Epithelium Lining Rat Renal Papilla: Nomenclature and Association with Chronic Progressive Nephropathy (CPN)
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1177/0192623318762694 http://hdl.handle.net/11449/176293 |
Resumo: | Chronic progressive nephropathy (CPN) occurs commonly in rats, more frequently and severely in males than females. High-grade CPN is characterized by increased layers of the renal papilla lining, designated as urothelial hyperplasia in the International Harmonization of Nomenclature and Diagnostic Criteria classification. However, urothelium lining the pelvis is not equivalent to the epithelium lining the papilla. To evaluate whether the epithelium lining the renal papilla is actually urothelial in nature and whether CPN-associated multicellularity represents proliferation, kidney tissues from aged rats with CPN, from rats with multicellularity of the renal papilla epithelium of either low-grade or marked severity, and from young rats with normal kidneys were analyzed and compared. Immunohistochemical staining for uroplakins (urothelial specific proteins) was negative in the papilla epithelium in all rats with multicellularity or not, indicating these cells are not urothelial. Mitotic figures were rarely observed in this epithelium, even with multicellularity. Immunohistochemical staining for Ki-67 was negative. Papilla lining cells and true urothelium differed by scanning electron microscopy. Based on these findings, we recommend that the epithelium lining the papilla not be classified as urothelial, and the CPN-associated lesion be designated as vesicular alteration of renal papilla instead of hyperplasia and distinguished in diagnostic systems from kidney pelvis urothelial hyperplasia. |
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Epithelium Lining Rat Renal Papilla: Nomenclature and Association with Chronic Progressive Nephropathy (CPN)chronic progressive nephropathyhyperplasiaproliferationrenal papilla epitheliumurotheliumChronic progressive nephropathy (CPN) occurs commonly in rats, more frequently and severely in males than females. High-grade CPN is characterized by increased layers of the renal papilla lining, designated as urothelial hyperplasia in the International Harmonization of Nomenclature and Diagnostic Criteria classification. However, urothelium lining the pelvis is not equivalent to the epithelium lining the papilla. To evaluate whether the epithelium lining the renal papilla is actually urothelial in nature and whether CPN-associated multicellularity represents proliferation, kidney tissues from aged rats with CPN, from rats with multicellularity of the renal papilla epithelium of either low-grade or marked severity, and from young rats with normal kidneys were analyzed and compared. Immunohistochemical staining for uroplakins (urothelial specific proteins) was negative in the papilla epithelium in all rats with multicellularity or not, indicating these cells are not urothelial. Mitotic figures were rarely observed in this epithelium, even with multicellularity. Immunohistochemical staining for Ki-67 was negative. Papilla lining cells and true urothelium differed by scanning electron microscopy. Based on these findings, we recommend that the epithelium lining the papilla not be classified as urothelial, and the CPN-associated lesion be designated as vesicular alteration of renal papilla instead of hyperplasia and distinguished in diagnostic systems from kidney pelvis urothelial hyperplasia.Department of Pathology and Microbiology University of Nebraska Medical CenterSão Paulo State University (UNESP) Botucatu Medical School Department of Pathology Center for the Evaluation of the Environmental Impact on Human Health (TOXICAM)Private ConsultantHavlik-Wall Professor of OncologySão Paulo State University (UNESP) Botucatu Medical School Department of Pathology Center for the Evaluation of the Environmental Impact on Human Health (TOXICAM)University of Nebraska Medical CenterUniversidade Estadual Paulista (Unesp)Private ConsultantHavlik-Wall Professor of OncologySouza, Nathália P. [UNESP]Hard, Gordon C.Arnold, Lora L.Foster, Kirk W.Pennington, Karen L.Cohen, Samuel M.2018-12-11T17:19:58Z2018-12-11T17:19:58Z2018-04-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article266-272application/pdfhttp://dx.doi.org/10.1177/0192623318762694Toxicologic Pathology, v. 46, n. 3, p. 266-272, 2018.1533-16010192-6233http://hdl.handle.net/11449/17629310.1177/01926233187626942-s2.0-850467179712-s2.0-85046717971.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengToxicologic Pathology0,8070,807info:eu-repo/semantics/openAccess2024-09-03T13:14:11Zoai:repositorio.unesp.br:11449/176293Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-03T13:14:11Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Epithelium Lining Rat Renal Papilla: Nomenclature and Association with Chronic Progressive Nephropathy (CPN) |
title |
Epithelium Lining Rat Renal Papilla: Nomenclature and Association with Chronic Progressive Nephropathy (CPN) |
spellingShingle |
Epithelium Lining Rat Renal Papilla: Nomenclature and Association with Chronic Progressive Nephropathy (CPN) Souza, Nathália P. [UNESP] chronic progressive nephropathy hyperplasia proliferation renal papilla epithelium urothelium |
title_short |
Epithelium Lining Rat Renal Papilla: Nomenclature and Association with Chronic Progressive Nephropathy (CPN) |
title_full |
Epithelium Lining Rat Renal Papilla: Nomenclature and Association with Chronic Progressive Nephropathy (CPN) |
title_fullStr |
Epithelium Lining Rat Renal Papilla: Nomenclature and Association with Chronic Progressive Nephropathy (CPN) |
title_full_unstemmed |
Epithelium Lining Rat Renal Papilla: Nomenclature and Association with Chronic Progressive Nephropathy (CPN) |
title_sort |
Epithelium Lining Rat Renal Papilla: Nomenclature and Association with Chronic Progressive Nephropathy (CPN) |
author |
Souza, Nathália P. [UNESP] |
author_facet |
Souza, Nathália P. [UNESP] Hard, Gordon C. Arnold, Lora L. Foster, Kirk W. Pennington, Karen L. Cohen, Samuel M. |
author_role |
author |
author2 |
Hard, Gordon C. Arnold, Lora L. Foster, Kirk W. Pennington, Karen L. Cohen, Samuel M. |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
University of Nebraska Medical Center Universidade Estadual Paulista (Unesp) Private Consultant Havlik-Wall Professor of Oncology |
dc.contributor.author.fl_str_mv |
Souza, Nathália P. [UNESP] Hard, Gordon C. Arnold, Lora L. Foster, Kirk W. Pennington, Karen L. Cohen, Samuel M. |
dc.subject.por.fl_str_mv |
chronic progressive nephropathy hyperplasia proliferation renal papilla epithelium urothelium |
topic |
chronic progressive nephropathy hyperplasia proliferation renal papilla epithelium urothelium |
description |
Chronic progressive nephropathy (CPN) occurs commonly in rats, more frequently and severely in males than females. High-grade CPN is characterized by increased layers of the renal papilla lining, designated as urothelial hyperplasia in the International Harmonization of Nomenclature and Diagnostic Criteria classification. However, urothelium lining the pelvis is not equivalent to the epithelium lining the papilla. To evaluate whether the epithelium lining the renal papilla is actually urothelial in nature and whether CPN-associated multicellularity represents proliferation, kidney tissues from aged rats with CPN, from rats with multicellularity of the renal papilla epithelium of either low-grade or marked severity, and from young rats with normal kidneys were analyzed and compared. Immunohistochemical staining for uroplakins (urothelial specific proteins) was negative in the papilla epithelium in all rats with multicellularity or not, indicating these cells are not urothelial. Mitotic figures were rarely observed in this epithelium, even with multicellularity. Immunohistochemical staining for Ki-67 was negative. Papilla lining cells and true urothelium differed by scanning electron microscopy. Based on these findings, we recommend that the epithelium lining the papilla not be classified as urothelial, and the CPN-associated lesion be designated as vesicular alteration of renal papilla instead of hyperplasia and distinguished in diagnostic systems from kidney pelvis urothelial hyperplasia. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-12-11T17:19:58Z 2018-12-11T17:19:58Z 2018-04-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1177/0192623318762694 Toxicologic Pathology, v. 46, n. 3, p. 266-272, 2018. 1533-1601 0192-6233 http://hdl.handle.net/11449/176293 10.1177/0192623318762694 2-s2.0-85046717971 2-s2.0-85046717971.pdf |
url |
http://dx.doi.org/10.1177/0192623318762694 http://hdl.handle.net/11449/176293 |
identifier_str_mv |
Toxicologic Pathology, v. 46, n. 3, p. 266-272, 2018. 1533-1601 0192-6233 10.1177/0192623318762694 2-s2.0-85046717971 2-s2.0-85046717971.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Toxicologic Pathology 0,807 0,807 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
266-272 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
repositoriounesp@unesp.br |
_version_ |
1810021356554682368 |