Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA): Molecular background, virulence, and relevance for public health
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://hdl.handle.net/11449/226633 |
Resumo: | Staphylococcus aureus and coagulase-negative Staphylococcus (CoNS) are frequently found in nosocomial environments as the main pathogen in several infections. In 1961, reports of nosocomial S. aureus resistant to methicillin, the drug of choice against penicillin-resistant strains, required new alternatives and vancomycin started being used to treat infections caused by methicillin-resistant S. aureus (MRSA). Community-acquired methicillin-resistant S. aureus (CA-MRSA) was first reported in 1990 affecting patients without risk factors for infection with MRSA of hospital origin. MRSA of community origin harbor the genes responsible for the synthesis of Panton-Valentine leukocidin (PVL), a toxin associated with skin and soft tissue infections and that carries the staphylococcal cassette chromosome mec (SCCmec) type IV. CA-MRSA emergence has caused great impact on the worldwide medical community since the presence of this pathogen in patients without risk factors represents a high risk to public health. © CEVAP 2011. |
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Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA): Molecular background, virulence, and relevance for public healthDrug resistanceEpidemiologyMecA geneMethicillin-resistant staphylococcus aureusOxacillinPanton-valentine leukocidinStaphylococcus aureus and coagulase-negative Staphylococcus (CoNS) are frequently found in nosocomial environments as the main pathogen in several infections. In 1961, reports of nosocomial S. aureus resistant to methicillin, the drug of choice against penicillin-resistant strains, required new alternatives and vancomycin started being used to treat infections caused by methicillin-resistant S. aureus (MRSA). Community-acquired methicillin-resistant S. aureus (CA-MRSA) was first reported in 1990 affecting patients without risk factors for infection with MRSA of hospital origin. MRSA of community origin harbor the genes responsible for the synthesis of Panton-Valentine leukocidin (PVL), a toxin associated with skin and soft tissue infections and that carries the staphylococcal cassette chromosome mec (SCCmec) type IV. CA-MRSA emergence has caused great impact on the worldwide medical community since the presence of this pathogen in patients without risk factors represents a high risk to public health. © CEVAP 2011.Department of Microbiology and Immunology, Botucatu Biosciences Institute São Paulo State University (UNESP - Univ Estadual Paulista), Botucatu, São Paulo StateDepartment of Tropical Diseases Botucatu Medical School São Paulo State University (UNESP - Univ Estadual Paulista), Botucatu, São Paulo StateDepartament of Dermatology e Radiotherapy Botucatu Medical School São Paulo State University (UNESP - Univ Estadual Paulista), Botucatu, São Paulo StateDepartment of Microbiology and Immunology, Botucatu Biosciences Institute São Paulo State University (UNESP - Univ Estadual Paulista), Botucatu, São Paulo StateDepartment of Tropical Diseases Botucatu Medical School São Paulo State University (UNESP - Univ Estadual Paulista), Botucatu, São Paulo StateDepartament of Dermatology e Radiotherapy Botucatu Medical School São Paulo State University (UNESP - Univ Estadual Paulista), Botucatu, São Paulo StateUniversidade Estadual Paulista (UNESP)Bonesso, M. F. [UNESP]Marques, S. A. [UNESP]Cunha, M. L.R.S. [UNESP]2022-04-29T02:16:57Z2022-04-29T02:16:57Z2011-12-14info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article378-386Journal of Venomous Animals and Toxins Including Tropical Diseases, v. 17, n. 4, p. 378-386, 2011.1678-91801678-9199http://hdl.handle.net/11449/2266332-s2.0-83155183915Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Venomous Animals and Toxins Including Tropical Diseasesinfo:eu-repo/semantics/openAccess2024-08-15T15:23:14Zoai:repositorio.unesp.br:11449/226633Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-15T15:23:14Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA): Molecular background, virulence, and relevance for public health |
title |
Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA): Molecular background, virulence, and relevance for public health |
spellingShingle |
Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA): Molecular background, virulence, and relevance for public health Bonesso, M. F. [UNESP] Drug resistance Epidemiology MecA gene Methicillin-resistant staphylococcus aureus Oxacillin Panton-valentine leukocidin |
title_short |
Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA): Molecular background, virulence, and relevance for public health |
title_full |
Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA): Molecular background, virulence, and relevance for public health |
title_fullStr |
Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA): Molecular background, virulence, and relevance for public health |
title_full_unstemmed |
Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA): Molecular background, virulence, and relevance for public health |
title_sort |
Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA): Molecular background, virulence, and relevance for public health |
author |
Bonesso, M. F. [UNESP] |
author_facet |
Bonesso, M. F. [UNESP] Marques, S. A. [UNESP] Cunha, M. L.R.S. [UNESP] |
author_role |
author |
author2 |
Marques, S. A. [UNESP] Cunha, M. L.R.S. [UNESP] |
author2_role |
author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) |
dc.contributor.author.fl_str_mv |
Bonesso, M. F. [UNESP] Marques, S. A. [UNESP] Cunha, M. L.R.S. [UNESP] |
dc.subject.por.fl_str_mv |
Drug resistance Epidemiology MecA gene Methicillin-resistant staphylococcus aureus Oxacillin Panton-valentine leukocidin |
topic |
Drug resistance Epidemiology MecA gene Methicillin-resistant staphylococcus aureus Oxacillin Panton-valentine leukocidin |
description |
Staphylococcus aureus and coagulase-negative Staphylococcus (CoNS) are frequently found in nosocomial environments as the main pathogen in several infections. In 1961, reports of nosocomial S. aureus resistant to methicillin, the drug of choice against penicillin-resistant strains, required new alternatives and vancomycin started being used to treat infections caused by methicillin-resistant S. aureus (MRSA). Community-acquired methicillin-resistant S. aureus (CA-MRSA) was first reported in 1990 affecting patients without risk factors for infection with MRSA of hospital origin. MRSA of community origin harbor the genes responsible for the synthesis of Panton-Valentine leukocidin (PVL), a toxin associated with skin and soft tissue infections and that carries the staphylococcal cassette chromosome mec (SCCmec) type IV. CA-MRSA emergence has caused great impact on the worldwide medical community since the presence of this pathogen in patients without risk factors represents a high risk to public health. © CEVAP 2011. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-12-14 2022-04-29T02:16:57Z 2022-04-29T02:16:57Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
Journal of Venomous Animals and Toxins Including Tropical Diseases, v. 17, n. 4, p. 378-386, 2011. 1678-9180 1678-9199 http://hdl.handle.net/11449/226633 2-s2.0-83155183915 |
identifier_str_mv |
Journal of Venomous Animals and Toxins Including Tropical Diseases, v. 17, n. 4, p. 378-386, 2011. 1678-9180 1678-9199 2-s2.0-83155183915 |
url |
http://hdl.handle.net/11449/226633 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of Venomous Animals and Toxins Including Tropical Diseases |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
378-386 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128183711563776 |