Actions of angiotensin II and dopamine in the medial preoptic area on prolactin secretion
Autor(a) principal: | |
---|---|
Data de Publicação: | 2008 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://www.biomed.cas.cz/physiolres/pdf/57/57_109.pdf http://hdl.handle.net/11449/14982 |
Resumo: | Dopamine (DA) is known as a primary regulator of prolactin secretion (PRL) and angiotensin II (Ang II) has been recognized as one brain inhibitory factor of this secretion. In this work, estrogen-primed or unprimed ovariectornized rats were submitted to the microinjection of saline or Ang II after previous microinjection of saline or of da antagonist (haloperidol, sulpiride or SCH) both in the medial preoptic area (MPOA). Our study of these interactions has shown that 1) estrogen-induced PRL secretion is mediated by Ang II and da actions in the MPOA, i.e. very high plasma PRL would be prevented by inhibitory action of Ang II, while very low levels would be prevented in part by stimulatory action of da through D-2 receptors, 2) the inhibitory action of Ang II depends on estrogen and is mediated in part by inhibitory action of da through D, receptors and in other part by inhibition of stimulatory action of da through D2 receptors. |
id |
UNSP_a0cb1c866be72022de5c3daf73f26ad1 |
---|---|
oai_identifier_str |
oai:repositorio.unesp.br:11449/14982 |
network_acronym_str |
UNSP |
network_name_str |
Repositório Institucional da UNESP |
repository_id_str |
2946 |
spelling |
Actions of angiotensin II and dopamine in the medial preoptic area on prolactin secretionprolactinmedial preoptic areaangiotensin IIdopaminergic antagonistsestrogenDopamine (DA) is known as a primary regulator of prolactin secretion (PRL) and angiotensin II (Ang II) has been recognized as one brain inhibitory factor of this secretion. In this work, estrogen-primed or unprimed ovariectornized rats were submitted to the microinjection of saline or Ang II after previous microinjection of saline or of da antagonist (haloperidol, sulpiride or SCH) both in the medial preoptic area (MPOA). Our study of these interactions has shown that 1) estrogen-induced PRL secretion is mediated by Ang II and da actions in the MPOA, i.e. very high plasma PRL would be prevented by inhibitory action of Ang II, while very low levels would be prevented in part by stimulatory action of da through D-2 receptors, 2) the inhibitory action of Ang II depends on estrogen and is mediated in part by inhibitory action of da through D, receptors and in other part by inhibition of stimulatory action of da through D2 receptors.Univ São Paulo, Fac Med Ribeirao Preto, Dept Fisiol, BR-14049900 Ribeirao Preto, SP, BrazilUniv Estadual Paulista, Fac Odontol, Dept Basic Sci, Aracatuba, BrazilUniv Estadual Paulista, Fac Odontol, Dept Basic Sci, Aracatuba, BrazilAcad Sciences Czech Republic, Inst PhysiologyUniversidade de São Paulo (USP)Universidade Estadual Paulista (Unesp)Leite, C. M.Machado, G. J. R. [UNESP]Dornelles, Rita Cassia Menegati [UNESP]Franci, C. R.2013-09-30T18:29:14Z2014-05-20T13:43:03Z2013-09-30T18:29:14Z2014-05-20T13:43:03Z2008-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article109-118http://www.biomed.cas.cz/physiolres/pdf/57/57_109.pdfPhysiological Research. Prague 4: Acad Sciences Czech Republic, Inst Physiology, v. 57, n. 1, p. 109-118, 2008.0862-8408http://hdl.handle.net/11449/14982WOS:00025499940001654359024227848890000-0003-0783-6612Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengPhysiological Research1.3240,568info:eu-repo/semantics/openAccess2021-10-22T20:28:43Zoai:repositorio.unesp.br:11449/14982Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T19:45:28.766252Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Actions of angiotensin II and dopamine in the medial preoptic area on prolactin secretion |
title |
Actions of angiotensin II and dopamine in the medial preoptic area on prolactin secretion |
spellingShingle |
Actions of angiotensin II and dopamine in the medial preoptic area on prolactin secretion Leite, C. M. prolactin medial preoptic area angiotensin II dopaminergic antagonists estrogen |
title_short |
Actions of angiotensin II and dopamine in the medial preoptic area on prolactin secretion |
title_full |
Actions of angiotensin II and dopamine in the medial preoptic area on prolactin secretion |
title_fullStr |
Actions of angiotensin II and dopamine in the medial preoptic area on prolactin secretion |
title_full_unstemmed |
Actions of angiotensin II and dopamine in the medial preoptic area on prolactin secretion |
title_sort |
Actions of angiotensin II and dopamine in the medial preoptic area on prolactin secretion |
author |
Leite, C. M. |
author_facet |
Leite, C. M. Machado, G. J. R. [UNESP] Dornelles, Rita Cassia Menegati [UNESP] Franci, C. R. |
author_role |
author |
author2 |
Machado, G. J. R. [UNESP] Dornelles, Rita Cassia Menegati [UNESP] Franci, C. R. |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Universidade de São Paulo (USP) Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Leite, C. M. Machado, G. J. R. [UNESP] Dornelles, Rita Cassia Menegati [UNESP] Franci, C. R. |
dc.subject.por.fl_str_mv |
prolactin medial preoptic area angiotensin II dopaminergic antagonists estrogen |
topic |
prolactin medial preoptic area angiotensin II dopaminergic antagonists estrogen |
description |
Dopamine (DA) is known as a primary regulator of prolactin secretion (PRL) and angiotensin II (Ang II) has been recognized as one brain inhibitory factor of this secretion. In this work, estrogen-primed or unprimed ovariectornized rats were submitted to the microinjection of saline or Ang II after previous microinjection of saline or of da antagonist (haloperidol, sulpiride or SCH) both in the medial preoptic area (MPOA). Our study of these interactions has shown that 1) estrogen-induced PRL secretion is mediated by Ang II and da actions in the MPOA, i.e. very high plasma PRL would be prevented by inhibitory action of Ang II, while very low levels would be prevented in part by stimulatory action of da through D-2 receptors, 2) the inhibitory action of Ang II depends on estrogen and is mediated in part by inhibitory action of da through D, receptors and in other part by inhibition of stimulatory action of da through D2 receptors. |
publishDate |
2008 |
dc.date.none.fl_str_mv |
2008-01-01 2013-09-30T18:29:14Z 2013-09-30T18:29:14Z 2014-05-20T13:43:03Z 2014-05-20T13:43:03Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://www.biomed.cas.cz/physiolres/pdf/57/57_109.pdf Physiological Research. Prague 4: Acad Sciences Czech Republic, Inst Physiology, v. 57, n. 1, p. 109-118, 2008. 0862-8408 http://hdl.handle.net/11449/14982 WOS:000254999400016 5435902422784889 0000-0003-0783-6612 |
url |
http://www.biomed.cas.cz/physiolres/pdf/57/57_109.pdf http://hdl.handle.net/11449/14982 |
identifier_str_mv |
Physiological Research. Prague 4: Acad Sciences Czech Republic, Inst Physiology, v. 57, n. 1, p. 109-118, 2008. 0862-8408 WOS:000254999400016 5435902422784889 0000-0003-0783-6612 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Physiological Research 1.324 0,568 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
109-118 |
dc.publisher.none.fl_str_mv |
Acad Sciences Czech Republic, Inst Physiology |
publisher.none.fl_str_mv |
Acad Sciences Czech Republic, Inst Physiology |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129114165477376 |