Extratemporal abnormalities in phosphorus magnetic resonance spectroscopy of patients with mesial temporal sclerosis

• Autor(a) principal: Park, Eun Joo
• Data de Publicação: 2016
• Outros Autores: Garcia Otaduy, Maria Concepcion, Lyra, Katarina Paz de, Andrade, Celi Santos, Martins Castro, Luiz Henrique, Passarelli, Valmir, Figueiredo Valerio, Rosa Maria, Jorge, Carmen Lisa, Tsunemi, Miriam Harumi [UNESP], Leite, Claudia da Costa
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://dx.doi.org/10.1590/0004-282X20160005; http://hdl.handle.net/11449/165104
• topic: phosphorus spectroscopy; magnetic resonance imaging; neurometabolism; mesial temporal sclerosis; epilepsy

Objective: We evaluated extratemporal metabolic changes with phosphorus magnetic resonance spectroscopy (P-31-MRS) in patients with unilateral mesial temporal sclerosis (MTS). Method: P-31-MRS of 33 patients with unilateral MTS was compared with 31 controls. The voxels were selected in the anterior, posterior insula-basal ganglia (AIBG, PIBG) and frontal lobes (FL). Relative values of phosphodiesters-PDE, phosphomonoesters-PME, inorganic phosphate - Pi, phosphocreatine-PCr, total adenosine triphosphate [ATP(t=) gamma- + a- + b-ATP] and the ratios PCr/ATP(t), PCr/gamma-ATP, PCr/Pi and PME/PDE were obtained. Results: We found energetic abnormalities in the MTS patients compared to the controls with Pi reduction bilaterally in the AIBG and ipsilaterally in the PIBG and the contralateral FL; there was also decreased PCr/gamma-ATP in the ipsilateral AIBG and PIBG. Increased ATP(T) in the contralateral AIBG and increased gamma-ATP in the ipsilateral PIBG were detected. Conclusion: Widespread energy dysfunction was detected in patients with unilateral MTS.