Development of stained polymeric nanocapsules loaded with model drugs: Use of a fluorescent poly(phenyleneethynylene)

Detalhes bibliográficos
Autor(a) principal: Campos, Estefania V. R. [UNESP]
Data de Publicação: 2016
Outros Autores: Oliveira, Jhones L. [UNESP], Zavala-Betancourt, Sara A., Ledezma, Antonio S., Arias, Eduardo, Moggio, Ivana, Romero, Jorge, Fraceto, Leonardo F. [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1016/j.colsurfb.2016.08.031
http://hdl.handle.net/11449/162003
Resumo: A phenyleneethynylene polymer (here denoted pPy3E-sqS) was synthesized and characterized by UV-vis spectroscopy, fluorescence spectroscopy, and TEM, and was used for the staining of polymeric nanocapsules. The nanocapsules presented good temporal stability, without changes in shape or fluorescence, and were suitable for use in drug release systems. The mean particle size was around 430 nm, the polydispersity index was below 0.2, and the zeta potential was around -13 mV. The release kinetics is one of the most important factors to consider in drug delivery systems, and here it was observed that nanocapsules containing the fluorescent polymer still maintained the ability to modulate the release of the fungicides tebuconazole and carbendazim (used as model drugs) after 4 days. Preliminary results indicated that staining with the fluorescent pPy3E-sqS polymer could be used as a valuable tool to track the behavior of polymeric systems in the environment. However, further studies will be needed to clarify the environmental behavior and possible toxicity. (C) 2016 Elsevier B.V. All rights reserved.
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spelling Development of stained polymeric nanocapsules loaded with model drugs: Use of a fluorescent poly(phenyleneethynylene)Stained nanocapsulesFluorescent polymerPolymeric nanocapsulesEnvironmental applicationsPhenyleneethynylene polymerA phenyleneethynylene polymer (here denoted pPy3E-sqS) was synthesized and characterized by UV-vis spectroscopy, fluorescence spectroscopy, and TEM, and was used for the staining of polymeric nanocapsules. The nanocapsules presented good temporal stability, without changes in shape or fluorescence, and were suitable for use in drug release systems. The mean particle size was around 430 nm, the polydispersity index was below 0.2, and the zeta potential was around -13 mV. The release kinetics is one of the most important factors to consider in drug delivery systems, and here it was observed that nanocapsules containing the fluorescent polymer still maintained the ability to modulate the release of the fungicides tebuconazole and carbendazim (used as model drugs) after 4 days. Preliminary results indicated that staining with the fluorescent pPy3E-sqS polymer could be used as a valuable tool to track the behavior of polymeric systems in the environment. However, further studies will be needed to clarify the environmental behavior and possible toxicity. (C) 2016 Elsevier B.V. All rights reserved.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Mexican National Council for Science and Technology (CONACYT, Mexico)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)CONACYTState Univ Sao Paulo, Dept Environm Engn, UNESP, Sorocaba, SP, BrazilState Univ Campinas UNICAMP, Inst Biol, Dept Biochem, Campinas, SP, BrazilCIQA, Blvd Enrique Reyna 140, Saltillo 25294, Coahuila, MexicoState Univ Sao Paulo, Dept Environm Engn, UNESP, Sorocaba, SP, BrazilFAPESP: 2014/20273-4FAPESP: 2014/20286-9FAPESP: 2013-12322-2FAPESP: 2015/15617-9Mexican National Council for Science and Technology (CONACYT, Mexico): 229761/INFR-2014-02CNPq: 174806CONACYT: 270878Elsevier B.V.Universidade Estadual Paulista (Unesp)Universidade Estadual de Campinas (UNICAMP)CIQACampos, Estefania V. R. [UNESP]Oliveira, Jhones L. [UNESP]Zavala-Betancourt, Sara A.Ledezma, Antonio S.Arias, EduardoMoggio, IvanaRomero, JorgeFraceto, Leonardo F. [UNESP]2018-11-26T17:06:29Z2018-11-26T17:06:29Z2016-11-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article442-449application/pdfhttp://dx.doi.org/10.1016/j.colsurfb.2016.08.031Colloids And Surfaces B-biointerfaces. Amsterdam: Elsevier Science Bv, v. 147, p. 442-449, 2016.0927-7765http://hdl.handle.net/11449/16200310.1016/j.colsurfb.2016.08.031WOS:000384851400051WOS000384851400051.pdfWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengColloids And Surfaces B-biointerfaces1,071info:eu-repo/semantics/openAccess2023-12-09T06:18:10Zoai:repositorio.unesp.br:11449/162003Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T19:49:58.312374Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Development of stained polymeric nanocapsules loaded with model drugs: Use of a fluorescent poly(phenyleneethynylene)
title Development of stained polymeric nanocapsules loaded with model drugs: Use of a fluorescent poly(phenyleneethynylene)
spellingShingle Development of stained polymeric nanocapsules loaded with model drugs: Use of a fluorescent poly(phenyleneethynylene)
Campos, Estefania V. R. [UNESP]
Stained nanocapsules
Fluorescent polymer
Polymeric nanocapsules
Environmental applications
Phenyleneethynylene polymer
title_short Development of stained polymeric nanocapsules loaded with model drugs: Use of a fluorescent poly(phenyleneethynylene)
title_full Development of stained polymeric nanocapsules loaded with model drugs: Use of a fluorescent poly(phenyleneethynylene)
title_fullStr Development of stained polymeric nanocapsules loaded with model drugs: Use of a fluorescent poly(phenyleneethynylene)
title_full_unstemmed Development of stained polymeric nanocapsules loaded with model drugs: Use of a fluorescent poly(phenyleneethynylene)
title_sort Development of stained polymeric nanocapsules loaded with model drugs: Use of a fluorescent poly(phenyleneethynylene)
author Campos, Estefania V. R. [UNESP]
author_facet Campos, Estefania V. R. [UNESP]
Oliveira, Jhones L. [UNESP]
Zavala-Betancourt, Sara A.
Ledezma, Antonio S.
Arias, Eduardo
Moggio, Ivana
Romero, Jorge
Fraceto, Leonardo F. [UNESP]
author_role author
author2 Oliveira, Jhones L. [UNESP]
Zavala-Betancourt, Sara A.
Ledezma, Antonio S.
Arias, Eduardo
Moggio, Ivana
Romero, Jorge
Fraceto, Leonardo F. [UNESP]
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
Universidade Estadual de Campinas (UNICAMP)
CIQA
dc.contributor.author.fl_str_mv Campos, Estefania V. R. [UNESP]
Oliveira, Jhones L. [UNESP]
Zavala-Betancourt, Sara A.
Ledezma, Antonio S.
Arias, Eduardo
Moggio, Ivana
Romero, Jorge
Fraceto, Leonardo F. [UNESP]
dc.subject.por.fl_str_mv Stained nanocapsules
Fluorescent polymer
Polymeric nanocapsules
Environmental applications
Phenyleneethynylene polymer
topic Stained nanocapsules
Fluorescent polymer
Polymeric nanocapsules
Environmental applications
Phenyleneethynylene polymer
description A phenyleneethynylene polymer (here denoted pPy3E-sqS) was synthesized and characterized by UV-vis spectroscopy, fluorescence spectroscopy, and TEM, and was used for the staining of polymeric nanocapsules. The nanocapsules presented good temporal stability, without changes in shape or fluorescence, and were suitable for use in drug release systems. The mean particle size was around 430 nm, the polydispersity index was below 0.2, and the zeta potential was around -13 mV. The release kinetics is one of the most important factors to consider in drug delivery systems, and here it was observed that nanocapsules containing the fluorescent polymer still maintained the ability to modulate the release of the fungicides tebuconazole and carbendazim (used as model drugs) after 4 days. Preliminary results indicated that staining with the fluorescent pPy3E-sqS polymer could be used as a valuable tool to track the behavior of polymeric systems in the environment. However, further studies will be needed to clarify the environmental behavior and possible toxicity. (C) 2016 Elsevier B.V. All rights reserved.
publishDate 2016
dc.date.none.fl_str_mv 2016-11-01
2018-11-26T17:06:29Z
2018-11-26T17:06:29Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/j.colsurfb.2016.08.031
Colloids And Surfaces B-biointerfaces. Amsterdam: Elsevier Science Bv, v. 147, p. 442-449, 2016.
0927-7765
http://hdl.handle.net/11449/162003
10.1016/j.colsurfb.2016.08.031
WOS:000384851400051
WOS000384851400051.pdf
url http://dx.doi.org/10.1016/j.colsurfb.2016.08.031
http://hdl.handle.net/11449/162003
identifier_str_mv Colloids And Surfaces B-biointerfaces. Amsterdam: Elsevier Science Bv, v. 147, p. 442-449, 2016.
0927-7765
10.1016/j.colsurfb.2016.08.031
WOS:000384851400051
WOS000384851400051.pdf
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Colloids And Surfaces B-biointerfaces
1,071
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 442-449
application/pdf
dc.publisher.none.fl_str_mv Elsevier B.V.
publisher.none.fl_str_mv Elsevier B.V.
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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