Toxic metal exposure as a possible risk factor for COVID-19 and other respiratory infectious diseases
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.fct.2020.111809 http://hdl.handle.net/11449/205374 |
Resumo: | Multiple medical, lifestyle, and environmental conditions, including smoking and particulate pollution, have been considered as risk factors for COronaVIrus Disease 2019 (COVID-19) susceptibility and severity. Taking into account the high level of toxic metals in both particulate matter (PM2.5) and tobacco smoke, the objective of this review is to discuss recent data on the role of heavy metal exposure in development of respiratory dysfunction, immunotoxicity, and severity of viral diseases in epidemiological and experimental studies, as to demonstrate the potential crossroads between heavy metal exposure and COVID-19 severity risk. The existing data demonstrate that As, Cd, Hg, and Pb exposure is associated with respiratory dysfunction and respiratory diseases (COPD, bronchitis). These observations corroborate laboratory findings on the role of heavy metal exposure in impaired mucociliary clearance, reduced barrier function, airway inflammation, oxidative stress, and apoptosis. The association between heavy metal exposure and severity of viral diseases, including influenza and respiratory syncytial virus has been also demonstrated. The latter may be considered a consequence of adverse effects of metal exposure on adaptive immunity. Therefore, reduction of toxic metal exposure may be considered as a potential tool for reducing susceptibility and severity of viral diseases affecting the respiratory system, including COVID-19. |
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Toxic metal exposure as a possible risk factor for COVID-19 and other respiratory infectious diseasesArsenicCadmiumImmunityLeadMercuryMultiple medical, lifestyle, and environmental conditions, including smoking and particulate pollution, have been considered as risk factors for COronaVIrus Disease 2019 (COVID-19) susceptibility and severity. Taking into account the high level of toxic metals in both particulate matter (PM2.5) and tobacco smoke, the objective of this review is to discuss recent data on the role of heavy metal exposure in development of respiratory dysfunction, immunotoxicity, and severity of viral diseases in epidemiological and experimental studies, as to demonstrate the potential crossroads between heavy metal exposure and COVID-19 severity risk. The existing data demonstrate that As, Cd, Hg, and Pb exposure is associated with respiratory dysfunction and respiratory diseases (COPD, bronchitis). These observations corroborate laboratory findings on the role of heavy metal exposure in impaired mucociliary clearance, reduced barrier function, airway inflammation, oxidative stress, and apoptosis. The association between heavy metal exposure and severity of viral diseases, including influenza and respiratory syncytial virus has been also demonstrated. The latter may be considered a consequence of adverse effects of metal exposure on adaptive immunity. Therefore, reduction of toxic metal exposure may be considered as a potential tool for reducing susceptibility and severity of viral diseases affecting the respiratory system, including COVID-19.Ministry of Science and Higher Education of the Russian FederationDeutsche ForschungsgemeinschaftNational Institute of Environmental Health SciencesIM Sechenov First Moscow State Medical University (Sechenov University)Federal Research Centre of Biological Systems and Agro-technologies of the Russian Academy of SciencesSão Paulo State University - UNESP Center for Evaluation of Environmental Impact on Human Health (TOXICAM)Department of Molecular Pharmacology Albert Einstein College of MedicineSchool of Public Health (Shenzhen) Sun Yat-sen UniversityFood Chemistry Faculty of Mathematics and Natural Sciences University of WuppertalI.I. Mechnikov North-Western State Medical UniversityK.A. Rauhfus Children's City Multidisciplinary Clinical Center for High Medical TechnologiesResearch Department Innlandet Hospital TrustLaboratory of Toxicology Medical School University of Crete, VoutesHERACLES Research Center on the Exposome and Health Center for Interdisciplinary Research and Innovation Aristotle University of ThessalonikiUniversity School of Advanced Studies IUSSYaroslavl State UniversitySão Paulo State University - UNESP Center for Evaluation of Environmental Impact on Human Health (TOXICAM)Ministry of Science and Higher Education of the Russian Federation: 0856-2020-00082Deutsche Forschungsgemeinschaft: FOR 2558National Institute of Environmental Health Sciences: R01ES07331National Institute of Environmental Health Sciences: R01ES105633IM Sechenov First Moscow State Medical University (Sechenov University)Federal Research Centre of Biological Systems and Agro-technologies of the Russian Academy of SciencesUniversidade Estadual Paulista (Unesp)Albert Einstein College of MedicineSun Yat-sen UniversityUniversity of WuppertalI.I. Mechnikov North-Western State Medical UniversityK.A. Rauhfus Children's City Multidisciplinary Clinical Center for High Medical TechnologiesInnlandet Hospital TrustUniversity of CreteAristotle University of ThessalonikiUniversity School of Advanced Studies IUSSYaroslavl State UniversitySkalny, Anatoly V.Lima, Thania Rios Rossi [UNESP]Ke, TaoZhou, Ji-ChangBornhorst, JuliaAlekseenko, Svetlana I.Aaseth, JanAnesti, OuraniaSarigiannis, Dimosthenis A.Tsatsakis, AristidesAschner, MichaelTinkov, Alexey A.2021-06-25T10:14:13Z2021-06-25T10:14:13Z2020-12-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.fct.2020.111809Food and Chemical Toxicology, v. 146.1873-63510278-6915http://hdl.handle.net/11449/20537410.1016/j.fct.2020.1118092-s2.0-85093941383Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengFood and Chemical Toxicologyinfo:eu-repo/semantics/openAccess2021-10-23T12:39:58Zoai:repositorio.unesp.br:11449/205374Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T17:21:08.301747Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Toxic metal exposure as a possible risk factor for COVID-19 and other respiratory infectious diseases |
title |
Toxic metal exposure as a possible risk factor for COVID-19 and other respiratory infectious diseases |
spellingShingle |
Toxic metal exposure as a possible risk factor for COVID-19 and other respiratory infectious diseases Skalny, Anatoly V. Arsenic Cadmium Immunity Lead Mercury |
title_short |
Toxic metal exposure as a possible risk factor for COVID-19 and other respiratory infectious diseases |
title_full |
Toxic metal exposure as a possible risk factor for COVID-19 and other respiratory infectious diseases |
title_fullStr |
Toxic metal exposure as a possible risk factor for COVID-19 and other respiratory infectious diseases |
title_full_unstemmed |
Toxic metal exposure as a possible risk factor for COVID-19 and other respiratory infectious diseases |
title_sort |
Toxic metal exposure as a possible risk factor for COVID-19 and other respiratory infectious diseases |
author |
Skalny, Anatoly V. |
author_facet |
Skalny, Anatoly V. Lima, Thania Rios Rossi [UNESP] Ke, Tao Zhou, Ji-Chang Bornhorst, Julia Alekseenko, Svetlana I. Aaseth, Jan Anesti, Ourania Sarigiannis, Dimosthenis A. Tsatsakis, Aristides Aschner, Michael Tinkov, Alexey A. |
author_role |
author |
author2 |
Lima, Thania Rios Rossi [UNESP] Ke, Tao Zhou, Ji-Chang Bornhorst, Julia Alekseenko, Svetlana I. Aaseth, Jan Anesti, Ourania Sarigiannis, Dimosthenis A. Tsatsakis, Aristides Aschner, Michael Tinkov, Alexey A. |
author2_role |
author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
IM Sechenov First Moscow State Medical University (Sechenov University) Federal Research Centre of Biological Systems and Agro-technologies of the Russian Academy of Sciences Universidade Estadual Paulista (Unesp) Albert Einstein College of Medicine Sun Yat-sen University University of Wuppertal I.I. Mechnikov North-Western State Medical University K.A. Rauhfus Children's City Multidisciplinary Clinical Center for High Medical Technologies Innlandet Hospital Trust University of Crete Aristotle University of Thessaloniki University School of Advanced Studies IUSS Yaroslavl State University |
dc.contributor.author.fl_str_mv |
Skalny, Anatoly V. Lima, Thania Rios Rossi [UNESP] Ke, Tao Zhou, Ji-Chang Bornhorst, Julia Alekseenko, Svetlana I. Aaseth, Jan Anesti, Ourania Sarigiannis, Dimosthenis A. Tsatsakis, Aristides Aschner, Michael Tinkov, Alexey A. |
dc.subject.por.fl_str_mv |
Arsenic Cadmium Immunity Lead Mercury |
topic |
Arsenic Cadmium Immunity Lead Mercury |
description |
Multiple medical, lifestyle, and environmental conditions, including smoking and particulate pollution, have been considered as risk factors for COronaVIrus Disease 2019 (COVID-19) susceptibility and severity. Taking into account the high level of toxic metals in both particulate matter (PM2.5) and tobacco smoke, the objective of this review is to discuss recent data on the role of heavy metal exposure in development of respiratory dysfunction, immunotoxicity, and severity of viral diseases in epidemiological and experimental studies, as to demonstrate the potential crossroads between heavy metal exposure and COVID-19 severity risk. The existing data demonstrate that As, Cd, Hg, and Pb exposure is associated with respiratory dysfunction and respiratory diseases (COPD, bronchitis). These observations corroborate laboratory findings on the role of heavy metal exposure in impaired mucociliary clearance, reduced barrier function, airway inflammation, oxidative stress, and apoptosis. The association between heavy metal exposure and severity of viral diseases, including influenza and respiratory syncytial virus has been also demonstrated. The latter may be considered a consequence of adverse effects of metal exposure on adaptive immunity. Therefore, reduction of toxic metal exposure may be considered as a potential tool for reducing susceptibility and severity of viral diseases affecting the respiratory system, including COVID-19. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-12-01 2021-06-25T10:14:13Z 2021-06-25T10:14:13Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.fct.2020.111809 Food and Chemical Toxicology, v. 146. 1873-6351 0278-6915 http://hdl.handle.net/11449/205374 10.1016/j.fct.2020.111809 2-s2.0-85093941383 |
url |
http://dx.doi.org/10.1016/j.fct.2020.111809 http://hdl.handle.net/11449/205374 |
identifier_str_mv |
Food and Chemical Toxicology, v. 146. 1873-6351 0278-6915 10.1016/j.fct.2020.111809 2-s2.0-85093941383 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Food and Chemical Toxicology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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1808128796643033088 |