Ultrastructural study of the ventral lobe of the prostate of mice with streptozotocin induced diabetes (C57BL/6J)

Detalhes bibliográficos
Autor(a) principal: Cagnon, V. H.A.
Data de Publicação: 2000
Outros Autores: Camargo, A. M., Rosa, R. M., Fabiani, R., Padovani, C. R. [UNESP], Martinez, F. E. [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1054/tice.2000.0123
http://hdl.handle.net/11449/230903
Resumo: Morphological and functional changes caused by diabetes in the accessory sex organs andespecially the prostate have been reported by several investigators. The aim of the present study was to examine the possible deleterious effects of experimentally induced diabetes on the secretory epithelium of the ventral prostate of mice. Sixteen adult male C57BL/6J mice were divided into two groups. The diabetic group received streptozotocin injection of 75 mg/kg while the control group received only 0.1 ml citrate buffer i.p. After 30 days the diabetic state was ascertained the animals were sacrificed and the ventral lobe of the prostate was collected for histological and ultrastructural examination. The results showed reduction in glandular epithelium cell height increased numbers of cytoplasmic vacuoles and thickening of the extracellular matrix.In conclusion experimental diabetes has harmfuleffects on the secretory epithelial cells of theventral lobe of the prostate of mice. (C) 2000 Harcourt Publishers Ltd.
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spelling Ultrastructural study of the ventral lobe of the prostate of mice with streptozotocin induced diabetes (C57BL/6J)DiabetesProstateUltrastructuralMorphological and functional changes caused by diabetes in the accessory sex organs andespecially the prostate have been reported by several investigators. The aim of the present study was to examine the possible deleterious effects of experimentally induced diabetes on the secretory epithelium of the ventral prostate of mice. Sixteen adult male C57BL/6J mice were divided into two groups. The diabetic group received streptozotocin injection of 75 mg/kg while the control group received only 0.1 ml citrate buffer i.p. After 30 days the diabetic state was ascertained the animals were sacrificed and the ventral lobe of the prostate was collected for histological and ultrastructural examination. The results showed reduction in glandular epithelium cell height increased numbers of cytoplasmic vacuoles and thickening of the extracellular matrix.In conclusion experimental diabetes has harmfuleffects on the secretory epithelial cells of theventral lobe of the prostate of mice. (C) 2000 Harcourt Publishers Ltd.Department of Anatomy Institute of Biology State University of Campinas, Campinas-SPDepartment of Anatomy Institute of Bioscience So Paulo State University, Botucatu-SPUniversidade Estadual de Campinas (UNICAMP)Universidade Estadual Paulista (UNESP)Cagnon, V. H.A.Camargo, A. M.Rosa, R. M.Fabiani, R.Padovani, C. R. [UNESP]Martinez, F. E. [UNESP]2022-04-29T08:42:42Z2022-04-29T08:42:42Z2000-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article275-283http://dx.doi.org/10.1054/tice.2000.0123Tissue and Cell, v. 32, n. 4, p. 275-283, 2000.0040-8166http://hdl.handle.net/11449/23090310.1054/tice.2000.01232-s2.0-0033696437Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengTissue and Cellinfo:eu-repo/semantics/openAccess2022-04-29T08:42:42Zoai:repositorio.unesp.br:11449/230903Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T14:20:02.885215Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Ultrastructural study of the ventral lobe of the prostate of mice with streptozotocin induced diabetes (C57BL/6J)
title Ultrastructural study of the ventral lobe of the prostate of mice with streptozotocin induced diabetes (C57BL/6J)
spellingShingle Ultrastructural study of the ventral lobe of the prostate of mice with streptozotocin induced diabetes (C57BL/6J)
Cagnon, V. H.A.
Diabetes
Prostate
Ultrastructural
title_short Ultrastructural study of the ventral lobe of the prostate of mice with streptozotocin induced diabetes (C57BL/6J)
title_full Ultrastructural study of the ventral lobe of the prostate of mice with streptozotocin induced diabetes (C57BL/6J)
title_fullStr Ultrastructural study of the ventral lobe of the prostate of mice with streptozotocin induced diabetes (C57BL/6J)
title_full_unstemmed Ultrastructural study of the ventral lobe of the prostate of mice with streptozotocin induced diabetes (C57BL/6J)
title_sort Ultrastructural study of the ventral lobe of the prostate of mice with streptozotocin induced diabetes (C57BL/6J)
author Cagnon, V. H.A.
author_facet Cagnon, V. H.A.
Camargo, A. M.
Rosa, R. M.
Fabiani, R.
Padovani, C. R. [UNESP]
Martinez, F. E. [UNESP]
author_role author
author2 Camargo, A. M.
Rosa, R. M.
Fabiani, R.
Padovani, C. R. [UNESP]
Martinez, F. E. [UNESP]
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual de Campinas (UNICAMP)
Universidade Estadual Paulista (UNESP)
dc.contributor.author.fl_str_mv Cagnon, V. H.A.
Camargo, A. M.
Rosa, R. M.
Fabiani, R.
Padovani, C. R. [UNESP]
Martinez, F. E. [UNESP]
dc.subject.por.fl_str_mv Diabetes
Prostate
Ultrastructural
topic Diabetes
Prostate
Ultrastructural
description Morphological and functional changes caused by diabetes in the accessory sex organs andespecially the prostate have been reported by several investigators. The aim of the present study was to examine the possible deleterious effects of experimentally induced diabetes on the secretory epithelium of the ventral prostate of mice. Sixteen adult male C57BL/6J mice were divided into two groups. The diabetic group received streptozotocin injection of 75 mg/kg while the control group received only 0.1 ml citrate buffer i.p. After 30 days the diabetic state was ascertained the animals were sacrificed and the ventral lobe of the prostate was collected for histological and ultrastructural examination. The results showed reduction in glandular epithelium cell height increased numbers of cytoplasmic vacuoles and thickening of the extracellular matrix.In conclusion experimental diabetes has harmfuleffects on the secretory epithelial cells of theventral lobe of the prostate of mice. (C) 2000 Harcourt Publishers Ltd.
publishDate 2000
dc.date.none.fl_str_mv 2000-01-01
2022-04-29T08:42:42Z
2022-04-29T08:42:42Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1054/tice.2000.0123
Tissue and Cell, v. 32, n. 4, p. 275-283, 2000.
0040-8166
http://hdl.handle.net/11449/230903
10.1054/tice.2000.0123
2-s2.0-0033696437
url http://dx.doi.org/10.1054/tice.2000.0123
http://hdl.handle.net/11449/230903
identifier_str_mv Tissue and Cell, v. 32, n. 4, p. 275-283, 2000.
0040-8166
10.1054/tice.2000.0123
2-s2.0-0033696437
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Tissue and Cell
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 275-283
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1808128348795174912

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