Testosterone Promotes an Anabolic Increase in the Rat Female Prostate (Skene's Paraurethral Gland) Which Acquires a Male Ventral Prostate Phenotype
Autor(a) principal: | |
---|---|
Data de Publicação: | 2010 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1002/ar.21250 http://hdl.handle.net/11449/21586 |
Resumo: | The female prostate (Skene's paraurethral gland) in the rat is morphologically similar to the ventral lobe of male adults and has been described in other rodent species and humans. Previous studies on prostate morphogenesis suggest that female Wistar rats (Rattus norvegicus) do not develop this gland due to the absence of testosterone during the embryonic and neonatal periods. on the other hand, studies conducted in our laboratory have shown that some females of this species can present an undeveloped but functional prostate. Recent studies on this gland have caused scientific interest because, besides being active in the processes of synthesis and secretion of prostatic material, it is also targeted by both malignant and benign lesions, mainly during senescence. Thus, this work aims to evaluate the structure of female prostate of adult rats (Rattus norvegicus) under normal conditions and under the effect of testosterone treatment and carry out comparative studies on the ventral prostate of young and adult male rats. Morphological and morphometric stereological analyses and immunocytochemical and ultrastructural studies were conducted. The results have shown that the prostate gland of rats exposed to androgen therapy have experienced intense growth, becoming more active in relation to synthesis and secretion. It may be concluded that the prostate in control adult female rats is morphologically very similar to the prostatic ventral lobe of young male rats. Besides, under androgenic action, the female prostate grows considerably and becomes similar to the prostatic ventral lobe in male adults. Anat Rec, 293:2163-2175, 2010. (C) 2010 Wiley-Liss, Inc. |
id |
UNSP_ad3cdf949dcac0e3a38043060c9e7bc3 |
---|---|
oai_identifier_str |
oai:repositorio.unesp.br:11449/21586 |
network_acronym_str |
UNSP |
network_name_str |
Repositório Institucional da UNESP |
repository_id_str |
2946 |
spelling |
Testosterone Promotes an Anabolic Increase in the Rat Female Prostate (Skene's Paraurethral Gland) Which Acquires a Male Ventral Prostate Phenotypefemale prostateventral male prostateandrogensratmorphologyThe female prostate (Skene's paraurethral gland) in the rat is morphologically similar to the ventral lobe of male adults and has been described in other rodent species and humans. Previous studies on prostate morphogenesis suggest that female Wistar rats (Rattus norvegicus) do not develop this gland due to the absence of testosterone during the embryonic and neonatal periods. on the other hand, studies conducted in our laboratory have shown that some females of this species can present an undeveloped but functional prostate. Recent studies on this gland have caused scientific interest because, besides being active in the processes of synthesis and secretion of prostatic material, it is also targeted by both malignant and benign lesions, mainly during senescence. Thus, this work aims to evaluate the structure of female prostate of adult rats (Rattus norvegicus) under normal conditions and under the effect of testosterone treatment and carry out comparative studies on the ventral prostate of young and adult male rats. Morphological and morphometric stereological analyses and immunocytochemical and ultrastructural studies were conducted. The results have shown that the prostate gland of rats exposed to androgen therapy have experienced intense growth, becoming more active in relation to synthesis and secretion. It may be concluded that the prostate in control adult female rats is morphologically very similar to the prostatic ventral lobe of young male rats. Besides, under androgenic action, the female prostate grows considerably and becomes similar to the prostatic ventral lobe in male adults. Anat Rec, 293:2163-2175, 2010. (C) 2010 Wiley-Liss, Inc.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Inst Biol, Dept Cell Biol, Campinas, SP, BrazilUniversidade Federal de Goiás (UFG), Dept Morphol, Goiania, Go, BrazilSão Paulo State Univ, UNESP IBILCE, Dept Biol, Lab Microscopy & Microanal, São Paulo, BrazilUNIRP, Rio Preto Universitary Ctr, Biol Sci & Vet Med Sch, São Paulo, BrazilSão Paulo State Univ, UNESP IB, Inst Biol, São Paulo, BrazilSão Paulo State Univ, UNESP IBILCE, Dept Biol, Lab Microscopy & Microanal, São Paulo, BrazilSão Paulo State Univ, UNESP IB, Inst Biol, São Paulo, BrazilFAPESP: 05/04647-2FAPESP: 06/06876-1FAPESP: 07/06862-3CNPq: 301111/05-7CNPq: 300163/2008-8CNPq: 302693/2008-4Wiley-BlackwellInst BiolUniversidade Federal de Goiás (UFG)Universidade Estadual Paulista (Unesp)UNIRPBiancardi, Manoel F.Santos, Fernanda C. A.Madi-Ravazzi, Liliam [UNESP]Goes, Rejane M. [UNESP]Vilamaior, Patricia S. L.Felisbino, Sergio L. [UNESP]Taboga, Sebastiao R. [UNESP]2014-05-20T14:01:05Z2014-05-20T14:01:05Z2010-12-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2163-2175http://dx.doi.org/10.1002/ar.21250Anatomical Record-advances In Integrative Anatomy and Evolutionary Biology. Malden: Wiley-blackwell, v. 293, n. 12, p. 2163-2175, 2010.1932-8486http://hdl.handle.net/11449/2158610.1002/ar.21250WOS:000285893100023706635812379043409471933473121570000-0002-0970-42880000-0002-3622-460X0000-0002-3622-460XWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengAnatomical Record-advances In Integrative Anatomy and Evolutionary Biology1.3730,766info:eu-repo/semantics/openAccess2024-04-11T19:33:51Zoai:repositorio.unesp.br:11449/21586Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-04-11T19:33:51Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Testosterone Promotes an Anabolic Increase in the Rat Female Prostate (Skene's Paraurethral Gland) Which Acquires a Male Ventral Prostate Phenotype |
title |
Testosterone Promotes an Anabolic Increase in the Rat Female Prostate (Skene's Paraurethral Gland) Which Acquires a Male Ventral Prostate Phenotype |
spellingShingle |
Testosterone Promotes an Anabolic Increase in the Rat Female Prostate (Skene's Paraurethral Gland) Which Acquires a Male Ventral Prostate Phenotype Biancardi, Manoel F. female prostate ventral male prostate androgens rat morphology |
title_short |
Testosterone Promotes an Anabolic Increase in the Rat Female Prostate (Skene's Paraurethral Gland) Which Acquires a Male Ventral Prostate Phenotype |
title_full |
Testosterone Promotes an Anabolic Increase in the Rat Female Prostate (Skene's Paraurethral Gland) Which Acquires a Male Ventral Prostate Phenotype |
title_fullStr |
Testosterone Promotes an Anabolic Increase in the Rat Female Prostate (Skene's Paraurethral Gland) Which Acquires a Male Ventral Prostate Phenotype |
title_full_unstemmed |
Testosterone Promotes an Anabolic Increase in the Rat Female Prostate (Skene's Paraurethral Gland) Which Acquires a Male Ventral Prostate Phenotype |
title_sort |
Testosterone Promotes an Anabolic Increase in the Rat Female Prostate (Skene's Paraurethral Gland) Which Acquires a Male Ventral Prostate Phenotype |
author |
Biancardi, Manoel F. |
author_facet |
Biancardi, Manoel F. Santos, Fernanda C. A. Madi-Ravazzi, Liliam [UNESP] Goes, Rejane M. [UNESP] Vilamaior, Patricia S. L. Felisbino, Sergio L. [UNESP] Taboga, Sebastiao R. [UNESP] |
author_role |
author |
author2 |
Santos, Fernanda C. A. Madi-Ravazzi, Liliam [UNESP] Goes, Rejane M. [UNESP] Vilamaior, Patricia S. L. Felisbino, Sergio L. [UNESP] Taboga, Sebastiao R. [UNESP] |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Inst Biol Universidade Federal de Goiás (UFG) Universidade Estadual Paulista (Unesp) UNIRP |
dc.contributor.author.fl_str_mv |
Biancardi, Manoel F. Santos, Fernanda C. A. Madi-Ravazzi, Liliam [UNESP] Goes, Rejane M. [UNESP] Vilamaior, Patricia S. L. Felisbino, Sergio L. [UNESP] Taboga, Sebastiao R. [UNESP] |
dc.subject.por.fl_str_mv |
female prostate ventral male prostate androgens rat morphology |
topic |
female prostate ventral male prostate androgens rat morphology |
description |
The female prostate (Skene's paraurethral gland) in the rat is morphologically similar to the ventral lobe of male adults and has been described in other rodent species and humans. Previous studies on prostate morphogenesis suggest that female Wistar rats (Rattus norvegicus) do not develop this gland due to the absence of testosterone during the embryonic and neonatal periods. on the other hand, studies conducted in our laboratory have shown that some females of this species can present an undeveloped but functional prostate. Recent studies on this gland have caused scientific interest because, besides being active in the processes of synthesis and secretion of prostatic material, it is also targeted by both malignant and benign lesions, mainly during senescence. Thus, this work aims to evaluate the structure of female prostate of adult rats (Rattus norvegicus) under normal conditions and under the effect of testosterone treatment and carry out comparative studies on the ventral prostate of young and adult male rats. Morphological and morphometric stereological analyses and immunocytochemical and ultrastructural studies were conducted. The results have shown that the prostate gland of rats exposed to androgen therapy have experienced intense growth, becoming more active in relation to synthesis and secretion. It may be concluded that the prostate in control adult female rats is morphologically very similar to the prostatic ventral lobe of young male rats. Besides, under androgenic action, the female prostate grows considerably and becomes similar to the prostatic ventral lobe in male adults. Anat Rec, 293:2163-2175, 2010. (C) 2010 Wiley-Liss, Inc. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010-12-01 2014-05-20T14:01:05Z 2014-05-20T14:01:05Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1002/ar.21250 Anatomical Record-advances In Integrative Anatomy and Evolutionary Biology. Malden: Wiley-blackwell, v. 293, n. 12, p. 2163-2175, 2010. 1932-8486 http://hdl.handle.net/11449/21586 10.1002/ar.21250 WOS:000285893100023 7066358123790434 0947193347312157 0000-0002-0970-4288 0000-0002-3622-460X 0000-0002-3622-460X |
url |
http://dx.doi.org/10.1002/ar.21250 http://hdl.handle.net/11449/21586 |
identifier_str_mv |
Anatomical Record-advances In Integrative Anatomy and Evolutionary Biology. Malden: Wiley-blackwell, v. 293, n. 12, p. 2163-2175, 2010. 1932-8486 10.1002/ar.21250 WOS:000285893100023 7066358123790434 0947193347312157 0000-0002-0970-4288 0000-0002-3622-460X |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Anatomical Record-advances In Integrative Anatomy and Evolutionary Biology 1.373 0,766 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
2163-2175 |
dc.publisher.none.fl_str_mv |
Wiley-Blackwell |
publisher.none.fl_str_mv |
Wiley-Blackwell |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799964921461473280 |