Toxic metal exposure as a possible risk factor for COVID-19 and other respiratory infectious diseases

Detalhes bibliográficos
Autor(a) principal: Skalny, Anatoly V.
Data de Publicação: 2020
Outros Autores: Lima, Thania Rios Rossi [UNESP], Ke, Tao, Zhou, Ji-Chang, Bornhorst, Julia, Alekseenko, Svetlana I., Aaseth, Jan, Anesti, Ourania, Sarigiannis, Dimosthenis A., Tsatsakis, Aristides, Aschner, Michael, Tinkov, Alexey A.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1016/j.fct.2020.111809
http://hdl.handle.net/11449/205374
Resumo: Multiple medical, lifestyle, and environmental conditions, including smoking and particulate pollution, have been considered as risk factors for COronaVIrus Disease 2019 (COVID-19) susceptibility and severity. Taking into account the high level of toxic metals in both particulate matter (PM2.5) and tobacco smoke, the objective of this review is to discuss recent data on the role of heavy metal exposure in development of respiratory dysfunction, immunotoxicity, and severity of viral diseases in epidemiological and experimental studies, as to demonstrate the potential crossroads between heavy metal exposure and COVID-19 severity risk. The existing data demonstrate that As, Cd, Hg, and Pb exposure is associated with respiratory dysfunction and respiratory diseases (COPD, bronchitis). These observations corroborate laboratory findings on the role of heavy metal exposure in impaired mucociliary clearance, reduced barrier function, airway inflammation, oxidative stress, and apoptosis. The association between heavy metal exposure and severity of viral diseases, including influenza and respiratory syncytial virus has been also demonstrated. The latter may be considered a consequence of adverse effects of metal exposure on adaptive immunity. Therefore, reduction of toxic metal exposure may be considered as a potential tool for reducing susceptibility and severity of viral diseases affecting the respiratory system, including COVID-19.
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spelling Toxic metal exposure as a possible risk factor for COVID-19 and other respiratory infectious diseasesArsenicCadmiumImmunityLeadMercuryMultiple medical, lifestyle, and environmental conditions, including smoking and particulate pollution, have been considered as risk factors for COronaVIrus Disease 2019 (COVID-19) susceptibility and severity. Taking into account the high level of toxic metals in both particulate matter (PM2.5) and tobacco smoke, the objective of this review is to discuss recent data on the role of heavy metal exposure in development of respiratory dysfunction, immunotoxicity, and severity of viral diseases in epidemiological and experimental studies, as to demonstrate the potential crossroads between heavy metal exposure and COVID-19 severity risk. The existing data demonstrate that As, Cd, Hg, and Pb exposure is associated with respiratory dysfunction and respiratory diseases (COPD, bronchitis). These observations corroborate laboratory findings on the role of heavy metal exposure in impaired mucociliary clearance, reduced barrier function, airway inflammation, oxidative stress, and apoptosis. The association between heavy metal exposure and severity of viral diseases, including influenza and respiratory syncytial virus has been also demonstrated. The latter may be considered a consequence of adverse effects of metal exposure on adaptive immunity. Therefore, reduction of toxic metal exposure may be considered as a potential tool for reducing susceptibility and severity of viral diseases affecting the respiratory system, including COVID-19.Ministry of Science and Higher Education of the Russian FederationDeutsche ForschungsgemeinschaftNational Institute of Environmental Health SciencesIM Sechenov First Moscow State Medical University (Sechenov University)Federal Research Centre of Biological Systems and Agro-technologies of the Russian Academy of SciencesSão Paulo State University - UNESP Center for Evaluation of Environmental Impact on Human Health (TOXICAM)Department of Molecular Pharmacology Albert Einstein College of MedicineSchool of Public Health (Shenzhen) Sun Yat-sen UniversityFood Chemistry Faculty of Mathematics and Natural Sciences University of WuppertalI.I. Mechnikov North-Western State Medical UniversityK.A. Rauhfus Children's City Multidisciplinary Clinical Center for High Medical TechnologiesResearch Department Innlandet Hospital TrustLaboratory of Toxicology Medical School University of Crete, VoutesHERACLES Research Center on the Exposome and Health Center for Interdisciplinary Research and Innovation Aristotle University of ThessalonikiUniversity School of Advanced Studies IUSSYaroslavl State UniversitySão Paulo State University - UNESP Center for Evaluation of Environmental Impact on Human Health (TOXICAM)Ministry of Science and Higher Education of the Russian Federation: 0856-2020-00082Deutsche Forschungsgemeinschaft: FOR 2558National Institute of Environmental Health Sciences: R01ES07331National Institute of Environmental Health Sciences: R01ES105633IM Sechenov First Moscow State Medical University (Sechenov University)Federal Research Centre of Biological Systems and Agro-technologies of the Russian Academy of SciencesUniversidade Estadual Paulista (Unesp)Albert Einstein College of MedicineSun Yat-sen UniversityUniversity of WuppertalI.I. Mechnikov North-Western State Medical UniversityK.A. Rauhfus Children's City Multidisciplinary Clinical Center for High Medical TechnologiesInnlandet Hospital TrustUniversity of CreteAristotle University of ThessalonikiUniversity School of Advanced Studies IUSSYaroslavl State UniversitySkalny, Anatoly V.Lima, Thania Rios Rossi [UNESP]Ke, TaoZhou, Ji-ChangBornhorst, JuliaAlekseenko, Svetlana I.Aaseth, JanAnesti, OuraniaSarigiannis, Dimosthenis A.Tsatsakis, AristidesAschner, MichaelTinkov, Alexey A.2021-06-25T10:14:13Z2021-06-25T10:14:13Z2020-12-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.fct.2020.111809Food and Chemical Toxicology, v. 146.1873-63510278-6915http://hdl.handle.net/11449/20537410.1016/j.fct.2020.1118092-s2.0-85093941383Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengFood and Chemical Toxicologyinfo:eu-repo/semantics/openAccess2021-10-23T12:39:58Zoai:repositorio.unesp.br:11449/205374Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T17:21:08.301747Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Toxic metal exposure as a possible risk factor for COVID-19 and other respiratory infectious diseases
title Toxic metal exposure as a possible risk factor for COVID-19 and other respiratory infectious diseases
spellingShingle Toxic metal exposure as a possible risk factor for COVID-19 and other respiratory infectious diseases
Skalny, Anatoly V.
Arsenic
Cadmium
Immunity
Lead
Mercury
title_short Toxic metal exposure as a possible risk factor for COVID-19 and other respiratory infectious diseases
title_full Toxic metal exposure as a possible risk factor for COVID-19 and other respiratory infectious diseases
title_fullStr Toxic metal exposure as a possible risk factor for COVID-19 and other respiratory infectious diseases
title_full_unstemmed Toxic metal exposure as a possible risk factor for COVID-19 and other respiratory infectious diseases
title_sort Toxic metal exposure as a possible risk factor for COVID-19 and other respiratory infectious diseases
author Skalny, Anatoly V.
author_facet Skalny, Anatoly V.
Lima, Thania Rios Rossi [UNESP]
Ke, Tao
Zhou, Ji-Chang
Bornhorst, Julia
Alekseenko, Svetlana I.
Aaseth, Jan
Anesti, Ourania
Sarigiannis, Dimosthenis A.
Tsatsakis, Aristides
Aschner, Michael
Tinkov, Alexey A.
author_role author
author2 Lima, Thania Rios Rossi [UNESP]
Ke, Tao
Zhou, Ji-Chang
Bornhorst, Julia
Alekseenko, Svetlana I.
Aaseth, Jan
Anesti, Ourania
Sarigiannis, Dimosthenis A.
Tsatsakis, Aristides
Aschner, Michael
Tinkov, Alexey A.
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv IM Sechenov First Moscow State Medical University (Sechenov University)
Federal Research Centre of Biological Systems and Agro-technologies of the Russian Academy of Sciences
Universidade Estadual Paulista (Unesp)
Albert Einstein College of Medicine
Sun Yat-sen University
University of Wuppertal
I.I. Mechnikov North-Western State Medical University
K.A. Rauhfus Children's City Multidisciplinary Clinical Center for High Medical Technologies
Innlandet Hospital Trust
University of Crete
Aristotle University of Thessaloniki
University School of Advanced Studies IUSS
Yaroslavl State University
dc.contributor.author.fl_str_mv Skalny, Anatoly V.
Lima, Thania Rios Rossi [UNESP]
Ke, Tao
Zhou, Ji-Chang
Bornhorst, Julia
Alekseenko, Svetlana I.
Aaseth, Jan
Anesti, Ourania
Sarigiannis, Dimosthenis A.
Tsatsakis, Aristides
Aschner, Michael
Tinkov, Alexey A.
dc.subject.por.fl_str_mv Arsenic
Cadmium
Immunity
Lead
Mercury
topic Arsenic
Cadmium
Immunity
Lead
Mercury
description Multiple medical, lifestyle, and environmental conditions, including smoking and particulate pollution, have been considered as risk factors for COronaVIrus Disease 2019 (COVID-19) susceptibility and severity. Taking into account the high level of toxic metals in both particulate matter (PM2.5) and tobacco smoke, the objective of this review is to discuss recent data on the role of heavy metal exposure in development of respiratory dysfunction, immunotoxicity, and severity of viral diseases in epidemiological and experimental studies, as to demonstrate the potential crossroads between heavy metal exposure and COVID-19 severity risk. The existing data demonstrate that As, Cd, Hg, and Pb exposure is associated with respiratory dysfunction and respiratory diseases (COPD, bronchitis). These observations corroborate laboratory findings on the role of heavy metal exposure in impaired mucociliary clearance, reduced barrier function, airway inflammation, oxidative stress, and apoptosis. The association between heavy metal exposure and severity of viral diseases, including influenza and respiratory syncytial virus has been also demonstrated. The latter may be considered a consequence of adverse effects of metal exposure on adaptive immunity. Therefore, reduction of toxic metal exposure may be considered as a potential tool for reducing susceptibility and severity of viral diseases affecting the respiratory system, including COVID-19.
publishDate 2020
dc.date.none.fl_str_mv 2020-12-01
2021-06-25T10:14:13Z
2021-06-25T10:14:13Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/j.fct.2020.111809
Food and Chemical Toxicology, v. 146.
1873-6351
0278-6915
http://hdl.handle.net/11449/205374
10.1016/j.fct.2020.111809
2-s2.0-85093941383
url http://dx.doi.org/10.1016/j.fct.2020.111809
http://hdl.handle.net/11449/205374
identifier_str_mv Food and Chemical Toxicology, v. 146.
1873-6351
0278-6915
10.1016/j.fct.2020.111809
2-s2.0-85093941383
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Food and Chemical Toxicology
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
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