Anti-hypertensive drugs have different effects on ventricular hypertrophy regression

Detalhes bibliográficos
Autor(a) principal: Ferreira Filho, Celso
Data de Publicação: 2010
Outros Autores: Abreu, Luiz Carlos de, Valenti, Vitor E., Ferreira, Marcelo, Meneghini, Adriano, Silveira, José Alexandre, Riera, Andrés R. Pérez, Colombari, Eduardo [UNESP], Murad, Neif, Santos-Silva, Paulo Roberto, Silva, Lovian José Henrique Pereira da, Vanderlei, Luiz Carlos Marques [UNESP], Carvalho, Tatiana D., Ferreira, Celso
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1590/S1807-59322010000700012
http://hdl.handle.net/11449/7035
Resumo: OBJECTIVES: There is a direct relationship between the regression of left ventricular hypertrophy (LVH) and a decreased risk of mortality. This investigation aimed to describe the effects of anti-hypertensive drugs on cardiac hypertrophy through a meta-analysis of the literature. METHODS: The Medline (via PubMed), Lilacs and Scielo databases were searched using the subject keywords cardiac hypertrophy, antihypertensive and mortality. We aimed to analyze the effect of anti-hypertensive drugs on ventricle hypertrophy. RESULTS: The main drugs we described were enalapril, verapamil, nifedipine, indapamina, losartan, angiotensin-converting enzyme inhibitors and atenolol. These drugs are usually used in follow up programs, however, the studies we investigated used different protocols. Enalapril (angiotensin-converting enzyme inhibitor) and verapamil (Ca++ channel blocker) caused hypertrophy to regress in LVH rats. The effects of enalapril and nifedipine (Ca++ channel blocker) were similar. Indapamina (diuretic) had a stronger effect than enalapril, and losartan (angiotensin II receptor type 1 (AT1) receptor antagonist) produced better results than atenolol (selective β1 receptor antagonist) with respect to LVH regression. CONCLUSION: The anti-hypertensive drugs induced various degrees of hypertrophic regression.
id UNSP_a89600a16ded885d5dc5ffc63dc5e7ba
oai_identifier_str oai:repositorio.unesp.br:11449/7035
network_acronym_str UNSP
network_name_str Repositório Institucional da UNESP
repository_id_str 2946
spelling Anti-hypertensive drugs have different effects on ventricular hypertrophy regressionHypertrophyCardiomyopathyHypertrophicLeft ventricle hypertensionCardiologyOBJECTIVES: There is a direct relationship between the regression of left ventricular hypertrophy (LVH) and a decreased risk of mortality. This investigation aimed to describe the effects of anti-hypertensive drugs on cardiac hypertrophy through a meta-analysis of the literature. METHODS: The Medline (via PubMed), Lilacs and Scielo databases were searched using the subject keywords cardiac hypertrophy, antihypertensive and mortality. We aimed to analyze the effect of anti-hypertensive drugs on ventricle hypertrophy. RESULTS: The main drugs we described were enalapril, verapamil, nifedipine, indapamina, losartan, angiotensin-converting enzyme inhibitors and atenolol. These drugs are usually used in follow up programs, however, the studies we investigated used different protocols. Enalapril (angiotensin-converting enzyme inhibitor) and verapamil (Ca++ channel blocker) caused hypertrophy to regress in LVH rats. The effects of enalapril and nifedipine (Ca++ channel blocker) were similar. Indapamina (diuretic) had a stronger effect than enalapril, and losartan (angiotensin II receptor type 1 (AT1) receptor antagonist) produced better results than atenolol (selective β1 receptor antagonist) with respect to LVH regression. CONCLUSION: The anti-hypertensive drugs induced various degrees of hypertrophic regression.NEPAS (Nucleo de Estudos, Pesquisas e Assessoria a Saúde da Faculdade de Medicina do ABC)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Faculdade de Medicina do ABC Disciplina de Cardiologia Departamento de Clínica MédicaFaculdade de Medicina do ABC Departamento de Morfologia e FisiologiaUniversidade Federal de São Paulo (UNIFESP) Disciplina de Cardiologia Departamento de MedicinaUniversidade Estadual Paulista Faculdade de Ciências e Tecnologia Departamento de FisioterapiaUniversidade Estadual Paulista Faculdade de Ciências e Tecnologia Departamento de FisioterapiaUniversidade de São Paulo (USP), Faculdade de MedicinaFaculdade de Medicina do ABC (FMABC)Universidade Federal de São Paulo (UNIFESP)Universidade Estadual Paulista (Unesp)Ferreira Filho, CelsoAbreu, Luiz Carlos deValenti, Vitor E.Ferreira, MarceloMeneghini, AdrianoSilveira, José AlexandreRiera, Andrés R. PérezColombari, Eduardo [UNESP]Murad, NeifSantos-Silva, Paulo RobertoSilva, Lovian José Henrique Pereira daVanderlei, Luiz Carlos Marques [UNESP]Carvalho, Tatiana D.Ferreira, Celso2014-05-20T13:23:21Z2014-05-20T13:23:21Z2010-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article723-728application/pdfhttp://dx.doi.org/10.1590/S1807-59322010000700012Clinics. Faculdade de Medicina / USP, v. 65, n. 7, p. 723-728, 2010.1807-5932http://hdl.handle.net/11449/703510.1590/S1807-59322010000700012S1807-59322010000700012WOS:000280808400012S1807-59322010000700012.pdf5860525135106995SciELOreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengClinics1.2450,536info:eu-repo/semantics/openAccess2024-06-18T18:44:01Zoai:repositorio.unesp.br:11449/7035Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T18:06:21.871464Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Anti-hypertensive drugs have different effects on ventricular hypertrophy regression
title Anti-hypertensive drugs have different effects on ventricular hypertrophy regression
spellingShingle Anti-hypertensive drugs have different effects on ventricular hypertrophy regression
Ferreira Filho, Celso
Hypertrophy
Cardiomyopathy
Hypertrophic
Left ventricle hypertension
Cardiology
title_short Anti-hypertensive drugs have different effects on ventricular hypertrophy regression
title_full Anti-hypertensive drugs have different effects on ventricular hypertrophy regression
title_fullStr Anti-hypertensive drugs have different effects on ventricular hypertrophy regression
title_full_unstemmed Anti-hypertensive drugs have different effects on ventricular hypertrophy regression
title_sort Anti-hypertensive drugs have different effects on ventricular hypertrophy regression
author Ferreira Filho, Celso
author_facet Ferreira Filho, Celso
Abreu, Luiz Carlos de
Valenti, Vitor E.
Ferreira, Marcelo
Meneghini, Adriano
Silveira, José Alexandre
Riera, Andrés R. Pérez
Colombari, Eduardo [UNESP]
Murad, Neif
Santos-Silva, Paulo Roberto
Silva, Lovian José Henrique Pereira da
Vanderlei, Luiz Carlos Marques [UNESP]
Carvalho, Tatiana D.
Ferreira, Celso
author_role author
author2 Abreu, Luiz Carlos de
Valenti, Vitor E.
Ferreira, Marcelo
Meneghini, Adriano
Silveira, José Alexandre
Riera, Andrés R. Pérez
Colombari, Eduardo [UNESP]
Murad, Neif
Santos-Silva, Paulo Roberto
Silva, Lovian José Henrique Pereira da
Vanderlei, Luiz Carlos Marques [UNESP]
Carvalho, Tatiana D.
Ferreira, Celso
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Faculdade de Medicina do ABC (FMABC)
Universidade Federal de São Paulo (UNIFESP)
Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Ferreira Filho, Celso
Abreu, Luiz Carlos de
Valenti, Vitor E.
Ferreira, Marcelo
Meneghini, Adriano
Silveira, José Alexandre
Riera, Andrés R. Pérez
Colombari, Eduardo [UNESP]
Murad, Neif
Santos-Silva, Paulo Roberto
Silva, Lovian José Henrique Pereira da
Vanderlei, Luiz Carlos Marques [UNESP]
Carvalho, Tatiana D.
Ferreira, Celso
dc.subject.por.fl_str_mv Hypertrophy
Cardiomyopathy
Hypertrophic
Left ventricle hypertension
Cardiology
topic Hypertrophy
Cardiomyopathy
Hypertrophic
Left ventricle hypertension
Cardiology
description OBJECTIVES: There is a direct relationship between the regression of left ventricular hypertrophy (LVH) and a decreased risk of mortality. This investigation aimed to describe the effects of anti-hypertensive drugs on cardiac hypertrophy through a meta-analysis of the literature. METHODS: The Medline (via PubMed), Lilacs and Scielo databases were searched using the subject keywords cardiac hypertrophy, antihypertensive and mortality. We aimed to analyze the effect of anti-hypertensive drugs on ventricle hypertrophy. RESULTS: The main drugs we described were enalapril, verapamil, nifedipine, indapamina, losartan, angiotensin-converting enzyme inhibitors and atenolol. These drugs are usually used in follow up programs, however, the studies we investigated used different protocols. Enalapril (angiotensin-converting enzyme inhibitor) and verapamil (Ca++ channel blocker) caused hypertrophy to regress in LVH rats. The effects of enalapril and nifedipine (Ca++ channel blocker) were similar. Indapamina (diuretic) had a stronger effect than enalapril, and losartan (angiotensin II receptor type 1 (AT1) receptor antagonist) produced better results than atenolol (selective β1 receptor antagonist) with respect to LVH regression. CONCLUSION: The anti-hypertensive drugs induced various degrees of hypertrophic regression.
publishDate 2010
dc.date.none.fl_str_mv 2010-01-01
2014-05-20T13:23:21Z
2014-05-20T13:23:21Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S1807-59322010000700012
Clinics. Faculdade de Medicina / USP, v. 65, n. 7, p. 723-728, 2010.
1807-5932
http://hdl.handle.net/11449/7035
10.1590/S1807-59322010000700012
S1807-59322010000700012
WOS:000280808400012
S1807-59322010000700012.pdf
5860525135106995
url http://dx.doi.org/10.1590/S1807-59322010000700012
http://hdl.handle.net/11449/7035
identifier_str_mv Clinics. Faculdade de Medicina / USP, v. 65, n. 7, p. 723-728, 2010.
1807-5932
10.1590/S1807-59322010000700012
S1807-59322010000700012
WOS:000280808400012
S1807-59322010000700012.pdf
5860525135106995
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Clinics
1.245
0,536
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 723-728
application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo (USP), Faculdade de Medicina
publisher.none.fl_str_mv Universidade de São Paulo (USP), Faculdade de Medicina
dc.source.none.fl_str_mv SciELO
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1808128895553110016