Gene expression in placentation of farm animals: An overview of gene function during development
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.theriogenology.2011.03.001 http://hdl.handle.net/11449/42567 |
Resumo: | Eutherian mammals share a common ancestor that evolved into two main placental types, i.e., hemotrophic (e.g., human and mouse) and histiotrophic (e.g., farm animals), which differ in invasiveness. Pregnancies initiated with assisted reproductive techniques (ART) in farm animals are at increased risk of failure; these losses were associated with placental defects, perhaps due to altered gene expression. Developmentally regulated genes in the placenta seem highly phylogenetically conserved, whereas those expressed later in pregnancy are more species-specific. To elucidate differences between hemotrophic and epitheliochorial placentae, gene expression data were compiled from microarray studies of bovine placental tissues at various stages of pregnancy. Moreover, an in silico subtractive library was constructed based on homology of bovine genes to the database of zebrafish - a nonplacental vertebrate. In addition, the list of placental preferentially expressed genes for the human and mouse were collected using bioinformatics tools (Tissue-specific Gene Expression and Regulation [TiGER] - for humans, and tissue-specific genes database (TiSGeD) - for mice and humans). Humans, mice, and cattle shared 93 genes expressed in their placentae. Most of these were related to immune function (based on analysis of gene ontology). Cattle and women shared expression of 23 genes, mostly related to hormonal activity, whereas mice and women shared 16 genes (primarily sexual differentiation and glycoprotein biology). Because the number of genes expressed by the placentae of both cattle and mice were similar (based on cluster analysis), we concluded that both cattle and mice were suitable models to study the biology of the human placenta. (C) 2011 Elsevier B.V. All rights reserved. |
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Repositório Institucional da UNESP |
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Gene expression in placentation of farm animals: An overview of gene function during developmentEpitheliochorial placentaGene expressionTranscription factorsPlacenta-specific genesFarm animalsEutherian mammals share a common ancestor that evolved into two main placental types, i.e., hemotrophic (e.g., human and mouse) and histiotrophic (e.g., farm animals), which differ in invasiveness. Pregnancies initiated with assisted reproductive techniques (ART) in farm animals are at increased risk of failure; these losses were associated with placental defects, perhaps due to altered gene expression. Developmentally regulated genes in the placenta seem highly phylogenetically conserved, whereas those expressed later in pregnancy are more species-specific. To elucidate differences between hemotrophic and epitheliochorial placentae, gene expression data were compiled from microarray studies of bovine placental tissues at various stages of pregnancy. Moreover, an in silico subtractive library was constructed based on homology of bovine genes to the database of zebrafish - a nonplacental vertebrate. In addition, the list of placental preferentially expressed genes for the human and mouse were collected using bioinformatics tools (Tissue-specific Gene Expression and Regulation [TiGER] - for humans, and tissue-specific genes database (TiSGeD) - for mice and humans). Humans, mice, and cattle shared 93 genes expressed in their placentae. Most of these were related to immune function (based on analysis of gene ontology). Cattle and women shared expression of 23 genes, mostly related to hormonal activity, whereas mice and women shared 16 genes (primarily sexual differentiation and glycoprotein biology). Because the number of genes expressed by the placentae of both cattle and mice were similar (based on cluster analysis), we concluded that both cattle and mice were suitable models to study the biology of the human placenta. (C) 2011 Elsevier B.V. All rights reserved.Univ São Paulo, Sect Anim Anat, Dept Surg, Fac Vet Med & Anim Sci, São Paulo, BrazilUniv São Paulo, Dept Basic Sci, Fac Anim Sci & Food Engn, Pirassununga, SP, BrazilUniv Estadual Paulista, Fac Anim Sci, Dracena, SP, BrazilUniv Estadual Paulista, Fac Anim Sci, Dracena, SP, BrazilElsevier B.V.Universidade de São Paulo (USP)Universidade Estadual Paulista (Unesp)Barreto, R. S. N.Bressan, F. F.Oiveira, L. J.Pereira, F. T. V. [UNESP]Perecin, F.Ambrosio, C. E.Meirelles, F. V.Miglino, M. A.2014-05-20T15:34:32Z2014-05-20T15:34:32Z2011-09-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article589-597application/pdfhttp://dx.doi.org/10.1016/j.theriogenology.2011.03.001Theriogenology. New York: Elsevier B.V., v. 76, n. 4, p. 589-597, 2011.0093-691Xhttp://hdl.handle.net/11449/4256710.1016/j.theriogenology.2011.03.001WOS:000293870100001WOS000293870100001.pdfWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengTheriogenology2.136info:eu-repo/semantics/openAccess2024-05-07T13:48:06Zoai:repositorio.unesp.br:11449/42567Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-05-07T13:48:06Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Gene expression in placentation of farm animals: An overview of gene function during development |
title |
Gene expression in placentation of farm animals: An overview of gene function during development |
spellingShingle |
Gene expression in placentation of farm animals: An overview of gene function during development Barreto, R. S. N. Epitheliochorial placenta Gene expression Transcription factors Placenta-specific genes Farm animals |
title_short |
Gene expression in placentation of farm animals: An overview of gene function during development |
title_full |
Gene expression in placentation of farm animals: An overview of gene function during development |
title_fullStr |
Gene expression in placentation of farm animals: An overview of gene function during development |
title_full_unstemmed |
Gene expression in placentation of farm animals: An overview of gene function during development |
title_sort |
Gene expression in placentation of farm animals: An overview of gene function during development |
author |
Barreto, R. S. N. |
author_facet |
Barreto, R. S. N. Bressan, F. F. Oiveira, L. J. Pereira, F. T. V. [UNESP] Perecin, F. Ambrosio, C. E. Meirelles, F. V. Miglino, M. A. |
author_role |
author |
author2 |
Bressan, F. F. Oiveira, L. J. Pereira, F. T. V. [UNESP] Perecin, F. Ambrosio, C. E. Meirelles, F. V. Miglino, M. A. |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade de São Paulo (USP) Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Barreto, R. S. N. Bressan, F. F. Oiveira, L. J. Pereira, F. T. V. [UNESP] Perecin, F. Ambrosio, C. E. Meirelles, F. V. Miglino, M. A. |
dc.subject.por.fl_str_mv |
Epitheliochorial placenta Gene expression Transcription factors Placenta-specific genes Farm animals |
topic |
Epitheliochorial placenta Gene expression Transcription factors Placenta-specific genes Farm animals |
description |
Eutherian mammals share a common ancestor that evolved into two main placental types, i.e., hemotrophic (e.g., human and mouse) and histiotrophic (e.g., farm animals), which differ in invasiveness. Pregnancies initiated with assisted reproductive techniques (ART) in farm animals are at increased risk of failure; these losses were associated with placental defects, perhaps due to altered gene expression. Developmentally regulated genes in the placenta seem highly phylogenetically conserved, whereas those expressed later in pregnancy are more species-specific. To elucidate differences between hemotrophic and epitheliochorial placentae, gene expression data were compiled from microarray studies of bovine placental tissues at various stages of pregnancy. Moreover, an in silico subtractive library was constructed based on homology of bovine genes to the database of zebrafish - a nonplacental vertebrate. In addition, the list of placental preferentially expressed genes for the human and mouse were collected using bioinformatics tools (Tissue-specific Gene Expression and Regulation [TiGER] - for humans, and tissue-specific genes database (TiSGeD) - for mice and humans). Humans, mice, and cattle shared 93 genes expressed in their placentae. Most of these were related to immune function (based on analysis of gene ontology). Cattle and women shared expression of 23 genes, mostly related to hormonal activity, whereas mice and women shared 16 genes (primarily sexual differentiation and glycoprotein biology). Because the number of genes expressed by the placentae of both cattle and mice were similar (based on cluster analysis), we concluded that both cattle and mice were suitable models to study the biology of the human placenta. (C) 2011 Elsevier B.V. All rights reserved. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-09-01 2014-05-20T15:34:32Z 2014-05-20T15:34:32Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.theriogenology.2011.03.001 Theriogenology. New York: Elsevier B.V., v. 76, n. 4, p. 589-597, 2011. 0093-691X http://hdl.handle.net/11449/42567 10.1016/j.theriogenology.2011.03.001 WOS:000293870100001 WOS000293870100001.pdf |
url |
http://dx.doi.org/10.1016/j.theriogenology.2011.03.001 http://hdl.handle.net/11449/42567 |
identifier_str_mv |
Theriogenology. New York: Elsevier B.V., v. 76, n. 4, p. 589-597, 2011. 0093-691X 10.1016/j.theriogenology.2011.03.001 WOS:000293870100001 WOS000293870100001.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Theriogenology 2.136 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
589-597 application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier B.V. |
publisher.none.fl_str_mv |
Elsevier B.V. |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1799965643035901952 |