Biocompatibilidade in vivo de membranas nanoestruturadas de Quitosana/Peo
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/1678-4162-8286 http://hdl.handle.net/11449/168105 |
Resumo: | Electrospinning is a technique that allows the preparation of nanofibers from various materials. Chitosan is a natural and abundant easily obtained polymer, which, in addition to those features, proved to be biocompatible. This work used nanostructured chitosan and polyoxyethylene membranes as subcutaneous implants in Wistar rats to evaluate the biocompatibility of the material. Samples of the material and tissues adjacent to the implant were collected 7, 15, 30, 45 and 60 days post-implantation. Macroscopic integration of the material to the tissues was observed in the samples and slides for histopathological examination that were prepared. It was noticed that the material does not stimulate the formation of adherences to the surrounding tissues and that there is initial predominance of neutrophilia and lymphocytosis, with a declining trend according to the increase of time, featuring a non-persistent acute inflammatory process. However, the material showed fast degradation, impairing the macroscopic observation after fifteen days of implantation. It was concluded that the material is biocompatible and that new studies should be conducted, modifying the time of degradation by changes in obtaining methods and verifying the biocompatibility in specific tissues for biomedical applications. |
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Biocompatibilidade in vivo de membranas nanoestruturadas de Quitosana/PeoBiomaterialsElectrospinningNanotechnologyElectrospinning is a technique that allows the preparation of nanofibers from various materials. Chitosan is a natural and abundant easily obtained polymer, which, in addition to those features, proved to be biocompatible. This work used nanostructured chitosan and polyoxyethylene membranes as subcutaneous implants in Wistar rats to evaluate the biocompatibility of the material. Samples of the material and tissues adjacent to the implant were collected 7, 15, 30, 45 and 60 days post-implantation. Macroscopic integration of the material to the tissues was observed in the samples and slides for histopathological examination that were prepared. It was noticed that the material does not stimulate the formation of adherences to the surrounding tissues and that there is initial predominance of neutrophilia and lymphocytosis, with a declining trend according to the increase of time, featuring a non-persistent acute inflammatory process. However, the material showed fast degradation, impairing the macroscopic observation after fifteen days of implantation. It was concluded that the material is biocompatible and that new studies should be conducted, modifying the time of degradation by changes in obtaining methods and verifying the biocompatibility in specific tissues for biomedical applications.Universidade Federal de Goiás-UFG-Regional JataíUniversidade Federal do Mato Grosso, UFMTEscola de Veterinária e Zootecnia, UFGFaculdade de Engenharia Mecânica, Universidade de Campinas-UNICAMPFaculdade de Ciências Agrárias e Veterinárias de Jaboticabal, UNESPFaculdade de Ciências Agrárias e Veterinárias de Jaboticabal, UNESPUniversidade Federal de Goiás (UFG)Universidade Federal do Mato Grosso, UFMTEscola de Veterinária e Zootecnia, UFGUniversidade Estadual de Campinas (UNICAMP)Universidade Estadual Paulista (Unesp)Vulcani, V. A.S.Franzo, V. S.Rabelo, R. E.Rabbers, A. S.Assis, B. M.D'ávila, M. A.Antoni, S. M.B. [UNESP]2018-12-11T16:39:46Z2018-12-11T16:39:46Z2015-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1039-1044application/pdfhttp://dx.doi.org/10.1590/1678-4162-8286Arquivo Brasileiro de Medicina Veterinaria e Zootecnia, v. 67, n. 4, p. 1039-1044, 2015.1678-41620102-0935http://hdl.handle.net/11449/16810510.1590/1678-4162-8286S0102-093520150004010392-s2.0-84945559855S0102-09352015000401039.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengArquivo Brasileiro de Medicina Veterinaria e Zootecnia0,248info:eu-repo/semantics/openAccess2023-11-01T06:10:41Zoai:repositorio.unesp.br:11449/168105Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-11-01T06:10:41Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Biocompatibilidade in vivo de membranas nanoestruturadas de Quitosana/Peo |
title |
Biocompatibilidade in vivo de membranas nanoestruturadas de Quitosana/Peo |
spellingShingle |
Biocompatibilidade in vivo de membranas nanoestruturadas de Quitosana/Peo Vulcani, V. A.S. Biomaterials Electrospinning Nanotechnology |
title_short |
Biocompatibilidade in vivo de membranas nanoestruturadas de Quitosana/Peo |
title_full |
Biocompatibilidade in vivo de membranas nanoestruturadas de Quitosana/Peo |
title_fullStr |
Biocompatibilidade in vivo de membranas nanoestruturadas de Quitosana/Peo |
title_full_unstemmed |
Biocompatibilidade in vivo de membranas nanoestruturadas de Quitosana/Peo |
title_sort |
Biocompatibilidade in vivo de membranas nanoestruturadas de Quitosana/Peo |
author |
Vulcani, V. A.S. |
author_facet |
Vulcani, V. A.S. Franzo, V. S. Rabelo, R. E. Rabbers, A. S. Assis, B. M. D'ávila, M. A. Antoni, S. M.B. [UNESP] |
author_role |
author |
author2 |
Franzo, V. S. Rabelo, R. E. Rabbers, A. S. Assis, B. M. D'ávila, M. A. Antoni, S. M.B. [UNESP] |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal de Goiás (UFG) Universidade Federal do Mato Grosso, UFMT Escola de Veterinária e Zootecnia, UFG Universidade Estadual de Campinas (UNICAMP) Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Vulcani, V. A.S. Franzo, V. S. Rabelo, R. E. Rabbers, A. S. Assis, B. M. D'ávila, M. A. Antoni, S. M.B. [UNESP] |
dc.subject.por.fl_str_mv |
Biomaterials Electrospinning Nanotechnology |
topic |
Biomaterials Electrospinning Nanotechnology |
description |
Electrospinning is a technique that allows the preparation of nanofibers from various materials. Chitosan is a natural and abundant easily obtained polymer, which, in addition to those features, proved to be biocompatible. This work used nanostructured chitosan and polyoxyethylene membranes as subcutaneous implants in Wistar rats to evaluate the biocompatibility of the material. Samples of the material and tissues adjacent to the implant were collected 7, 15, 30, 45 and 60 days post-implantation. Macroscopic integration of the material to the tissues was observed in the samples and slides for histopathological examination that were prepared. It was noticed that the material does not stimulate the formation of adherences to the surrounding tissues and that there is initial predominance of neutrophilia and lymphocytosis, with a declining trend according to the increase of time, featuring a non-persistent acute inflammatory process. However, the material showed fast degradation, impairing the macroscopic observation after fifteen days of implantation. It was concluded that the material is biocompatible and that new studies should be conducted, modifying the time of degradation by changes in obtaining methods and verifying the biocompatibility in specific tissues for biomedical applications. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-01-01 2018-12-11T16:39:46Z 2018-12-11T16:39:46Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/1678-4162-8286 Arquivo Brasileiro de Medicina Veterinaria e Zootecnia, v. 67, n. 4, p. 1039-1044, 2015. 1678-4162 0102-0935 http://hdl.handle.net/11449/168105 10.1590/1678-4162-8286 S0102-09352015000401039 2-s2.0-84945559855 S0102-09352015000401039.pdf |
url |
http://dx.doi.org/10.1590/1678-4162-8286 http://hdl.handle.net/11449/168105 |
identifier_str_mv |
Arquivo Brasileiro de Medicina Veterinaria e Zootecnia, v. 67, n. 4, p. 1039-1044, 2015. 1678-4162 0102-0935 10.1590/1678-4162-8286 S0102-09352015000401039 2-s2.0-84945559855 S0102-09352015000401039.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Arquivo Brasileiro de Medicina Veterinaria e Zootecnia 0,248 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
1039-1044 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799964779603820544 |