Teratoma Associated With Testicular Tissue in a Female-Like Horse With 64,XY (SRY-Positive) Disorder of Sex Development
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.jevs.2020.103177 http://hdl.handle.net/11449/199094 |
Resumo: | A four-year-old female-like Quarter Horse was admitted for clinical evaluation because of masculinized-aggressive behavior and lack of estrous signs. On external inspection, a hypertrophied clitoris and prominent muscles were observed. On gynecological examination, apparently normal mammary glands, vulva, vagina, and cervix were noted. On the other hand, the uterus had no tone and was smaller than normal. The left gonad was very soft on palpation and the right gonad was mostly firm, irregular, and wider than the left gonad. On ultrasound examination, there were no signs of regular ovarian structure or follicular activity. Because of the different shapes and consistencies of the gonads and a suspicion of increased testosterone production, a bilateral gonadectomy was recommended. Blood was collected for testosterone levels quantification and for cytogenetic and molecular investigations. After removal, gonads were analyzed macroscopically and sections were sent for histopathological examination. A final diagnosis of benign adult teratoma associated with seminiferous tubules and Leydig cells was made. On cytogenetic and molecular analyses, a normal diploid number of 64 chromosomes and the presence of the XY sex chromosomes were seen in all cells, as well as the SRY gene. Testosterone levels were higher than normal before surgery and were reduced after gonads removal. In conclusion, the masculinized behavior was probably caused by increased testosterone levels produced by testicular tissue, in a female-like horse with 64,XY SRY-positive disorder of sex development, which was associated with a teratoma. |
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Teratoma Associated With Testicular Tissue in a Female-Like Horse With 64,XY (SRY-Positive) Disorder of Sex DevelopmentHorseKaryotypeNeoplasmSex abnormalitiesA four-year-old female-like Quarter Horse was admitted for clinical evaluation because of masculinized-aggressive behavior and lack of estrous signs. On external inspection, a hypertrophied clitoris and prominent muscles were observed. On gynecological examination, apparently normal mammary glands, vulva, vagina, and cervix were noted. On the other hand, the uterus had no tone and was smaller than normal. The left gonad was very soft on palpation and the right gonad was mostly firm, irregular, and wider than the left gonad. On ultrasound examination, there were no signs of regular ovarian structure or follicular activity. Because of the different shapes and consistencies of the gonads and a suspicion of increased testosterone production, a bilateral gonadectomy was recommended. Blood was collected for testosterone levels quantification and for cytogenetic and molecular investigations. After removal, gonads were analyzed macroscopically and sections were sent for histopathological examination. A final diagnosis of benign adult teratoma associated with seminiferous tubules and Leydig cells was made. On cytogenetic and molecular analyses, a normal diploid number of 64 chromosomes and the presence of the XY sex chromosomes were seen in all cells, as well as the SRY gene. Testosterone levels were higher than normal before surgery and were reduced after gonads removal. In conclusion, the masculinized behavior was probably caused by increased testosterone levels produced by testicular tissue, in a female-like horse with 64,XY SRY-positive disorder of sex development, which was associated with a teratoma.School of Veterinary Medicine - Universidade Federal de UberlândiaDepartment of Pathology School of Medicine São Paulo State University (UNESP)Department of Chemistry and Biological Sciences Institute of Biosciences São Paulo State University (UNESP)Department of Pathology School of Medicine São Paulo State University (UNESP)Department of Chemistry and Biological Sciences Institute of Biosciences São Paulo State University (UNESP)Universidade Federal de Uberlândia (UFU)Universidade Estadual Paulista (Unesp)Sant'Anna Monteiro da Silva, ElisaZanzarini Delfiol, Diego JoséFabris, Viciany Henrique [UNESP]Mendonça Santos, Bruna [UNESP]Nogueira, Geison MorelOliveira Guimarães, Gilmar BrenoPaulo de Oliveira Nogueira, Pedro [UNESP]Lima Silveira da Mota, Lígia Souza [UNESP]2020-12-12T01:30:38Z2020-12-12T01:30:38Z2020-09-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.jevs.2020.103177Journal of Equine Veterinary Science, v. 92.0737-0806http://hdl.handle.net/11449/19909410.1016/j.jevs.2020.1031772-s2.0-85087755478Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Equine Veterinary Scienceinfo:eu-repo/semantics/openAccess2021-10-23T03:03:53Zoai:repositorio.unesp.br:11449/199094Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T23:35:25.941977Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Teratoma Associated With Testicular Tissue in a Female-Like Horse With 64,XY (SRY-Positive) Disorder of Sex Development |
title |
Teratoma Associated With Testicular Tissue in a Female-Like Horse With 64,XY (SRY-Positive) Disorder of Sex Development |
spellingShingle |
Teratoma Associated With Testicular Tissue in a Female-Like Horse With 64,XY (SRY-Positive) Disorder of Sex Development Sant'Anna Monteiro da Silva, Elisa Horse Karyotype Neoplasm Sex abnormalities |
title_short |
Teratoma Associated With Testicular Tissue in a Female-Like Horse With 64,XY (SRY-Positive) Disorder of Sex Development |
title_full |
Teratoma Associated With Testicular Tissue in a Female-Like Horse With 64,XY (SRY-Positive) Disorder of Sex Development |
title_fullStr |
Teratoma Associated With Testicular Tissue in a Female-Like Horse With 64,XY (SRY-Positive) Disorder of Sex Development |
title_full_unstemmed |
Teratoma Associated With Testicular Tissue in a Female-Like Horse With 64,XY (SRY-Positive) Disorder of Sex Development |
title_sort |
Teratoma Associated With Testicular Tissue in a Female-Like Horse With 64,XY (SRY-Positive) Disorder of Sex Development |
author |
Sant'Anna Monteiro da Silva, Elisa |
author_facet |
Sant'Anna Monteiro da Silva, Elisa Zanzarini Delfiol, Diego José Fabris, Viciany Henrique [UNESP] Mendonça Santos, Bruna [UNESP] Nogueira, Geison Morel Oliveira Guimarães, Gilmar Breno Paulo de Oliveira Nogueira, Pedro [UNESP] Lima Silveira da Mota, Lígia Souza [UNESP] |
author_role |
author |
author2 |
Zanzarini Delfiol, Diego José Fabris, Viciany Henrique [UNESP] Mendonça Santos, Bruna [UNESP] Nogueira, Geison Morel Oliveira Guimarães, Gilmar Breno Paulo de Oliveira Nogueira, Pedro [UNESP] Lima Silveira da Mota, Lígia Souza [UNESP] |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal de Uberlândia (UFU) Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Sant'Anna Monteiro da Silva, Elisa Zanzarini Delfiol, Diego José Fabris, Viciany Henrique [UNESP] Mendonça Santos, Bruna [UNESP] Nogueira, Geison Morel Oliveira Guimarães, Gilmar Breno Paulo de Oliveira Nogueira, Pedro [UNESP] Lima Silveira da Mota, Lígia Souza [UNESP] |
dc.subject.por.fl_str_mv |
Horse Karyotype Neoplasm Sex abnormalities |
topic |
Horse Karyotype Neoplasm Sex abnormalities |
description |
A four-year-old female-like Quarter Horse was admitted for clinical evaluation because of masculinized-aggressive behavior and lack of estrous signs. On external inspection, a hypertrophied clitoris and prominent muscles were observed. On gynecological examination, apparently normal mammary glands, vulva, vagina, and cervix were noted. On the other hand, the uterus had no tone and was smaller than normal. The left gonad was very soft on palpation and the right gonad was mostly firm, irregular, and wider than the left gonad. On ultrasound examination, there were no signs of regular ovarian structure or follicular activity. Because of the different shapes and consistencies of the gonads and a suspicion of increased testosterone production, a bilateral gonadectomy was recommended. Blood was collected for testosterone levels quantification and for cytogenetic and molecular investigations. After removal, gonads were analyzed macroscopically and sections were sent for histopathological examination. A final diagnosis of benign adult teratoma associated with seminiferous tubules and Leydig cells was made. On cytogenetic and molecular analyses, a normal diploid number of 64 chromosomes and the presence of the XY sex chromosomes were seen in all cells, as well as the SRY gene. Testosterone levels were higher than normal before surgery and were reduced after gonads removal. In conclusion, the masculinized behavior was probably caused by increased testosterone levels produced by testicular tissue, in a female-like horse with 64,XY SRY-positive disorder of sex development, which was associated with a teratoma. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-12-12T01:30:38Z 2020-12-12T01:30:38Z 2020-09-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.jevs.2020.103177 Journal of Equine Veterinary Science, v. 92. 0737-0806 http://hdl.handle.net/11449/199094 10.1016/j.jevs.2020.103177 2-s2.0-85087755478 |
url |
http://dx.doi.org/10.1016/j.jevs.2020.103177 http://hdl.handle.net/11449/199094 |
identifier_str_mv |
Journal of Equine Veterinary Science, v. 92. 0737-0806 10.1016/j.jevs.2020.103177 2-s2.0-85087755478 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of Equine Veterinary Science |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129533936664576 |