Evaluation of the antimicrobial susceptibility of methicillin-resistant Staphylococcus aureus isolated from human infections
Autor(a) principal: | |
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Data de Publicação: | 2006 |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/S1678-91992006000300014 http://hdl.handle.net/11449/69164 |
Resumo: | Multiresistant Staphylococcus aureus constitutes an important public health problem, especially in view of its possible spread in nosocomial environments. In the present work, we analyzed the susceptibility profile of 80 S. aureus stains from human infections resistant to at least 10 drugs. For this study, the techniques used were the disk method and minimum inhibitory concentration (MIC) of the following drugs: cefuroxime, ciprofloxacin, clindamycin, erythromycin, gentamycin, imipenem, oxacillin, rifampicin, tetracycline and vancomycin, according the criteria of the National Committee for Clinical Laboratory Standards (NCCLS). Methicillin was included in the antibiogram as a marker, which is usually used in drugs selection for the treatment of staphylococcal infections. Results indicated that the most effective drug was vancomycin. For the other 10 drugs, the percentage of resistant strains ranged from 85% to 93.75%. In relation to the MICs, it was observed that vancomycin (MIC 90% = 0.615ug/ml) was the most effective drug; followed by rifampicin (MIC 90% = 2.6ug/ml) and ciprofloxacin (MIC 90% = 26.6ug/ml). The drugs that showed the least effective activity were cefuroxime, clindamycin, erythromycin, gentamycin, and oxacillin. On the other hand, observation of β-lactamase production revealed that most of the methicillin-resistant strains produced β-lactamase (83.7%), potentiating the risks of nosocomial infections. In general, vancomycin still continues to be one of the most effective drugs for staphylococcal infections therapy. |
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Evaluation of the antimicrobial susceptibility of methicillin-resistant Staphylococcus aureus isolated from human infectionsDrugsHuman infectionsMethicillinStaphylococcus aureusmethicillin resistant Staphylococcus aureusStaphylococcusMultiresistant Staphylococcus aureus constitutes an important public health problem, especially in view of its possible spread in nosocomial environments. In the present work, we analyzed the susceptibility profile of 80 S. aureus stains from human infections resistant to at least 10 drugs. For this study, the techniques used were the disk method and minimum inhibitory concentration (MIC) of the following drugs: cefuroxime, ciprofloxacin, clindamycin, erythromycin, gentamycin, imipenem, oxacillin, rifampicin, tetracycline and vancomycin, according the criteria of the National Committee for Clinical Laboratory Standards (NCCLS). Methicillin was included in the antibiogram as a marker, which is usually used in drugs selection for the treatment of staphylococcal infections. Results indicated that the most effective drug was vancomycin. For the other 10 drugs, the percentage of resistant strains ranged from 85% to 93.75%. In relation to the MICs, it was observed that vancomycin (MIC 90% = 0.615ug/ml) was the most effective drug; followed by rifampicin (MIC 90% = 2.6ug/ml) and ciprofloxacin (MIC 90% = 26.6ug/ml). The drugs that showed the least effective activity were cefuroxime, clindamycin, erythromycin, gentamycin, and oxacillin. On the other hand, observation of β-lactamase production revealed that most of the methicillin-resistant strains produced β-lactamase (83.7%), potentiating the risks of nosocomial infections. In general, vancomycin still continues to be one of the most effective drugs for staphylococcal infections therapy.Departamento de Microbiologia e Imunologia Instituto de Biociências UNESP, Botucatu, SP, 18618-000Departamento de Microbiologia e Imunologia Instituto de Biociências UNESP, Botucatu, SP, 18618-000Universidade Estadual Paulista (Unesp)Domingues, Andréa [UNESP]2014-05-27T11:22:00Z2014-05-27T11:22:00Z2006-10-05info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article521application/pdfhttp://dx.doi.org/10.1590/S1678-91992006000300014Journal of Venomous Animals and Toxins Including Tropical Diseases, v. 12, n. 3, p. 521-, 2006.1678-9199http://hdl.handle.net/11449/6916410.1590/S1678-91992006000300014S1678-919920060003000142-s2.0-337491710902-s2.0-33749171090.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Venomous Animals and Toxins Including Tropical Diseases1.7820,573info:eu-repo/semantics/openAccess2023-11-19T06:09:38Zoai:repositorio.unesp.br:11449/69164Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T18:06:44.407027Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Evaluation of the antimicrobial susceptibility of methicillin-resistant Staphylococcus aureus isolated from human infections |
title |
Evaluation of the antimicrobial susceptibility of methicillin-resistant Staphylococcus aureus isolated from human infections |
spellingShingle |
Evaluation of the antimicrobial susceptibility of methicillin-resistant Staphylococcus aureus isolated from human infections Domingues, Andréa [UNESP] Drugs Human infections Methicillin Staphylococcus aureus methicillin resistant Staphylococcus aureus Staphylococcus |
title_short |
Evaluation of the antimicrobial susceptibility of methicillin-resistant Staphylococcus aureus isolated from human infections |
title_full |
Evaluation of the antimicrobial susceptibility of methicillin-resistant Staphylococcus aureus isolated from human infections |
title_fullStr |
Evaluation of the antimicrobial susceptibility of methicillin-resistant Staphylococcus aureus isolated from human infections |
title_full_unstemmed |
Evaluation of the antimicrobial susceptibility of methicillin-resistant Staphylococcus aureus isolated from human infections |
title_sort |
Evaluation of the antimicrobial susceptibility of methicillin-resistant Staphylococcus aureus isolated from human infections |
author |
Domingues, Andréa [UNESP] |
author_facet |
Domingues, Andréa [UNESP] |
author_role |
author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Domingues, Andréa [UNESP] |
dc.subject.por.fl_str_mv |
Drugs Human infections Methicillin Staphylococcus aureus methicillin resistant Staphylococcus aureus Staphylococcus |
topic |
Drugs Human infections Methicillin Staphylococcus aureus methicillin resistant Staphylococcus aureus Staphylococcus |
description |
Multiresistant Staphylococcus aureus constitutes an important public health problem, especially in view of its possible spread in nosocomial environments. In the present work, we analyzed the susceptibility profile of 80 S. aureus stains from human infections resistant to at least 10 drugs. For this study, the techniques used were the disk method and minimum inhibitory concentration (MIC) of the following drugs: cefuroxime, ciprofloxacin, clindamycin, erythromycin, gentamycin, imipenem, oxacillin, rifampicin, tetracycline and vancomycin, according the criteria of the National Committee for Clinical Laboratory Standards (NCCLS). Methicillin was included in the antibiogram as a marker, which is usually used in drugs selection for the treatment of staphylococcal infections. Results indicated that the most effective drug was vancomycin. For the other 10 drugs, the percentage of resistant strains ranged from 85% to 93.75%. In relation to the MICs, it was observed that vancomycin (MIC 90% = 0.615ug/ml) was the most effective drug; followed by rifampicin (MIC 90% = 2.6ug/ml) and ciprofloxacin (MIC 90% = 26.6ug/ml). The drugs that showed the least effective activity were cefuroxime, clindamycin, erythromycin, gentamycin, and oxacillin. On the other hand, observation of β-lactamase production revealed that most of the methicillin-resistant strains produced β-lactamase (83.7%), potentiating the risks of nosocomial infections. In general, vancomycin still continues to be one of the most effective drugs for staphylococcal infections therapy. |
publishDate |
2006 |
dc.date.none.fl_str_mv |
2006-10-05 2014-05-27T11:22:00Z 2014-05-27T11:22:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S1678-91992006000300014 Journal of Venomous Animals and Toxins Including Tropical Diseases, v. 12, n. 3, p. 521-, 2006. 1678-9199 http://hdl.handle.net/11449/69164 10.1590/S1678-91992006000300014 S1678-91992006000300014 2-s2.0-33749171090 2-s2.0-33749171090.pdf |
url |
http://dx.doi.org/10.1590/S1678-91992006000300014 http://hdl.handle.net/11449/69164 |
identifier_str_mv |
Journal of Venomous Animals and Toxins Including Tropical Diseases, v. 12, n. 3, p. 521-, 2006. 1678-9199 10.1590/S1678-91992006000300014 S1678-91992006000300014 2-s2.0-33749171090 2-s2.0-33749171090.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of Venomous Animals and Toxins Including Tropical Diseases 1.782 0,573 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
521 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128897264386048 |