Comparative analysis of two different models of swimming applied to pregnant rats born small for pregnant age
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/0001-3765201720160285 http://hdl.handle.net/11449/174480 |
Resumo: | The aim of this study was to compare two models of swimming applied to pregnant rats born small for pregnancy age (SPA). Diabetes was chemically induced in adult female rats to develop an inadequate intrauterine environment, leading to birth of a SPA offspring. In adulthood, the female SPA rats were mated and submitted to different swimming programs. The exercise program 1 (Ex1) consisted of swimming for 15 minutes, followed by 15 minutes of rest and another 15 minutes of swimming, 3 days a week before and during pregnancy. Another program (Ex2) was applied during 60 minutes uninterrupted a day, 6 days/ week during pregnancy. The pregnant rats presented no interference on body weight and glycemia. The rats submitted to Ex2 model showed decreased insulin and blood glucose levels by oral glucose tolerance test, and reduction in area under curve values. The offspring from dams submitted to both exercise protocols presented an increased rate of newborns SPA. However, the offspring from Ex2 dams showed percentage twice higher of newborns SPA than Ex1 offspring. Our data suggests that continuous exercise of 60 min/ day ameliorated the enhanced peripheral insulin sensitivity in growth-restricted females. However, this protocol employed at pregnancy leads to intrauterine growth restriction. |
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Comparative analysis of two different models of swimming applied to pregnant rats born small for pregnant ageDiabetesExerciseOffspringPregnancyRatsThe aim of this study was to compare two models of swimming applied to pregnant rats born small for pregnancy age (SPA). Diabetes was chemically induced in adult female rats to develop an inadequate intrauterine environment, leading to birth of a SPA offspring. In adulthood, the female SPA rats were mated and submitted to different swimming programs. The exercise program 1 (Ex1) consisted of swimming for 15 minutes, followed by 15 minutes of rest and another 15 minutes of swimming, 3 days a week before and during pregnancy. Another program (Ex2) was applied during 60 minutes uninterrupted a day, 6 days/ week during pregnancy. The pregnant rats presented no interference on body weight and glycemia. The rats submitted to Ex2 model showed decreased insulin and blood glucose levels by oral glucose tolerance test, and reduction in area under curve values. The offspring from dams submitted to both exercise protocols presented an increased rate of newborns SPA. However, the offspring from Ex2 dams showed percentage twice higher of newborns SPA than Ex1 offspring. Our data suggests that continuous exercise of 60 min/ day ameliorated the enhanced peripheral insulin sensitivity in growth-restricted females. However, this protocol employed at pregnancy leads to intrauterine growth restriction.Laboratório de Pesquisa Experimental de Ginecologia e Obstetrícia Faculdade de Medicina de Botucatu Universidade Estadual Paulista/UNESP Distrito de Rubião Jr s/nDepartment of Reproductive Biology Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán Cidade do MéxicoLaboratório de Fisiologia de Sistemas e Toxicologia Reprodutiva Instituto de Ciências Biológicas e da Saúde Universidade Federal de Mato Grosso/UFMT, Av. Valdon Varjão, 6390Laboratório de Pesquisa Experimental de Ginecologia e Obstetrícia Faculdade de Medicina de Botucatu Universidade Estadual Paulista/UNESP Distrito de Rubião Jr s/nUniversidade Estadual Paulista (Unesp)Cidade do MéxicoUniversidade Federal de Mato Grosso/UFMTCorvino, Silvana B. [UNESP]Damasceno, Débora C. [UNESP]Sinzato, Yuri K. [UNESP]Netto, Aline O. [UNESP]Macedo, Nathália C. D. [UNESP]Zambrano, ElenaVolpato, Gustavo T. [UNESP]2018-12-11T17:11:19Z2018-12-11T17:11:19Z2017-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article223-230application/pdfhttp://dx.doi.org/10.1590/0001-3765201720160285Anais da Academia Brasileira de Ciencias, v. 89, n. 1, p. 223-230, 2017.1678-26900001-3765http://hdl.handle.net/11449/17448010.1590/0001-3765201720160285S0001-376520170001002232-s2.0-85017627827S0001-37652017000100223.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengAnais da Academia Brasileira de Ciencias0,4180,418info:eu-repo/semantics/openAccess2023-12-02T06:11:31Zoai:repositorio.unesp.br:11449/174480Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-12-02T06:11:31Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Comparative analysis of two different models of swimming applied to pregnant rats born small for pregnant age |
title |
Comparative analysis of two different models of swimming applied to pregnant rats born small for pregnant age |
spellingShingle |
Comparative analysis of two different models of swimming applied to pregnant rats born small for pregnant age Corvino, Silvana B. [UNESP] Diabetes Exercise Offspring Pregnancy Rats |
title_short |
Comparative analysis of two different models of swimming applied to pregnant rats born small for pregnant age |
title_full |
Comparative analysis of two different models of swimming applied to pregnant rats born small for pregnant age |
title_fullStr |
Comparative analysis of two different models of swimming applied to pregnant rats born small for pregnant age |
title_full_unstemmed |
Comparative analysis of two different models of swimming applied to pregnant rats born small for pregnant age |
title_sort |
Comparative analysis of two different models of swimming applied to pregnant rats born small for pregnant age |
author |
Corvino, Silvana B. [UNESP] |
author_facet |
Corvino, Silvana B. [UNESP] Damasceno, Débora C. [UNESP] Sinzato, Yuri K. [UNESP] Netto, Aline O. [UNESP] Macedo, Nathália C. D. [UNESP] Zambrano, Elena Volpato, Gustavo T. [UNESP] |
author_role |
author |
author2 |
Damasceno, Débora C. [UNESP] Sinzato, Yuri K. [UNESP] Netto, Aline O. [UNESP] Macedo, Nathália C. D. [UNESP] Zambrano, Elena Volpato, Gustavo T. [UNESP] |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Cidade do México Universidade Federal de Mato Grosso/UFMT |
dc.contributor.author.fl_str_mv |
Corvino, Silvana B. [UNESP] Damasceno, Débora C. [UNESP] Sinzato, Yuri K. [UNESP] Netto, Aline O. [UNESP] Macedo, Nathália C. D. [UNESP] Zambrano, Elena Volpato, Gustavo T. [UNESP] |
dc.subject.por.fl_str_mv |
Diabetes Exercise Offspring Pregnancy Rats |
topic |
Diabetes Exercise Offspring Pregnancy Rats |
description |
The aim of this study was to compare two models of swimming applied to pregnant rats born small for pregnancy age (SPA). Diabetes was chemically induced in adult female rats to develop an inadequate intrauterine environment, leading to birth of a SPA offspring. In adulthood, the female SPA rats were mated and submitted to different swimming programs. The exercise program 1 (Ex1) consisted of swimming for 15 minutes, followed by 15 minutes of rest and another 15 minutes of swimming, 3 days a week before and during pregnancy. Another program (Ex2) was applied during 60 minutes uninterrupted a day, 6 days/ week during pregnancy. The pregnant rats presented no interference on body weight and glycemia. The rats submitted to Ex2 model showed decreased insulin and blood glucose levels by oral glucose tolerance test, and reduction in area under curve values. The offspring from dams submitted to both exercise protocols presented an increased rate of newborns SPA. However, the offspring from Ex2 dams showed percentage twice higher of newborns SPA than Ex1 offspring. Our data suggests that continuous exercise of 60 min/ day ameliorated the enhanced peripheral insulin sensitivity in growth-restricted females. However, this protocol employed at pregnancy leads to intrauterine growth restriction. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-01-01 2018-12-11T17:11:19Z 2018-12-11T17:11:19Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/0001-3765201720160285 Anais da Academia Brasileira de Ciencias, v. 89, n. 1, p. 223-230, 2017. 1678-2690 0001-3765 http://hdl.handle.net/11449/174480 10.1590/0001-3765201720160285 S0001-37652017000100223 2-s2.0-85017627827 S0001-37652017000100223.pdf |
url |
http://dx.doi.org/10.1590/0001-3765201720160285 http://hdl.handle.net/11449/174480 |
identifier_str_mv |
Anais da Academia Brasileira de Ciencias, v. 89, n. 1, p. 223-230, 2017. 1678-2690 0001-3765 10.1590/0001-3765201720160285 S0001-37652017000100223 2-s2.0-85017627827 S0001-37652017000100223.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Anais da Academia Brasileira de Ciencias 0,418 0,418 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
223-230 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1803046755629006848 |