86,7% (p <0,0001); o IVP não demonstrou habilidade preditiva (p = 0,062). O intervalo de valores de VPP associados à alta probabilidade de resultados falsos positivos (18–23%) foi maior e incluiu mais animais (11/27 gatos) que o intervalo associado à alta probabilidade de resultados falsos negativos (14–17% e 4/27 gatos, respectivamente). Conclusões e relevância clínica– A VPP >17% predisse respondedores à expansão volêmica com alta probabilidade de resultados falsos positivos, sugerindo que o VT de 12 mL/kg seja excessivamente alto para a predição acurada da FR em gatos. O IVP demonstrou aplicabilidade clínica limitada em gatos.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)CAPES: 001Universidade Estadual Paulista (Unesp)Teixeira Neto, Francisco José [UNESP]Universidade Estadual Paulista (Unesp)Dalmagro, Tábata Larissa2023-03-30T21:48:29Z2023-03-30T21:48:29Z2023-02-27info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesisapplication/pdfhttp://hdl.handle.net/11449/24275033004064076P6enginfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESP2024-09-02T15:32:02Zoai:repositorio.unesp.br:11449/242750Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-02T15:32:02Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Comparison of pulse pressure variation and plethysmographic variability index to predict fluid responsiveness in anesthetized cats Comparação da variação da pressão de pulso e do índice de variabilidade pletismográfica para predição da fluido responsividade em gatos anestesiados com isoflurano |
title |
Comparison of pulse pressure variation and plethysmographic variability index to predict fluid responsiveness in anesthetized cats |
spellingShingle |
Comparison of pulse pressure variation and plethysmographic variability index to predict fluid responsiveness in anesthetized cats Dalmagro, Tábata Larissa Domestic cats Gatos Hidratação Pressão arterial Pletismografia Goal-directed fluid therapy Fluid responsiveness Pulse pressure variation Plethysmographic variability index |
title_short |
Comparison of pulse pressure variation and plethysmographic variability index to predict fluid responsiveness in anesthetized cats |
title_full |
Comparison of pulse pressure variation and plethysmographic variability index to predict fluid responsiveness in anesthetized cats |
title_fullStr |
Comparison of pulse pressure variation and plethysmographic variability index to predict fluid responsiveness in anesthetized cats |
title_full_unstemmed |
Comparison of pulse pressure variation and plethysmographic variability index to predict fluid responsiveness in anesthetized cats |
title_sort |
Comparison of pulse pressure variation and plethysmographic variability index to predict fluid responsiveness in anesthetized cats |
author |
Dalmagro, Tábata Larissa |
author_facet |
Dalmagro, Tábata Larissa |
author_role |
author |
dc.contributor.none.fl_str_mv |
Teixeira Neto, Francisco José [UNESP] Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Dalmagro, Tábata Larissa |
dc.subject.por.fl_str_mv |
Domestic cats Gatos Hidratação Pressão arterial Pletismografia Goal-directed fluid therapy Fluid responsiveness Pulse pressure variation Plethysmographic variability index |
topic |
Domestic cats Gatos Hidratação Pressão arterial Pletismografia Goal-directed fluid therapy Fluid responsiveness Pulse pressure variation Plethysmographic variability index |
description |
Objective To compare the ability/accuracy of pulse pressure variation (PPV) and plethysmographic variability index (PVI) to predict fluid responsiveness (FR) in anesthetized cats. Study design Prospective, experimental study. Animal population Thirty-one healthy cats (2.7–5.0 kg). Methods During isoflurane anesthesia and volume-controlled ventilation [tidal volume (VT): 12 mL kg-1, 30% of inspiratory pause] a femoral artery catheter was used to measure transpulmonary thermodilution stroke volume (SVTPTD) and PPV. A pulse oximeter probe placed on the tongue measured PVI. Variables were recorded before and after a fluid challenge (FC) with 10 mL kg-1 of lactated Ringer´s over 10 minutes. Based on percent changes in SVTPTD induced by the FC, cats were grouped into responders (SVTPTD ≥15%) or nonresponders (SVTPTD <15%) to volume expansion. Results Four animals were excluded from analysis because of unstable hemodynamic conditions. The FC increased SVTPTD by 21.7 (17.5–38.1)% [median (range)] in responders (n = 15) and by 8.8 (-10.6–14.3)% in nonresponders (n = 12). In two cats, the monitor failed to provide PVI values. The area under the receiver operating characteristics curve (95% confidence intervals) was 0.853 (0.664–0.959) for PPV and 0.702 (0.490–0.914) for PVI. PPV values >17% predicted responders to volume expansion with 75% specificity and 86.7% sensitivity (p <0.0001); PVI did not show predictive ability (p = 0.062). The range of PPV values associated with higher probability of false positives (18–23%) was larger and included more animals (11/27 cats) than the range associated with higher probability of false negatives (14–17% and 4/27 cats, respectively). Conclusions and clinical relevance PPV >17% predicted responders to volume expansion with an increased probability of false positive results, suggesting that a VT of 12 mL kg-1 is excessively large for accurate prediction of FR in feline species. PVI showed limited clinical application in cats. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-03-30T21:48:29Z 2023-03-30T21:48:29Z 2023-02-27 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/doctoralThesis |
format |
doctoralThesis |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/11449/242750 33004064076P6 |
url |
http://hdl.handle.net/11449/242750 |
identifier_str_mv |
33004064076P6 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
publisher.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
repositoriounesp@unesp.br |
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1810021415033765888 |