Importance of xenarthrans in the eco-epidemiology of Paracoccidioides brasiliensis

Detalhes bibliográficos
Autor(a) principal: Richini-Pereira, Virgínia [UNESP]
Data de Publicação: 2009
Outros Autores: Bosco, Sandra [UNESP], Theodoro, Raquel [UNESP], Barrozo, Lígia, Pedrini, Silvia, Rosa, Patrícia, Bagagli, Eduardo [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1186/1756-0500-2-228
http://hdl.handle.net/11449/71318
Resumo: Background. Several pathogens that cause important zoonotic diseases have been frequently associated with armadillos and other xenarthrans. This mammal group typically has evolved on the South American continent and many of its extant species are seriously threatened with extinction. Natural infection of armadillos with Paracoccidioides brasiliensis in hyperendemic areas has provided a valuable opportunity for understanding the role of this mammal in the eco-epidemiology of Paracoccidioidomycosis (PCM), one of the most important systemic mycoses in Latin America. Findings. This study aimed to detect P. brasiliensis in different xenarthran species (Dasypus novemcinctus, Cabassous spp., Euphractus sexcinctus, Tamandua tetradactyla and Myrmecophaga tridactyla), by molecular and mycological approaches, in samples obtained by one of the following strategies: i) from road-killed animals (n = 6); ii) from naturally dead animals (n = 8); iii) from animals that died in captivity (n = 9); and iv) from living animals captured from the wild (n = 2). Specific P. brasiliensis DNA was detected in several organs among 7/20 nine-banded armadillos (D. novemcinctus) and in 2/2 anteaters (M. tridactyla). The fungus was also cultured in tissue samples from one of two armadillos captured from the wild. Conclusion. Members of the Xenarthra Order, especially armadillos, have some characteristics, including a weak cellular immune response and low body temperature, which make them suitable models for studying host-pathogen interaction. P. brasiliensis infection in wild animals, from PCM endemic areas, may be more common than initially postulated and reinforces the use of these animals as sentinels for the pathogen in the environment. © 2009 Bagagli et al; licensee BioMed Central Ltd.
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spelling Importance of xenarthrans in the eco-epidemiology of Paracoccidioides brasiliensisAnimaliaArmadilloCabassousDasypodidaeDasypus novemcinctusEdentataEuphractus sexcinctusFungiMammaliaMyrmecophaga tridactylaMyrmecophagidaeParacoccidioides brasiliensisTamandua tetradactylaXenarthraBackground. Several pathogens that cause important zoonotic diseases have been frequently associated with armadillos and other xenarthrans. This mammal group typically has evolved on the South American continent and many of its extant species are seriously threatened with extinction. Natural infection of armadillos with Paracoccidioides brasiliensis in hyperendemic areas has provided a valuable opportunity for understanding the role of this mammal in the eco-epidemiology of Paracoccidioidomycosis (PCM), one of the most important systemic mycoses in Latin America. Findings. This study aimed to detect P. brasiliensis in different xenarthran species (Dasypus novemcinctus, Cabassous spp., Euphractus sexcinctus, Tamandua tetradactyla and Myrmecophaga tridactyla), by molecular and mycological approaches, in samples obtained by one of the following strategies: i) from road-killed animals (n = 6); ii) from naturally dead animals (n = 8); iii) from animals that died in captivity (n = 9); and iv) from living animals captured from the wild (n = 2). Specific P. brasiliensis DNA was detected in several organs among 7/20 nine-banded armadillos (D. novemcinctus) and in 2/2 anteaters (M. tridactyla). The fungus was also cultured in tissue samples from one of two armadillos captured from the wild. Conclusion. Members of the Xenarthra Order, especially armadillos, have some characteristics, including a weak cellular immune response and low body temperature, which make them suitable models for studying host-pathogen interaction. P. brasiliensis infection in wild animals, from PCM endemic areas, may be more common than initially postulated and reinforces the use of these animals as sentinels for the pathogen in the environment. © 2009 Bagagli et al; licensee BioMed Central Ltd.Departamento de Microbiologia e Imunologia Instituto de Biocincias de Botucatu Universidade Estadual Paulista, Botucatu, SPDepartamento de Geografia Faculdade de Filosofia, Letras e Cincias Humanas Universidade de so Paulo, So Paulo, SPInstituto Lauro de Souza Lima, Bauru, SPDepartamento de Microbiologia e Imunologia Instituto de Biocincias de Botucatu Universidade Estadual Paulista, Botucatu, SPUniversidade Estadual Paulista (Unesp)Universidade de São Paulo (USP)Instituto Lauro de Souza Lima (ILSL)Richini-Pereira, Virgínia [UNESP]Bosco, Sandra [UNESP]Theodoro, Raquel [UNESP]Barrozo, LígiaPedrini, SilviaRosa, PatríciaBagagli, Eduardo [UNESP]2014-05-27T11:24:04Z2014-05-27T11:24:04Z2009-12-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://dx.doi.org/10.1186/1756-0500-2-228BMC Research Notes, v. 2.1756-0500http://hdl.handle.net/11449/7131810.1186/1756-0500-2-2282-s2.0-771491627172-s2.0-77149162717.pdf33203275704295390000-0002-8003-4109Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBMC Research Notes0,691info:eu-repo/semantics/openAccess2024-10-14T15:05:33Zoai:repositorio.unesp.br:11449/71318Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-10-14T15:05:33Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Importance of xenarthrans in the eco-epidemiology of Paracoccidioides brasiliensis
title Importance of xenarthrans in the eco-epidemiology of Paracoccidioides brasiliensis
spellingShingle Importance of xenarthrans in the eco-epidemiology of Paracoccidioides brasiliensis
Richini-Pereira, Virgínia [UNESP]
Animalia
Armadillo
Cabassous
Dasypodidae
Dasypus novemcinctus
Edentata
Euphractus sexcinctus
Fungi
Mammalia
Myrmecophaga tridactyla
Myrmecophagidae
Paracoccidioides brasiliensis
Tamandua tetradactyla
Xenarthra
title_short Importance of xenarthrans in the eco-epidemiology of Paracoccidioides brasiliensis
title_full Importance of xenarthrans in the eco-epidemiology of Paracoccidioides brasiliensis
title_fullStr Importance of xenarthrans in the eco-epidemiology of Paracoccidioides brasiliensis
title_full_unstemmed Importance of xenarthrans in the eco-epidemiology of Paracoccidioides brasiliensis
title_sort Importance of xenarthrans in the eco-epidemiology of Paracoccidioides brasiliensis
author Richini-Pereira, Virgínia [UNESP]
author_facet Richini-Pereira, Virgínia [UNESP]
Bosco, Sandra [UNESP]
Theodoro, Raquel [UNESP]
Barrozo, Lígia
Pedrini, Silvia
Rosa, Patrícia
Bagagli, Eduardo [UNESP]
author_role author
author2 Bosco, Sandra [UNESP]
Theodoro, Raquel [UNESP]
Barrozo, Lígia
Pedrini, Silvia
Rosa, Patrícia
Bagagli, Eduardo [UNESP]
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
Universidade de São Paulo (USP)
Instituto Lauro de Souza Lima (ILSL)
dc.contributor.author.fl_str_mv Richini-Pereira, Virgínia [UNESP]
Bosco, Sandra [UNESP]
Theodoro, Raquel [UNESP]
Barrozo, Lígia
Pedrini, Silvia
Rosa, Patrícia
Bagagli, Eduardo [UNESP]
dc.subject.por.fl_str_mv Animalia
Armadillo
Cabassous
Dasypodidae
Dasypus novemcinctus
Edentata
Euphractus sexcinctus
Fungi
Mammalia
Myrmecophaga tridactyla
Myrmecophagidae
Paracoccidioides brasiliensis
Tamandua tetradactyla
Xenarthra
topic Animalia
Armadillo
Cabassous
Dasypodidae
Dasypus novemcinctus
Edentata
Euphractus sexcinctus
Fungi
Mammalia
Myrmecophaga tridactyla
Myrmecophagidae
Paracoccidioides brasiliensis
Tamandua tetradactyla
Xenarthra
description Background. Several pathogens that cause important zoonotic diseases have been frequently associated with armadillos and other xenarthrans. This mammal group typically has evolved on the South American continent and many of its extant species are seriously threatened with extinction. Natural infection of armadillos with Paracoccidioides brasiliensis in hyperendemic areas has provided a valuable opportunity for understanding the role of this mammal in the eco-epidemiology of Paracoccidioidomycosis (PCM), one of the most important systemic mycoses in Latin America. Findings. This study aimed to detect P. brasiliensis in different xenarthran species (Dasypus novemcinctus, Cabassous spp., Euphractus sexcinctus, Tamandua tetradactyla and Myrmecophaga tridactyla), by molecular and mycological approaches, in samples obtained by one of the following strategies: i) from road-killed animals (n = 6); ii) from naturally dead animals (n = 8); iii) from animals that died in captivity (n = 9); and iv) from living animals captured from the wild (n = 2). Specific P. brasiliensis DNA was detected in several organs among 7/20 nine-banded armadillos (D. novemcinctus) and in 2/2 anteaters (M. tridactyla). The fungus was also cultured in tissue samples from one of two armadillos captured from the wild. Conclusion. Members of the Xenarthra Order, especially armadillos, have some characteristics, including a weak cellular immune response and low body temperature, which make them suitable models for studying host-pathogen interaction. P. brasiliensis infection in wild animals, from PCM endemic areas, may be more common than initially postulated and reinforces the use of these animals as sentinels for the pathogen in the environment. © 2009 Bagagli et al; licensee BioMed Central Ltd.
publishDate 2009
dc.date.none.fl_str_mv 2009-12-01
2014-05-27T11:24:04Z
2014-05-27T11:24:04Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1186/1756-0500-2-228
BMC Research Notes, v. 2.
1756-0500
http://hdl.handle.net/11449/71318
10.1186/1756-0500-2-228
2-s2.0-77149162717
2-s2.0-77149162717.pdf
3320327570429539
0000-0002-8003-4109
url http://dx.doi.org/10.1186/1756-0500-2-228
http://hdl.handle.net/11449/71318
identifier_str_mv BMC Research Notes, v. 2.
1756-0500
10.1186/1756-0500-2-228
2-s2.0-77149162717
2-s2.0-77149162717.pdf
3320327570429539
0000-0002-8003-4109
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv BMC Research Notes
0,691
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
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instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv repositoriounesp@unesp.br
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