Association between MUC1 gene polymorphism and expected progeny differences in Nelore cattle (Bos primigenius indicus)

Detalhes bibliográficos
Autor(a) principal: Souza, Fabio Ricardo Pablos de
Data de Publicação: 2010
Outros Autores: Vozzi, Pedro Alejandro, Vila, Reginaldo Aparecido, Boligon, Arione Augusti [UNESP], Galerani, Marli Aparecida Vani, Lobo, Raysildo Barbosa, Martelli, Lucia Regina
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1590/S1415-47572009005000098
http://hdl.handle.net/11449/4700
Resumo: MUC1 is a heavily glycosylated mammalian transmembrane protein expressed by mucosal secretory tissues for both protection against microbial infection and lubrication. An important characteristic of MUC1 is its variable number of tandem repeats (VNTR) containing several sites for O-glycosylation. VNTR length has been associated with many human diseases and with certain economically important traits in domestic ruminants. The aim of the present study was to correlate the length of MUC1 gene VNTR with expected progeny differences (EPDs) obtained for growth, fertility and carcass traits. Five alleles were identified, with alleles containing short VNTRs being more frequent than those with long, thereby demonstrating that Brazilian Nelore cattle are characterized by high frequencies in short MUC1 VNTRs. Statistical analyses revealed there to be no significant association between VNTR length and EPDs for weight at 120 days (W120), scrotal circumference at 365 (SC365) and 450 (SC450) days, age at first calving (AFC), and rib eye area (REA).
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spelling Association between MUC1 gene polymorphism and expected progeny differences in Nelore cattle (Bos primigenius indicus)Beef cattleMolecular markerProductive traitsquantitative trait locusMUC1 is a heavily glycosylated mammalian transmembrane protein expressed by mucosal secretory tissues for both protection against microbial infection and lubrication. An important characteristic of MUC1 is its variable number of tandem repeats (VNTR) containing several sites for O-glycosylation. VNTR length has been associated with many human diseases and with certain economically important traits in domestic ruminants. The aim of the present study was to correlate the length of MUC1 gene VNTR with expected progeny differences (EPDs) obtained for growth, fertility and carcass traits. Five alleles were identified, with alleles containing short VNTRs being more frequent than those with long, thereby demonstrating that Brazilian Nelore cattle are characterized by high frequencies in short MUC1 VNTRs. Statistical analyses revealed there to be no significant association between VNTR length and EPDs for weight at 120 days (W120), scrotal circumference at 365 (SC365) and 450 (SC450) days, age at first calving (AFC), and rib eye area (REA).Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Universidade de São Paulo Faculdade de Medicina de Ribeirão Preto Departamento de GenéticaUniversidade Estadual Paulista Júlio de Mesquita Filho Faculdade de Ciências Agrárias e Veterinárias Departamento de ZootecniaUniversidade Estadual Paulista Júlio de Mesquita Filho Faculdade de Ciências Agrárias e Veterinárias Departamento de ZootecniaSociedade Brasileira de GenéticaUniversidade de São Paulo (USP)Universidade Estadual Paulista (Unesp)Souza, Fabio Ricardo Pablos deVozzi, Pedro AlejandroVila, Reginaldo AparecidoBoligon, Arione Augusti [UNESP]Galerani, Marli Aparecida VaniLobo, Raysildo BarbosaMartelli, Lucia Regina2014-05-20T13:18:43Z2014-05-20T13:18:43Z2010-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article68-70application/pdfhttp://dx.doi.org/10.1590/S1415-47572009005000098Genetics and Molecular Biology. Sociedade Brasileira de Genética, v. 33, n. 1, p. 68-70, 2010.1415-4757http://hdl.handle.net/11449/470010.1590/S1415-47572009005000098S1415-47572010000100013WOS:000275106000013S1415-47572010000100013.pdfSciELOreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengGenetics and Molecular Biology1.4930,638info:eu-repo/semantics/openAccess2024-06-07T18:45:07Zoai:repositorio.unesp.br:11449/4700Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T23:54:14.332315Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Association between MUC1 gene polymorphism and expected progeny differences in Nelore cattle (Bos primigenius indicus)
title Association between MUC1 gene polymorphism and expected progeny differences in Nelore cattle (Bos primigenius indicus)
spellingShingle Association between MUC1 gene polymorphism and expected progeny differences in Nelore cattle (Bos primigenius indicus)
Souza, Fabio Ricardo Pablos de
Beef cattle
Molecular marker
Productive traits
quantitative trait locus
title_short Association between MUC1 gene polymorphism and expected progeny differences in Nelore cattle (Bos primigenius indicus)
title_full Association between MUC1 gene polymorphism and expected progeny differences in Nelore cattle (Bos primigenius indicus)
title_fullStr Association between MUC1 gene polymorphism and expected progeny differences in Nelore cattle (Bos primigenius indicus)
title_full_unstemmed Association between MUC1 gene polymorphism and expected progeny differences in Nelore cattle (Bos primigenius indicus)
title_sort Association between MUC1 gene polymorphism and expected progeny differences in Nelore cattle (Bos primigenius indicus)
author Souza, Fabio Ricardo Pablos de
author_facet Souza, Fabio Ricardo Pablos de
Vozzi, Pedro Alejandro
Vila, Reginaldo Aparecido
Boligon, Arione Augusti [UNESP]
Galerani, Marli Aparecida Vani
Lobo, Raysildo Barbosa
Martelli, Lucia Regina
author_role author
author2 Vozzi, Pedro Alejandro
Vila, Reginaldo Aparecido
Boligon, Arione Augusti [UNESP]
Galerani, Marli Aparecida Vani
Lobo, Raysildo Barbosa
Martelli, Lucia Regina
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade de São Paulo (USP)
Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Souza, Fabio Ricardo Pablos de
Vozzi, Pedro Alejandro
Vila, Reginaldo Aparecido
Boligon, Arione Augusti [UNESP]
Galerani, Marli Aparecida Vani
Lobo, Raysildo Barbosa
Martelli, Lucia Regina
dc.subject.por.fl_str_mv Beef cattle
Molecular marker
Productive traits
quantitative trait locus
topic Beef cattle
Molecular marker
Productive traits
quantitative trait locus
description MUC1 is a heavily glycosylated mammalian transmembrane protein expressed by mucosal secretory tissues for both protection against microbial infection and lubrication. An important characteristic of MUC1 is its variable number of tandem repeats (VNTR) containing several sites for O-glycosylation. VNTR length has been associated with many human diseases and with certain economically important traits in domestic ruminants. The aim of the present study was to correlate the length of MUC1 gene VNTR with expected progeny differences (EPDs) obtained for growth, fertility and carcass traits. Five alleles were identified, with alleles containing short VNTRs being more frequent than those with long, thereby demonstrating that Brazilian Nelore cattle are characterized by high frequencies in short MUC1 VNTRs. Statistical analyses revealed there to be no significant association between VNTR length and EPDs for weight at 120 days (W120), scrotal circumference at 365 (SC365) and 450 (SC450) days, age at first calving (AFC), and rib eye area (REA).
publishDate 2010
dc.date.none.fl_str_mv 2010-01-01
2014-05-20T13:18:43Z
2014-05-20T13:18:43Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S1415-47572009005000098
Genetics and Molecular Biology. Sociedade Brasileira de Genética, v. 33, n. 1, p. 68-70, 2010.
1415-4757
http://hdl.handle.net/11449/4700
10.1590/S1415-47572009005000098
S1415-47572010000100013
WOS:000275106000013
S1415-47572010000100013.pdf
url http://dx.doi.org/10.1590/S1415-47572009005000098
http://hdl.handle.net/11449/4700
identifier_str_mv Genetics and Molecular Biology. Sociedade Brasileira de Genética, v. 33, n. 1, p. 68-70, 2010.
1415-4757
10.1590/S1415-47572009005000098
S1415-47572010000100013
WOS:000275106000013
S1415-47572010000100013.pdf
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Genetics and Molecular Biology
1.493
0,638
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 68-70
application/pdf
dc.publisher.none.fl_str_mv Sociedade Brasileira de Genética
publisher.none.fl_str_mv Sociedade Brasileira de Genética
dc.source.none.fl_str_mv SciELO
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1808129563010531328

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