Development of stained polymeric nanocapsules loaded with model drugs: Use of a fluorescent poly(phenyleneethynylene)
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.colsurfb.2016.08.031 http://hdl.handle.net/11449/162003 |
Resumo: | A phenyleneethynylene polymer (here denoted pPy3E-sqS) was synthesized and characterized by UV-vis spectroscopy, fluorescence spectroscopy, and TEM, and was used for the staining of polymeric nanocapsules. The nanocapsules presented good temporal stability, without changes in shape or fluorescence, and were suitable for use in drug release systems. The mean particle size was around 430 nm, the polydispersity index was below 0.2, and the zeta potential was around -13 mV. The release kinetics is one of the most important factors to consider in drug delivery systems, and here it was observed that nanocapsules containing the fluorescent polymer still maintained the ability to modulate the release of the fungicides tebuconazole and carbendazim (used as model drugs) after 4 days. Preliminary results indicated that staining with the fluorescent pPy3E-sqS polymer could be used as a valuable tool to track the behavior of polymeric systems in the environment. However, further studies will be needed to clarify the environmental behavior and possible toxicity. (C) 2016 Elsevier B.V. All rights reserved. |
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Development of stained polymeric nanocapsules loaded with model drugs: Use of a fluorescent poly(phenyleneethynylene)Stained nanocapsulesFluorescent polymerPolymeric nanocapsulesEnvironmental applicationsPhenyleneethynylene polymerA phenyleneethynylene polymer (here denoted pPy3E-sqS) was synthesized and characterized by UV-vis spectroscopy, fluorescence spectroscopy, and TEM, and was used for the staining of polymeric nanocapsules. The nanocapsules presented good temporal stability, without changes in shape or fluorescence, and were suitable for use in drug release systems. The mean particle size was around 430 nm, the polydispersity index was below 0.2, and the zeta potential was around -13 mV. The release kinetics is one of the most important factors to consider in drug delivery systems, and here it was observed that nanocapsules containing the fluorescent polymer still maintained the ability to modulate the release of the fungicides tebuconazole and carbendazim (used as model drugs) after 4 days. Preliminary results indicated that staining with the fluorescent pPy3E-sqS polymer could be used as a valuable tool to track the behavior of polymeric systems in the environment. However, further studies will be needed to clarify the environmental behavior and possible toxicity. (C) 2016 Elsevier B.V. All rights reserved.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Mexican National Council for Science and Technology (CONACYT, Mexico)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)CONACYTState Univ Sao Paulo, Dept Environm Engn, UNESP, Sorocaba, SP, BrazilState Univ Campinas UNICAMP, Inst Biol, Dept Biochem, Campinas, SP, BrazilCIQA, Blvd Enrique Reyna 140, Saltillo 25294, Coahuila, MexicoState Univ Sao Paulo, Dept Environm Engn, UNESP, Sorocaba, SP, BrazilFAPESP: 2014/20273-4FAPESP: 2014/20286-9FAPESP: 2013-12322-2FAPESP: 2015/15617-9Mexican National Council for Science and Technology (CONACYT, Mexico): 229761/INFR-2014-02CNPq: 174806CONACYT: 270878Elsevier B.V.Universidade Estadual Paulista (Unesp)Universidade Estadual de Campinas (UNICAMP)CIQACampos, Estefania V. R. [UNESP]Oliveira, Jhones L. [UNESP]Zavala-Betancourt, Sara A.Ledezma, Antonio S.Arias, EduardoMoggio, IvanaRomero, JorgeFraceto, Leonardo F. [UNESP]2018-11-26T17:06:29Z2018-11-26T17:06:29Z2016-11-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article442-449application/pdfhttp://dx.doi.org/10.1016/j.colsurfb.2016.08.031Colloids And Surfaces B-biointerfaces. Amsterdam: Elsevier Science Bv, v. 147, p. 442-449, 2016.0927-7765http://hdl.handle.net/11449/16200310.1016/j.colsurfb.2016.08.031WOS:000384851400051WOS000384851400051.pdfWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengColloids And Surfaces B-biointerfaces1,071info:eu-repo/semantics/openAccess2023-12-09T06:18:10Zoai:repositorio.unesp.br:11449/162003Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T19:49:58.312374Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Development of stained polymeric nanocapsules loaded with model drugs: Use of a fluorescent poly(phenyleneethynylene) |
title |
Development of stained polymeric nanocapsules loaded with model drugs: Use of a fluorescent poly(phenyleneethynylene) |
spellingShingle |
Development of stained polymeric nanocapsules loaded with model drugs: Use of a fluorescent poly(phenyleneethynylene) Campos, Estefania V. R. [UNESP] Stained nanocapsules Fluorescent polymer Polymeric nanocapsules Environmental applications Phenyleneethynylene polymer |
title_short |
Development of stained polymeric nanocapsules loaded with model drugs: Use of a fluorescent poly(phenyleneethynylene) |
title_full |
Development of stained polymeric nanocapsules loaded with model drugs: Use of a fluorescent poly(phenyleneethynylene) |
title_fullStr |
Development of stained polymeric nanocapsules loaded with model drugs: Use of a fluorescent poly(phenyleneethynylene) |
title_full_unstemmed |
Development of stained polymeric nanocapsules loaded with model drugs: Use of a fluorescent poly(phenyleneethynylene) |
title_sort |
Development of stained polymeric nanocapsules loaded with model drugs: Use of a fluorescent poly(phenyleneethynylene) |
author |
Campos, Estefania V. R. [UNESP] |
author_facet |
Campos, Estefania V. R. [UNESP] Oliveira, Jhones L. [UNESP] Zavala-Betancourt, Sara A. Ledezma, Antonio S. Arias, Eduardo Moggio, Ivana Romero, Jorge Fraceto, Leonardo F. [UNESP] |
author_role |
author |
author2 |
Oliveira, Jhones L. [UNESP] Zavala-Betancourt, Sara A. Ledezma, Antonio S. Arias, Eduardo Moggio, Ivana Romero, Jorge Fraceto, Leonardo F. [UNESP] |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Universidade Estadual de Campinas (UNICAMP) CIQA |
dc.contributor.author.fl_str_mv |
Campos, Estefania V. R. [UNESP] Oliveira, Jhones L. [UNESP] Zavala-Betancourt, Sara A. Ledezma, Antonio S. Arias, Eduardo Moggio, Ivana Romero, Jorge Fraceto, Leonardo F. [UNESP] |
dc.subject.por.fl_str_mv |
Stained nanocapsules Fluorescent polymer Polymeric nanocapsules Environmental applications Phenyleneethynylene polymer |
topic |
Stained nanocapsules Fluorescent polymer Polymeric nanocapsules Environmental applications Phenyleneethynylene polymer |
description |
A phenyleneethynylene polymer (here denoted pPy3E-sqS) was synthesized and characterized by UV-vis spectroscopy, fluorescence spectroscopy, and TEM, and was used for the staining of polymeric nanocapsules. The nanocapsules presented good temporal stability, without changes in shape or fluorescence, and were suitable for use in drug release systems. The mean particle size was around 430 nm, the polydispersity index was below 0.2, and the zeta potential was around -13 mV. The release kinetics is one of the most important factors to consider in drug delivery systems, and here it was observed that nanocapsules containing the fluorescent polymer still maintained the ability to modulate the release of the fungicides tebuconazole and carbendazim (used as model drugs) after 4 days. Preliminary results indicated that staining with the fluorescent pPy3E-sqS polymer could be used as a valuable tool to track the behavior of polymeric systems in the environment. However, further studies will be needed to clarify the environmental behavior and possible toxicity. (C) 2016 Elsevier B.V. All rights reserved. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-11-01 2018-11-26T17:06:29Z 2018-11-26T17:06:29Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.colsurfb.2016.08.031 Colloids And Surfaces B-biointerfaces. Amsterdam: Elsevier Science Bv, v. 147, p. 442-449, 2016. 0927-7765 http://hdl.handle.net/11449/162003 10.1016/j.colsurfb.2016.08.031 WOS:000384851400051 WOS000384851400051.pdf |
url |
http://dx.doi.org/10.1016/j.colsurfb.2016.08.031 http://hdl.handle.net/11449/162003 |
identifier_str_mv |
Colloids And Surfaces B-biointerfaces. Amsterdam: Elsevier Science Bv, v. 147, p. 442-449, 2016. 0927-7765 10.1016/j.colsurfb.2016.08.031 WOS:000384851400051 WOS000384851400051.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Colloids And Surfaces B-biointerfaces 1,071 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
442-449 application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier B.V. |
publisher.none.fl_str_mv |
Elsevier B.V. |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129125628510208 |