Recent mouse and rat methods for the study of experimental oral candidiasis

• Autor(a) principal: Costa, Anna C.B.P. [UNESP]
• Data de Publicação: 2013
• Outros Autores: Pereira, Cristiane A. [UNESP], Junqueira, Juliana Campos [UNESP], Jorge, Antonio O.C. [UNESP]
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://dx.doi.org/10.4161/viru.25199; http://hdl.handle.net/11449/75997
• topic: Candida albicans; Murine model; Oral candidiasis; Oral cavity; amphotericin B; dexamethasone; farnesol; fluconazole; lactoferrin; tetracycline; bacterial colonization; colony forming unit; confocal laser microscopy; disease severity; epithelium hyperplasia; gene expression; histopathology; immunization; immunocompromised patient; muscle cell; nonhuman; photodynamic therapy; risk factor; Sprague Dawley rat; thrush; tongue; Wistar rat

The Candida genus expresses virulence factors that, when combined with immunosuppression and other risk factors, can cause different manifestations of oral candidiasis. The treatment of mucosal infections caused by Candida and the elucidation of the disease process have proven challenging. Therefore, the study of experimentally induced oral candidiasis in rats and mice is useful to clarify the etiopathology of this condition, improve diagnosis, and search for new therapeutic options because the disease process in these animals is similar to that of human candidiasis lesions. Here, we describe and discuss new studies involving rat and mouse models of oral candidiasis with respect to methods for inducing experimental infection, methods for evaluating the development of experimental candidiasis, and new treatment strategies for oral candidiasis. © 2013 Landes Bioscience.