Primary squamous cell carcinoma of the thyroid diagnosed as anaplastic carcinoma: failure in fine-needle aspiration cytology?
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1155/2014/301780 http://hdl.handle.net/11449/130971 |
Resumo: | A case of primary squamous-cell carcinoma (SCC) of the thyroid which had been initially diagnosed as an anaplastic carcinoma (ATC) is described: female, 73 years old, with a fast-growing cervical nodule on the left side and hoarseness for 3 months. Ultrasonography showed a 4.5 cm solid nodule. FNA was compatible with poorly differentiated carcinoma with immunoreactivity for AE1/AE3, EMA. Thyroidectomy was performed. Histopathological examination showed a nonencapsulated tumor. Immunohistochemistry disclosed positivity for AE1/AE3, p53,p63, and Ki67. The diagnosis was ATC. A second opinion reported tumor consisting of squamous cells, with intense inflammatory infiltrate both in tumor and in the adjacent thyroid, with final diagnosis of SCC, associated with Hashimoto thyroiditis. No other primary focus of SCC was found. Patient has shown a 48-month survival period. Clinically, primary SCCs of the thyroid and ATCs are similar. The distinction is often difficult particularly when based on the cytological analysis of FNA material. |
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spelling |
Primary squamous cell carcinoma of the thyroid diagnosed as anaplastic carcinoma: failure in fine-needle aspiration cytology?A case of primary squamous-cell carcinoma (SCC) of the thyroid which had been initially diagnosed as an anaplastic carcinoma (ATC) is described: female, 73 years old, with a fast-growing cervical nodule on the left side and hoarseness for 3 months. Ultrasonography showed a 4.5 cm solid nodule. FNA was compatible with poorly differentiated carcinoma with immunoreactivity for AE1/AE3, EMA. Thyroidectomy was performed. Histopathological examination showed a nonencapsulated tumor. Immunohistochemistry disclosed positivity for AE1/AE3, p53,p63, and Ki67. The diagnosis was ATC. A second opinion reported tumor consisting of squamous cells, with intense inflammatory infiltrate both in tumor and in the adjacent thyroid, with final diagnosis of SCC, associated with Hashimoto thyroiditis. No other primary focus of SCC was found. Patient has shown a 48-month survival period. Clinically, primary SCCs of the thyroid and ATCs are similar. The distinction is often difficult particularly when based on the cytological analysis of FNA material.Disciplina de Endocrinologia e Metabolismo, Departamento de Medicina Interna, Faculdade de Medicina de Botucatu (FMB), Universidade Estadual Paulista (UNESP), Botucatu, SP, BrasilDepartamento de Patologia, Faculdade de Medicina de Botucatu (FMB), Universidade Estadual Paulista (UNESP), Botucatu, SP, BrasilInstituto de Patologia e Imunologia Molecular da Universidade do Porto (IPATIMUP), Porto, PortugalDepartamento de Oftalmologia, Otorrinolaringologia e Cirurgia de Cabeça e Pescoço, Faculdade de Medicina de Botucatu (FMB), Universidade Estadual Paulista (UNESP), Botucatu, SP, BrasilDisciplina de Oncologia Clínica, Departamento de Medicina Interna, Faculdade de Medicina de Botucatu (FMB), Universidade Estadual Paulista (UNESP), Botucatu, SP, BrasilDisciplina de Radioterapia, Departamento de Dermatologia e Radioterapia, Faculdade de Medicina de Botucatu (FMB), Universidade Estadual Paulista (UNESP), Botucatu, SP, BrasilUniversidade Estadual Paulista, Departamento de Clínica Médica, Faculdade de Medicina de BotucatuUniversidade Estadual Paulista, Departamento de Patologia, Faculdade de Medicina de BotucatuUniversidade Estadual Paulista, Departamento de Oftalmologia, Otorrinolaringologia e Cirurgia de Cabeça e Pescoço, Faculdade de Medicina de BotucatuUniversidade Estadual Paulista, Departamento de Dermatologia e Radioterapia, Faculdade de Medicina de BotucatuHindawi Publishing CorporationUniversidade Estadual Paulista (Unesp)University of PortoBolfi, Fernanda [UNESP]Domingues, Maria A. C. [UNESP]Sobrinho-Simões, ManuelSoares, PaulaCelestino, RicardoCastilho, Emanuel C. [UNESP]Carelli, Guareide [UNESP]Paes, Norberto S. [UNESP]Mazeto, Glaucia M. F. S. [UNESP]2015-12-07T15:30:31Z2015-12-07T15:30:31Z2014info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1-4application/pdfhttp://dx.doi.org/10.1155/2014/301780Case Reports in Pathology, v. 2014, p. 1-4, 2014.2090-6781http://hdl.handle.net/11449/13097110.1155/2014/301780PMC4175754.pdf25295208PMC4175754PubMedreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengCase Reports in Pathologyinfo:eu-repo/semantics/openAccess2024-09-03T13:18:34Zoai:repositorio.unesp.br:11449/130971Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-03T13:18:34Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Primary squamous cell carcinoma of the thyroid diagnosed as anaplastic carcinoma: failure in fine-needle aspiration cytology? |
title |
Primary squamous cell carcinoma of the thyroid diagnosed as anaplastic carcinoma: failure in fine-needle aspiration cytology? |
spellingShingle |
Primary squamous cell carcinoma of the thyroid diagnosed as anaplastic carcinoma: failure in fine-needle aspiration cytology? Bolfi, Fernanda [UNESP] |
title_short |
Primary squamous cell carcinoma of the thyroid diagnosed as anaplastic carcinoma: failure in fine-needle aspiration cytology? |
title_full |
Primary squamous cell carcinoma of the thyroid diagnosed as anaplastic carcinoma: failure in fine-needle aspiration cytology? |
title_fullStr |
Primary squamous cell carcinoma of the thyroid diagnosed as anaplastic carcinoma: failure in fine-needle aspiration cytology? |
title_full_unstemmed |
Primary squamous cell carcinoma of the thyroid diagnosed as anaplastic carcinoma: failure in fine-needle aspiration cytology? |
title_sort |
Primary squamous cell carcinoma of the thyroid diagnosed as anaplastic carcinoma: failure in fine-needle aspiration cytology? |
author |
Bolfi, Fernanda [UNESP] |
author_facet |
Bolfi, Fernanda [UNESP] Domingues, Maria A. C. [UNESP] Sobrinho-Simões, Manuel Soares, Paula Celestino, Ricardo Castilho, Emanuel C. [UNESP] Carelli, Guareide [UNESP] Paes, Norberto S. [UNESP] Mazeto, Glaucia M. F. S. [UNESP] |
author_role |
author |
author2 |
Domingues, Maria A. C. [UNESP] Sobrinho-Simões, Manuel Soares, Paula Celestino, Ricardo Castilho, Emanuel C. [UNESP] Carelli, Guareide [UNESP] Paes, Norberto S. [UNESP] Mazeto, Glaucia M. F. S. [UNESP] |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) University of Porto |
dc.contributor.author.fl_str_mv |
Bolfi, Fernanda [UNESP] Domingues, Maria A. C. [UNESP] Sobrinho-Simões, Manuel Soares, Paula Celestino, Ricardo Castilho, Emanuel C. [UNESP] Carelli, Guareide [UNESP] Paes, Norberto S. [UNESP] Mazeto, Glaucia M. F. S. [UNESP] |
description |
A case of primary squamous-cell carcinoma (SCC) of the thyroid which had been initially diagnosed as an anaplastic carcinoma (ATC) is described: female, 73 years old, with a fast-growing cervical nodule on the left side and hoarseness for 3 months. Ultrasonography showed a 4.5 cm solid nodule. FNA was compatible with poorly differentiated carcinoma with immunoreactivity for AE1/AE3, EMA. Thyroidectomy was performed. Histopathological examination showed a nonencapsulated tumor. Immunohistochemistry disclosed positivity for AE1/AE3, p53,p63, and Ki67. The diagnosis was ATC. A second opinion reported tumor consisting of squamous cells, with intense inflammatory infiltrate both in tumor and in the adjacent thyroid, with final diagnosis of SCC, associated with Hashimoto thyroiditis. No other primary focus of SCC was found. Patient has shown a 48-month survival period. Clinically, primary SCCs of the thyroid and ATCs are similar. The distinction is often difficult particularly when based on the cytological analysis of FNA material. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014 2015-12-07T15:30:31Z 2015-12-07T15:30:31Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1155/2014/301780 Case Reports in Pathology, v. 2014, p. 1-4, 2014. 2090-6781 http://hdl.handle.net/11449/130971 10.1155/2014/301780 PMC4175754.pdf 25295208 PMC4175754 |
url |
http://dx.doi.org/10.1155/2014/301780 http://hdl.handle.net/11449/130971 |
identifier_str_mv |
Case Reports in Pathology, v. 2014, p. 1-4, 2014. 2090-6781 10.1155/2014/301780 PMC4175754.pdf 25295208 PMC4175754 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Case Reports in Pathology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
1-4 application/pdf |
dc.publisher.none.fl_str_mv |
Hindawi Publishing Corporation |
publisher.none.fl_str_mv |
Hindawi Publishing Corporation |
dc.source.none.fl_str_mv |
PubMed reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
repositoriounesp@unesp.br |
_version_ |
1810021421058883584 |