Recent mouse and rat methods for the study of experimental oral candidiasis
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.4161/viru.25199 http://hdl.handle.net/11449/75997 |
Resumo: | The Candida genus expresses virulence factors that, when combined with immunosuppression and other risk factors, can cause different manifestations of oral candidiasis. The treatment of mucosal infections caused by Candida and the elucidation of the disease process have proven challenging. Therefore, the study of experimentally induced oral candidiasis in rats and mice is useful to clarify the etiopathology of this condition, improve diagnosis, and search for new therapeutic options because the disease process in these animals is similar to that of human candidiasis lesions. Here, we describe and discuss new studies involving rat and mouse models of oral candidiasis with respect to methods for inducing experimental infection, methods for evaluating the development of experimental candidiasis, and new treatment strategies for oral candidiasis. © 2013 Landes Bioscience. |
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Recent mouse and rat methods for the study of experimental oral candidiasisCandida albicansMurine modelOral candidiasisOral cavityamphotericin Bdexamethasonefarnesolfluconazolelactoferrintetracyclinebacterial colonizationcolony forming unitconfocal laser microscopydisease severityepithelium hyperplasiagene expressionhistopathologyimmunizationimmunocompromised patientmuscle cellnonhumanphotodynamic therapyrisk factorSprague Dawley ratthrushtongueWistar ratThe Candida genus expresses virulence factors that, when combined with immunosuppression and other risk factors, can cause different manifestations of oral candidiasis. The treatment of mucosal infections caused by Candida and the elucidation of the disease process have proven challenging. Therefore, the study of experimentally induced oral candidiasis in rats and mice is useful to clarify the etiopathology of this condition, improve diagnosis, and search for new therapeutic options because the disease process in these animals is similar to that of human candidiasis lesions. Here, we describe and discuss new studies involving rat and mouse models of oral candidiasis with respect to methods for inducing experimental infection, methods for evaluating the development of experimental candidiasis, and new treatment strategies for oral candidiasis. © 2013 Landes Bioscience.Department of Biosciences and Oral Diagnosis Institute of Science and Technology UNESP -Univ Estadual Paulista, São José dos CamposDepartment of Microbial Pathogenicity Mechanisms Hans-Knoell-Institute, JenaDepartment of Biosciences and Oral Diagnosis Institute of Science and Technology UNESP -Univ Estadual Paulista, São José dos CamposUniversidade Estadual Paulista (Unesp)Hans-Knoell-InstituteCosta, Anna C.B.P. [UNESP]Pereira, Cristiane A. [UNESP]Junqueira, Juliana Campos [UNESP]Jorge, Antonio O.C. [UNESP]2014-05-27T11:29:58Z2014-05-27T11:29:58Z2013-07-17info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article391-399application/pdfhttp://dx.doi.org/10.4161/viru.25199Virulence, v. 4, n. 5, p. 391-399, 2013.2150-55942150-5608http://hdl.handle.net/11449/7599710.4161/viru.25199WOS:0003233242000072-s2.0-848800785842-s2.0-84880078584.pdf0322020541055900Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengVirulence3.9471,6351,635info:eu-repo/semantics/openAccess2023-12-28T06:18:53Zoai:repositorio.unesp.br:11449/75997Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T21:31:32.180644Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Recent mouse and rat methods for the study of experimental oral candidiasis |
title |
Recent mouse and rat methods for the study of experimental oral candidiasis |
spellingShingle |
Recent mouse and rat methods for the study of experimental oral candidiasis Costa, Anna C.B.P. [UNESP] Candida albicans Murine model Oral candidiasis Oral cavity amphotericin B dexamethasone farnesol fluconazole lactoferrin tetracycline bacterial colonization colony forming unit confocal laser microscopy disease severity epithelium hyperplasia gene expression histopathology immunization immunocompromised patient muscle cell nonhuman photodynamic therapy risk factor Sprague Dawley rat thrush tongue Wistar rat |
title_short |
Recent mouse and rat methods for the study of experimental oral candidiasis |
title_full |
Recent mouse and rat methods for the study of experimental oral candidiasis |
title_fullStr |
Recent mouse and rat methods for the study of experimental oral candidiasis |
title_full_unstemmed |
Recent mouse and rat methods for the study of experimental oral candidiasis |
title_sort |
Recent mouse and rat methods for the study of experimental oral candidiasis |
author |
Costa, Anna C.B.P. [UNESP] |
author_facet |
Costa, Anna C.B.P. [UNESP] Pereira, Cristiane A. [UNESP] Junqueira, Juliana Campos [UNESP] Jorge, Antonio O.C. [UNESP] |
author_role |
author |
author2 |
Pereira, Cristiane A. [UNESP] Junqueira, Juliana Campos [UNESP] Jorge, Antonio O.C. [UNESP] |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Hans-Knoell-Institute |
dc.contributor.author.fl_str_mv |
Costa, Anna C.B.P. [UNESP] Pereira, Cristiane A. [UNESP] Junqueira, Juliana Campos [UNESP] Jorge, Antonio O.C. [UNESP] |
dc.subject.por.fl_str_mv |
Candida albicans Murine model Oral candidiasis Oral cavity amphotericin B dexamethasone farnesol fluconazole lactoferrin tetracycline bacterial colonization colony forming unit confocal laser microscopy disease severity epithelium hyperplasia gene expression histopathology immunization immunocompromised patient muscle cell nonhuman photodynamic therapy risk factor Sprague Dawley rat thrush tongue Wistar rat |
topic |
Candida albicans Murine model Oral candidiasis Oral cavity amphotericin B dexamethasone farnesol fluconazole lactoferrin tetracycline bacterial colonization colony forming unit confocal laser microscopy disease severity epithelium hyperplasia gene expression histopathology immunization immunocompromised patient muscle cell nonhuman photodynamic therapy risk factor Sprague Dawley rat thrush tongue Wistar rat |
description |
The Candida genus expresses virulence factors that, when combined with immunosuppression and other risk factors, can cause different manifestations of oral candidiasis. The treatment of mucosal infections caused by Candida and the elucidation of the disease process have proven challenging. Therefore, the study of experimentally induced oral candidiasis in rats and mice is useful to clarify the etiopathology of this condition, improve diagnosis, and search for new therapeutic options because the disease process in these animals is similar to that of human candidiasis lesions. Here, we describe and discuss new studies involving rat and mouse models of oral candidiasis with respect to methods for inducing experimental infection, methods for evaluating the development of experimental candidiasis, and new treatment strategies for oral candidiasis. © 2013 Landes Bioscience. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-07-17 2014-05-27T11:29:58Z 2014-05-27T11:29:58Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.4161/viru.25199 Virulence, v. 4, n. 5, p. 391-399, 2013. 2150-5594 2150-5608 http://hdl.handle.net/11449/75997 10.4161/viru.25199 WOS:000323324200007 2-s2.0-84880078584 2-s2.0-84880078584.pdf 0322020541055900 |
url |
http://dx.doi.org/10.4161/viru.25199 http://hdl.handle.net/11449/75997 |
identifier_str_mv |
Virulence, v. 4, n. 5, p. 391-399, 2013. 2150-5594 2150-5608 10.4161/viru.25199 WOS:000323324200007 2-s2.0-84880078584 2-s2.0-84880078584.pdf 0322020541055900 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Virulence 3.947 1,635 1,635 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
391-399 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129330340954112 |