Natural infection of Neotropical bats with hantavirus in Brazil
Autor(a) principal: | |
---|---|
Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1038/s41598-018-27442-w http://hdl.handle.net/11449/164310 |
Resumo: | Bats (Order: Chiroptera) harbor a high diversity of emerging pathogens presumably because their ability to fly and social behavior favor the maintenance, evolution, and dissemination of these pathogens. Until 2012, there was only one report of the presence of Hantavirus in bats. Historically, it was thought that these viruses were harbored primarily by rodent and insectivore small mammals. Recently, new species of hantaviruses have been identified in bats from Africa and Asia continents expanding the potential reservoirs and range of these viruses. To assess the potential of Neotropical bats as hosts for hantaviruses and its transmission dynamics in nature, we tested 53 bats for active hantaviral infection from specimens collected in Southeastern Brazil. Part of the hantaviral S segment was amplified from the frugivorous Carollia perspicillata and the common vampire bat Desmodus rotundus. DNA sequencing showed high similarity with the genome of Araraquara orthohantavirus (ARQV), which belongs to one of the more lethal hantavirus clades (Andes orthohantavirus). ARQV-like infection was detected in the blood, urine, and organs of D. rotundus. Therefore, we describe a systemic infection in Neotropical bats by a human pathogenic Hantavirus. We also propose here a schematic transmission dynamics of hantavirus in the study region. Our results give insights to new, under-appreciated questions that need to be addressed in future studies to clarify hantavirus transmission in nature and avoid hantavirus outbreaks. |
id |
UNSP_a8b45aee407979d0da70adb7db6b0d27 |
---|---|
oai_identifier_str |
oai:repositorio.unesp.br:11449/164310 |
network_acronym_str |
UNSP |
network_name_str |
Repositório Institucional da UNESP |
repository_id_str |
2946 |
spelling |
Natural infection of Neotropical bats with hantavirus in BrazilBats (Order: Chiroptera) harbor a high diversity of emerging pathogens presumably because their ability to fly and social behavior favor the maintenance, evolution, and dissemination of these pathogens. Until 2012, there was only one report of the presence of Hantavirus in bats. Historically, it was thought that these viruses were harbored primarily by rodent and insectivore small mammals. Recently, new species of hantaviruses have been identified in bats from Africa and Asia continents expanding the potential reservoirs and range of these viruses. To assess the potential of Neotropical bats as hosts for hantaviruses and its transmission dynamics in nature, we tested 53 bats for active hantaviral infection from specimens collected in Southeastern Brazil. Part of the hantaviral S segment was amplified from the frugivorous Carollia perspicillata and the common vampire bat Desmodus rotundus. DNA sequencing showed high similarity with the genome of Araraquara orthohantavirus (ARQV), which belongs to one of the more lethal hantavirus clades (Andes orthohantavirus). ARQV-like infection was detected in the blood, urine, and organs of D. rotundus. Therefore, we describe a systemic infection in Neotropical bats by a human pathogenic Hantavirus. We also propose here a schematic transmission dynamics of hantavirus in the study region. Our results give insights to new, under-appreciated questions that need to be addressed in future studies to clarify hantavirus transmission in nature and avoid hantavirus outbreaks.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)Univ Sao Paulo, Ribeirao Preto Med Sch, Ctr Virol Res, Ribeirao Preto, BrazilUniv Sao Paulo, Inst Biomed Sci, Dept Microbiol, Sao Paulo, BrazilSao Paulo State Univ, Dept Ecol, Rio Claro, BrazilUniv Sao Paulo, Ribeirao Preto Med Sch, Dept Cell & Mol Biol, Ribeirao Preto, BrazilUniv Estadual Montes Claros, Dept Biol Sci, Montes Claros, MG, BrazilUniv Fed Minas Gerais, Inst Biol Sci, Dept Parasitol, Belo Horizonte, MG, BrazilNatl Inst Math & Biol Synth, Dept Microbiol, Knoxville, TN USAKansas State Univ, Dept Geog, Manhattan, KS 66506 USATexas Tech Univ, Dept Biol Sci, Lubbock, TX 79409 USASao Paulo State Univ, Dept Ecol, Rio Claro, BrazilFAPESP: 11/06810-9FAPESP: 16/02568-2FAPESP: 11/22663-6FAPESP: 13/06380-0FAPESP: 12/03700-0FAPESP: 12/24150-9FAPESP: 15/06142-7FAPESP: 12/04096-0FAPESP: 15/05354-0FAPESP: 11/19897-5FAPESP: 14/02438-6FAPEMIG: APQ-00606-14Nature Publishing GroupUniversidade de São Paulo (USP)Universidade Estadual Paulista (Unesp)Univ Estadual Montes ClarosUniversidade Federal de Minas Gerais (UFMG)Natl Inst Math & Biol SynthKansas State UnivTexas Tech UnivSabino-Santos, GilbertoMotta Maia, Felipe GoncalvesMartins, Ronaldo BragancaGagliardi, Talita BiancaSouza, William Marciel deMuylaert, Renata Lara [UNESP]Souza Luna, Luciano Kleber deMelo, Danilo MachadoCardoso, Ricardo de SouzaBarbosa, Natalia da SilvaPontelli, Marjorie CornejoMamani-Zapana, Priscila RosseVieira, Thallyta MariaMelo, Norma MariaJonsson, Colleen B.Goodin, DouglasSalazar-Bravo, JorgePinto dasilva, Luis LambertiArruda, EuricoMoraes Figueiredo, Luiz Tadeu2018-11-26T17:52:05Z2018-11-26T17:52:05Z2018-06-13info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article8application/pdfhttp://dx.doi.org/10.1038/s41598-018-27442-wScientific Reports. London: Nature Publishing Group, v. 8, 8 p., 2018.2045-2322http://hdl.handle.net/11449/16431010.1038/s41598-018-27442-wWOS:000435076900021WOS000435076900021.pdfWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengScientific Reports1,533info:eu-repo/semantics/openAccess2024-01-04T06:28:31Zoai:repositorio.unesp.br:11449/164310Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T22:08:06.030184Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Natural infection of Neotropical bats with hantavirus in Brazil |
title |
Natural infection of Neotropical bats with hantavirus in Brazil |
spellingShingle |
Natural infection of Neotropical bats with hantavirus in Brazil Sabino-Santos, Gilberto |
title_short |
Natural infection of Neotropical bats with hantavirus in Brazil |
title_full |
Natural infection of Neotropical bats with hantavirus in Brazil |
title_fullStr |
Natural infection of Neotropical bats with hantavirus in Brazil |
title_full_unstemmed |
Natural infection of Neotropical bats with hantavirus in Brazil |
title_sort |
Natural infection of Neotropical bats with hantavirus in Brazil |
author |
Sabino-Santos, Gilberto |
author_facet |
Sabino-Santos, Gilberto Motta Maia, Felipe Goncalves Martins, Ronaldo Braganca Gagliardi, Talita Bianca Souza, William Marciel de Muylaert, Renata Lara [UNESP] Souza Luna, Luciano Kleber de Melo, Danilo Machado Cardoso, Ricardo de Souza Barbosa, Natalia da Silva Pontelli, Marjorie Cornejo Mamani-Zapana, Priscila Rosse Vieira, Thallyta Maria Melo, Norma Maria Jonsson, Colleen B. Goodin, Douglas Salazar-Bravo, Jorge Pinto dasilva, Luis Lamberti Arruda, Eurico Moraes Figueiredo, Luiz Tadeu |
author_role |
author |
author2 |
Motta Maia, Felipe Goncalves Martins, Ronaldo Braganca Gagliardi, Talita Bianca Souza, William Marciel de Muylaert, Renata Lara [UNESP] Souza Luna, Luciano Kleber de Melo, Danilo Machado Cardoso, Ricardo de Souza Barbosa, Natalia da Silva Pontelli, Marjorie Cornejo Mamani-Zapana, Priscila Rosse Vieira, Thallyta Maria Melo, Norma Maria Jonsson, Colleen B. Goodin, Douglas Salazar-Bravo, Jorge Pinto dasilva, Luis Lamberti Arruda, Eurico Moraes Figueiredo, Luiz Tadeu |
author2_role |
author author author author author author author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade de São Paulo (USP) Universidade Estadual Paulista (Unesp) Univ Estadual Montes Claros Universidade Federal de Minas Gerais (UFMG) Natl Inst Math & Biol Synth Kansas State Univ Texas Tech Univ |
dc.contributor.author.fl_str_mv |
Sabino-Santos, Gilberto Motta Maia, Felipe Goncalves Martins, Ronaldo Braganca Gagliardi, Talita Bianca Souza, William Marciel de Muylaert, Renata Lara [UNESP] Souza Luna, Luciano Kleber de Melo, Danilo Machado Cardoso, Ricardo de Souza Barbosa, Natalia da Silva Pontelli, Marjorie Cornejo Mamani-Zapana, Priscila Rosse Vieira, Thallyta Maria Melo, Norma Maria Jonsson, Colleen B. Goodin, Douglas Salazar-Bravo, Jorge Pinto dasilva, Luis Lamberti Arruda, Eurico Moraes Figueiredo, Luiz Tadeu |
description |
Bats (Order: Chiroptera) harbor a high diversity of emerging pathogens presumably because their ability to fly and social behavior favor the maintenance, evolution, and dissemination of these pathogens. Until 2012, there was only one report of the presence of Hantavirus in bats. Historically, it was thought that these viruses were harbored primarily by rodent and insectivore small mammals. Recently, new species of hantaviruses have been identified in bats from Africa and Asia continents expanding the potential reservoirs and range of these viruses. To assess the potential of Neotropical bats as hosts for hantaviruses and its transmission dynamics in nature, we tested 53 bats for active hantaviral infection from specimens collected in Southeastern Brazil. Part of the hantaviral S segment was amplified from the frugivorous Carollia perspicillata and the common vampire bat Desmodus rotundus. DNA sequencing showed high similarity with the genome of Araraquara orthohantavirus (ARQV), which belongs to one of the more lethal hantavirus clades (Andes orthohantavirus). ARQV-like infection was detected in the blood, urine, and organs of D. rotundus. Therefore, we describe a systemic infection in Neotropical bats by a human pathogenic Hantavirus. We also propose here a schematic transmission dynamics of hantavirus in the study region. Our results give insights to new, under-appreciated questions that need to be addressed in future studies to clarify hantavirus transmission in nature and avoid hantavirus outbreaks. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-11-26T17:52:05Z 2018-11-26T17:52:05Z 2018-06-13 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1038/s41598-018-27442-w Scientific Reports. London: Nature Publishing Group, v. 8, 8 p., 2018. 2045-2322 http://hdl.handle.net/11449/164310 10.1038/s41598-018-27442-w WOS:000435076900021 WOS000435076900021.pdf |
url |
http://dx.doi.org/10.1038/s41598-018-27442-w http://hdl.handle.net/11449/164310 |
identifier_str_mv |
Scientific Reports. London: Nature Publishing Group, v. 8, 8 p., 2018. 2045-2322 10.1038/s41598-018-27442-w WOS:000435076900021 WOS000435076900021.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Scientific Reports 1,533 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
8 application/pdf |
dc.publisher.none.fl_str_mv |
Nature Publishing Group |
publisher.none.fl_str_mv |
Nature Publishing Group |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129395937771520 |