Análise da incidência de comorbidades em pacientes com câncer de boca e orofaringe e sua associação com as variáveis clinicopatológicas e sobrevida

• Autor(a) principal: Curvo, Ana Raphaela Maia Dezan Couto [UNESP]
• Data de Publicação: 2015
• Tipo de documento: Trabalho de conclusão de curso
• Idioma: por
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://hdl.handle.net/11449/149667; http://www.athena.biblioteca.unesp.br/exlibris/bd/capelo/2017-01-31/000867598.pdf
• topic: Neoplasias bucais; Neoplasias orofaríngeas; Comorbidade; Mouth neoplasms

The objective of this study was to evaluate the incidence of comorbidities in paientes with squamous cell carcinoma (OSCC) and oropharynx and its association with clinical and survival variables. We retrospectively reviewed the records of patients with head and neck cancer treated at the Oral Oncology Center (COB) Araçatuba School of Dentistry - FOA between 1991 and 2013. The univariate analyzes were used to evaluate the association between the presence of comorbidities and clinical variables and Kaplan-Meier test to verify the association with the global and specific survival. The study included 473 patients with squamous cell carcinoma of the mouth and oropharynx. Of all patients, 44.4% had a history of some type of comorbidity. The most common comorbidity in cancer patients was hypertension, followed gastritis, diabetes, stroke and pulmonary emphysema. There was a higher incidence of co-morbidities patients and in women over 65 years. The presence of comorbidities was also associated with clinical staging and size of the initial primary tumor (T1 / T2). There was no association of the occurrence of comorbidities with a history of smoking and alcohol abuse, presence of regional metastasis, histological grade of the primary tumor and the occurrence of recurrence and second primary tumor. There was no association between the presence of comorbidity and the overall and specific survival of patients with squamous cell carcinoma of the mouth and oropharynx. When the occurrence of hypertension was analyzed as an isolated variable, the results showed that patients with oral squamous cell carcinoma and hypertensive oropharynx also fewer women and older than non-hypertensive patients had early-stage cancer and relapse rates smaller. The presence of hypertension was associated with a higher overall and specific...