Effects of magnesium sulfate and dioctyl sodium sulfosuccinate on fecal hydration, output and systemic hydration in healthy horses
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/1678-4162-11794 http://hdl.handle.net/11449/209061 |
Resumo: | Magnesium sulphate (MS) and dioctyl sodium sulphosuccinate (DSS) are laxative drugs frequently used for the treatment of impactions. The aim of this study was to compare the effects of MS and DSS in fecal hydration, output and systemic hydration in healthy horses. Five healthy horses received 3 treatments with a 21-day interval. Treatment 1 was performed with administration of 4 liters of warm water; treatment 2: administration of 4 liters of warm water associated with 1g/kg of MS; and treatment 3: administration of 4 liters of warm water associated with 20mg/kg DSS. General and specific physical examination of the digestive system were performed, alongside with packed cell volume and total plasma protein measurement, abdominal ultrasonography and quantification of the amount and hydration of feces, before and 6, 12, 24, 36 and 48 hours after the treatments. No adverse effects were observed. The administration of laxatives promoted greater fecal output and hydration without resulting in systemic dehydration, yet no differences were observed between treatments. The absence of adverse effects of DSS demonstrates the safety of its use as a laxative drug at a dose of 20mg/kg. Studies comparing the effects of the laxative drugs in horses with large colon impaction are needed. |
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Effects of magnesium sulfate and dioctyl sodium sulfosuccinate on fecal hydration, output and systemic hydration in healthy horseslaxativesdehydrationcolon impactionMagnesium sulphate (MS) and dioctyl sodium sulphosuccinate (DSS) are laxative drugs frequently used for the treatment of impactions. The aim of this study was to compare the effects of MS and DSS in fecal hydration, output and systemic hydration in healthy horses. Five healthy horses received 3 treatments with a 21-day interval. Treatment 1 was performed with administration of 4 liters of warm water; treatment 2: administration of 4 liters of warm water associated with 1g/kg of MS; and treatment 3: administration of 4 liters of warm water associated with 20mg/kg DSS. General and specific physical examination of the digestive system were performed, alongside with packed cell volume and total plasma protein measurement, abdominal ultrasonography and quantification of the amount and hydration of feces, before and 6, 12, 24, 36 and 48 hours after the treatments. No adverse effects were observed. The administration of laxatives promoted greater fecal output and hydration without resulting in systemic dehydration, yet no differences were observed between treatments. The absence of adverse effects of DSS demonstrates the safety of its use as a laxative drug at a dose of 20mg/kg. Studies comparing the effects of the laxative drugs in horses with large colon impaction are needed.Univ Estadual Paulista, Fac Med Vet & Zootecnia, Botucatu, SP, BrazilUniv Estadual Paulista, Fac Med Vet & Zootecnia, Botucatu, SP, BrazilArquivo Brasileiro Medicina Veterinaria ZootecniaUniversidade Estadual Paulista (Unesp)Alonso, J. M. [UNESP]Esper, C. S. [UNESP]Rosa, G. S. [UNESP]Schmitt, F. P. [UNESP]Araujo, F. L. [UNESP]Melo Neto, G. B. [UNESP]Pantoja, J. C. F. [UNESP]Watanabe, M. J. [UNESP]Alves, A. L. G. [UNESP]Rodrigues, C. A. [UNESP]Hussni, C. A. [UNESP]2021-06-25T11:47:13Z2021-06-25T11:47:13Z2020-09-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1625-1630application/pdfhttp://dx.doi.org/10.1590/1678-4162-11794Arquivo Brasileiro De Medicina Veterinaria E Zootecnia. Minas Gerais: Arquivo Brasileiro Medicina Veterinaria Zootecnia, v. 72, n. 5, p. 1625-1630, 2020.0102-0935http://hdl.handle.net/11449/20906110.1590/1678-4162-11794S0102-09352020000501625WOS:000604333500007S0102-09352020000501625.pdfWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengArquivo Brasileiro De Medicina Veterinaria E Zootecniainfo:eu-repo/semantics/openAccess2023-10-23T06:06:22Zoai:repositorio.unesp.br:11449/209061Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T15:41:44.817898Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Effects of magnesium sulfate and dioctyl sodium sulfosuccinate on fecal hydration, output and systemic hydration in healthy horses |
title |
Effects of magnesium sulfate and dioctyl sodium sulfosuccinate on fecal hydration, output and systemic hydration in healthy horses |
spellingShingle |
Effects of magnesium sulfate and dioctyl sodium sulfosuccinate on fecal hydration, output and systemic hydration in healthy horses Alonso, J. M. [UNESP] laxatives dehydration colon impaction |
title_short |
Effects of magnesium sulfate and dioctyl sodium sulfosuccinate on fecal hydration, output and systemic hydration in healthy horses |
title_full |
Effects of magnesium sulfate and dioctyl sodium sulfosuccinate on fecal hydration, output and systemic hydration in healthy horses |
title_fullStr |
Effects of magnesium sulfate and dioctyl sodium sulfosuccinate on fecal hydration, output and systemic hydration in healthy horses |
title_full_unstemmed |
Effects of magnesium sulfate and dioctyl sodium sulfosuccinate on fecal hydration, output and systemic hydration in healthy horses |
title_sort |
Effects of magnesium sulfate and dioctyl sodium sulfosuccinate on fecal hydration, output and systemic hydration in healthy horses |
author |
Alonso, J. M. [UNESP] |
author_facet |
Alonso, J. M. [UNESP] Esper, C. S. [UNESP] Rosa, G. S. [UNESP] Schmitt, F. P. [UNESP] Araujo, F. L. [UNESP] Melo Neto, G. B. [UNESP] Pantoja, J. C. F. [UNESP] Watanabe, M. J. [UNESP] Alves, A. L. G. [UNESP] Rodrigues, C. A. [UNESP] Hussni, C. A. [UNESP] |
author_role |
author |
author2 |
Esper, C. S. [UNESP] Rosa, G. S. [UNESP] Schmitt, F. P. [UNESP] Araujo, F. L. [UNESP] Melo Neto, G. B. [UNESP] Pantoja, J. C. F. [UNESP] Watanabe, M. J. [UNESP] Alves, A. L. G. [UNESP] Rodrigues, C. A. [UNESP] Hussni, C. A. [UNESP] |
author2_role |
author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Alonso, J. M. [UNESP] Esper, C. S. [UNESP] Rosa, G. S. [UNESP] Schmitt, F. P. [UNESP] Araujo, F. L. [UNESP] Melo Neto, G. B. [UNESP] Pantoja, J. C. F. [UNESP] Watanabe, M. J. [UNESP] Alves, A. L. G. [UNESP] Rodrigues, C. A. [UNESP] Hussni, C. A. [UNESP] |
dc.subject.por.fl_str_mv |
laxatives dehydration colon impaction |
topic |
laxatives dehydration colon impaction |
description |
Magnesium sulphate (MS) and dioctyl sodium sulphosuccinate (DSS) are laxative drugs frequently used for the treatment of impactions. The aim of this study was to compare the effects of MS and DSS in fecal hydration, output and systemic hydration in healthy horses. Five healthy horses received 3 treatments with a 21-day interval. Treatment 1 was performed with administration of 4 liters of warm water; treatment 2: administration of 4 liters of warm water associated with 1g/kg of MS; and treatment 3: administration of 4 liters of warm water associated with 20mg/kg DSS. General and specific physical examination of the digestive system were performed, alongside with packed cell volume and total plasma protein measurement, abdominal ultrasonography and quantification of the amount and hydration of feces, before and 6, 12, 24, 36 and 48 hours after the treatments. No adverse effects were observed. The administration of laxatives promoted greater fecal output and hydration without resulting in systemic dehydration, yet no differences were observed between treatments. The absence of adverse effects of DSS demonstrates the safety of its use as a laxative drug at a dose of 20mg/kg. Studies comparing the effects of the laxative drugs in horses with large colon impaction are needed. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-09-01 2021-06-25T11:47:13Z 2021-06-25T11:47:13Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/1678-4162-11794 Arquivo Brasileiro De Medicina Veterinaria E Zootecnia. Minas Gerais: Arquivo Brasileiro Medicina Veterinaria Zootecnia, v. 72, n. 5, p. 1625-1630, 2020. 0102-0935 http://hdl.handle.net/11449/209061 10.1590/1678-4162-11794 S0102-09352020000501625 WOS:000604333500007 S0102-09352020000501625.pdf |
url |
http://dx.doi.org/10.1590/1678-4162-11794 http://hdl.handle.net/11449/209061 |
identifier_str_mv |
Arquivo Brasileiro De Medicina Veterinaria E Zootecnia. Minas Gerais: Arquivo Brasileiro Medicina Veterinaria Zootecnia, v. 72, n. 5, p. 1625-1630, 2020. 0102-0935 10.1590/1678-4162-11794 S0102-09352020000501625 WOS:000604333500007 S0102-09352020000501625.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Arquivo Brasileiro De Medicina Veterinaria E Zootecnia |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
1625-1630 application/pdf |
dc.publisher.none.fl_str_mv |
Arquivo Brasileiro Medicina Veterinaria Zootecnia |
publisher.none.fl_str_mv |
Arquivo Brasileiro Medicina Veterinaria Zootecnia |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
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UNESP |
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Repositório Institucional da UNESP |
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Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
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1808128552048001024 |