Infection caused by Candida auris: state of the art
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
DOI: | 10.5943/mycosphere/13/1/10 |
Texto Completo: | http://dx.doi.org/10.5943/mycosphere/13/1/10 http://hdl.handle.net/11449/247877 |
Resumo: | Candida auris, a new emerging yeast that was isolated for the first time in 2009 in the ear canal of a Japanese patient, are increasingly been associated with outbreaks, threatening the whole world. As a highly lethal and contagious microorganism, C. auris can be considered a threat to public health, mainly due to the high death rate in hospital environments and ability to resist to the main first-line antifungal agents (echinocandins, azoles and polyenes), which limits its treatment and infection control. As it is a microorganism with little scientific and clinical knowledge, controlling its infection is still a great challenge. Faced with the worrying situation, this review presents important information concerning the morphology and biology of C. auris, as well as resistance mechanisms, updated epidemiology, virulence, immune response escape mechanisms, pathogenesis and processor involved in the pathogenesis mechanism, clinical manifestations, laboratory diagnosis and sample collection methods, molecular diagnostics, treatment of infection (main drugs used and future therapies) and prophylactic methods, with the objective not only of clarifying doubts of the scientific and medical population, but also of helping to control new outbreaks of C. auris worldwide. |
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Infection caused by Candida auris: state of the artAntifungal therapyCandidemiaEmerging fungusInfectious diseasesResistanceCandida auris, a new emerging yeast that was isolated for the first time in 2009 in the ear canal of a Japanese patient, are increasingly been associated with outbreaks, threatening the whole world. As a highly lethal and contagious microorganism, C. auris can be considered a threat to public health, mainly due to the high death rate in hospital environments and ability to resist to the main first-line antifungal agents (echinocandins, azoles and polyenes), which limits its treatment and infection control. As it is a microorganism with little scientific and clinical knowledge, controlling its infection is still a great challenge. Faced with the worrying situation, this review presents important information concerning the morphology and biology of C. auris, as well as resistance mechanisms, updated epidemiology, virulence, immune response escape mechanisms, pathogenesis and processor involved in the pathogenesis mechanism, clinical manifestations, laboratory diagnosis and sample collection methods, molecular diagnostics, treatment of infection (main drugs used and future therapies) and prophylactic methods, with the objective not only of clarifying doubts of the scientific and medical population, but also of helping to control new outbreaks of C. auris worldwide.Department of Drugs and Medicines São Paulo State University (UNESP) School of Pharmaceutical Sciences Campus AraraquaraUniversity of Araraquara (UNIARA), São PauloFederal University of Mato Grosso do SulDepartment of Infectious Diseases Faculty of Medicine of São José do Rio Preto (FAMERP), São PauloInstitute of Biosciences Humanities and Exact Sciences São Paulo State University (UNESP), São PauloDepartment of Drugs and Medicines São Paulo State University (UNESP) School of Pharmaceutical Sciences Campus AraraquaraInstitute of Biosciences Humanities and Exact Sciences São Paulo State University (UNESP), São PauloUniversidade Estadual Paulista (UNESP)University of Araraquara (UNIARA)Federal University of Mato Grosso do SulFaculty of Medicine of São José do Rio Preto (FAMERP)Marena, G. D. [UNESP]Carvalho, G. C. [UNESP]Monazzi, L. C.S.Maschio-Lima, T. [UNESP]De Almeida, M. T.G.Da Silva, J. L.M.Fortunato, G. C. [UNESP]Araújo, V. H.S. [UNESP]Venancio, D. C.V.Chang, M. R.Chorilli, M. [UNESP]2023-07-29T13:28:20Z2023-07-29T13:28:20Z2022-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article820-861http://dx.doi.org/10.5943/mycosphere/13/1/10Mycosphere, v. 13, n. 1, p. 820-861, 2022.2077-70192077-7000http://hdl.handle.net/11449/24787710.5943/mycosphere/13/1/102-s2.0-85141811306Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengMycosphereinfo:eu-repo/semantics/openAccess2024-06-24T13:45:39Zoai:repositorio.unesp.br:11449/247877Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T17:55:12.912996Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Infection caused by Candida auris: state of the art |
title |
Infection caused by Candida auris: state of the art |
spellingShingle |
Infection caused by Candida auris: state of the art Infection caused by Candida auris: state of the art Marena, G. D. [UNESP] Antifungal therapy Candidemia Emerging fungus Infectious diseases Resistance Marena, G. D. [UNESP] Antifungal therapy Candidemia Emerging fungus Infectious diseases Resistance |
title_short |
Infection caused by Candida auris: state of the art |
title_full |
Infection caused by Candida auris: state of the art |
title_fullStr |
Infection caused by Candida auris: state of the art Infection caused by Candida auris: state of the art |
title_full_unstemmed |
Infection caused by Candida auris: state of the art Infection caused by Candida auris: state of the art |
title_sort |
Infection caused by Candida auris: state of the art |
author |
Marena, G. D. [UNESP] |
author_facet |
Marena, G. D. [UNESP] Marena, G. D. [UNESP] Carvalho, G. C. [UNESP] Monazzi, L. C.S. Maschio-Lima, T. [UNESP] De Almeida, M. T.G. Da Silva, J. L.M. Fortunato, G. C. [UNESP] Araújo, V. H.S. [UNESP] Venancio, D. C.V. Chang, M. R. Chorilli, M. [UNESP] Carvalho, G. C. [UNESP] Monazzi, L. C.S. Maschio-Lima, T. [UNESP] De Almeida, M. T.G. Da Silva, J. L.M. Fortunato, G. C. [UNESP] Araújo, V. H.S. [UNESP] Venancio, D. C.V. Chang, M. R. Chorilli, M. [UNESP] |
author_role |
author |
author2 |
Carvalho, G. C. [UNESP] Monazzi, L. C.S. Maschio-Lima, T. [UNESP] De Almeida, M. T.G. Da Silva, J. L.M. Fortunato, G. C. [UNESP] Araújo, V. H.S. [UNESP] Venancio, D. C.V. Chang, M. R. Chorilli, M. [UNESP] |
author2_role |
author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) University of Araraquara (UNIARA) Federal University of Mato Grosso do Sul Faculty of Medicine of São José do Rio Preto (FAMERP) |
dc.contributor.author.fl_str_mv |
Marena, G. D. [UNESP] Carvalho, G. C. [UNESP] Monazzi, L. C.S. Maschio-Lima, T. [UNESP] De Almeida, M. T.G. Da Silva, J. L.M. Fortunato, G. C. [UNESP] Araújo, V. H.S. [UNESP] Venancio, D. C.V. Chang, M. R. Chorilli, M. [UNESP] |
dc.subject.por.fl_str_mv |
Antifungal therapy Candidemia Emerging fungus Infectious diseases Resistance |
topic |
Antifungal therapy Candidemia Emerging fungus Infectious diseases Resistance |
description |
Candida auris, a new emerging yeast that was isolated for the first time in 2009 in the ear canal of a Japanese patient, are increasingly been associated with outbreaks, threatening the whole world. As a highly lethal and contagious microorganism, C. auris can be considered a threat to public health, mainly due to the high death rate in hospital environments and ability to resist to the main first-line antifungal agents (echinocandins, azoles and polyenes), which limits its treatment and infection control. As it is a microorganism with little scientific and clinical knowledge, controlling its infection is still a great challenge. Faced with the worrying situation, this review presents important information concerning the morphology and biology of C. auris, as well as resistance mechanisms, updated epidemiology, virulence, immune response escape mechanisms, pathogenesis and processor involved in the pathogenesis mechanism, clinical manifestations, laboratory diagnosis and sample collection methods, molecular diagnostics, treatment of infection (main drugs used and future therapies) and prophylactic methods, with the objective not only of clarifying doubts of the scientific and medical population, but also of helping to control new outbreaks of C. auris worldwide. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-01-01 2023-07-29T13:28:20Z 2023-07-29T13:28:20Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.5943/mycosphere/13/1/10 Mycosphere, v. 13, n. 1, p. 820-861, 2022. 2077-7019 2077-7000 http://hdl.handle.net/11449/247877 10.5943/mycosphere/13/1/10 2-s2.0-85141811306 |
url |
http://dx.doi.org/10.5943/mycosphere/13/1/10 http://hdl.handle.net/11449/247877 |
identifier_str_mv |
Mycosphere, v. 13, n. 1, p. 820-861, 2022. 2077-7019 2077-7000 10.5943/mycosphere/13/1/10 2-s2.0-85141811306 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Mycosphere |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
820-861 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1822182326151413760 |
dc.identifier.doi.none.fl_str_mv |
10.5943/mycosphere/13/1/10 |