Low-level laser therapy (LLLT) in sites grafted with osteoconductive bone substitutes improves osseointegration
Autor(a) principal: | |
---|---|
Data de Publicação: | 2020 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1007/s10103-019-02943-w http://hdl.handle.net/11449/200051 |
Resumo: | The aim of this study was to evaluate the osseointegration of implants placed in areas grafted with different osteoconductive bone substitutes irradiated with infrared low-level laser therapy (LLLT). Fifty-six rats were randomly allocated into 4 groups: DBB, bone defects filled with deproteinized bovine bone graft (DBB); HA/TCP, bone defects filled with biphasic ceramic made of hydroxyapatite and β-tricalcium phosphate (HA/TCP); DBB-L, bone defects filled with DBB and treated by LLLT; HA/TCP-L, bone defects filled with HA/TCP and treated by LLLT. Bone defects were performed in the tibia of each animal and filled with the different biomaterials. The grafted areas were treated with LLLT (λ 808 nm, 100 mW, ϕ ∼ 0.60 mm) in 7 sessions with 48 h between the irradiations. After the 60-day period, the implants were placed, and the animals were euthanized after 15 and 45 days. The osseointegration and bone repair in the grafted area were evaluated by biomechanical, microtomographic and histometric analyses, and the expression of some bone biomarkers was evaluated by immunohistochemistry analysis. LLLT induced higher degree of osseointegration, which was associated with the greater expression of BMP2 and OCN. LLLT performed in areas grafted with osteoconductive bone substitutes prior to implant placement improves osseointegration. |
id |
UNSP_ac142c6cb8d6636a78888de37eb4d51c |
---|---|
oai_identifier_str |
oai:repositorio.unesp.br:11449/200051 |
network_acronym_str |
UNSP |
network_name_str |
Repositório Institucional da UNESP |
repository_id_str |
2946 |
spelling |
Low-level laser therapy (LLLT) in sites grafted with osteoconductive bone substitutes improves osseointegrationBone substitutesLow-level laser therapyOsseointegrationPreclinical studyThe aim of this study was to evaluate the osseointegration of implants placed in areas grafted with different osteoconductive bone substitutes irradiated with infrared low-level laser therapy (LLLT). Fifty-six rats were randomly allocated into 4 groups: DBB, bone defects filled with deproteinized bovine bone graft (DBB); HA/TCP, bone defects filled with biphasic ceramic made of hydroxyapatite and β-tricalcium phosphate (HA/TCP); DBB-L, bone defects filled with DBB and treated by LLLT; HA/TCP-L, bone defects filled with HA/TCP and treated by LLLT. Bone defects were performed in the tibia of each animal and filled with the different biomaterials. The grafted areas were treated with LLLT (λ 808 nm, 100 mW, ϕ ∼ 0.60 mm) in 7 sessions with 48 h between the irradiations. After the 60-day period, the implants were placed, and the animals were euthanized after 15 and 45 days. The osseointegration and bone repair in the grafted area were evaluated by biomechanical, microtomographic and histometric analyses, and the expression of some bone biomarkers was evaluated by immunohistochemistry analysis. LLLT induced higher degree of osseointegration, which was associated with the greater expression of BMP2 and OCN. LLLT performed in areas grafted with osteoconductive bone substitutes prior to implant placement improves osseointegration.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Department of Periodontology Dental School Universidade Federal de Uberlândia (UFU), Pará Av, 1720Department of Diagnosis and Surgery School of Dentistry Campus of Araraquara São Paulo State University (UNESP), Humaitá St. 1680Department of Diagnosis and Surgery School of Dentistry Campus of Araraquara São Paulo State University (UNESP), Humaitá St. 1680FAPESP: 2013/24318-0CNPq: 459984/2014-4Universidade Federal de Uberlândia (UFU)Universidade Estadual Paulista (Unesp)de Oliveira, Guilherme José Pimentel LopesAroni, Maurício Andres Tinajero [UNESP]Pinotti, Felipe Eduardo [UNESP]Marcantonio, Elcio [UNESP]Marcantonio, Rosemary Adriana Chiérici [UNESP]2020-12-12T01:56:18Z2020-12-12T01:56:18Z2020-09-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1519-1529http://dx.doi.org/10.1007/s10103-019-02943-wLasers in Medical Science, v. 35, n. 7, p. 1519-1529, 2020.1435-604X0268-8921http://hdl.handle.net/11449/20005110.1007/s10103-019-02943-w2-s2.0-85079180829Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengLasers in Medical Scienceinfo:eu-repo/semantics/openAccess2024-09-26T15:21:56Zoai:repositorio.unesp.br:11449/200051Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-26T15:21:56Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Low-level laser therapy (LLLT) in sites grafted with osteoconductive bone substitutes improves osseointegration |
title |
Low-level laser therapy (LLLT) in sites grafted with osteoconductive bone substitutes improves osseointegration |
spellingShingle |
Low-level laser therapy (LLLT) in sites grafted with osteoconductive bone substitutes improves osseointegration de Oliveira, Guilherme José Pimentel Lopes Bone substitutes Low-level laser therapy Osseointegration Preclinical study |
title_short |
Low-level laser therapy (LLLT) in sites grafted with osteoconductive bone substitutes improves osseointegration |
title_full |
Low-level laser therapy (LLLT) in sites grafted with osteoconductive bone substitutes improves osseointegration |
title_fullStr |
Low-level laser therapy (LLLT) in sites grafted with osteoconductive bone substitutes improves osseointegration |
title_full_unstemmed |
Low-level laser therapy (LLLT) in sites grafted with osteoconductive bone substitutes improves osseointegration |
title_sort |
Low-level laser therapy (LLLT) in sites grafted with osteoconductive bone substitutes improves osseointegration |
author |
de Oliveira, Guilherme José Pimentel Lopes |
author_facet |
de Oliveira, Guilherme José Pimentel Lopes Aroni, Maurício Andres Tinajero [UNESP] Pinotti, Felipe Eduardo [UNESP] Marcantonio, Elcio [UNESP] Marcantonio, Rosemary Adriana Chiérici [UNESP] |
author_role |
author |
author2 |
Aroni, Maurício Andres Tinajero [UNESP] Pinotti, Felipe Eduardo [UNESP] Marcantonio, Elcio [UNESP] Marcantonio, Rosemary Adriana Chiérici [UNESP] |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal de Uberlândia (UFU) Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
de Oliveira, Guilherme José Pimentel Lopes Aroni, Maurício Andres Tinajero [UNESP] Pinotti, Felipe Eduardo [UNESP] Marcantonio, Elcio [UNESP] Marcantonio, Rosemary Adriana Chiérici [UNESP] |
dc.subject.por.fl_str_mv |
Bone substitutes Low-level laser therapy Osseointegration Preclinical study |
topic |
Bone substitutes Low-level laser therapy Osseointegration Preclinical study |
description |
The aim of this study was to evaluate the osseointegration of implants placed in areas grafted with different osteoconductive bone substitutes irradiated with infrared low-level laser therapy (LLLT). Fifty-six rats were randomly allocated into 4 groups: DBB, bone defects filled with deproteinized bovine bone graft (DBB); HA/TCP, bone defects filled with biphasic ceramic made of hydroxyapatite and β-tricalcium phosphate (HA/TCP); DBB-L, bone defects filled with DBB and treated by LLLT; HA/TCP-L, bone defects filled with HA/TCP and treated by LLLT. Bone defects were performed in the tibia of each animal and filled with the different biomaterials. The grafted areas were treated with LLLT (λ 808 nm, 100 mW, ϕ ∼ 0.60 mm) in 7 sessions with 48 h between the irradiations. After the 60-day period, the implants were placed, and the animals were euthanized after 15 and 45 days. The osseointegration and bone repair in the grafted area were evaluated by biomechanical, microtomographic and histometric analyses, and the expression of some bone biomarkers was evaluated by immunohistochemistry analysis. LLLT induced higher degree of osseointegration, which was associated with the greater expression of BMP2 and OCN. LLLT performed in areas grafted with osteoconductive bone substitutes prior to implant placement improves osseointegration. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-12-12T01:56:18Z 2020-12-12T01:56:18Z 2020-09-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1007/s10103-019-02943-w Lasers in Medical Science, v. 35, n. 7, p. 1519-1529, 2020. 1435-604X 0268-8921 http://hdl.handle.net/11449/200051 10.1007/s10103-019-02943-w 2-s2.0-85079180829 |
url |
http://dx.doi.org/10.1007/s10103-019-02943-w http://hdl.handle.net/11449/200051 |
identifier_str_mv |
Lasers in Medical Science, v. 35, n. 7, p. 1519-1529, 2020. 1435-604X 0268-8921 10.1007/s10103-019-02943-w 2-s2.0-85079180829 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Lasers in Medical Science |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
1519-1529 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
repositoriounesp@unesp.br |
_version_ |
1813546481912643584 |