Cardiovascular changes in patients with non-severe Plasmodium vivax malaria

Detalhes bibliográficos
Autor(a) principal: Alencar-Filho, Aristoteles Comte
Data de Publicação: 2016
Outros Autores: Ferreira, Joao Marcos Bemfica Barbosa, Salinas, Jorge Luis, Fabbri, Camila, Monteiro, Wuelton Marcelo, Siqueira, Andre Machado, Okoshi, Katashi [UNESP], Lacerda, Marcus Vinicius Guimaraes, Okoshi, Marina Politi [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1016/j.ijcha.2016.03.004
http://hdl.handle.net/11449/177867
Resumo: Background: Cardiovascular system involvement in patients with Plasmodium vivax malaria has been poorly addressed. The aim of this study was to evaluate cardiac structures and function, and serum markers of cardiovascular injury in patients with the non-severe form of vivax malaria in Manaus, Amazonas State, Brazil. Methods and results: We prospectively evaluated 26 patients with vivax malaria in an outpatient referral hospital and compared results with a control group of 25 gender- and age-matched healthy individuals. Patients underwent clinical evaluation, laboratory tests, and transthoracic echocardiography at first evaluation (day zero, D0) and seven days (D7) after malaria diagnosis. At D0 echocardiography showed higher left ventricular (LV) systolic diameter (28.8 ± 2.82 vs 30.9 ± 4.03 mm; p = 0.037) and LV diastolic volume (82.4 ± 12.3 vs 93.8 ± 25.9 ml; p = 0.05), and lower LV ejection fraction (Teicholz method: 73.2 ± 6.59 vs 68.4 ± 4.87%; p = 0.004) in patients compared to controls. Right ventricle (RV) fractional area change (54.7 ± 5.11 vs 50.5 ± 6.71%; p = 0.014) was lower, and RV myocardial performance index (0.21 ± 0.07 vs 0.33 ± 0.19; p = 0.007), and pulmonary vascular resistance (1.13 ± 0.25 vs 1.32 ± 0.26 Woods unit; p = 0.012) were higher in patients than controls. Patients presented higher serum levels of unconjugated bilirubin (0.24 ± 0.15 vs 1.30 ± 0.89 mg/dL; p < 0.001), soluble vascular cell adhesion molecule-1 (sVCAM-1; 453 ± 143 vs 1983 ± 880 ng/mL; p < 0.001), N-terminal prohormone brain natriuretic peptide (0.59 ± 0.86 vs 1.08 ± 0.81 pg/mL; p = 0.045), and troponin T (861 ± 338 vs 1037 ± 264 pg/mL; p = 0.045), and lower levels of plasma nitrite (13.42 ± 8.15 vs 8.98 ± 3.97 μM; p = 0.016) than controls. Most alterations had reversed by D7. Conclusion: Patients with non-severe Plasmodium vivax malaria present subclinical reversible cardiovascular changes.
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spelling Cardiovascular changes in patients with non-severe Plasmodium vivax malariaEchocardiogramMyocardial injuryPrognosisPulmonary artery pressureRight ventricleVentricular functionBackground: Cardiovascular system involvement in patients with Plasmodium vivax malaria has been poorly addressed. The aim of this study was to evaluate cardiac structures and function, and serum markers of cardiovascular injury in patients with the non-severe form of vivax malaria in Manaus, Amazonas State, Brazil. Methods and results: We prospectively evaluated 26 patients with vivax malaria in an outpatient referral hospital and compared results with a control group of 25 gender- and age-matched healthy individuals. Patients underwent clinical evaluation, laboratory tests, and transthoracic echocardiography at first evaluation (day zero, D0) and seven days (D7) after malaria diagnosis. At D0 echocardiography showed higher left ventricular (LV) systolic diameter (28.8 ± 2.82 vs 30.9 ± 4.03 mm; p = 0.037) and LV diastolic volume (82.4 ± 12.3 vs 93.8 ± 25.9 ml; p = 0.05), and lower LV ejection fraction (Teicholz method: 73.2 ± 6.59 vs 68.4 ± 4.87%; p = 0.004) in patients compared to controls. Right ventricle (RV) fractional area change (54.7 ± 5.11 vs 50.5 ± 6.71%; p = 0.014) was lower, and RV myocardial performance index (0.21 ± 0.07 vs 0.33 ± 0.19; p = 0.007), and pulmonary vascular resistance (1.13 ± 0.25 vs 1.32 ± 0.26 Woods unit; p = 0.012) were higher in patients than controls. Patients presented higher serum levels of unconjugated bilirubin (0.24 ± 0.15 vs 1.30 ± 0.89 mg/dL; p < 0.001), soluble vascular cell adhesion molecule-1 (sVCAM-1; 453 ± 143 vs 1983 ± 880 ng/mL; p < 0.001), N-terminal prohormone brain natriuretic peptide (0.59 ± 0.86 vs 1.08 ± 0.81 pg/mL; p = 0.045), and troponin T (861 ± 338 vs 1037 ± 264 pg/mL; p = 0.045), and lower levels of plasma nitrite (13.42 ± 8.15 vs 8.98 ± 3.97 μM; p = 0.016) than controls. Most alterations had reversed by D7. Conclusion: Patients with non-severe Plasmodium vivax malaria present subclinical reversible cardiovascular changes.Amazonas Federal UniversityAmazonas State University (UEA)Emory UniversityNorth University Center Pharmacy SchoolTropical Disease Center Dr. Heitor Vieira DouradoNational Institute of Infectology Evandro Chagas Fundação Oswaldo CruzBotucatu Medical School UNESPResearch Center Leonidas and Maria Deane Fundação Oswaldo CruzBotucatu Medical School UNESPAmazonas Federal UniversityAmazonas State University (UEA)Emory UniversityPharmacy SchoolTropical Disease Center Dr. Heitor Vieira DouradoFundação Oswaldo CruzUniversidade Estadual Paulista (Unesp)Alencar-Filho, Aristoteles ComteFerreira, Joao Marcos Bemfica BarbosaSalinas, Jorge LuisFabbri, CamilaMonteiro, Wuelton MarceloSiqueira, Andre MachadoOkoshi, Katashi [UNESP]Lacerda, Marcus Vinicius GuimaraesOkoshi, Marina Politi [UNESP]2018-12-11T17:27:29Z2018-12-11T17:27:29Z2016-06-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article12-16application/pdfhttp://dx.doi.org/10.1016/j.ijcha.2016.03.004IJC Heart and Vasculature, v. 11, p. 12-16.2352-9067http://hdl.handle.net/11449/17786710.1016/j.ijcha.2016.03.0042-s2.0-849604174412-s2.0-84960417441.pdf159097157630942044631386719984320000-0001-8980-8839Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengIJC Heart and Vasculature0,342info:eu-repo/semantics/openAccess2024-01-07T06:25:59Zoai:repositorio.unesp.br:11449/177867Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-01-07T06:25:59Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Cardiovascular changes in patients with non-severe Plasmodium vivax malaria
title Cardiovascular changes in patients with non-severe Plasmodium vivax malaria
spellingShingle Cardiovascular changes in patients with non-severe Plasmodium vivax malaria
Alencar-Filho, Aristoteles Comte
Echocardiogram
Myocardial injury
Prognosis
Pulmonary artery pressure
Right ventricle
Ventricular function
title_short Cardiovascular changes in patients with non-severe Plasmodium vivax malaria
title_full Cardiovascular changes in patients with non-severe Plasmodium vivax malaria
title_fullStr Cardiovascular changes in patients with non-severe Plasmodium vivax malaria
title_full_unstemmed Cardiovascular changes in patients with non-severe Plasmodium vivax malaria
title_sort Cardiovascular changes in patients with non-severe Plasmodium vivax malaria
author Alencar-Filho, Aristoteles Comte
author_facet Alencar-Filho, Aristoteles Comte
Ferreira, Joao Marcos Bemfica Barbosa
Salinas, Jorge Luis
Fabbri, Camila
Monteiro, Wuelton Marcelo
Siqueira, Andre Machado
Okoshi, Katashi [UNESP]
Lacerda, Marcus Vinicius Guimaraes
Okoshi, Marina Politi [UNESP]
author_role author
author2 Ferreira, Joao Marcos Bemfica Barbosa
Salinas, Jorge Luis
Fabbri, Camila
Monteiro, Wuelton Marcelo
Siqueira, Andre Machado
Okoshi, Katashi [UNESP]
Lacerda, Marcus Vinicius Guimaraes
Okoshi, Marina Politi [UNESP]
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Amazonas Federal University
Amazonas State University (UEA)
Emory University
Pharmacy School
Tropical Disease Center Dr. Heitor Vieira Dourado
Fundação Oswaldo Cruz
Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Alencar-Filho, Aristoteles Comte
Ferreira, Joao Marcos Bemfica Barbosa
Salinas, Jorge Luis
Fabbri, Camila
Monteiro, Wuelton Marcelo
Siqueira, Andre Machado
Okoshi, Katashi [UNESP]
Lacerda, Marcus Vinicius Guimaraes
Okoshi, Marina Politi [UNESP]
dc.subject.por.fl_str_mv Echocardiogram
Myocardial injury
Prognosis
Pulmonary artery pressure
Right ventricle
Ventricular function
topic Echocardiogram
Myocardial injury
Prognosis
Pulmonary artery pressure
Right ventricle
Ventricular function
description Background: Cardiovascular system involvement in patients with Plasmodium vivax malaria has been poorly addressed. The aim of this study was to evaluate cardiac structures and function, and serum markers of cardiovascular injury in patients with the non-severe form of vivax malaria in Manaus, Amazonas State, Brazil. Methods and results: We prospectively evaluated 26 patients with vivax malaria in an outpatient referral hospital and compared results with a control group of 25 gender- and age-matched healthy individuals. Patients underwent clinical evaluation, laboratory tests, and transthoracic echocardiography at first evaluation (day zero, D0) and seven days (D7) after malaria diagnosis. At D0 echocardiography showed higher left ventricular (LV) systolic diameter (28.8 ± 2.82 vs 30.9 ± 4.03 mm; p = 0.037) and LV diastolic volume (82.4 ± 12.3 vs 93.8 ± 25.9 ml; p = 0.05), and lower LV ejection fraction (Teicholz method: 73.2 ± 6.59 vs 68.4 ± 4.87%; p = 0.004) in patients compared to controls. Right ventricle (RV) fractional area change (54.7 ± 5.11 vs 50.5 ± 6.71%; p = 0.014) was lower, and RV myocardial performance index (0.21 ± 0.07 vs 0.33 ± 0.19; p = 0.007), and pulmonary vascular resistance (1.13 ± 0.25 vs 1.32 ± 0.26 Woods unit; p = 0.012) were higher in patients than controls. Patients presented higher serum levels of unconjugated bilirubin (0.24 ± 0.15 vs 1.30 ± 0.89 mg/dL; p < 0.001), soluble vascular cell adhesion molecule-1 (sVCAM-1; 453 ± 143 vs 1983 ± 880 ng/mL; p < 0.001), N-terminal prohormone brain natriuretic peptide (0.59 ± 0.86 vs 1.08 ± 0.81 pg/mL; p = 0.045), and troponin T (861 ± 338 vs 1037 ± 264 pg/mL; p = 0.045), and lower levels of plasma nitrite (13.42 ± 8.15 vs 8.98 ± 3.97 μM; p = 0.016) than controls. Most alterations had reversed by D7. Conclusion: Patients with non-severe Plasmodium vivax malaria present subclinical reversible cardiovascular changes.
publishDate 2016
dc.date.none.fl_str_mv 2016-06-01
2018-12-11T17:27:29Z
2018-12-11T17:27:29Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/j.ijcha.2016.03.004
IJC Heart and Vasculature, v. 11, p. 12-16.
2352-9067
http://hdl.handle.net/11449/177867
10.1016/j.ijcha.2016.03.004
2-s2.0-84960417441
2-s2.0-84960417441.pdf
1590971576309420
4463138671998432
0000-0001-8980-8839
url http://dx.doi.org/10.1016/j.ijcha.2016.03.004
http://hdl.handle.net/11449/177867
identifier_str_mv IJC Heart and Vasculature, v. 11, p. 12-16.
2352-9067
10.1016/j.ijcha.2016.03.004
2-s2.0-84960417441
2-s2.0-84960417441.pdf
1590971576309420
4463138671998432
0000-0001-8980-8839
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv IJC Heart and Vasculature
0,342
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eu_rights_str_mv openAccess
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dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
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instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
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