Evaluation of chemical restraint, isoflurane anesthesia and methadone or tramadol as preventive analgesia in spotted pacas (Cuniculus paca) subjected to laparoscopy

Detalhes bibliográficos
Autor(a) principal: Uscategui, Ricardo AR. [UNESP]
Data de Publicação: 2021
Outros Autores: Barros, Felipe FPC., Almeida, Vívian T. [UNESP], Kawanami, Aline E. [UNESP], Feliciano, Marcus AR., Vicente, Wilter RR. [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1016/j.vaa.2020.09.001
http://hdl.handle.net/11449/208198
Resumo: Objective: To evaluate the efficacy and cardiopulmonary effects of ketamine–midazolam for chemical restraint, isoflurane anesthesia and tramadol or methadone as preventive analgesia in spotted pacas subjected to laparoscopy. Study design: Prospective placebo-controlled blinded trial. Animals: A total of eight captive female Cuniculus paca weighing 9.3 ± 0.9 kg. Methods: Animals were anesthetized on three occasions with 15 day intervals. Manually restrained animals were administered midazolam (0.5 mg kg–1) and ketamine (25 mg kg–1) intramuscularly. Anesthesia was induced and maintained with isoflurane 30 minutes later. Tramadol (5 mg kg–1), methadone (0.5 mg kg–1) or saline (0.05 mL kg–1) were administered intramuscularly 15 minutes prior to laparoscopy. Heart rate (HR), respiratory rate, mean arterial pressure (MAP), peripheral oxygen saturation (SpO2), end-tidal CO2 partial pressure (PE′CO2), end-tidal concentration of isoflurane (FE′Iso), pH, PaO2, PaCO2, bicarbonate (HCO3−), anion gap (AG) and base excess (BE) were monitored after chemical restraint, anesthesia induction and at different laparoscopy stages. Postoperative pain was assessed by visual analog scale (VAS) for 24 hours. Variables were compared using ANOVA or Friedman test (p < 0.05). Results: Chemical restraint was effective in 92% of animals. Isoflurane anesthesia was effective; however, HR, MAP, pH and AG decreased, whereas PE′CO2, PaO2, PaCO2, HCO3− and BE increased. MAP was stable with tramadol and methadone treatments; HR, FE′Iso and postoperative VAS decreased. VAS was lower for a longer time with methadone treatment; SpO2 and AG decreased, whereas PE′CO2, PaCO2 and HCO3− increased. Conclusions and clinical relevance: Ketamine–midazolam provided satisfactory restraint. Isoflurane anesthesia for laparoscopy was effective but resulted in hypotension and respiratory acidosis. Tramadol and methadone reduced isoflurane requirements, provided postoperative analgesia and caused hypercapnia, with methadone causing severe respiratory depression. Thus, the anesthetic protocol is adequate for laparoscopy in Cuniculus paca; however, methadone should be avoided.
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spelling Evaluation of chemical restraint, isoflurane anesthesia and methadone or tramadol as preventive analgesia in spotted pacas (Cuniculus paca) subjected to laparoscopyisofluraneketaminemethadonemidazolamrodentstramadolObjective: To evaluate the efficacy and cardiopulmonary effects of ketamine–midazolam for chemical restraint, isoflurane anesthesia and tramadol or methadone as preventive analgesia in spotted pacas subjected to laparoscopy. Study design: Prospective placebo-controlled blinded trial. Animals: A total of eight captive female Cuniculus paca weighing 9.3 ± 0.9 kg. Methods: Animals were anesthetized on three occasions with 15 day intervals. Manually restrained animals were administered midazolam (0.5 mg kg–1) and ketamine (25 mg kg–1) intramuscularly. Anesthesia was induced and maintained with isoflurane 30 minutes later. Tramadol (5 mg kg–1), methadone (0.5 mg kg–1) or saline (0.05 mL kg–1) were administered intramuscularly 15 minutes prior to laparoscopy. Heart rate (HR), respiratory rate, mean arterial pressure (MAP), peripheral oxygen saturation (SpO2), end-tidal CO2 partial pressure (PE′CO2), end-tidal concentration of isoflurane (FE′Iso), pH, PaO2, PaCO2, bicarbonate (HCO3−), anion gap (AG) and base excess (BE) were monitored after chemical restraint, anesthesia induction and at different laparoscopy stages. Postoperative pain was assessed by visual analog scale (VAS) for 24 hours. Variables were compared using ANOVA or Friedman test (p < 0.05). Results: Chemical restraint was effective in 92% of animals. Isoflurane anesthesia was effective; however, HR, MAP, pH and AG decreased, whereas PE′CO2, PaO2, PaCO2, HCO3− and BE increased. MAP was stable with tramadol and methadone treatments; HR, FE′Iso and postoperative VAS decreased. VAS was lower for a longer time with methadone treatment; SpO2 and AG decreased, whereas PE′CO2, PaCO2 and HCO3− increased. Conclusions and clinical relevance: Ketamine–midazolam provided satisfactory restraint. Isoflurane anesthesia for laparoscopy was effective but resulted in hypotension and respiratory acidosis. Tramadol and methadone reduced isoflurane requirements, provided postoperative analgesia and caused hypercapnia, with methadone causing severe respiratory depression. Thus, the anesthetic protocol is adequate for laparoscopy in Cuniculus paca; however, methadone should be avoided.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Institute of Agrarian Sciences Federal University of Jequithonha and Mucury Valleys (UFVJM)Department of Veterinary Pathobiology and Theriogenology São Paulo State University (Unesp) “Julio de Mesquita Filho”Department of Medicine and Veterinary Surgery Federal Rural University of Rio de Janeiro (UFRRJ)Department of Large Animal Clinic Federal University of Santa Maria (UFSM)Department of Veterinary Pathobiology and Theriogenology São Paulo State University (Unesp) “Julio de Mesquita Filho”CAPES: 14835126FAPESP: FAPESP 2012/00724-6Universidade Federal de Viçosa (UFV)Universidade Estadual Paulista (Unesp)Federal Rural University of Rio de Janeiro (UFRRJ)Universidade Federal de Sergipe (UFS)Uscategui, Ricardo AR. [UNESP]Barros, Felipe FPC.Almeida, Vívian T. [UNESP]Kawanami, Aline E. [UNESP]Feliciano, Marcus AR.Vicente, Wilter RR. [UNESP]2021-06-25T11:08:06Z2021-06-25T11:08:06Z2021-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article82-91http://dx.doi.org/10.1016/j.vaa.2020.09.001Veterinary Anaesthesia and Analgesia, v. 48, n. 1, p. 82-91, 2021.1467-29951467-2987http://hdl.handle.net/11449/20819810.1016/j.vaa.2020.09.0012-s2.0-85096900406Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengVeterinary Anaesthesia and Analgesiainfo:eu-repo/semantics/openAccess2024-06-06T18:09:01Zoai:repositorio.unesp.br:11449/208198Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T14:21:11.326520Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Evaluation of chemical restraint, isoflurane anesthesia and methadone or tramadol as preventive analgesia in spotted pacas (Cuniculus paca) subjected to laparoscopy
title Evaluation of chemical restraint, isoflurane anesthesia and methadone or tramadol as preventive analgesia in spotted pacas (Cuniculus paca) subjected to laparoscopy
spellingShingle Evaluation of chemical restraint, isoflurane anesthesia and methadone or tramadol as preventive analgesia in spotted pacas (Cuniculus paca) subjected to laparoscopy
Uscategui, Ricardo AR. [UNESP]
isoflurane
ketamine
methadone
midazolam
rodents
tramadol
title_short Evaluation of chemical restraint, isoflurane anesthesia and methadone or tramadol as preventive analgesia in spotted pacas (Cuniculus paca) subjected to laparoscopy
title_full Evaluation of chemical restraint, isoflurane anesthesia and methadone or tramadol as preventive analgesia in spotted pacas (Cuniculus paca) subjected to laparoscopy
title_fullStr Evaluation of chemical restraint, isoflurane anesthesia and methadone or tramadol as preventive analgesia in spotted pacas (Cuniculus paca) subjected to laparoscopy
title_full_unstemmed Evaluation of chemical restraint, isoflurane anesthesia and methadone or tramadol as preventive analgesia in spotted pacas (Cuniculus paca) subjected to laparoscopy
title_sort Evaluation of chemical restraint, isoflurane anesthesia and methadone or tramadol as preventive analgesia in spotted pacas (Cuniculus paca) subjected to laparoscopy
author Uscategui, Ricardo AR. [UNESP]
author_facet Uscategui, Ricardo AR. [UNESP]
Barros, Felipe FPC.
Almeida, Vívian T. [UNESP]
Kawanami, Aline E. [UNESP]
Feliciano, Marcus AR.
Vicente, Wilter RR. [UNESP]
author_role author
author2 Barros, Felipe FPC.
Almeida, Vívian T. [UNESP]
Kawanami, Aline E. [UNESP]
Feliciano, Marcus AR.
Vicente, Wilter RR. [UNESP]
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Federal de Viçosa (UFV)
Universidade Estadual Paulista (Unesp)
Federal Rural University of Rio de Janeiro (UFRRJ)
Universidade Federal de Sergipe (UFS)
dc.contributor.author.fl_str_mv Uscategui, Ricardo AR. [UNESP]
Barros, Felipe FPC.
Almeida, Vívian T. [UNESP]
Kawanami, Aline E. [UNESP]
Feliciano, Marcus AR.
Vicente, Wilter RR. [UNESP]
dc.subject.por.fl_str_mv isoflurane
ketamine
methadone
midazolam
rodents
tramadol
topic isoflurane
ketamine
methadone
midazolam
rodents
tramadol
description Objective: To evaluate the efficacy and cardiopulmonary effects of ketamine–midazolam for chemical restraint, isoflurane anesthesia and tramadol or methadone as preventive analgesia in spotted pacas subjected to laparoscopy. Study design: Prospective placebo-controlled blinded trial. Animals: A total of eight captive female Cuniculus paca weighing 9.3 ± 0.9 kg. Methods: Animals were anesthetized on three occasions with 15 day intervals. Manually restrained animals were administered midazolam (0.5 mg kg–1) and ketamine (25 mg kg–1) intramuscularly. Anesthesia was induced and maintained with isoflurane 30 minutes later. Tramadol (5 mg kg–1), methadone (0.5 mg kg–1) or saline (0.05 mL kg–1) were administered intramuscularly 15 minutes prior to laparoscopy. Heart rate (HR), respiratory rate, mean arterial pressure (MAP), peripheral oxygen saturation (SpO2), end-tidal CO2 partial pressure (PE′CO2), end-tidal concentration of isoflurane (FE′Iso), pH, PaO2, PaCO2, bicarbonate (HCO3−), anion gap (AG) and base excess (BE) were monitored after chemical restraint, anesthesia induction and at different laparoscopy stages. Postoperative pain was assessed by visual analog scale (VAS) for 24 hours. Variables were compared using ANOVA or Friedman test (p < 0.05). Results: Chemical restraint was effective in 92% of animals. Isoflurane anesthesia was effective; however, HR, MAP, pH and AG decreased, whereas PE′CO2, PaO2, PaCO2, HCO3− and BE increased. MAP was stable with tramadol and methadone treatments; HR, FE′Iso and postoperative VAS decreased. VAS was lower for a longer time with methadone treatment; SpO2 and AG decreased, whereas PE′CO2, PaCO2 and HCO3− increased. Conclusions and clinical relevance: Ketamine–midazolam provided satisfactory restraint. Isoflurane anesthesia for laparoscopy was effective but resulted in hypotension and respiratory acidosis. Tramadol and methadone reduced isoflurane requirements, provided postoperative analgesia and caused hypercapnia, with methadone causing severe respiratory depression. Thus, the anesthetic protocol is adequate for laparoscopy in Cuniculus paca; however, methadone should be avoided.
publishDate 2021
dc.date.none.fl_str_mv 2021-06-25T11:08:06Z
2021-06-25T11:08:06Z
2021-01-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/j.vaa.2020.09.001
Veterinary Anaesthesia and Analgesia, v. 48, n. 1, p. 82-91, 2021.
1467-2995
1467-2987
http://hdl.handle.net/11449/208198
10.1016/j.vaa.2020.09.001
2-s2.0-85096900406
url http://dx.doi.org/10.1016/j.vaa.2020.09.001
http://hdl.handle.net/11449/208198
identifier_str_mv Veterinary Anaesthesia and Analgesia, v. 48, n. 1, p. 82-91, 2021.
1467-2995
1467-2987
10.1016/j.vaa.2020.09.001
2-s2.0-85096900406
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Veterinary Anaesthesia and Analgesia
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 82-91
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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