Cardiovascular changes in patients with non-severe Plasmodium vivax malaria
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.ijcha.2016.03.004 http://hdl.handle.net/11449/177867 |
Resumo: | Background: Cardiovascular system involvement in patients with Plasmodium vivax malaria has been poorly addressed. The aim of this study was to evaluate cardiac structures and function, and serum markers of cardiovascular injury in patients with the non-severe form of vivax malaria in Manaus, Amazonas State, Brazil. Methods and results: We prospectively evaluated 26 patients with vivax malaria in an outpatient referral hospital and compared results with a control group of 25 gender- and age-matched healthy individuals. Patients underwent clinical evaluation, laboratory tests, and transthoracic echocardiography at first evaluation (day zero, D0) and seven days (D7) after malaria diagnosis. At D0 echocardiography showed higher left ventricular (LV) systolic diameter (28.8 ± 2.82 vs 30.9 ± 4.03 mm; p = 0.037) and LV diastolic volume (82.4 ± 12.3 vs 93.8 ± 25.9 ml; p = 0.05), and lower LV ejection fraction (Teicholz method: 73.2 ± 6.59 vs 68.4 ± 4.87%; p = 0.004) in patients compared to controls. Right ventricle (RV) fractional area change (54.7 ± 5.11 vs 50.5 ± 6.71%; p = 0.014) was lower, and RV myocardial performance index (0.21 ± 0.07 vs 0.33 ± 0.19; p = 0.007), and pulmonary vascular resistance (1.13 ± 0.25 vs 1.32 ± 0.26 Woods unit; p = 0.012) were higher in patients than controls. Patients presented higher serum levels of unconjugated bilirubin (0.24 ± 0.15 vs 1.30 ± 0.89 mg/dL; p < 0.001), soluble vascular cell adhesion molecule-1 (sVCAM-1; 453 ± 143 vs 1983 ± 880 ng/mL; p < 0.001), N-terminal prohormone brain natriuretic peptide (0.59 ± 0.86 vs 1.08 ± 0.81 pg/mL; p = 0.045), and troponin T (861 ± 338 vs 1037 ± 264 pg/mL; p = 0.045), and lower levels of plasma nitrite (13.42 ± 8.15 vs 8.98 ± 3.97 μM; p = 0.016) than controls. Most alterations had reversed by D7. Conclusion: Patients with non-severe Plasmodium vivax malaria present subclinical reversible cardiovascular changes. |
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Cardiovascular changes in patients with non-severe Plasmodium vivax malariaEchocardiogramMyocardial injuryPrognosisPulmonary artery pressureRight ventricleVentricular functionBackground: Cardiovascular system involvement in patients with Plasmodium vivax malaria has been poorly addressed. The aim of this study was to evaluate cardiac structures and function, and serum markers of cardiovascular injury in patients with the non-severe form of vivax malaria in Manaus, Amazonas State, Brazil. Methods and results: We prospectively evaluated 26 patients with vivax malaria in an outpatient referral hospital and compared results with a control group of 25 gender- and age-matched healthy individuals. Patients underwent clinical evaluation, laboratory tests, and transthoracic echocardiography at first evaluation (day zero, D0) and seven days (D7) after malaria diagnosis. At D0 echocardiography showed higher left ventricular (LV) systolic diameter (28.8 ± 2.82 vs 30.9 ± 4.03 mm; p = 0.037) and LV diastolic volume (82.4 ± 12.3 vs 93.8 ± 25.9 ml; p = 0.05), and lower LV ejection fraction (Teicholz method: 73.2 ± 6.59 vs 68.4 ± 4.87%; p = 0.004) in patients compared to controls. Right ventricle (RV) fractional area change (54.7 ± 5.11 vs 50.5 ± 6.71%; p = 0.014) was lower, and RV myocardial performance index (0.21 ± 0.07 vs 0.33 ± 0.19; p = 0.007), and pulmonary vascular resistance (1.13 ± 0.25 vs 1.32 ± 0.26 Woods unit; p = 0.012) were higher in patients than controls. Patients presented higher serum levels of unconjugated bilirubin (0.24 ± 0.15 vs 1.30 ± 0.89 mg/dL; p < 0.001), soluble vascular cell adhesion molecule-1 (sVCAM-1; 453 ± 143 vs 1983 ± 880 ng/mL; p < 0.001), N-terminal prohormone brain natriuretic peptide (0.59 ± 0.86 vs 1.08 ± 0.81 pg/mL; p = 0.045), and troponin T (861 ± 338 vs 1037 ± 264 pg/mL; p = 0.045), and lower levels of plasma nitrite (13.42 ± 8.15 vs 8.98 ± 3.97 μM; p = 0.016) than controls. Most alterations had reversed by D7. Conclusion: Patients with non-severe Plasmodium vivax malaria present subclinical reversible cardiovascular changes.Amazonas Federal UniversityAmazonas State University (UEA)Emory UniversityNorth University Center Pharmacy SchoolTropical Disease Center Dr. Heitor Vieira DouradoNational Institute of Infectology Evandro Chagas Fundação Oswaldo CruzBotucatu Medical School UNESPResearch Center Leonidas and Maria Deane Fundação Oswaldo CruzBotucatu Medical School UNESPAmazonas Federal UniversityAmazonas State University (UEA)Emory UniversityPharmacy SchoolTropical Disease Center Dr. Heitor Vieira DouradoFundação Oswaldo CruzUniversidade Estadual Paulista (Unesp)Alencar-Filho, Aristoteles ComteFerreira, Joao Marcos Bemfica BarbosaSalinas, Jorge LuisFabbri, CamilaMonteiro, Wuelton MarceloSiqueira, Andre MachadoOkoshi, Katashi [UNESP]Lacerda, Marcus Vinicius GuimaraesOkoshi, Marina Politi [UNESP]2018-12-11T17:27:29Z2018-12-11T17:27:29Z2016-06-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article12-16application/pdfhttp://dx.doi.org/10.1016/j.ijcha.2016.03.004IJC Heart and Vasculature, v. 11, p. 12-16.2352-9067http://hdl.handle.net/11449/17786710.1016/j.ijcha.2016.03.0042-s2.0-849604174412-s2.0-84960417441.pdf159097157630942044631386719984320000-0001-8980-8839Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengIJC Heart and Vasculature0,342info:eu-repo/semantics/openAccess2024-01-07T06:25:59Zoai:repositorio.unesp.br:11449/177867Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-01-07T06:25:59Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Cardiovascular changes in patients with non-severe Plasmodium vivax malaria |
title |
Cardiovascular changes in patients with non-severe Plasmodium vivax malaria |
spellingShingle |
Cardiovascular changes in patients with non-severe Plasmodium vivax malaria Alencar-Filho, Aristoteles Comte Echocardiogram Myocardial injury Prognosis Pulmonary artery pressure Right ventricle Ventricular function |
title_short |
Cardiovascular changes in patients with non-severe Plasmodium vivax malaria |
title_full |
Cardiovascular changes in patients with non-severe Plasmodium vivax malaria |
title_fullStr |
Cardiovascular changes in patients with non-severe Plasmodium vivax malaria |
title_full_unstemmed |
Cardiovascular changes in patients with non-severe Plasmodium vivax malaria |
title_sort |
Cardiovascular changes in patients with non-severe Plasmodium vivax malaria |
author |
Alencar-Filho, Aristoteles Comte |
author_facet |
Alencar-Filho, Aristoteles Comte Ferreira, Joao Marcos Bemfica Barbosa Salinas, Jorge Luis Fabbri, Camila Monteiro, Wuelton Marcelo Siqueira, Andre Machado Okoshi, Katashi [UNESP] Lacerda, Marcus Vinicius Guimaraes Okoshi, Marina Politi [UNESP] |
author_role |
author |
author2 |
Ferreira, Joao Marcos Bemfica Barbosa Salinas, Jorge Luis Fabbri, Camila Monteiro, Wuelton Marcelo Siqueira, Andre Machado Okoshi, Katashi [UNESP] Lacerda, Marcus Vinicius Guimaraes Okoshi, Marina Politi [UNESP] |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
Amazonas Federal University Amazonas State University (UEA) Emory University Pharmacy School Tropical Disease Center Dr. Heitor Vieira Dourado Fundação Oswaldo Cruz Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Alencar-Filho, Aristoteles Comte Ferreira, Joao Marcos Bemfica Barbosa Salinas, Jorge Luis Fabbri, Camila Monteiro, Wuelton Marcelo Siqueira, Andre Machado Okoshi, Katashi [UNESP] Lacerda, Marcus Vinicius Guimaraes Okoshi, Marina Politi [UNESP] |
dc.subject.por.fl_str_mv |
Echocardiogram Myocardial injury Prognosis Pulmonary artery pressure Right ventricle Ventricular function |
topic |
Echocardiogram Myocardial injury Prognosis Pulmonary artery pressure Right ventricle Ventricular function |
description |
Background: Cardiovascular system involvement in patients with Plasmodium vivax malaria has been poorly addressed. The aim of this study was to evaluate cardiac structures and function, and serum markers of cardiovascular injury in patients with the non-severe form of vivax malaria in Manaus, Amazonas State, Brazil. Methods and results: We prospectively evaluated 26 patients with vivax malaria in an outpatient referral hospital and compared results with a control group of 25 gender- and age-matched healthy individuals. Patients underwent clinical evaluation, laboratory tests, and transthoracic echocardiography at first evaluation (day zero, D0) and seven days (D7) after malaria diagnosis. At D0 echocardiography showed higher left ventricular (LV) systolic diameter (28.8 ± 2.82 vs 30.9 ± 4.03 mm; p = 0.037) and LV diastolic volume (82.4 ± 12.3 vs 93.8 ± 25.9 ml; p = 0.05), and lower LV ejection fraction (Teicholz method: 73.2 ± 6.59 vs 68.4 ± 4.87%; p = 0.004) in patients compared to controls. Right ventricle (RV) fractional area change (54.7 ± 5.11 vs 50.5 ± 6.71%; p = 0.014) was lower, and RV myocardial performance index (0.21 ± 0.07 vs 0.33 ± 0.19; p = 0.007), and pulmonary vascular resistance (1.13 ± 0.25 vs 1.32 ± 0.26 Woods unit; p = 0.012) were higher in patients than controls. Patients presented higher serum levels of unconjugated bilirubin (0.24 ± 0.15 vs 1.30 ± 0.89 mg/dL; p < 0.001), soluble vascular cell adhesion molecule-1 (sVCAM-1; 453 ± 143 vs 1983 ± 880 ng/mL; p < 0.001), N-terminal prohormone brain natriuretic peptide (0.59 ± 0.86 vs 1.08 ± 0.81 pg/mL; p = 0.045), and troponin T (861 ± 338 vs 1037 ± 264 pg/mL; p = 0.045), and lower levels of plasma nitrite (13.42 ± 8.15 vs 8.98 ± 3.97 μM; p = 0.016) than controls. Most alterations had reversed by D7. Conclusion: Patients with non-severe Plasmodium vivax malaria present subclinical reversible cardiovascular changes. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-06-01 2018-12-11T17:27:29Z 2018-12-11T17:27:29Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.ijcha.2016.03.004 IJC Heart and Vasculature, v. 11, p. 12-16. 2352-9067 http://hdl.handle.net/11449/177867 10.1016/j.ijcha.2016.03.004 2-s2.0-84960417441 2-s2.0-84960417441.pdf 1590971576309420 4463138671998432 0000-0001-8980-8839 |
url |
http://dx.doi.org/10.1016/j.ijcha.2016.03.004 http://hdl.handle.net/11449/177867 |
identifier_str_mv |
IJC Heart and Vasculature, v. 11, p. 12-16. 2352-9067 10.1016/j.ijcha.2016.03.004 2-s2.0-84960417441 2-s2.0-84960417441.pdf 1590971576309420 4463138671998432 0000-0001-8980-8839 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
IJC Heart and Vasculature 0,342 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
12-16 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1799965545714417664 |