Importance of xenarthrans in the eco-epidemiology of Paracoccidioides brasiliensis
Autor(a) principal: | |
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Data de Publicação: | 2009 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1186/1756-0500-2-228 http://hdl.handle.net/11449/71318 |
Resumo: | Background. Several pathogens that cause important zoonotic diseases have been frequently associated with armadillos and other xenarthrans. This mammal group typically has evolved on the South American continent and many of its extant species are seriously threatened with extinction. Natural infection of armadillos with Paracoccidioides brasiliensis in hyperendemic areas has provided a valuable opportunity for understanding the role of this mammal in the eco-epidemiology of Paracoccidioidomycosis (PCM), one of the most important systemic mycoses in Latin America. Findings. This study aimed to detect P. brasiliensis in different xenarthran species (Dasypus novemcinctus, Cabassous spp., Euphractus sexcinctus, Tamandua tetradactyla and Myrmecophaga tridactyla), by molecular and mycological approaches, in samples obtained by one of the following strategies: i) from road-killed animals (n = 6); ii) from naturally dead animals (n = 8); iii) from animals that died in captivity (n = 9); and iv) from living animals captured from the wild (n = 2). Specific P. brasiliensis DNA was detected in several organs among 7/20 nine-banded armadillos (D. novemcinctus) and in 2/2 anteaters (M. tridactyla). The fungus was also cultured in tissue samples from one of two armadillos captured from the wild. Conclusion. Members of the Xenarthra Order, especially armadillos, have some characteristics, including a weak cellular immune response and low body temperature, which make them suitable models for studying host-pathogen interaction. P. brasiliensis infection in wild animals, from PCM endemic areas, may be more common than initially postulated and reinforces the use of these animals as sentinels for the pathogen in the environment. © 2009 Bagagli et al; licensee BioMed Central Ltd. |
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Importance of xenarthrans in the eco-epidemiology of Paracoccidioides brasiliensisAnimaliaArmadilloCabassousDasypodidaeDasypus novemcinctusEdentataEuphractus sexcinctusFungiMammaliaMyrmecophaga tridactylaMyrmecophagidaeParacoccidioides brasiliensisTamandua tetradactylaXenarthraBackground. Several pathogens that cause important zoonotic diseases have been frequently associated with armadillos and other xenarthrans. This mammal group typically has evolved on the South American continent and many of its extant species are seriously threatened with extinction. Natural infection of armadillos with Paracoccidioides brasiliensis in hyperendemic areas has provided a valuable opportunity for understanding the role of this mammal in the eco-epidemiology of Paracoccidioidomycosis (PCM), one of the most important systemic mycoses in Latin America. Findings. This study aimed to detect P. brasiliensis in different xenarthran species (Dasypus novemcinctus, Cabassous spp., Euphractus sexcinctus, Tamandua tetradactyla and Myrmecophaga tridactyla), by molecular and mycological approaches, in samples obtained by one of the following strategies: i) from road-killed animals (n = 6); ii) from naturally dead animals (n = 8); iii) from animals that died in captivity (n = 9); and iv) from living animals captured from the wild (n = 2). Specific P. brasiliensis DNA was detected in several organs among 7/20 nine-banded armadillos (D. novemcinctus) and in 2/2 anteaters (M. tridactyla). The fungus was also cultured in tissue samples from one of two armadillos captured from the wild. Conclusion. Members of the Xenarthra Order, especially armadillos, have some characteristics, including a weak cellular immune response and low body temperature, which make them suitable models for studying host-pathogen interaction. P. brasiliensis infection in wild animals, from PCM endemic areas, may be more common than initially postulated and reinforces the use of these animals as sentinels for the pathogen in the environment. © 2009 Bagagli et al; licensee BioMed Central Ltd.Departamento de Microbiologia e Imunologia Instituto de Biocincias de Botucatu Universidade Estadual Paulista, Botucatu, SPDepartamento de Geografia Faculdade de Filosofia, Letras e Cincias Humanas Universidade de so Paulo, So Paulo, SPInstituto Lauro de Souza Lima, Bauru, SPDepartamento de Microbiologia e Imunologia Instituto de Biocincias de Botucatu Universidade Estadual Paulista, Botucatu, SPUniversidade Estadual Paulista (Unesp)Universidade de São Paulo (USP)Instituto Lauro de Souza Lima (ILSL)Richini-Pereira, Virgínia [UNESP]Bosco, Sandra [UNESP]Theodoro, Raquel [UNESP]Barrozo, LígiaPedrini, SilviaRosa, PatríciaBagagli, Eduardo [UNESP]2014-05-27T11:24:04Z2014-05-27T11:24:04Z2009-12-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://dx.doi.org/10.1186/1756-0500-2-228BMC Research Notes, v. 2.1756-0500http://hdl.handle.net/11449/7131810.1186/1756-0500-2-2282-s2.0-771491627172-s2.0-77149162717.pdf33203275704295390000-0002-8003-4109Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBMC Research Notes0,691info:eu-repo/semantics/openAccess2024-10-14T15:05:33Zoai:repositorio.unesp.br:11449/71318Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-10-14T15:05:33Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Importance of xenarthrans in the eco-epidemiology of Paracoccidioides brasiliensis |
title |
Importance of xenarthrans in the eco-epidemiology of Paracoccidioides brasiliensis |
spellingShingle |
Importance of xenarthrans in the eco-epidemiology of Paracoccidioides brasiliensis Richini-Pereira, Virgínia [UNESP] Animalia Armadillo Cabassous Dasypodidae Dasypus novemcinctus Edentata Euphractus sexcinctus Fungi Mammalia Myrmecophaga tridactyla Myrmecophagidae Paracoccidioides brasiliensis Tamandua tetradactyla Xenarthra |
title_short |
Importance of xenarthrans in the eco-epidemiology of Paracoccidioides brasiliensis |
title_full |
Importance of xenarthrans in the eco-epidemiology of Paracoccidioides brasiliensis |
title_fullStr |
Importance of xenarthrans in the eco-epidemiology of Paracoccidioides brasiliensis |
title_full_unstemmed |
Importance of xenarthrans in the eco-epidemiology of Paracoccidioides brasiliensis |
title_sort |
Importance of xenarthrans in the eco-epidemiology of Paracoccidioides brasiliensis |
author |
Richini-Pereira, Virgínia [UNESP] |
author_facet |
Richini-Pereira, Virgínia [UNESP] Bosco, Sandra [UNESP] Theodoro, Raquel [UNESP] Barrozo, Lígia Pedrini, Silvia Rosa, Patrícia Bagagli, Eduardo [UNESP] |
author_role |
author |
author2 |
Bosco, Sandra [UNESP] Theodoro, Raquel [UNESP] Barrozo, Lígia Pedrini, Silvia Rosa, Patrícia Bagagli, Eduardo [UNESP] |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Universidade de São Paulo (USP) Instituto Lauro de Souza Lima (ILSL) |
dc.contributor.author.fl_str_mv |
Richini-Pereira, Virgínia [UNESP] Bosco, Sandra [UNESP] Theodoro, Raquel [UNESP] Barrozo, Lígia Pedrini, Silvia Rosa, Patrícia Bagagli, Eduardo [UNESP] |
dc.subject.por.fl_str_mv |
Animalia Armadillo Cabassous Dasypodidae Dasypus novemcinctus Edentata Euphractus sexcinctus Fungi Mammalia Myrmecophaga tridactyla Myrmecophagidae Paracoccidioides brasiliensis Tamandua tetradactyla Xenarthra |
topic |
Animalia Armadillo Cabassous Dasypodidae Dasypus novemcinctus Edentata Euphractus sexcinctus Fungi Mammalia Myrmecophaga tridactyla Myrmecophagidae Paracoccidioides brasiliensis Tamandua tetradactyla Xenarthra |
description |
Background. Several pathogens that cause important zoonotic diseases have been frequently associated with armadillos and other xenarthrans. This mammal group typically has evolved on the South American continent and many of its extant species are seriously threatened with extinction. Natural infection of armadillos with Paracoccidioides brasiliensis in hyperendemic areas has provided a valuable opportunity for understanding the role of this mammal in the eco-epidemiology of Paracoccidioidomycosis (PCM), one of the most important systemic mycoses in Latin America. Findings. This study aimed to detect P. brasiliensis in different xenarthran species (Dasypus novemcinctus, Cabassous spp., Euphractus sexcinctus, Tamandua tetradactyla and Myrmecophaga tridactyla), by molecular and mycological approaches, in samples obtained by one of the following strategies: i) from road-killed animals (n = 6); ii) from naturally dead animals (n = 8); iii) from animals that died in captivity (n = 9); and iv) from living animals captured from the wild (n = 2). Specific P. brasiliensis DNA was detected in several organs among 7/20 nine-banded armadillos (D. novemcinctus) and in 2/2 anteaters (M. tridactyla). The fungus was also cultured in tissue samples from one of two armadillos captured from the wild. Conclusion. Members of the Xenarthra Order, especially armadillos, have some characteristics, including a weak cellular immune response and low body temperature, which make them suitable models for studying host-pathogen interaction. P. brasiliensis infection in wild animals, from PCM endemic areas, may be more common than initially postulated and reinforces the use of these animals as sentinels for the pathogen in the environment. © 2009 Bagagli et al; licensee BioMed Central Ltd. |
publishDate |
2009 |
dc.date.none.fl_str_mv |
2009-12-01 2014-05-27T11:24:04Z 2014-05-27T11:24:04Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1186/1756-0500-2-228 BMC Research Notes, v. 2. 1756-0500 http://hdl.handle.net/11449/71318 10.1186/1756-0500-2-228 2-s2.0-77149162717 2-s2.0-77149162717.pdf 3320327570429539 0000-0002-8003-4109 |
url |
http://dx.doi.org/10.1186/1756-0500-2-228 http://hdl.handle.net/11449/71318 |
identifier_str_mv |
BMC Research Notes, v. 2. 1756-0500 10.1186/1756-0500-2-228 2-s2.0-77149162717 2-s2.0-77149162717.pdf 3320327570429539 0000-0002-8003-4109 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
BMC Research Notes 0,691 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
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Repositório Institucional da UNESP |
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Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
repositoriounesp@unesp.br |
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