Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA): Molecular background, virulence, and relevance for public health

Detalhes bibliográficos
Autor(a) principal: Bonesso, M. F. [UNESP]
Data de Publicação: 2011
Outros Autores: Marques, S. A. [UNESP], Cunha, M. L.R.S. [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://hdl.handle.net/11449/226633
Resumo: Staphylococcus aureus and coagulase-negative Staphylococcus (CoNS) are frequently found in nosocomial environments as the main pathogen in several infections. In 1961, reports of nosocomial S. aureus resistant to methicillin, the drug of choice against penicillin-resistant strains, required new alternatives and vancomycin started being used to treat infections caused by methicillin-resistant S. aureus (MRSA). Community-acquired methicillin-resistant S. aureus (CA-MRSA) was first reported in 1990 affecting patients without risk factors for infection with MRSA of hospital origin. MRSA of community origin harbor the genes responsible for the synthesis of Panton-Valentine leukocidin (PVL), a toxin associated with skin and soft tissue infections and that carries the staphylococcal cassette chromosome mec (SCCmec) type IV. CA-MRSA emergence has caused great impact on the worldwide medical community since the presence of this pathogen in patients without risk factors represents a high risk to public health. © CEVAP 2011.
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spelling Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA): Molecular background, virulence, and relevance for public healthDrug resistanceEpidemiologyMecA geneMethicillin-resistant staphylococcus aureusOxacillinPanton-valentine leukocidinStaphylococcus aureus and coagulase-negative Staphylococcus (CoNS) are frequently found in nosocomial environments as the main pathogen in several infections. In 1961, reports of nosocomial S. aureus resistant to methicillin, the drug of choice against penicillin-resistant strains, required new alternatives and vancomycin started being used to treat infections caused by methicillin-resistant S. aureus (MRSA). Community-acquired methicillin-resistant S. aureus (CA-MRSA) was first reported in 1990 affecting patients without risk factors for infection with MRSA of hospital origin. MRSA of community origin harbor the genes responsible for the synthesis of Panton-Valentine leukocidin (PVL), a toxin associated with skin and soft tissue infections and that carries the staphylococcal cassette chromosome mec (SCCmec) type IV. CA-MRSA emergence has caused great impact on the worldwide medical community since the presence of this pathogen in patients without risk factors represents a high risk to public health. © CEVAP 2011.Department of Microbiology and Immunology, Botucatu Biosciences Institute São Paulo State University (UNESP - Univ Estadual Paulista), Botucatu, São Paulo StateDepartment of Tropical Diseases Botucatu Medical School São Paulo State University (UNESP - Univ Estadual Paulista), Botucatu, São Paulo StateDepartament of Dermatology e Radiotherapy Botucatu Medical School São Paulo State University (UNESP - Univ Estadual Paulista), Botucatu, São Paulo StateDepartment of Microbiology and Immunology, Botucatu Biosciences Institute São Paulo State University (UNESP - Univ Estadual Paulista), Botucatu, São Paulo StateDepartment of Tropical Diseases Botucatu Medical School São Paulo State University (UNESP - Univ Estadual Paulista), Botucatu, São Paulo StateDepartament of Dermatology e Radiotherapy Botucatu Medical School São Paulo State University (UNESP - Univ Estadual Paulista), Botucatu, São Paulo StateUniversidade Estadual Paulista (UNESP)Bonesso, M. F. [UNESP]Marques, S. A. [UNESP]Cunha, M. L.R.S. [UNESP]2022-04-29T02:16:57Z2022-04-29T02:16:57Z2011-12-14info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article378-386Journal of Venomous Animals and Toxins Including Tropical Diseases, v. 17, n. 4, p. 378-386, 2011.1678-91801678-9199http://hdl.handle.net/11449/2266332-s2.0-83155183915Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Venomous Animals and Toxins Including Tropical Diseasesinfo:eu-repo/semantics/openAccess2024-08-15T15:23:14Zoai:repositorio.unesp.br:11449/226633Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-15T15:23:14Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA): Molecular background, virulence, and relevance for public health
title Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA): Molecular background, virulence, and relevance for public health
spellingShingle Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA): Molecular background, virulence, and relevance for public health
Bonesso, M. F. [UNESP]
Drug resistance
Epidemiology
MecA gene
Methicillin-resistant staphylococcus aureus
Oxacillin
Panton-valentine leukocidin
title_short Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA): Molecular background, virulence, and relevance for public health
title_full Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA): Molecular background, virulence, and relevance for public health
title_fullStr Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA): Molecular background, virulence, and relevance for public health
title_full_unstemmed Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA): Molecular background, virulence, and relevance for public health
title_sort Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA): Molecular background, virulence, and relevance for public health
author Bonesso, M. F. [UNESP]
author_facet Bonesso, M. F. [UNESP]
Marques, S. A. [UNESP]
Cunha, M. L.R.S. [UNESP]
author_role author
author2 Marques, S. A. [UNESP]
Cunha, M. L.R.S. [UNESP]
author2_role author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (UNESP)
dc.contributor.author.fl_str_mv Bonesso, M. F. [UNESP]
Marques, S. A. [UNESP]
Cunha, M. L.R.S. [UNESP]
dc.subject.por.fl_str_mv Drug resistance
Epidemiology
MecA gene
Methicillin-resistant staphylococcus aureus
Oxacillin
Panton-valentine leukocidin
topic Drug resistance
Epidemiology
MecA gene
Methicillin-resistant staphylococcus aureus
Oxacillin
Panton-valentine leukocidin
description Staphylococcus aureus and coagulase-negative Staphylococcus (CoNS) are frequently found in nosocomial environments as the main pathogen in several infections. In 1961, reports of nosocomial S. aureus resistant to methicillin, the drug of choice against penicillin-resistant strains, required new alternatives and vancomycin started being used to treat infections caused by methicillin-resistant S. aureus (MRSA). Community-acquired methicillin-resistant S. aureus (CA-MRSA) was first reported in 1990 affecting patients without risk factors for infection with MRSA of hospital origin. MRSA of community origin harbor the genes responsible for the synthesis of Panton-Valentine leukocidin (PVL), a toxin associated with skin and soft tissue infections and that carries the staphylococcal cassette chromosome mec (SCCmec) type IV. CA-MRSA emergence has caused great impact on the worldwide medical community since the presence of this pathogen in patients without risk factors represents a high risk to public health. © CEVAP 2011.
publishDate 2011
dc.date.none.fl_str_mv 2011-12-14
2022-04-29T02:16:57Z
2022-04-29T02:16:57Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv Journal of Venomous Animals and Toxins Including Tropical Diseases, v. 17, n. 4, p. 378-386, 2011.
1678-9180
1678-9199
http://hdl.handle.net/11449/226633
2-s2.0-83155183915
identifier_str_mv Journal of Venomous Animals and Toxins Including Tropical Diseases, v. 17, n. 4, p. 378-386, 2011.
1678-9180
1678-9199
2-s2.0-83155183915
url http://hdl.handle.net/11449/226633
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Journal of Venomous Animals and Toxins Including Tropical Diseases
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 378-386
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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