Aerobic training prevents cardiometabolic changes triggered by myocardial infarction in ovariectomized rats

Detalhes bibliográficos
Autor(a) principal: Ruberti, Olívia Moraes
Data de Publicação: 2020
Outros Autores: Sousa, Andressa Silva, Viana, Laís Rosa, Pereira Gomes, Moisés Felipe, Medeiros, Alessandra, Gomes Marcondes, Maria Cristina Cintra, Borges, Luciano de Figueiredo, Crestani, Carlos Cesar [UNESP], Mostarda, Cristiano, Moraes, Telma Fátima da Cunha, Canevarolo, Rafael Renatino, Delbin, Maria Andreia, Rodrigues, Bruno
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1002/jcp.29919
http://hdl.handle.net/11449/201940
Resumo: This study aimed to evaluate the impact of aerobic training (AT) on autonomic, cardiometabolic, ubiquitin-proteasome activity, and inflammatory changes evoked by myocardial infarction (MI) in ovariectomized rats. Female Wistar rats were ovariectomized and divided into four groups: sedentary + sham (SS), sedentary + MI (SI), AT + sham surgery (TS), AT + MI (TI). AT was performed on a treadmill for 8 weeks before MI. Infarcted rats previously subjected to AT presented improved physical capacity, increased interleukin-10, and decreased pro-inflammatory cytokines. Metabolomic analysis identified and quantified 62 metabolites, 9 were considered significant by the Vip Score. SS, SI, and TS groups presented distinct metabolic profiles; however, TI could not be distinguished from the SS group. MI dramatically increased levels of dimethylamine, and AT prevented this response. Our findings suggest that AT may be useful in preventing the negative changes in functional, inflammatory, and metabolic parameters related to MI in ovariectomized rats.
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spelling Aerobic training prevents cardiometabolic changes triggered by myocardial infarction in ovariectomized ratsautonomic nervous systemexercisemetabolomicsmyocardial infarctionovariectomyThis study aimed to evaluate the impact of aerobic training (AT) on autonomic, cardiometabolic, ubiquitin-proteasome activity, and inflammatory changes evoked by myocardial infarction (MI) in ovariectomized rats. Female Wistar rats were ovariectomized and divided into four groups: sedentary + sham (SS), sedentary + MI (SI), AT + sham surgery (TS), AT + MI (TI). AT was performed on a treadmill for 8 weeks before MI. Infarcted rats previously subjected to AT presented improved physical capacity, increased interleukin-10, and decreased pro-inflammatory cytokines. Metabolomic analysis identified and quantified 62 metabolites, 9 were considered significant by the Vip Score. SS, SI, and TS groups presented distinct metabolic profiles; however, TI could not be distinguished from the SS group. MI dramatically increased levels of dimethylamine, and AT prevented this response. Our findings suggest that AT may be useful in preventing the negative changes in functional, inflammatory, and metabolic parameters related to MI in ovariectomized rats.Department of Structural and Functional Biology Institute of Biology University of Campinas (UNICAMP)Department of Bioscience Federal University of São Paulo (UNIFESP)Laboratory of Pharmacology School of Pharmaceutical Sciences São Paulo State University (UNESP)Department of Physical Education Federal University of Maranhão (UFMA)School of Physical Education and Sport University of São PauloDepartment of Cancer Physiology H. Lee Moffitt Cancer Center and Research InstituteDepartment of Adapted Physical Activity School of Physical Education University of Campinas (UNICAMP)Laboratory of Pharmacology School of Pharmaceutical Sciences São Paulo State University (UNESP)Universidade Estadual de Campinas (UNICAMP)Universidade de São Paulo (USP)Universidade Estadual Paulista (Unesp)Federal University of Maranhão (UFMA)H. Lee Moffitt Cancer Center and Research InstituteRuberti, Olívia MoraesSousa, Andressa SilvaViana, Laís RosaPereira Gomes, Moisés FelipeMedeiros, AlessandraGomes Marcondes, Maria Cristina CintraBorges, Luciano de FigueiredoCrestani, Carlos Cesar [UNESP]Mostarda, CristianoMoraes, Telma Fátima da CunhaCanevarolo, Rafael RenatinoDelbin, Maria AndreiaRodrigues, Bruno2020-12-12T02:45:48Z2020-12-12T02:45:48Z2020-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1002/jcp.29919Journal of Cellular Physiology.1097-46520021-9541http://hdl.handle.net/11449/20194010.1002/jcp.299192-s2.0-85087643501Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Cellular Physiologyinfo:eu-repo/semantics/openAccess2024-06-24T14:51:52Zoai:repositorio.unesp.br:11449/201940Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T19:14:41.952855Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Aerobic training prevents cardiometabolic changes triggered by myocardial infarction in ovariectomized rats
title Aerobic training prevents cardiometabolic changes triggered by myocardial infarction in ovariectomized rats
spellingShingle Aerobic training prevents cardiometabolic changes triggered by myocardial infarction in ovariectomized rats
Ruberti, Olívia Moraes
autonomic nervous system
exercise
metabolomics
myocardial infarction
ovariectomy
title_short Aerobic training prevents cardiometabolic changes triggered by myocardial infarction in ovariectomized rats
title_full Aerobic training prevents cardiometabolic changes triggered by myocardial infarction in ovariectomized rats
title_fullStr Aerobic training prevents cardiometabolic changes triggered by myocardial infarction in ovariectomized rats
title_full_unstemmed Aerobic training prevents cardiometabolic changes triggered by myocardial infarction in ovariectomized rats
title_sort Aerobic training prevents cardiometabolic changes triggered by myocardial infarction in ovariectomized rats
author Ruberti, Olívia Moraes
author_facet Ruberti, Olívia Moraes
Sousa, Andressa Silva
Viana, Laís Rosa
Pereira Gomes, Moisés Felipe
Medeiros, Alessandra
Gomes Marcondes, Maria Cristina Cintra
Borges, Luciano de Figueiredo
Crestani, Carlos Cesar [UNESP]
Mostarda, Cristiano
Moraes, Telma Fátima da Cunha
Canevarolo, Rafael Renatino
Delbin, Maria Andreia
Rodrigues, Bruno
author_role author
author2 Sousa, Andressa Silva
Viana, Laís Rosa
Pereira Gomes, Moisés Felipe
Medeiros, Alessandra
Gomes Marcondes, Maria Cristina Cintra
Borges, Luciano de Figueiredo
Crestani, Carlos Cesar [UNESP]
Mostarda, Cristiano
Moraes, Telma Fátima da Cunha
Canevarolo, Rafael Renatino
Delbin, Maria Andreia
Rodrigues, Bruno
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual de Campinas (UNICAMP)
Universidade de São Paulo (USP)
Universidade Estadual Paulista (Unesp)
Federal University of Maranhão (UFMA)
H. Lee Moffitt Cancer Center and Research Institute
dc.contributor.author.fl_str_mv Ruberti, Olívia Moraes
Sousa, Andressa Silva
Viana, Laís Rosa
Pereira Gomes, Moisés Felipe
Medeiros, Alessandra
Gomes Marcondes, Maria Cristina Cintra
Borges, Luciano de Figueiredo
Crestani, Carlos Cesar [UNESP]
Mostarda, Cristiano
Moraes, Telma Fátima da Cunha
Canevarolo, Rafael Renatino
Delbin, Maria Andreia
Rodrigues, Bruno
dc.subject.por.fl_str_mv autonomic nervous system
exercise
metabolomics
myocardial infarction
ovariectomy
topic autonomic nervous system
exercise
metabolomics
myocardial infarction
ovariectomy
description This study aimed to evaluate the impact of aerobic training (AT) on autonomic, cardiometabolic, ubiquitin-proteasome activity, and inflammatory changes evoked by myocardial infarction (MI) in ovariectomized rats. Female Wistar rats were ovariectomized and divided into four groups: sedentary + sham (SS), sedentary + MI (SI), AT + sham surgery (TS), AT + MI (TI). AT was performed on a treadmill for 8 weeks before MI. Infarcted rats previously subjected to AT presented improved physical capacity, increased interleukin-10, and decreased pro-inflammatory cytokines. Metabolomic analysis identified and quantified 62 metabolites, 9 were considered significant by the Vip Score. SS, SI, and TS groups presented distinct metabolic profiles; however, TI could not be distinguished from the SS group. MI dramatically increased levels of dimethylamine, and AT prevented this response. Our findings suggest that AT may be useful in preventing the negative changes in functional, inflammatory, and metabolic parameters related to MI in ovariectomized rats.
publishDate 2020
dc.date.none.fl_str_mv 2020-12-12T02:45:48Z
2020-12-12T02:45:48Z
2020-01-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1002/jcp.29919
Journal of Cellular Physiology.
1097-4652
0021-9541
http://hdl.handle.net/11449/201940
10.1002/jcp.29919
2-s2.0-85087643501
url http://dx.doi.org/10.1002/jcp.29919
http://hdl.handle.net/11449/201940
identifier_str_mv Journal of Cellular Physiology.
1097-4652
0021-9541
10.1002/jcp.29919
2-s2.0-85087643501
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Journal of Cellular Physiology
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1808129040358309888

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