2(3) central composite rotatable design for the production of neem oil nanoemulsion for antifungal and antiparasitic applications
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1002/jctb.6623 http://hdl.handle.net/11449/209007 |
Resumo: | BACKGROUND The present study describes the design and production of an oil-in-water nanoemulsion composed of neem oil as the inner phase for use as an antifungal and antiparasitic control in aquaculture. A 2(3) central composite rotatable design adopting surface response was used as the experimental design, setting the neem oil concentration (4-15%), surfactant concentration (0.5-10%) and sonication power (20-90%) as the independent variables, while the droplet size, polydispersity index (PDI) and zeta potential were set as the response (dependent) variables. RESULTS Droplet size and PDI showed the best results using the sonication method with 5 min of process. The coefficients of determination were greater than 0.900 for all response. The best formulation was obtained with 9% of neem oil and 5.25% of polysorbate 20. CONCLUSION Antifungal activity of the optimized nanoemulsion against Saprolegnia parasitica was demonstrated, also attributed to the presence of the surfactant. Concentrations of 200 mg L-1 of nanoemulsion resulted in 100% parasitic mortality. (c) 2020 Society of Chemical Industry |
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2(3) central composite rotatable design for the production of neem oil nanoemulsion for antifungal and antiparasitic applicationsemulsionsneem oilultrasonicantifungalantiprotozoalexperimental designBACKGROUND The present study describes the design and production of an oil-in-water nanoemulsion composed of neem oil as the inner phase for use as an antifungal and antiparasitic control in aquaculture. A 2(3) central composite rotatable design adopting surface response was used as the experimental design, setting the neem oil concentration (4-15%), surfactant concentration (0.5-10%) and sonication power (20-90%) as the independent variables, while the droplet size, polydispersity index (PDI) and zeta potential were set as the response (dependent) variables. RESULTS Droplet size and PDI showed the best results using the sonication method with 5 min of process. The coefficients of determination were greater than 0.900 for all response. The best formulation was obtained with 9% of neem oil and 5.25% of polysorbate 20. CONCLUSION Antifungal activity of the optimized nanoemulsion against Saprolegnia parasitica was demonstrated, also attributed to the presence of the surfactant. Concentrations of 200 mg L-1 of nanoemulsion resulted in 100% parasitic mortality. (c) 2020 Society of Chemical IndustryBanco do NordesteCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)FundacAo de amparo a Pesquisa do Estado de Sergipe (FAPITEC)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Portuguese Science and Technology Foundation (FCT)Univ Coimbra FFUC, Fac Pharm, Polo Ciencias Saude, P-3000548 Coimbra, PortugalUniv Tiradentes, Aracaju, BrazilSao Paulo State Univ, Sao Paulo, BrazilInst Technol & Res ITP, Aracaju, BrazilTiradentes Inst, Dorchester, MA USAUniv Minho, CEB Ctr Biol Engn, Braga, PortugalEmbrapa Tabuleiros Costeiros, Aracaju, BrazilSao Paulo State Univ, Sao Paulo, BrazilBanco do Nordeste: FUNDECI/2016.0015CAPES: PROCESSO: 88887.159533/2017-2100FundacAo de amparo a Pesquisa do Estado de Sergipe (FAPITEC): 88887.159533/2017-2100CNPq: CNPq 301964/2019-0CNPq: 06/2019Portuguese Science and Technology Foundation (FCT): UIDB/04469/2020CNPq: 01/2019Wiley-BlackwellUniv Coimbra FFUCUniv TiradentesUniversidade Estadual Paulista (Unesp)Inst Technol & Res ITPTiradentes InstUniv MinhoEmpresa Brasileira de Pesquisa Agropecuária (EMBRAPA)Rabelo, Alessandra S.Sutili, Felipe K. [UNESP]Meneses, Juliana O.Severino, PatriciaSouto, Eliana B.Fujimoto, Rodrigo Y.Cardoso, Juliana C.2021-06-25T11:45:43Z2021-06-25T11:45:43Z2020-12-15info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article9http://dx.doi.org/10.1002/jctb.6623Journal Of Chemical Technology And Biotechnology. Hoboken: Wiley, 9 p., 2020.0268-2575http://hdl.handle.net/11449/20900710.1002/jctb.6623WOS:000598668400001Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal Of Chemical Technology And Biotechnologyinfo:eu-repo/semantics/openAccess2021-10-23T19:23:28Zoai:repositorio.unesp.br:11449/209007Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462021-10-23T19:23:28Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
2(3) central composite rotatable design for the production of neem oil nanoemulsion for antifungal and antiparasitic applications |
title |
2(3) central composite rotatable design for the production of neem oil nanoemulsion for antifungal and antiparasitic applications |
spellingShingle |
2(3) central composite rotatable design for the production of neem oil nanoemulsion for antifungal and antiparasitic applications Rabelo, Alessandra S. emulsions neem oil ultrasonic antifungal antiprotozoal experimental design |
title_short |
2(3) central composite rotatable design for the production of neem oil nanoemulsion for antifungal and antiparasitic applications |
title_full |
2(3) central composite rotatable design for the production of neem oil nanoemulsion for antifungal and antiparasitic applications |
title_fullStr |
2(3) central composite rotatable design for the production of neem oil nanoemulsion for antifungal and antiparasitic applications |
title_full_unstemmed |
2(3) central composite rotatable design for the production of neem oil nanoemulsion for antifungal and antiparasitic applications |
title_sort |
2(3) central composite rotatable design for the production of neem oil nanoemulsion for antifungal and antiparasitic applications |
author |
Rabelo, Alessandra S. |
author_facet |
Rabelo, Alessandra S. Sutili, Felipe K. [UNESP] Meneses, Juliana O. Severino, Patricia Souto, Eliana B. Fujimoto, Rodrigo Y. Cardoso, Juliana C. |
author_role |
author |
author2 |
Sutili, Felipe K. [UNESP] Meneses, Juliana O. Severino, Patricia Souto, Eliana B. Fujimoto, Rodrigo Y. Cardoso, Juliana C. |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Univ Coimbra FFUC Univ Tiradentes Universidade Estadual Paulista (Unesp) Inst Technol & Res ITP Tiradentes Inst Univ Minho Empresa Brasileira de Pesquisa Agropecuária (EMBRAPA) |
dc.contributor.author.fl_str_mv |
Rabelo, Alessandra S. Sutili, Felipe K. [UNESP] Meneses, Juliana O. Severino, Patricia Souto, Eliana B. Fujimoto, Rodrigo Y. Cardoso, Juliana C. |
dc.subject.por.fl_str_mv |
emulsions neem oil ultrasonic antifungal antiprotozoal experimental design |
topic |
emulsions neem oil ultrasonic antifungal antiprotozoal experimental design |
description |
BACKGROUND The present study describes the design and production of an oil-in-water nanoemulsion composed of neem oil as the inner phase for use as an antifungal and antiparasitic control in aquaculture. A 2(3) central composite rotatable design adopting surface response was used as the experimental design, setting the neem oil concentration (4-15%), surfactant concentration (0.5-10%) and sonication power (20-90%) as the independent variables, while the droplet size, polydispersity index (PDI) and zeta potential were set as the response (dependent) variables. RESULTS Droplet size and PDI showed the best results using the sonication method with 5 min of process. The coefficients of determination were greater than 0.900 for all response. The best formulation was obtained with 9% of neem oil and 5.25% of polysorbate 20. CONCLUSION Antifungal activity of the optimized nanoemulsion against Saprolegnia parasitica was demonstrated, also attributed to the presence of the surfactant. Concentrations of 200 mg L-1 of nanoemulsion resulted in 100% parasitic mortality. (c) 2020 Society of Chemical Industry |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-12-15 2021-06-25T11:45:43Z 2021-06-25T11:45:43Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1002/jctb.6623 Journal Of Chemical Technology And Biotechnology. Hoboken: Wiley, 9 p., 2020. 0268-2575 http://hdl.handle.net/11449/209007 10.1002/jctb.6623 WOS:000598668400001 |
url |
http://dx.doi.org/10.1002/jctb.6623 http://hdl.handle.net/11449/209007 |
identifier_str_mv |
Journal Of Chemical Technology And Biotechnology. Hoboken: Wiley, 9 p., 2020. 0268-2575 10.1002/jctb.6623 WOS:000598668400001 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal Of Chemical Technology And Biotechnology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
9 |
dc.publisher.none.fl_str_mv |
Wiley-Blackwell |
publisher.none.fl_str_mv |
Wiley-Blackwell |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1803046762380787712 |