tDCS application for postural control in Parkinson’s disease: effects are associated with baseline characteristics
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://hdl.handle.net/11449/215756 |
Resumo: | Introduction: Transcranial direct current stimulation (tDCS) improves postural response to perturbation in patients with Parkinson’s disease (PwPD). However, the influence of baseline characteristics such as clinical/cognitive and postural performance on the response to tDCS remains unclear. Objective: To investigate whether baseline level of postural control (performance during sham condition) and clinical/cognitive characteristics are associated with tDCS-related changes in postural responses to external perturbations in PwPD. Methods: Twenty-four PwPD participated in this study. Clinical assessment included disease severity, disease duration, levodopa equivalent dose and global cognition. Anodal tDCS protocols targeting the primary motor cortex were applied in two separate sessions (at least 2 weeks apart): active (2 mA for 20 min) and sham stimulation. Seven trials with the backward translation of the support base (20 cm/s and 5 cm) were performed after tDCS. Postural outcomes included the recovery time to stable position and onset latency of the medial gastrocnemius (MG). Pearson and Spearman correlation tests were performed. Results: No significant correlations were observed between clinical/cognitive characteristics and tDCS-related changes in postural responses. Negative associations were observed between the baseline level of postural control and tDCS-related changes in postural responses for the recovery time (r = − 0.657; p < 0.001) and the MG onset latency (rs = − 0.539; p = 0.007). PwPD with worse baseline postural control demonstrated greater improvement after active stimulation. Conclusions: Findings suggest that tDCS-related effects on postural response to perturbation are related to the baseline level of postural control, but not to clinical characteristics in PwPD. Those with worse baseline postural control responded better to tDCS. |
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Repositório Institucional da UNESP |
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tDCS application for postural control in Parkinson’s disease: effects are associated with baseline characteristicsEquilíbrio posturalDoença de ParkinsonEstimulação cerebralEletromiografiaDegeneração do sistema nervosoIntroduction: Transcranial direct current stimulation (tDCS) improves postural response to perturbation in patients with Parkinson’s disease (PwPD). However, the influence of baseline characteristics such as clinical/cognitive and postural performance on the response to tDCS remains unclear. Objective: To investigate whether baseline level of postural control (performance during sham condition) and clinical/cognitive characteristics are associated with tDCS-related changes in postural responses to external perturbations in PwPD. Methods: Twenty-four PwPD participated in this study. Clinical assessment included disease severity, disease duration, levodopa equivalent dose and global cognition. Anodal tDCS protocols targeting the primary motor cortex were applied in two separate sessions (at least 2 weeks apart): active (2 mA for 20 min) and sham stimulation. Seven trials with the backward translation of the support base (20 cm/s and 5 cm) were performed after tDCS. Postural outcomes included the recovery time to stable position and onset latency of the medial gastrocnemius (MG). Pearson and Spearman correlation tests were performed. Results: No significant correlations were observed between clinical/cognitive characteristics and tDCS-related changes in postural responses. Negative associations were observed between the baseline level of postural control and tDCS-related changes in postural responses for the recovery time (r = − 0.657; p < 0.001) and the MG onset latency (rs = − 0.539; p = 0.007). PwPD with worse baseline postural control demonstrated greater improvement after active stimulation. Conclusions: Findings suggest that tDCS-related effects on postural response to perturbation are related to the baseline level of postural control, but not to clinical characteristics in PwPD. Those with worse baseline postural control responded better to tDCS.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)PostprintSão Paulo State University (Unesp), Institute of Biosciences, Graduate Program in Movement Sciences, Posture and Gait Studies Laboratory (LEPLO), Rio Claro, BrazilDepartment of Sport, Exercise and Rehabilitation, Northumbria University, Newcastle upon Tyne, United KingdomFAPESP: 2018/07385-9FAPESP: 2016/21499-1FAPESP: 2014/ 22308-0CNPq: 429549/2018-0CNPq: 309045/2017-7Capes: 001Elsevier LtdUniversidade Estadual Paulista (Unesp)Beretta, Victor Spiandor [UNESP]Orcioli-silva, Diego [UNESP]Conceição, Núbia Ribeiro [UNESP]Nóbrega-Sousa, Priscila [UNESP]Pereira, Marcelo PintoGobbi, Lilian Teresa Bucken [UNESP]Vitório, Rodrigo [UNESP]2022-01-06T14:29:36Z2022-01-06T14:29:36Z2021-11-13info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfapplication/pdfParkinsonism & related disorders, v. 93, p. 62-65, 20211353-8020http://hdl.handle.net/11449/21575610.1016/j.parkreldis.2021.11.01240077001717518247451056032351695650630977170334143982354238918541824925368833543986883527182242103384035682047100000-0002-4640-77330000-0002-2278-80920000-0003-2213-62000000-0001-9448-01610000-0002-9442-03850000-0003-3984-34030000-0001-7128-9452engParkinsonism and related disordersinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESP2023-10-25T06:06:41Zoai:repositorio.unesp.br:11449/215756Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-10-25T06:06:41Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
tDCS application for postural control in Parkinson’s disease: effects are associated with baseline characteristics |
title |
tDCS application for postural control in Parkinson’s disease: effects are associated with baseline characteristics |
spellingShingle |
tDCS application for postural control in Parkinson’s disease: effects are associated with baseline characteristics Beretta, Victor Spiandor [UNESP] Equilíbrio postural Doença de Parkinson Estimulação cerebral Eletromiografia Degeneração do sistema nervoso |
title_short |
tDCS application for postural control in Parkinson’s disease: effects are associated with baseline characteristics |
title_full |
tDCS application for postural control in Parkinson’s disease: effects are associated with baseline characteristics |
title_fullStr |
tDCS application for postural control in Parkinson’s disease: effects are associated with baseline characteristics |
title_full_unstemmed |
tDCS application for postural control in Parkinson’s disease: effects are associated with baseline characteristics |
title_sort |
tDCS application for postural control in Parkinson’s disease: effects are associated with baseline characteristics |
author |
Beretta, Victor Spiandor [UNESP] |
author_facet |
Beretta, Victor Spiandor [UNESP] Orcioli-silva, Diego [UNESP] Conceição, Núbia Ribeiro [UNESP] Nóbrega-Sousa, Priscila [UNESP] Pereira, Marcelo Pinto Gobbi, Lilian Teresa Bucken [UNESP] Vitório, Rodrigo [UNESP] |
author_role |
author |
author2 |
Orcioli-silva, Diego [UNESP] Conceição, Núbia Ribeiro [UNESP] Nóbrega-Sousa, Priscila [UNESP] Pereira, Marcelo Pinto Gobbi, Lilian Teresa Bucken [UNESP] Vitório, Rodrigo [UNESP] |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Beretta, Victor Spiandor [UNESP] Orcioli-silva, Diego [UNESP] Conceição, Núbia Ribeiro [UNESP] Nóbrega-Sousa, Priscila [UNESP] Pereira, Marcelo Pinto Gobbi, Lilian Teresa Bucken [UNESP] Vitório, Rodrigo [UNESP] |
dc.subject.por.fl_str_mv |
Equilíbrio postural Doença de Parkinson Estimulação cerebral Eletromiografia Degeneração do sistema nervoso |
topic |
Equilíbrio postural Doença de Parkinson Estimulação cerebral Eletromiografia Degeneração do sistema nervoso |
description |
Introduction: Transcranial direct current stimulation (tDCS) improves postural response to perturbation in patients with Parkinson’s disease (PwPD). However, the influence of baseline characteristics such as clinical/cognitive and postural performance on the response to tDCS remains unclear. Objective: To investigate whether baseline level of postural control (performance during sham condition) and clinical/cognitive characteristics are associated with tDCS-related changes in postural responses to external perturbations in PwPD. Methods: Twenty-four PwPD participated in this study. Clinical assessment included disease severity, disease duration, levodopa equivalent dose and global cognition. Anodal tDCS protocols targeting the primary motor cortex were applied in two separate sessions (at least 2 weeks apart): active (2 mA for 20 min) and sham stimulation. Seven trials with the backward translation of the support base (20 cm/s and 5 cm) were performed after tDCS. Postural outcomes included the recovery time to stable position and onset latency of the medial gastrocnemius (MG). Pearson and Spearman correlation tests were performed. Results: No significant correlations were observed between clinical/cognitive characteristics and tDCS-related changes in postural responses. Negative associations were observed between the baseline level of postural control and tDCS-related changes in postural responses for the recovery time (r = − 0.657; p < 0.001) and the MG onset latency (rs = − 0.539; p = 0.007). PwPD with worse baseline postural control demonstrated greater improvement after active stimulation. Conclusions: Findings suggest that tDCS-related effects on postural response to perturbation are related to the baseline level of postural control, but not to clinical characteristics in PwPD. Those with worse baseline postural control responded better to tDCS. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-11-13 2022-01-06T14:29:36Z 2022-01-06T14:29:36Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
Parkinsonism & related disorders, v. 93, p. 62-65, 2021 1353-8020 http://hdl.handle.net/11449/215756 10.1016/j.parkreldis.2021.11.012 4007700171751824 7451056032351695 6506309771703341 4398235423891854 1824925368833543 9868835271822421 0338403568204710 0000-0002-4640-7733 0000-0002-2278-8092 0000-0003-2213-6200 0000-0001-9448-0161 0000-0002-9442-0385 0000-0003-3984-3403 0000-0001-7128-9452 |
identifier_str_mv |
Parkinsonism & related disorders, v. 93, p. 62-65, 2021 1353-8020 10.1016/j.parkreldis.2021.11.012 4007700171751824 7451056032351695 6506309771703341 4398235423891854 1824925368833543 9868835271822421 0338403568204710 0000-0002-4640-7733 0000-0002-2278-8092 0000-0003-2213-6200 0000-0001-9448-0161 0000-0002-9442-0385 0000-0003-3984-3403 0000-0001-7128-9452 |
url |
http://hdl.handle.net/11449/215756 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Parkinsonism and related disorders |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier Ltd |
publisher.none.fl_str_mv |
Elsevier Ltd |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1803046147172859904 |