Neuroelectrostimulation on Adult Mice’s Back and Hip Muscles, Through a Special Vest: a Pilot Study

Detalhes bibliográficos
Autor(a) principal: Cosin Shindo, João Vitor Tadashi
Data de Publicação: 2021
Outros Autores: Rodokas, José Eduardo Petit [UNESP], dos Santos Sousa, Guilherme, Maciel, Fabio Oliveira, Couto, Maira Cristina Rondina, Matsumoto, Mariza Akemi [UNESP], Sangalette, Beatriz, German, Iris Jasmin Santos, Pomini, Karina Torres, Andreo, Jesus Carlos, Shinohara, André Luís
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.51929/jms.38.69.2021
http://hdl.handle.net/11449/223672
Resumo: Introduction: neuromuscular electrostimulation (NMES) is a promising strategy for recovering muscle mass and function, including in elderly patients suffering from sarcopenia. We developed a vest with coupled electrodes to introduce electrostimulation throughout the body of young mice and verify the morphological changes in the scapular and pelvic region muscles. Material and Methods: a vest based on the semi-flexible resin was developed with the electrodes already attached, printed by 3D printing with connectivity to the Neurodyn III electrostimulation device (Ibramed ®). Based on this, six 14-weeks old C57BL/6 WT mice were used to conduct this pilot study. Results: After four weeks, we found that using the vest with the coupled electrodes was able to generate an increase in CSA in the gluteus and trapezius muscle compared to control mice (p<0.05). The gluteus of the experimental group (EG) hypertrophied 15% more than the control group (CG). As occurred in the gluteus, in the trapezius muscle, the CSA was 37% higher in EG than in CG. Conclusions: we conclude that this model of NMES in mice leaded to morphological changes in scapular and pelvic region muscles. For future work, we intend to include molecular and functional analyzes to evaluate if our model can reproduce the same functional effects reported in studies and afterward apply this model to elderly animals.
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spelling Neuroelectrostimulation on Adult Mice’s Back and Hip Muscles, Through a Special Vest: a Pilot StudyElectrostimulationHypertrophySarcopeniaSkeletal MuscleIntroduction: neuromuscular electrostimulation (NMES) is a promising strategy for recovering muscle mass and function, including in elderly patients suffering from sarcopenia. We developed a vest with coupled electrodes to introduce electrostimulation throughout the body of young mice and verify the morphological changes in the scapular and pelvic region muscles. Material and Methods: a vest based on the semi-flexible resin was developed with the electrodes already attached, printed by 3D printing with connectivity to the Neurodyn III electrostimulation device (Ibramed ®). Based on this, six 14-weeks old C57BL/6 WT mice were used to conduct this pilot study. Results: After four weeks, we found that using the vest with the coupled electrodes was able to generate an increase in CSA in the gluteus and trapezius muscle compared to control mice (p<0.05). The gluteus of the experimental group (EG) hypertrophied 15% more than the control group (CG). As occurred in the gluteus, in the trapezius muscle, the CSA was 37% higher in EG than in CG. Conclusions: we conclude that this model of NMES in mice leaded to morphological changes in scapular and pelvic region muscles. For future work, we intend to include molecular and functional analyzes to evaluate if our model can reproduce the same functional effects reported in studies and afterward apply this model to elderly animals.Department of Anatomy Bauru School of Dentistry University of São Paulo FOB-USP, SPSão Paulo State University (UNESP), SPDepartment of Bioceramics Federal Univesity of São Paulo (UNIFESP), SPFederal University of Amazonas UFAM, AMDepartment of Basic Sciences School of Dentistry São Paulo State University (UNESP), SPSão Paulo State University (UNESP), SPDepartment of Basic Sciences School of Dentistry São Paulo State University (UNESP), SPUniversidade de São Paulo (USP)Universidade Estadual Paulista (UNESP)Universidade Federal de São Paulo (UNIFESP)UFAMCosin Shindo, João Vitor TadashiRodokas, José Eduardo Petit [UNESP]dos Santos Sousa, GuilhermeMaciel, Fabio OliveiraCouto, Maira Cristina RondinaMatsumoto, Mariza Akemi [UNESP]Sangalette, BeatrizGerman, Iris Jasmin SantosPomini, Karina TorresAndreo, Jesus CarlosShinohara, André Luís2022-04-28T19:52:03Z2022-04-28T19:52:03Z2021-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article398-403http://dx.doi.org/10.51929/jms.38.69.2021Journal of Morphological Sciences, v. 38, p. 398-403.2177-0298http://hdl.handle.net/11449/22367210.51929/jms.38.69.20212-s2.0-85126560996Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Morphological Sciencesinfo:eu-repo/semantics/openAccess2022-04-28T19:52:03Zoai:repositorio.unesp.br:11449/223672Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T15:15:54.329176Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Neuroelectrostimulation on Adult Mice’s Back and Hip Muscles, Through a Special Vest: a Pilot Study
title Neuroelectrostimulation on Adult Mice’s Back and Hip Muscles, Through a Special Vest: a Pilot Study
spellingShingle Neuroelectrostimulation on Adult Mice’s Back and Hip Muscles, Through a Special Vest: a Pilot Study
Cosin Shindo, João Vitor Tadashi
Electrostimulation
Hypertrophy
Sarcopenia
Skeletal Muscle
title_short Neuroelectrostimulation on Adult Mice’s Back and Hip Muscles, Through a Special Vest: a Pilot Study
title_full Neuroelectrostimulation on Adult Mice’s Back and Hip Muscles, Through a Special Vest: a Pilot Study
title_fullStr Neuroelectrostimulation on Adult Mice’s Back and Hip Muscles, Through a Special Vest: a Pilot Study
title_full_unstemmed Neuroelectrostimulation on Adult Mice’s Back and Hip Muscles, Through a Special Vest: a Pilot Study
title_sort Neuroelectrostimulation on Adult Mice’s Back and Hip Muscles, Through a Special Vest: a Pilot Study
author Cosin Shindo, João Vitor Tadashi
author_facet Cosin Shindo, João Vitor Tadashi
Rodokas, José Eduardo Petit [UNESP]
dos Santos Sousa, Guilherme
Maciel, Fabio Oliveira
Couto, Maira Cristina Rondina
Matsumoto, Mariza Akemi [UNESP]
Sangalette, Beatriz
German, Iris Jasmin Santos
Pomini, Karina Torres
Andreo, Jesus Carlos
Shinohara, André Luís
author_role author
author2 Rodokas, José Eduardo Petit [UNESP]
dos Santos Sousa, Guilherme
Maciel, Fabio Oliveira
Couto, Maira Cristina Rondina
Matsumoto, Mariza Akemi [UNESP]
Sangalette, Beatriz
German, Iris Jasmin Santos
Pomini, Karina Torres
Andreo, Jesus Carlos
Shinohara, André Luís
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade de São Paulo (USP)
Universidade Estadual Paulista (UNESP)
Universidade Federal de São Paulo (UNIFESP)
UFAM
dc.contributor.author.fl_str_mv Cosin Shindo, João Vitor Tadashi
Rodokas, José Eduardo Petit [UNESP]
dos Santos Sousa, Guilherme
Maciel, Fabio Oliveira
Couto, Maira Cristina Rondina
Matsumoto, Mariza Akemi [UNESP]
Sangalette, Beatriz
German, Iris Jasmin Santos
Pomini, Karina Torres
Andreo, Jesus Carlos
Shinohara, André Luís
dc.subject.por.fl_str_mv Electrostimulation
Hypertrophy
Sarcopenia
Skeletal Muscle
topic Electrostimulation
Hypertrophy
Sarcopenia
Skeletal Muscle
description Introduction: neuromuscular electrostimulation (NMES) is a promising strategy for recovering muscle mass and function, including in elderly patients suffering from sarcopenia. We developed a vest with coupled electrodes to introduce electrostimulation throughout the body of young mice and verify the morphological changes in the scapular and pelvic region muscles. Material and Methods: a vest based on the semi-flexible resin was developed with the electrodes already attached, printed by 3D printing with connectivity to the Neurodyn III electrostimulation device (Ibramed ®). Based on this, six 14-weeks old C57BL/6 WT mice were used to conduct this pilot study. Results: After four weeks, we found that using the vest with the coupled electrodes was able to generate an increase in CSA in the gluteus and trapezius muscle compared to control mice (p<0.05). The gluteus of the experimental group (EG) hypertrophied 15% more than the control group (CG). As occurred in the gluteus, in the trapezius muscle, the CSA was 37% higher in EG than in CG. Conclusions: we conclude that this model of NMES in mice leaded to morphological changes in scapular and pelvic region muscles. For future work, we intend to include molecular and functional analyzes to evaluate if our model can reproduce the same functional effects reported in studies and afterward apply this model to elderly animals.
publishDate 2021
dc.date.none.fl_str_mv 2021-01-01
2022-04-28T19:52:03Z
2022-04-28T19:52:03Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.51929/jms.38.69.2021
Journal of Morphological Sciences, v. 38, p. 398-403.
2177-0298
http://hdl.handle.net/11449/223672
10.51929/jms.38.69.2021
2-s2.0-85126560996
url http://dx.doi.org/10.51929/jms.38.69.2021
http://hdl.handle.net/11449/223672
identifier_str_mv Journal of Morphological Sciences, v. 38, p. 398-403.
2177-0298
10.51929/jms.38.69.2021
2-s2.0-85126560996
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Journal of Morphological Sciences
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 398-403
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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