Exercise at anaerobic threshold intensity and insulin secretion by isolated pancreatic islets of rats
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.4161/isl.2.4.12266 http://hdl.handle.net/11449/71758 |
Resumo: | To evaluate the effect of acute exercise and exercise training at the anaerobic threshold (AT) intensity on aerobic conditioning and insulin secretion by pancreatic islets, adult male Wistar rats were submitted to the lactate minimum test (LMT) for AT determination. Half of the animals were submitted to swimming exercise training (trained), 1 h/day, 5 days/week during 8 weeks, with an overload equivalent to the AT. The other half was kept sedentary. At the end of the experimental period, the rats were submitted to an oral glucose tolerance test and to another LMT. Then, the animals were sacrificed at rest or immediately after 20 minutes of swimming exercise at the AT intensity for pancreatic islets isolation. At the end of the experiment mean workload (% bw) at AT was higher and blood lactate concentration (mmol/L) was lower in the trained than in the control group. Rats trained at the AT intensity showed no alteration in the areas under blood glucose and insulin during OGTT test. Islet insulin content of trained rats was higher than in the sedentary rats while islet glucose uptake did not differ among the groups. The static insulin secretion in response to the high glucose concentration (16.7 mM) of the sedentary group at rest was lower than the sedentary group submitted to the acute exercise and the inverse was observed in relation to the trained groups. physical training at the AT intensity improved the aerobic condition and altered insulin secretory pattern by pancreatic islets. © 2010 Landes Bioscience. |
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Exercise at anaerobic threshold intensity and insulin secretion by isolated pancreatic islets of ratsAnaerobic thresholdExerciseGlucose homeostasisInsulin secretionRatsglucoseinsulinlactic acidaerobic capacityanaerobic thresholdanimal experimentanimal tissuecontrolled studyexerciseexercise physiologyglucose blood levelglucose transportinsulin blood levelinsulin releaseisolated pancreas isletlactate blood levelmalenonhumanoral glucose tolerance testratsittingswimmingtrainingworkloadAnaerobiosisAnimalsBlood GlucoseCell SeparationExercise TestGlucose Tolerance TestInsulinIslets of LangerhansLactic AcidMalePhysical Conditioning, AnimalRats, WistarSwimmingTo evaluate the effect of acute exercise and exercise training at the anaerobic threshold (AT) intensity on aerobic conditioning and insulin secretion by pancreatic islets, adult male Wistar rats were submitted to the lactate minimum test (LMT) for AT determination. Half of the animals were submitted to swimming exercise training (trained), 1 h/day, 5 days/week during 8 weeks, with an overload equivalent to the AT. The other half was kept sedentary. At the end of the experimental period, the rats were submitted to an oral glucose tolerance test and to another LMT. Then, the animals were sacrificed at rest or immediately after 20 minutes of swimming exercise at the AT intensity for pancreatic islets isolation. At the end of the experiment mean workload (% bw) at AT was higher and blood lactate concentration (mmol/L) was lower in the trained than in the control group. Rats trained at the AT intensity showed no alteration in the areas under blood glucose and insulin during OGTT test. Islet insulin content of trained rats was higher than in the sedentary rats while islet glucose uptake did not differ among the groups. The static insulin secretion in response to the high glucose concentration (16.7 mM) of the sedentary group at rest was lower than the sedentary group submitted to the acute exercise and the inverse was observed in relation to the trained groups. physical training at the AT intensity improved the aerobic condition and altered insulin secretory pattern by pancreatic islets. © 2010 Landes Bioscience.Department of Anatomy; Cellular Biology; Physiology and Biophysics Unicamp, CampinasDepartment of Physical Education Unesp, São PauloDepartment of Physical Education Unesp, São PauloUniversidade Estadual de Campinas (UNICAMP)Universidade Estadual Paulista (Unesp)Machado de Oliveira, Camila AparecidaPaiva, Mauricio Ferreira [UNESP]Soares Mota, Clécia Alencar [UNESP]Ribeiro, Carla [UNESP]De Almeida Leme, José Alexandre Curiacos [UNESP]Luciano, Eliete [UNESP]Rostom de Mello, Maria Alice [UNESP]2014-05-27T11:24:43Z2014-05-27T11:24:43Z2010-07-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article240-246application/pdfhttp://dx.doi.org/10.4161/isl.2.4.12266Islets, v. 2, n. 4, p. 240-246, 2010.1938-20141938-2022http://hdl.handle.net/11449/7175810.4161/isl.2.4.122662-s2.0-779570874062-s2.0-77957087406.pdf2933779830637191Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengIslets1.6770,9410,941info:eu-repo/semantics/openAccess2023-12-09T06:22:21Zoai:repositorio.unesp.br:11449/71758Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T19:52:05.334774Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Exercise at anaerobic threshold intensity and insulin secretion by isolated pancreatic islets of rats |
title |
Exercise at anaerobic threshold intensity and insulin secretion by isolated pancreatic islets of rats |
spellingShingle |
Exercise at anaerobic threshold intensity and insulin secretion by isolated pancreatic islets of rats Machado de Oliveira, Camila Aparecida Anaerobic threshold Exercise Glucose homeostasis Insulin secretion Rats glucose insulin lactic acid aerobic capacity anaerobic threshold animal experiment animal tissue controlled study exercise exercise physiology glucose blood level glucose transport insulin blood level insulin release isolated pancreas islet lactate blood level male nonhuman oral glucose tolerance test rat sitting swimming training workload Anaerobiosis Animals Blood Glucose Cell Separation Exercise Test Glucose Tolerance Test Insulin Islets of Langerhans Lactic Acid Male Physical Conditioning, Animal Rats, Wistar Swimming |
title_short |
Exercise at anaerobic threshold intensity and insulin secretion by isolated pancreatic islets of rats |
title_full |
Exercise at anaerobic threshold intensity and insulin secretion by isolated pancreatic islets of rats |
title_fullStr |
Exercise at anaerobic threshold intensity and insulin secretion by isolated pancreatic islets of rats |
title_full_unstemmed |
Exercise at anaerobic threshold intensity and insulin secretion by isolated pancreatic islets of rats |
title_sort |
Exercise at anaerobic threshold intensity and insulin secretion by isolated pancreatic islets of rats |
author |
Machado de Oliveira, Camila Aparecida |
author_facet |
Machado de Oliveira, Camila Aparecida Paiva, Mauricio Ferreira [UNESP] Soares Mota, Clécia Alencar [UNESP] Ribeiro, Carla [UNESP] De Almeida Leme, José Alexandre Curiacos [UNESP] Luciano, Eliete [UNESP] Rostom de Mello, Maria Alice [UNESP] |
author_role |
author |
author2 |
Paiva, Mauricio Ferreira [UNESP] Soares Mota, Clécia Alencar [UNESP] Ribeiro, Carla [UNESP] De Almeida Leme, José Alexandre Curiacos [UNESP] Luciano, Eliete [UNESP] Rostom de Mello, Maria Alice [UNESP] |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual de Campinas (UNICAMP) Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Machado de Oliveira, Camila Aparecida Paiva, Mauricio Ferreira [UNESP] Soares Mota, Clécia Alencar [UNESP] Ribeiro, Carla [UNESP] De Almeida Leme, José Alexandre Curiacos [UNESP] Luciano, Eliete [UNESP] Rostom de Mello, Maria Alice [UNESP] |
dc.subject.por.fl_str_mv |
Anaerobic threshold Exercise Glucose homeostasis Insulin secretion Rats glucose insulin lactic acid aerobic capacity anaerobic threshold animal experiment animal tissue controlled study exercise exercise physiology glucose blood level glucose transport insulin blood level insulin release isolated pancreas islet lactate blood level male nonhuman oral glucose tolerance test rat sitting swimming training workload Anaerobiosis Animals Blood Glucose Cell Separation Exercise Test Glucose Tolerance Test Insulin Islets of Langerhans Lactic Acid Male Physical Conditioning, Animal Rats, Wistar Swimming |
topic |
Anaerobic threshold Exercise Glucose homeostasis Insulin secretion Rats glucose insulin lactic acid aerobic capacity anaerobic threshold animal experiment animal tissue controlled study exercise exercise physiology glucose blood level glucose transport insulin blood level insulin release isolated pancreas islet lactate blood level male nonhuman oral glucose tolerance test rat sitting swimming training workload Anaerobiosis Animals Blood Glucose Cell Separation Exercise Test Glucose Tolerance Test Insulin Islets of Langerhans Lactic Acid Male Physical Conditioning, Animal Rats, Wistar Swimming |
description |
To evaluate the effect of acute exercise and exercise training at the anaerobic threshold (AT) intensity on aerobic conditioning and insulin secretion by pancreatic islets, adult male Wistar rats were submitted to the lactate minimum test (LMT) for AT determination. Half of the animals were submitted to swimming exercise training (trained), 1 h/day, 5 days/week during 8 weeks, with an overload equivalent to the AT. The other half was kept sedentary. At the end of the experimental period, the rats were submitted to an oral glucose tolerance test and to another LMT. Then, the animals were sacrificed at rest or immediately after 20 minutes of swimming exercise at the AT intensity for pancreatic islets isolation. At the end of the experiment mean workload (% bw) at AT was higher and blood lactate concentration (mmol/L) was lower in the trained than in the control group. Rats trained at the AT intensity showed no alteration in the areas under blood glucose and insulin during OGTT test. Islet insulin content of trained rats was higher than in the sedentary rats while islet glucose uptake did not differ among the groups. The static insulin secretion in response to the high glucose concentration (16.7 mM) of the sedentary group at rest was lower than the sedentary group submitted to the acute exercise and the inverse was observed in relation to the trained groups. physical training at the AT intensity improved the aerobic condition and altered insulin secretory pattern by pancreatic islets. © 2010 Landes Bioscience. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010-07-01 2014-05-27T11:24:43Z 2014-05-27T11:24:43Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.4161/isl.2.4.12266 Islets, v. 2, n. 4, p. 240-246, 2010. 1938-2014 1938-2022 http://hdl.handle.net/11449/71758 10.4161/isl.2.4.12266 2-s2.0-77957087406 2-s2.0-77957087406.pdf 2933779830637191 |
url |
http://dx.doi.org/10.4161/isl.2.4.12266 http://hdl.handle.net/11449/71758 |
identifier_str_mv |
Islets, v. 2, n. 4, p. 240-246, 2010. 1938-2014 1938-2022 10.4161/isl.2.4.12266 2-s2.0-77957087406 2-s2.0-77957087406.pdf 2933779830637191 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Islets 1.677 0,941 0,941 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
240-246 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129131242586112 |