Evaluation of Vitamin D isolated or Associated with Teriparatide in Peri-Implant Bone Repair in Tibia of Orchiectomized Rats
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.3390/biology12020228 http://hdl.handle.net/11449/248422 |
Resumo: | (1) Background: The objective of this study was to evaluate the morphometry of peri-implant bone tissue in orchiectomized rats, treated with vitamin D isolated or associated with teriparatide. (2) Methods: 24 rats were divided into 4 groups: ORQ—orchiectomy, without drug treatment, ORQ+D—orchiectomy, treated with vitamin D, ORQTERI—orchiectomy, treated with teriparatide and ORQTERI+D—orchiectomy, treated with teriparatide + vitamin D. Each animal received an implant in the tibial metaphysis. Euthanasia occurred 60 days after implant surgery. Computed microtomography (micro-CT) was performed to evaluate the parameters of volume and percentage of bone volume (BV, BV/TV), trabecular thickness (Tb.Th), number and separation of trabeculae (Tb.N, Tb.Sp) and percentage of total porosity (Po-tot). Data were subjected to 1-way ANOVA and Tukey post-test, with a significance level of 5%. (3) Results: For the parameters BV, BV/TV, Tb.Th, the ORQTERI+D group showed the highest values in relation to the other groups and for Po-tot, the lowest values were for ORQTERI+D. For Tb.Sp and Tb.N, there was no statistically significant difference when comparing intragroup results (p > 0.05). (4) Conclusions: It was possible to conclude that treatment with vitamin D associated with teriparatide increases bone volume and improves bone quality. |
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Evaluation of Vitamin D isolated or Associated with Teriparatide in Peri-Implant Bone Repair in Tibia of Orchiectomized Ratsdental implantsmenosteoporosisteriparatidevitamin D(1) Background: The objective of this study was to evaluate the morphometry of peri-implant bone tissue in orchiectomized rats, treated with vitamin D isolated or associated with teriparatide. (2) Methods: 24 rats were divided into 4 groups: ORQ—orchiectomy, without drug treatment, ORQ+D—orchiectomy, treated with vitamin D, ORQTERI—orchiectomy, treated with teriparatide and ORQTERI+D—orchiectomy, treated with teriparatide + vitamin D. Each animal received an implant in the tibial metaphysis. Euthanasia occurred 60 days after implant surgery. Computed microtomography (micro-CT) was performed to evaluate the parameters of volume and percentage of bone volume (BV, BV/TV), trabecular thickness (Tb.Th), number and separation of trabeculae (Tb.N, Tb.Sp) and percentage of total porosity (Po-tot). Data were subjected to 1-way ANOVA and Tukey post-test, with a significance level of 5%. (3) Results: For the parameters BV, BV/TV, Tb.Th, the ORQTERI+D group showed the highest values in relation to the other groups and for Po-tot, the lowest values were for ORQTERI+D. For Tb.Sp and Tb.N, there was no statistically significant difference when comparing intragroup results (p > 0.05). (4) Conclusions: It was possible to conclude that treatment with vitamin D associated with teriparatide increases bone volume and improves bone quality.Department of Diagnosis and Surgery Araçatuba Dental School São Paulo State University Júlio de Mesquita Filho—UNESPDepartment of Basic Sciences Araçatuba Dental School São Paulo State University Júlio de Mesquita Filho—UNESPDepartment of Materials Science and Engineering McMaster UniversitySchool of Biomedical Engineering McMaster UniversityDepartment of Diagnosis and Surgery Araçatuba Dental School São Paulo State University Júlio de Mesquita Filho—UNESPDepartment of Basic Sciences Araçatuba Dental School São Paulo State University Júlio de Mesquita Filho—UNESPUniversidade Estadual Paulista (UNESP)McMaster UniversityGomes-Ferreira, Pedro Henrique Silva [UNESP]Frigério, Paula Buzo [UNESP]de Moura, Juliana [UNESP]Duarte, Nathália Dantas [UNESP]de Oliveira, Danila [UNESP]Deering, JosephGrandfield, KathrynOkamoto, Roberta [UNESP]2023-07-29T13:43:36Z2023-07-29T13:43:36Z2023-02-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.3390/biology12020228Biology, v. 12, n. 2, 2023.2079-7737http://hdl.handle.net/11449/24842210.3390/biology120202282-s2.0-85148936891Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBiologyinfo:eu-repo/semantics/openAccess2023-07-29T13:43:36Zoai:repositorio.unesp.br:11449/248422Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T17:05:17.028315Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Evaluation of Vitamin D isolated or Associated with Teriparatide in Peri-Implant Bone Repair in Tibia of Orchiectomized Rats |
title |
Evaluation of Vitamin D isolated or Associated with Teriparatide in Peri-Implant Bone Repair in Tibia of Orchiectomized Rats |
spellingShingle |
Evaluation of Vitamin D isolated or Associated with Teriparatide in Peri-Implant Bone Repair in Tibia of Orchiectomized Rats Gomes-Ferreira, Pedro Henrique Silva [UNESP] dental implants men osteoporosis teriparatide vitamin D |
title_short |
Evaluation of Vitamin D isolated or Associated with Teriparatide in Peri-Implant Bone Repair in Tibia of Orchiectomized Rats |
title_full |
Evaluation of Vitamin D isolated or Associated with Teriparatide in Peri-Implant Bone Repair in Tibia of Orchiectomized Rats |
title_fullStr |
Evaluation of Vitamin D isolated or Associated with Teriparatide in Peri-Implant Bone Repair in Tibia of Orchiectomized Rats |
title_full_unstemmed |
Evaluation of Vitamin D isolated or Associated with Teriparatide in Peri-Implant Bone Repair in Tibia of Orchiectomized Rats |
title_sort |
Evaluation of Vitamin D isolated or Associated with Teriparatide in Peri-Implant Bone Repair in Tibia of Orchiectomized Rats |
author |
Gomes-Ferreira, Pedro Henrique Silva [UNESP] |
author_facet |
Gomes-Ferreira, Pedro Henrique Silva [UNESP] Frigério, Paula Buzo [UNESP] de Moura, Juliana [UNESP] Duarte, Nathália Dantas [UNESP] de Oliveira, Danila [UNESP] Deering, Joseph Grandfield, Kathryn Okamoto, Roberta [UNESP] |
author_role |
author |
author2 |
Frigério, Paula Buzo [UNESP] de Moura, Juliana [UNESP] Duarte, Nathália Dantas [UNESP] de Oliveira, Danila [UNESP] Deering, Joseph Grandfield, Kathryn Okamoto, Roberta [UNESP] |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) McMaster University |
dc.contributor.author.fl_str_mv |
Gomes-Ferreira, Pedro Henrique Silva [UNESP] Frigério, Paula Buzo [UNESP] de Moura, Juliana [UNESP] Duarte, Nathália Dantas [UNESP] de Oliveira, Danila [UNESP] Deering, Joseph Grandfield, Kathryn Okamoto, Roberta [UNESP] |
dc.subject.por.fl_str_mv |
dental implants men osteoporosis teriparatide vitamin D |
topic |
dental implants men osteoporosis teriparatide vitamin D |
description |
(1) Background: The objective of this study was to evaluate the morphometry of peri-implant bone tissue in orchiectomized rats, treated with vitamin D isolated or associated with teriparatide. (2) Methods: 24 rats were divided into 4 groups: ORQ—orchiectomy, without drug treatment, ORQ+D—orchiectomy, treated with vitamin D, ORQTERI—orchiectomy, treated with teriparatide and ORQTERI+D—orchiectomy, treated with teriparatide + vitamin D. Each animal received an implant in the tibial metaphysis. Euthanasia occurred 60 days after implant surgery. Computed microtomography (micro-CT) was performed to evaluate the parameters of volume and percentage of bone volume (BV, BV/TV), trabecular thickness (Tb.Th), number and separation of trabeculae (Tb.N, Tb.Sp) and percentage of total porosity (Po-tot). Data were subjected to 1-way ANOVA and Tukey post-test, with a significance level of 5%. (3) Results: For the parameters BV, BV/TV, Tb.Th, the ORQTERI+D group showed the highest values in relation to the other groups and for Po-tot, the lowest values were for ORQTERI+D. For Tb.Sp and Tb.N, there was no statistically significant difference when comparing intragroup results (p > 0.05). (4) Conclusions: It was possible to conclude that treatment with vitamin D associated with teriparatide increases bone volume and improves bone quality. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-07-29T13:43:36Z 2023-07-29T13:43:36Z 2023-02-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.3390/biology12020228 Biology, v. 12, n. 2, 2023. 2079-7737 http://hdl.handle.net/11449/248422 10.3390/biology12020228 2-s2.0-85148936891 |
url |
http://dx.doi.org/10.3390/biology12020228 http://hdl.handle.net/11449/248422 |
identifier_str_mv |
Biology, v. 12, n. 2, 2023. 2079-7737 10.3390/biology12020228 2-s2.0-85148936891 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Biology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128753753128960 |