Fusobacterium nucleatum tumor DNA levels are associated with survival in colorectal cancer patients
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1007/s10096-019-03649-1 http://hdl.handle.net/11449/190541 |
Resumo: | There is increasing evidence indicating a role for Fusobacterium nucleatum (F. nucleatum) in colorectal cancer (CRC) development and prognosis. This study evaluated F. nucleatum as a prognostic biomarker, by assessing its association with post-diagnosis survival from CRC. From September 2008 to April 2012 CRC patients (n = 190) were recruited from three hospitals within the Czech Republic. F. nucleatum DNA copies were measured in adjacent non-malignant and colorectal tumor tissues using quantitative real-time PCR. Cox Proportional Hazards (HR) models were applied to evaluate the association between F. nucleatum DNA and overall survival, adjusting for key confounders. Risk prediction modeling was conducted to evaluate the ability to predict survival based on F. nucleatum status. High, compared with low, levels of F. nucleatum in colorectal tumor tissues were associated with poorer overall survival (adjusted HR 1.68, 95% CI 1.02–2.77), which was slightly attenuated after additional adjustment for microsatellite instability status. However, inclusion of F. nucleatum in risk prediction models did not improve the ability to identify patients who died beyond known prognostic factors such as disease pathology staging. Although the increased presence of F. nucleatum was associated with poorer prognosis in CRC patients, this may have limited clinical relevance as a prognostic biomarker. |
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Fusobacterium nucleatum tumor DNA levels are associated with survival in colorectal cancer patientsBacterial infectionColorectal cancerColorectal neoplasmDisease survivalFusobacterium nucleatumThere is increasing evidence indicating a role for Fusobacterium nucleatum (F. nucleatum) in colorectal cancer (CRC) development and prognosis. This study evaluated F. nucleatum as a prognostic biomarker, by assessing its association with post-diagnosis survival from CRC. From September 2008 to April 2012 CRC patients (n = 190) were recruited from three hospitals within the Czech Republic. F. nucleatum DNA copies were measured in adjacent non-malignant and colorectal tumor tissues using quantitative real-time PCR. Cox Proportional Hazards (HR) models were applied to evaluate the association between F. nucleatum DNA and overall survival, adjusting for key confounders. Risk prediction modeling was conducted to evaluate the ability to predict survival based on F. nucleatum status. High, compared with low, levels of F. nucleatum in colorectal tumor tissues were associated with poorer overall survival (adjusted HR 1.68, 95% CI 1.02–2.77), which was slightly attenuated after additional adjustment for microsatellite instability status. However, inclusion of F. nucleatum in risk prediction models did not improve the ability to identify patients who died beyond known prognostic factors such as disease pathology staging. Although the increased presence of F. nucleatum was associated with poorer prognosis in CRC patients, this may have limited clinical relevance as a prognostic biomarker.Centre for Public Health Queen’s University BelfastDepartment of Biology São Paulo State University UNESPInstitute of Biology and Medical Genetics First Faculty of Medicine Charles UniversityDepartment of Molecular Biology of Cancer Institute of Experimental Medicine of the Czech Academy of SciencesDepartment of Surgery General University Hospital in PragueDepartment of Surgery First Faculty of Medicine Charles University and Thomayer HospitalBiomedical Centre Faculty of Medicine in Pilsen Charles UniversityDepartment of Oncology First Faculty of Medicine Charles University and Thomayer HospitalCancer Biology and Therapeutics Group School of Biomolecular and Biomedical Science UCD Conway Institute University College DublinDepartment of Biology São Paulo State University UNESPQueen’s University BelfastUniversidade Estadual Paulista (Unesp)Charles UniversityInstitute of Experimental Medicine of the Czech Academy of SciencesGeneral University Hospital in PragueCharles University and Thomayer HospitalUniversity College DublinKunzmann, Andrew T.Proença, Marcela Alcântara [UNESP]Jordao, Haydee WtJiraskova, KaterinaSchneiderova, MichaelaLevy, MiroslavLiska, VáclavBuchler, TomasVodickova, LudmilaVymetalkova, VeronikaSilva, Ana Elizabete [UNESP]Vodicka, PavelHughes, David J.2019-10-06T17:16:30Z2019-10-06T17:16:30Z2019-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1007/s10096-019-03649-1European Journal of Clinical Microbiology and Infectious Diseases.1435-43730934-9723http://hdl.handle.net/11449/19054110.1007/s10096-019-03649-12-s2.0-85069950591Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengEuropean Journal of Clinical Microbiology and Infectious Diseasesinfo:eu-repo/semantics/openAccess2021-10-23T04:16:33Zoai:repositorio.unesp.br:11449/190541Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T13:50:25.407266Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Fusobacterium nucleatum tumor DNA levels are associated with survival in colorectal cancer patients |
title |
Fusobacterium nucleatum tumor DNA levels are associated with survival in colorectal cancer patients |
spellingShingle |
Fusobacterium nucleatum tumor DNA levels are associated with survival in colorectal cancer patients Kunzmann, Andrew T. Bacterial infection Colorectal cancer Colorectal neoplasm Disease survival Fusobacterium nucleatum |
title_short |
Fusobacterium nucleatum tumor DNA levels are associated with survival in colorectal cancer patients |
title_full |
Fusobacterium nucleatum tumor DNA levels are associated with survival in colorectal cancer patients |
title_fullStr |
Fusobacterium nucleatum tumor DNA levels are associated with survival in colorectal cancer patients |
title_full_unstemmed |
Fusobacterium nucleatum tumor DNA levels are associated with survival in colorectal cancer patients |
title_sort |
Fusobacterium nucleatum tumor DNA levels are associated with survival in colorectal cancer patients |
author |
Kunzmann, Andrew T. |
author_facet |
Kunzmann, Andrew T. Proença, Marcela Alcântara [UNESP] Jordao, Haydee Wt Jiraskova, Katerina Schneiderova, Michaela Levy, Miroslav Liska, Václav Buchler, Tomas Vodickova, Ludmila Vymetalkova, Veronika Silva, Ana Elizabete [UNESP] Vodicka, Pavel Hughes, David J. |
author_role |
author |
author2 |
Proença, Marcela Alcântara [UNESP] Jordao, Haydee Wt Jiraskova, Katerina Schneiderova, Michaela Levy, Miroslav Liska, Václav Buchler, Tomas Vodickova, Ludmila Vymetalkova, Veronika Silva, Ana Elizabete [UNESP] Vodicka, Pavel Hughes, David J. |
author2_role |
author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Queen’s University Belfast Universidade Estadual Paulista (Unesp) Charles University Institute of Experimental Medicine of the Czech Academy of Sciences General University Hospital in Prague Charles University and Thomayer Hospital University College Dublin |
dc.contributor.author.fl_str_mv |
Kunzmann, Andrew T. Proença, Marcela Alcântara [UNESP] Jordao, Haydee Wt Jiraskova, Katerina Schneiderova, Michaela Levy, Miroslav Liska, Václav Buchler, Tomas Vodickova, Ludmila Vymetalkova, Veronika Silva, Ana Elizabete [UNESP] Vodicka, Pavel Hughes, David J. |
dc.subject.por.fl_str_mv |
Bacterial infection Colorectal cancer Colorectal neoplasm Disease survival Fusobacterium nucleatum |
topic |
Bacterial infection Colorectal cancer Colorectal neoplasm Disease survival Fusobacterium nucleatum |
description |
There is increasing evidence indicating a role for Fusobacterium nucleatum (F. nucleatum) in colorectal cancer (CRC) development and prognosis. This study evaluated F. nucleatum as a prognostic biomarker, by assessing its association with post-diagnosis survival from CRC. From September 2008 to April 2012 CRC patients (n = 190) were recruited from three hospitals within the Czech Republic. F. nucleatum DNA copies were measured in adjacent non-malignant and colorectal tumor tissues using quantitative real-time PCR. Cox Proportional Hazards (HR) models were applied to evaluate the association between F. nucleatum DNA and overall survival, adjusting for key confounders. Risk prediction modeling was conducted to evaluate the ability to predict survival based on F. nucleatum status. High, compared with low, levels of F. nucleatum in colorectal tumor tissues were associated with poorer overall survival (adjusted HR 1.68, 95% CI 1.02–2.77), which was slightly attenuated after additional adjustment for microsatellite instability status. However, inclusion of F. nucleatum in risk prediction models did not improve the ability to identify patients who died beyond known prognostic factors such as disease pathology staging. Although the increased presence of F. nucleatum was associated with poorer prognosis in CRC patients, this may have limited clinical relevance as a prognostic biomarker. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-10-06T17:16:30Z 2019-10-06T17:16:30Z 2019-01-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1007/s10096-019-03649-1 European Journal of Clinical Microbiology and Infectious Diseases. 1435-4373 0934-9723 http://hdl.handle.net/11449/190541 10.1007/s10096-019-03649-1 2-s2.0-85069950591 |
url |
http://dx.doi.org/10.1007/s10096-019-03649-1 http://hdl.handle.net/11449/190541 |
identifier_str_mv |
European Journal of Clinical Microbiology and Infectious Diseases. 1435-4373 0934-9723 10.1007/s10096-019-03649-1 2-s2.0-85069950591 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
European Journal of Clinical Microbiology and Infectious Diseases |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128282711818240 |