Primary squamous cell carcinoma of the thyroid diagnosed as anaplastic carcinoma: failure in fine-needle aspiration cytology?

Detalhes bibliográficos
Autor(a) principal: Bolfi, Fernanda [UNESP]
Data de Publicação: 2014
Outros Autores: Domingues, Maria A. C. [UNESP], Sobrinho-Simões, Manuel, Soares, Paula, Celestino, Ricardo, Castilho, Emanuel C. [UNESP], Carelli, Guareide [UNESP], Paes, Norberto S. [UNESP], Mazeto, Glaucia M. F. S. [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1155/2014/301780
http://hdl.handle.net/11449/130971
Resumo: A case of primary squamous-cell carcinoma (SCC) of the thyroid which had been initially diagnosed as an anaplastic carcinoma (ATC) is described: female, 73 years old, with a fast-growing cervical nodule on the left side and hoarseness for 3 months. Ultrasonography showed a 4.5 cm solid nodule. FNA was compatible with poorly differentiated carcinoma with immunoreactivity for AE1/AE3, EMA. Thyroidectomy was performed. Histopathological examination showed a nonencapsulated tumor. Immunohistochemistry disclosed positivity for AE1/AE3, p53,p63, and Ki67. The diagnosis was ATC. A second opinion reported tumor consisting of squamous cells, with intense inflammatory infiltrate both in tumor and in the adjacent thyroid, with final diagnosis of SCC, associated with Hashimoto thyroiditis. No other primary focus of SCC was found. Patient has shown a 48-month survival period. Clinically, primary SCCs of the thyroid and ATCs are similar. The distinction is often difficult particularly when based on the cytological analysis of FNA material.
id UNSP_aae648a77a5ffec2fce62cf7e8932b97
oai_identifier_str oai:repositorio.unesp.br:11449/130971
network_acronym_str UNSP
network_name_str Repositório Institucional da UNESP
repository_id_str 2946
spelling Primary squamous cell carcinoma of the thyroid diagnosed as anaplastic carcinoma: failure in fine-needle aspiration cytology?A case of primary squamous-cell carcinoma (SCC) of the thyroid which had been initially diagnosed as an anaplastic carcinoma (ATC) is described: female, 73 years old, with a fast-growing cervical nodule on the left side and hoarseness for 3 months. Ultrasonography showed a 4.5 cm solid nodule. FNA was compatible with poorly differentiated carcinoma with immunoreactivity for AE1/AE3, EMA. Thyroidectomy was performed. Histopathological examination showed a nonencapsulated tumor. Immunohistochemistry disclosed positivity for AE1/AE3, p53,p63, and Ki67. The diagnosis was ATC. A second opinion reported tumor consisting of squamous cells, with intense inflammatory infiltrate both in tumor and in the adjacent thyroid, with final diagnosis of SCC, associated with Hashimoto thyroiditis. No other primary focus of SCC was found. Patient has shown a 48-month survival period. Clinically, primary SCCs of the thyroid and ATCs are similar. The distinction is often difficult particularly when based on the cytological analysis of FNA material.Disciplina de Endocrinologia e Metabolismo, Departamento de Medicina Interna, Faculdade de Medicina de Botucatu (FMB), Universidade Estadual Paulista (UNESP), Botucatu, SP, BrasilDepartamento de Patologia, Faculdade de Medicina de Botucatu (FMB), Universidade Estadual Paulista (UNESP), Botucatu, SP, BrasilInstituto de Patologia e Imunologia Molecular da Universidade do Porto (IPATIMUP), Porto, PortugalDepartamento de Oftalmologia, Otorrinolaringologia e Cirurgia de Cabeça e Pescoço, Faculdade de Medicina de Botucatu (FMB), Universidade Estadual Paulista (UNESP), Botucatu, SP, BrasilDisciplina de Oncologia Clínica, Departamento de Medicina Interna, Faculdade de Medicina de Botucatu (FMB), Universidade Estadual Paulista (UNESP), Botucatu, SP, BrasilDisciplina de Radioterapia, Departamento de Dermatologia e Radioterapia, Faculdade de Medicina de Botucatu (FMB), Universidade Estadual Paulista (UNESP), Botucatu, SP, BrasilUniversidade Estadual Paulista, Departamento de Clínica Médica, Faculdade de Medicina de BotucatuUniversidade Estadual Paulista, Departamento de Patologia, Faculdade de Medicina de BotucatuUniversidade Estadual Paulista, Departamento de Oftalmologia, Otorrinolaringologia e Cirurgia de Cabeça e Pescoço, Faculdade de Medicina de BotucatuUniversidade Estadual Paulista, Departamento de Dermatologia e Radioterapia, Faculdade de Medicina de BotucatuHindawi Publishing CorporationUniversidade Estadual Paulista (Unesp)University of PortoBolfi, Fernanda [UNESP]Domingues, Maria A. C. [UNESP]Sobrinho-Simões, ManuelSoares, PaulaCelestino, RicardoCastilho, Emanuel C. [UNESP]Carelli, Guareide [UNESP]Paes, Norberto S. [UNESP]Mazeto, Glaucia M. F. S. [UNESP]2015-12-07T15:30:31Z2015-12-07T15:30:31Z2014info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1-4application/pdfhttp://dx.doi.org/10.1155/2014/301780Case Reports in Pathology, v. 2014, p. 1-4, 2014.2090-6781http://hdl.handle.net/11449/13097110.1155/2014/301780PMC4175754.pdf25295208PMC4175754PubMedreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengCase Reports in Pathologyinfo:eu-repo/semantics/openAccess2024-09-03T13:18:34Zoai:repositorio.unesp.br:11449/130971Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-03T13:18:34Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Primary squamous cell carcinoma of the thyroid diagnosed as anaplastic carcinoma: failure in fine-needle aspiration cytology?
title Primary squamous cell carcinoma of the thyroid diagnosed as anaplastic carcinoma: failure in fine-needle aspiration cytology?
spellingShingle Primary squamous cell carcinoma of the thyroid diagnosed as anaplastic carcinoma: failure in fine-needle aspiration cytology?
Bolfi, Fernanda [UNESP]
title_short Primary squamous cell carcinoma of the thyroid diagnosed as anaplastic carcinoma: failure in fine-needle aspiration cytology?
title_full Primary squamous cell carcinoma of the thyroid diagnosed as anaplastic carcinoma: failure in fine-needle aspiration cytology?
title_fullStr Primary squamous cell carcinoma of the thyroid diagnosed as anaplastic carcinoma: failure in fine-needle aspiration cytology?
title_full_unstemmed Primary squamous cell carcinoma of the thyroid diagnosed as anaplastic carcinoma: failure in fine-needle aspiration cytology?
title_sort Primary squamous cell carcinoma of the thyroid diagnosed as anaplastic carcinoma: failure in fine-needle aspiration cytology?
author Bolfi, Fernanda [UNESP]
author_facet Bolfi, Fernanda [UNESP]
Domingues, Maria A. C. [UNESP]
Sobrinho-Simões, Manuel
Soares, Paula
Celestino, Ricardo
Castilho, Emanuel C. [UNESP]
Carelli, Guareide [UNESP]
Paes, Norberto S. [UNESP]
Mazeto, Glaucia M. F. S. [UNESP]
author_role author
author2 Domingues, Maria A. C. [UNESP]
Sobrinho-Simões, Manuel
Soares, Paula
Celestino, Ricardo
Castilho, Emanuel C. [UNESP]
Carelli, Guareide [UNESP]
Paes, Norberto S. [UNESP]
Mazeto, Glaucia M. F. S. [UNESP]
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
University of Porto
dc.contributor.author.fl_str_mv Bolfi, Fernanda [UNESP]
Domingues, Maria A. C. [UNESP]
Sobrinho-Simões, Manuel
Soares, Paula
Celestino, Ricardo
Castilho, Emanuel C. [UNESP]
Carelli, Guareide [UNESP]
Paes, Norberto S. [UNESP]
Mazeto, Glaucia M. F. S. [UNESP]
description A case of primary squamous-cell carcinoma (SCC) of the thyroid which had been initially diagnosed as an anaplastic carcinoma (ATC) is described: female, 73 years old, with a fast-growing cervical nodule on the left side and hoarseness for 3 months. Ultrasonography showed a 4.5 cm solid nodule. FNA was compatible with poorly differentiated carcinoma with immunoreactivity for AE1/AE3, EMA. Thyroidectomy was performed. Histopathological examination showed a nonencapsulated tumor. Immunohistochemistry disclosed positivity for AE1/AE3, p53,p63, and Ki67. The diagnosis was ATC. A second opinion reported tumor consisting of squamous cells, with intense inflammatory infiltrate both in tumor and in the adjacent thyroid, with final diagnosis of SCC, associated with Hashimoto thyroiditis. No other primary focus of SCC was found. Patient has shown a 48-month survival period. Clinically, primary SCCs of the thyroid and ATCs are similar. The distinction is often difficult particularly when based on the cytological analysis of FNA material.
publishDate 2014
dc.date.none.fl_str_mv 2014
2015-12-07T15:30:31Z
2015-12-07T15:30:31Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1155/2014/301780
Case Reports in Pathology, v. 2014, p. 1-4, 2014.
2090-6781
http://hdl.handle.net/11449/130971
10.1155/2014/301780
PMC4175754.pdf
25295208
PMC4175754
url http://dx.doi.org/10.1155/2014/301780
http://hdl.handle.net/11449/130971
identifier_str_mv Case Reports in Pathology, v. 2014, p. 1-4, 2014.
2090-6781
10.1155/2014/301780
PMC4175754.pdf
25295208
PMC4175754
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Case Reports in Pathology
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 1-4
application/pdf
dc.publisher.none.fl_str_mv Hindawi Publishing Corporation
publisher.none.fl_str_mv Hindawi Publishing Corporation
dc.source.none.fl_str_mv PubMed
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv repositoriounesp@unesp.br
_version_ 1810021421058883584