The role of single-nucleotide polymorphism (SNPs) in toxicity of induction chemotherapy based on cisplatin and paclitaxel in patients with advanced head and neck cancer
Autor(a) principal: | |
---|---|
Data de Publicação: | 2019 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.oraloncology.2019.09.013 http://hdl.handle.net/11449/221365 |
Resumo: | Background: Induction chemotherapy in locally-advanced head and neck squamous cell carcinoma (LAHNSCC) patients is potentially associated to serious adverse events. Biomarkers associated with toxicity could tailor its indication. This study evaluated the association between single-nucleotide polymorphisms (SNPs) in metabolic genes and toxicity to induction chemotherapy. Methods: 59 LAHNSCC phase II clinical trial patients (NCT00959387) were assessed regarding 47 metabolic genes (366 SNPs). Toxicities were graded (CTCAE 3.0) and statistical analysis was performed. Results: The SNPs rs8187710 (ABCC2) and rs1801131 (MTHFR) were associated to increased risk of gastrointestinal toxicity, whereas the SNPs rs3788007 (ABCG1) and rs4148943 (CHST3) were associated to decreased risk. Two other SNPs, rs2301159 (SLC10A2) and rs2470890 (CYP1A2), were associated with increased risk of hematological toxicity. Nevertheless, these SNPs did not remain significant after adjusting for multiple comparisons. Conclusions: This study could not demonstrate relationship between SNPs and toxicity to induction chemotherapy in LAHNSCC patients. The small number of patients may have affected the results. |
id |
UNSP_ab29e5dc510155425d5b580d3479466f |
---|---|
oai_identifier_str |
oai:repositorio.unesp.br:11449/221365 |
network_acronym_str |
UNSP |
network_name_str |
Repositório Institucional da UNESP |
repository_id_str |
2946 |
spelling |
The role of single-nucleotide polymorphism (SNPs) in toxicity of induction chemotherapy based on cisplatin and paclitaxel in patients with advanced head and neck cancerHead and neck cancerInduction chemotherapyLAHNSCCPharmacogenomicSNPToxicityBackground: Induction chemotherapy in locally-advanced head and neck squamous cell carcinoma (LAHNSCC) patients is potentially associated to serious adverse events. Biomarkers associated with toxicity could tailor its indication. This study evaluated the association between single-nucleotide polymorphisms (SNPs) in metabolic genes and toxicity to induction chemotherapy. Methods: 59 LAHNSCC phase II clinical trial patients (NCT00959387) were assessed regarding 47 metabolic genes (366 SNPs). Toxicities were graded (CTCAE 3.0) and statistical analysis was performed. Results: The SNPs rs8187710 (ABCC2) and rs1801131 (MTHFR) were associated to increased risk of gastrointestinal toxicity, whereas the SNPs rs3788007 (ABCG1) and rs4148943 (CHST3) were associated to decreased risk. Two other SNPs, rs2301159 (SLC10A2) and rs2470890 (CYP1A2), were associated with increased risk of hematological toxicity. Nevertheless, these SNPs did not remain significant after adjusting for multiple comparisons. Conclusions: This study could not demonstrate relationship between SNPs and toxicity to induction chemotherapy in LAHNSCC patients. The small number of patients may have affected the results.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Department of Medical Oncology Barretos Cancer HospitalMolecular Oncology Research Center Barretos Cancer HospitalDepartment of Head and Neck Surgery Barretos Cancer HospitalUniversidade do Estado de São PauloCNPq: 473210/2012-6Barretos Cancer HospitalUniversidade do Estado de São PauloDe Marchi, PedroMelendez, Matias E.Laus, Ana C.Kuhlmann, Pamela A.de Carvalho, Ana CarolinaArantes, Lidia Maria R.B.Evangelista, Adriane F.Andrade, Edilene S.de Castro, GilbertoReis, Rui M.Carvalho, André Lopesde Souza Viana, Luciano2022-04-28T19:27:47Z2022-04-28T19:27:47Z2019-11-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article48-52http://dx.doi.org/10.1016/j.oraloncology.2019.09.013Oral Oncology, v. 98, p. 48-52.1879-05931368-8375http://hdl.handle.net/11449/22136510.1016/j.oraloncology.2019.09.0132-s2.0-85072246763Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengOral Oncologyinfo:eu-repo/semantics/openAccess2022-04-28T19:27:47Zoai:repositorio.unesp.br:11449/221365Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T14:48:06.453259Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
The role of single-nucleotide polymorphism (SNPs) in toxicity of induction chemotherapy based on cisplatin and paclitaxel in patients with advanced head and neck cancer |
title |
The role of single-nucleotide polymorphism (SNPs) in toxicity of induction chemotherapy based on cisplatin and paclitaxel in patients with advanced head and neck cancer |
spellingShingle |
The role of single-nucleotide polymorphism (SNPs) in toxicity of induction chemotherapy based on cisplatin and paclitaxel in patients with advanced head and neck cancer De Marchi, Pedro Head and neck cancer Induction chemotherapy LAHNSCC Pharmacogenomic SNP Toxicity |
title_short |
The role of single-nucleotide polymorphism (SNPs) in toxicity of induction chemotherapy based on cisplatin and paclitaxel in patients with advanced head and neck cancer |
title_full |
The role of single-nucleotide polymorphism (SNPs) in toxicity of induction chemotherapy based on cisplatin and paclitaxel in patients with advanced head and neck cancer |
title_fullStr |
The role of single-nucleotide polymorphism (SNPs) in toxicity of induction chemotherapy based on cisplatin and paclitaxel in patients with advanced head and neck cancer |
title_full_unstemmed |
The role of single-nucleotide polymorphism (SNPs) in toxicity of induction chemotherapy based on cisplatin and paclitaxel in patients with advanced head and neck cancer |
title_sort |
The role of single-nucleotide polymorphism (SNPs) in toxicity of induction chemotherapy based on cisplatin and paclitaxel in patients with advanced head and neck cancer |
author |
De Marchi, Pedro |
author_facet |
De Marchi, Pedro Melendez, Matias E. Laus, Ana C. Kuhlmann, Pamela A. de Carvalho, Ana Carolina Arantes, Lidia Maria R.B. Evangelista, Adriane F. Andrade, Edilene S. de Castro, Gilberto Reis, Rui M. Carvalho, André Lopes de Souza Viana, Luciano |
author_role |
author |
author2 |
Melendez, Matias E. Laus, Ana C. Kuhlmann, Pamela A. de Carvalho, Ana Carolina Arantes, Lidia Maria R.B. Evangelista, Adriane F. Andrade, Edilene S. de Castro, Gilberto Reis, Rui M. Carvalho, André Lopes de Souza Viana, Luciano |
author2_role |
author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Barretos Cancer Hospital Universidade do Estado de São Paulo |
dc.contributor.author.fl_str_mv |
De Marchi, Pedro Melendez, Matias E. Laus, Ana C. Kuhlmann, Pamela A. de Carvalho, Ana Carolina Arantes, Lidia Maria R.B. Evangelista, Adriane F. Andrade, Edilene S. de Castro, Gilberto Reis, Rui M. Carvalho, André Lopes de Souza Viana, Luciano |
dc.subject.por.fl_str_mv |
Head and neck cancer Induction chemotherapy LAHNSCC Pharmacogenomic SNP Toxicity |
topic |
Head and neck cancer Induction chemotherapy LAHNSCC Pharmacogenomic SNP Toxicity |
description |
Background: Induction chemotherapy in locally-advanced head and neck squamous cell carcinoma (LAHNSCC) patients is potentially associated to serious adverse events. Biomarkers associated with toxicity could tailor its indication. This study evaluated the association between single-nucleotide polymorphisms (SNPs) in metabolic genes and toxicity to induction chemotherapy. Methods: 59 LAHNSCC phase II clinical trial patients (NCT00959387) were assessed regarding 47 metabolic genes (366 SNPs). Toxicities were graded (CTCAE 3.0) and statistical analysis was performed. Results: The SNPs rs8187710 (ABCC2) and rs1801131 (MTHFR) were associated to increased risk of gastrointestinal toxicity, whereas the SNPs rs3788007 (ABCG1) and rs4148943 (CHST3) were associated to decreased risk. Two other SNPs, rs2301159 (SLC10A2) and rs2470890 (CYP1A2), were associated with increased risk of hematological toxicity. Nevertheless, these SNPs did not remain significant after adjusting for multiple comparisons. Conclusions: This study could not demonstrate relationship between SNPs and toxicity to induction chemotherapy in LAHNSCC patients. The small number of patients may have affected the results. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-11-01 2022-04-28T19:27:47Z 2022-04-28T19:27:47Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.oraloncology.2019.09.013 Oral Oncology, v. 98, p. 48-52. 1879-0593 1368-8375 http://hdl.handle.net/11449/221365 10.1016/j.oraloncology.2019.09.013 2-s2.0-85072246763 |
url |
http://dx.doi.org/10.1016/j.oraloncology.2019.09.013 http://hdl.handle.net/11449/221365 |
identifier_str_mv |
Oral Oncology, v. 98, p. 48-52. 1879-0593 1368-8375 10.1016/j.oraloncology.2019.09.013 2-s2.0-85072246763 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Oral Oncology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
48-52 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128419457662976 |