Insulin favors acute inflammatory reaction in alloxan-diabetic tilapia during infectious aerocystitis
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/1678-5150-PVB-5532 http://hdl.handle.net/11449/188660 |
Resumo: | In vertebrates, the inflammatory reaction is responsible for modulating the initial nonspecific defense until specific immunity is acquired. In this context, numerous studies in mammals have demonstrated the participation of insulin in the inflammatory response, favoring cell proliferation and the migratory capacity of endothelial cells, vascular smooth muscle cells and monocytes, as well as mediating the expression of pro-thrombotic and pro-fibrotic factors. However, little is known about the effect of this peptidic hormone on the inflammatory reaction in teleostean fish. In order to evaluate the participation of insulin in the acute inflammatory response of Nile tilapia, Oreochromis niloticus, during aerocystitis induced by Aeromonas hydrophila, and 48 aloxane-diabetic tilapia were used, constituting two groups: Diabetics treated with insulin and diabetics without treatment. After six, 24, and 48 hours of inflammatory stimulation, tilapia were submitted to deep anesthesia for euthanasia and necropsy, and thus, obtaining exudate and harvesting of the swim bladder for analysis of the inflammatory reaction. Based on this premise, the present study demonstrated the participation of insulin in the acute inflammatory reaction of alloxan-diabetic tilapia by favors the cellular accumulation in the exudate, the proliferative effect of fibrous tissue and neovascularization in the inflamed site. Such findings reinforce the old hypothesis that insulin plays an important role in the innate immune response during acute inflammatory reaction, being an important pro-inflammatory hormone. However, Nile tilapia proved to be a promising experimental model for studies and advances in research involving diabetes mellitus. |
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Insulin favors acute inflammatory reaction in alloxan-diabetic tilapia during infectious aerocystitisacute inflammatory reactionaerocystitisAeromonas Hydrophilaalloxan-diabeticcichlidsclinicsdiabetesinflammationInsulinOreochromis niloticuspeptidic hormonestilapiaIn vertebrates, the inflammatory reaction is responsible for modulating the initial nonspecific defense until specific immunity is acquired. In this context, numerous studies in mammals have demonstrated the participation of insulin in the inflammatory response, favoring cell proliferation and the migratory capacity of endothelial cells, vascular smooth muscle cells and monocytes, as well as mediating the expression of pro-thrombotic and pro-fibrotic factors. However, little is known about the effect of this peptidic hormone on the inflammatory reaction in teleostean fish. In order to evaluate the participation of insulin in the acute inflammatory response of Nile tilapia, Oreochromis niloticus, during aerocystitis induced by Aeromonas hydrophila, and 48 aloxane-diabetic tilapia were used, constituting two groups: Diabetics treated with insulin and diabetics without treatment. After six, 24, and 48 hours of inflammatory stimulation, tilapia were submitted to deep anesthesia for euthanasia and necropsy, and thus, obtaining exudate and harvesting of the swim bladder for analysis of the inflammatory reaction. Based on this premise, the present study demonstrated the participation of insulin in the acute inflammatory reaction of alloxan-diabetic tilapia by favors the cellular accumulation in the exudate, the proliferative effect of fibrous tissue and neovascularization in the inflamed site. Such findings reinforce the old hypothesis that insulin plays an important role in the innate immune response during acute inflammatory reaction, being an important pro-inflammatory hormone. However, Nile tilapia proved to be a promising experimental model for studies and advances in research involving diabetes mellitus.Faculdade de Ciências Agrárias e Veterinárias (FCAV) Universidade Estadual Paulista Júlio de Mesquita Filho (Unesp) Campus de Jaboticabal, Via de acesso Prof. Paulo Donato Castellane s/nUniversidade Brasil, Av. Hilário da Silva Passos 950Centro de Aquicultura Universidade Estadual Paulista Júlio de Mesquita Filho (Unesp), Via de acesso Prof. Paulo Donato Castellane s/nFaculdade de Ciências Agrárias e Veterinárias (FCAV) Universidade Estadual Paulista Júlio de Mesquita Filho (Unesp) Campus de Jaboticabal, Via de acesso Prof. Paulo Donato Castellane s/nCentro de Aquicultura Universidade Estadual Paulista Júlio de Mesquita Filho (Unesp), Via de acesso Prof. Paulo Donato Castellane s/nUniversidade Estadual Paulista (Unesp)Universidade BrasilPrado, Ed Johnny R. [UNESP]Belo, Marco Antonio A. [UNESP]Moraes, Alessandra C. [UNESP]Barbuio, Roberto [UNESP]Foz, Elizabeth P.Faria, Vanessa P.Sebastião, Fernanda A. [UNESP]2019-10-06T16:15:09Z2019-10-06T16:15:09Z2018-12-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2190-2193application/pdfhttp://dx.doi.org/10.1590/1678-5150-PVB-5532Pesquisa Veterinaria Brasileira, v. 38, n. 12, p. 2190-2193, 2018.1678-51500100-736Xhttp://hdl.handle.net/11449/18866010.1590/1678-5150-PVB-5532S0100-736X20180012021902-s2.0-85060525250S0100-736X2018001202190.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengPesquisa Veterinaria Brasileirainfo:eu-repo/semantics/openAccess2023-11-03T06:07:05Zoai:repositorio.unesp.br:11449/188660Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-11-03T06:07:05Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Insulin favors acute inflammatory reaction in alloxan-diabetic tilapia during infectious aerocystitis |
title |
Insulin favors acute inflammatory reaction in alloxan-diabetic tilapia during infectious aerocystitis |
spellingShingle |
Insulin favors acute inflammatory reaction in alloxan-diabetic tilapia during infectious aerocystitis Prado, Ed Johnny R. [UNESP] acute inflammatory reaction aerocystitis Aeromonas Hydrophila alloxan-diabetic cichlids clinics diabetes inflammation Insulin Oreochromis niloticus peptidic hormones tilapia |
title_short |
Insulin favors acute inflammatory reaction in alloxan-diabetic tilapia during infectious aerocystitis |
title_full |
Insulin favors acute inflammatory reaction in alloxan-diabetic tilapia during infectious aerocystitis |
title_fullStr |
Insulin favors acute inflammatory reaction in alloxan-diabetic tilapia during infectious aerocystitis |
title_full_unstemmed |
Insulin favors acute inflammatory reaction in alloxan-diabetic tilapia during infectious aerocystitis |
title_sort |
Insulin favors acute inflammatory reaction in alloxan-diabetic tilapia during infectious aerocystitis |
author |
Prado, Ed Johnny R. [UNESP] |
author_facet |
Prado, Ed Johnny R. [UNESP] Belo, Marco Antonio A. [UNESP] Moraes, Alessandra C. [UNESP] Barbuio, Roberto [UNESP] Foz, Elizabeth P. Faria, Vanessa P. Sebastião, Fernanda A. [UNESP] |
author_role |
author |
author2 |
Belo, Marco Antonio A. [UNESP] Moraes, Alessandra C. [UNESP] Barbuio, Roberto [UNESP] Foz, Elizabeth P. Faria, Vanessa P. Sebastião, Fernanda A. [UNESP] |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Universidade Brasil |
dc.contributor.author.fl_str_mv |
Prado, Ed Johnny R. [UNESP] Belo, Marco Antonio A. [UNESP] Moraes, Alessandra C. [UNESP] Barbuio, Roberto [UNESP] Foz, Elizabeth P. Faria, Vanessa P. Sebastião, Fernanda A. [UNESP] |
dc.subject.por.fl_str_mv |
acute inflammatory reaction aerocystitis Aeromonas Hydrophila alloxan-diabetic cichlids clinics diabetes inflammation Insulin Oreochromis niloticus peptidic hormones tilapia |
topic |
acute inflammatory reaction aerocystitis Aeromonas Hydrophila alloxan-diabetic cichlids clinics diabetes inflammation Insulin Oreochromis niloticus peptidic hormones tilapia |
description |
In vertebrates, the inflammatory reaction is responsible for modulating the initial nonspecific defense until specific immunity is acquired. In this context, numerous studies in mammals have demonstrated the participation of insulin in the inflammatory response, favoring cell proliferation and the migratory capacity of endothelial cells, vascular smooth muscle cells and monocytes, as well as mediating the expression of pro-thrombotic and pro-fibrotic factors. However, little is known about the effect of this peptidic hormone on the inflammatory reaction in teleostean fish. In order to evaluate the participation of insulin in the acute inflammatory response of Nile tilapia, Oreochromis niloticus, during aerocystitis induced by Aeromonas hydrophila, and 48 aloxane-diabetic tilapia were used, constituting two groups: Diabetics treated with insulin and diabetics without treatment. After six, 24, and 48 hours of inflammatory stimulation, tilapia were submitted to deep anesthesia for euthanasia and necropsy, and thus, obtaining exudate and harvesting of the swim bladder for analysis of the inflammatory reaction. Based on this premise, the present study demonstrated the participation of insulin in the acute inflammatory reaction of alloxan-diabetic tilapia by favors the cellular accumulation in the exudate, the proliferative effect of fibrous tissue and neovascularization in the inflamed site. Such findings reinforce the old hypothesis that insulin plays an important role in the innate immune response during acute inflammatory reaction, being an important pro-inflammatory hormone. However, Nile tilapia proved to be a promising experimental model for studies and advances in research involving diabetes mellitus. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-12-01 2019-10-06T16:15:09Z 2019-10-06T16:15:09Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/1678-5150-PVB-5532 Pesquisa Veterinaria Brasileira, v. 38, n. 12, p. 2190-2193, 2018. 1678-5150 0100-736X http://hdl.handle.net/11449/188660 10.1590/1678-5150-PVB-5532 S0100-736X2018001202190 2-s2.0-85060525250 S0100-736X2018001202190.pdf |
url |
http://dx.doi.org/10.1590/1678-5150-PVB-5532 http://hdl.handle.net/11449/188660 |
identifier_str_mv |
Pesquisa Veterinaria Brasileira, v. 38, n. 12, p. 2190-2193, 2018. 1678-5150 0100-736X 10.1590/1678-5150-PVB-5532 S0100-736X2018001202190 2-s2.0-85060525250 S0100-736X2018001202190.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Pesquisa Veterinaria Brasileira |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
2190-2193 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1792961722316750848 |