Parents ethanol use impairs ethanol-naive offspring development and reproduction
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1530/REP-20-0316 http://hdl.handle.net/11449/208364 |
Resumo: | Parental ethanol consumption can influence the offspring phenotype. In this way, we analyzed the impairments of maternal and paternal high ethanol consumption during postpuberty on the physical development, feeding pattern, puberty onset and reproductive function of ethanol-naive offspring to birth to adulthood. Female and male UChB rats (voluntary 10%, v/v ethanol consumer) were divided into a control group (C) and an ethanol exposed group (E) from 65 to 80 days of age. The C and E were mated at 100 days. The maternal parameters and offspring development and reproduction parameters were monitored. We observed reduced feeding intake and body weight in the dams of E group throughout gestation and lactation period. Delay in physical development, lower body weight and altered feeding pattern were observed in female and male offspring of E group. In addition, the puberty onset was delayed in both sexes, with lower testosterone levels in the juvenile and pubertal males. There was a prolongation on the estrous and proestrus phases in females from E but the estrous cycle duration did not change between groups. Ovary and uterus weight were reduced in pubertal and adult females from E group. Reduced epididymis and seminal vesicle weight, increased sperm abnormalities, decrease in the daily sperm production and accelerated epididymal transit time were observed in E males. The high maternal and paternal ethanol use on postpuberty impairs the parameters of ethanol-naive offspring inducing alteration on development and reproduction. |
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Parents ethanol use impairs ethanol-naive offspring development and reproductionParental ethanol consumption can influence the offspring phenotype. In this way, we analyzed the impairments of maternal and paternal high ethanol consumption during postpuberty on the physical development, feeding pattern, puberty onset and reproductive function of ethanol-naive offspring to birth to adulthood. Female and male UChB rats (voluntary 10%, v/v ethanol consumer) were divided into a control group (C) and an ethanol exposed group (E) from 65 to 80 days of age. The C and E were mated at 100 days. The maternal parameters and offspring development and reproduction parameters were monitored. We observed reduced feeding intake and body weight in the dams of E group throughout gestation and lactation period. Delay in physical development, lower body weight and altered feeding pattern were observed in female and male offspring of E group. In addition, the puberty onset was delayed in both sexes, with lower testosterone levels in the juvenile and pubertal males. There was a prolongation on the estrous and proestrus phases in females from E but the estrous cycle duration did not change between groups. Ovary and uterus weight were reduced in pubertal and adult females from E group. Reduced epididymis and seminal vesicle weight, increased sperm abnormalities, decrease in the daily sperm production and accelerated epididymal transit time were observed in E males. The high maternal and paternal ethanol use on postpuberty impairs the parameters of ethanol-naive offspring inducing alteration on development and reproduction.Department of Structural and Functional Biology Institute of Biosciences of Botucatu (IBB) UNESP – Univ Estadual PaulistaGeneral and Applied Biology Program Institute of Biosciences of Botucatu (IBB) UNESP – Univ Estadual PaulistaDepartment of Structural and Functional Biology Institute of Biosciences of Botucatu (IBB) UNESP – Univ Estadual PaulistaGeneral and Applied Biology Program Institute of Biosciences of Botucatu (IBB) UNESP – Univ Estadual PaulistaUniversidade Estadual Paulista (Unesp)Fioravante, Vanessa Caroline [UNESP]Godoi, Alana Rezende [UNESP]De Barros Camargo, Victória Mokarzel [UNESP]Do Nascimento, Renata Steffany [UNESP]Felipe Pinheiro, Patricia Fernanda [UNESP]Martinez, Francisco Eduardo [UNESP]2021-06-25T11:10:55Z2021-06-25T11:10:55Z2021-02-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article195-204http://dx.doi.org/10.1530/REP-20-0316Reproduction, v. 161, n. 2, p. 195-204, 2021.1741-78991470-1626http://hdl.handle.net/11449/20836410.1530/REP-20-03162-s2.0-85100280142Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengReproductioninfo:eu-repo/semantics/openAccess2021-10-23T19:02:09Zoai:repositorio.unesp.br:11449/208364Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T19:39:30.944401Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Parents ethanol use impairs ethanol-naive offspring development and reproduction |
title |
Parents ethanol use impairs ethanol-naive offspring development and reproduction |
spellingShingle |
Parents ethanol use impairs ethanol-naive offspring development and reproduction Fioravante, Vanessa Caroline [UNESP] |
title_short |
Parents ethanol use impairs ethanol-naive offspring development and reproduction |
title_full |
Parents ethanol use impairs ethanol-naive offspring development and reproduction |
title_fullStr |
Parents ethanol use impairs ethanol-naive offspring development and reproduction |
title_full_unstemmed |
Parents ethanol use impairs ethanol-naive offspring development and reproduction |
title_sort |
Parents ethanol use impairs ethanol-naive offspring development and reproduction |
author |
Fioravante, Vanessa Caroline [UNESP] |
author_facet |
Fioravante, Vanessa Caroline [UNESP] Godoi, Alana Rezende [UNESP] De Barros Camargo, Victória Mokarzel [UNESP] Do Nascimento, Renata Steffany [UNESP] Felipe Pinheiro, Patricia Fernanda [UNESP] Martinez, Francisco Eduardo [UNESP] |
author_role |
author |
author2 |
Godoi, Alana Rezende [UNESP] De Barros Camargo, Victória Mokarzel [UNESP] Do Nascimento, Renata Steffany [UNESP] Felipe Pinheiro, Patricia Fernanda [UNESP] Martinez, Francisco Eduardo [UNESP] |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Fioravante, Vanessa Caroline [UNESP] Godoi, Alana Rezende [UNESP] De Barros Camargo, Victória Mokarzel [UNESP] Do Nascimento, Renata Steffany [UNESP] Felipe Pinheiro, Patricia Fernanda [UNESP] Martinez, Francisco Eduardo [UNESP] |
description |
Parental ethanol consumption can influence the offspring phenotype. In this way, we analyzed the impairments of maternal and paternal high ethanol consumption during postpuberty on the physical development, feeding pattern, puberty onset and reproductive function of ethanol-naive offspring to birth to adulthood. Female and male UChB rats (voluntary 10%, v/v ethanol consumer) were divided into a control group (C) and an ethanol exposed group (E) from 65 to 80 days of age. The C and E were mated at 100 days. The maternal parameters and offspring development and reproduction parameters were monitored. We observed reduced feeding intake and body weight in the dams of E group throughout gestation and lactation period. Delay in physical development, lower body weight and altered feeding pattern were observed in female and male offspring of E group. In addition, the puberty onset was delayed in both sexes, with lower testosterone levels in the juvenile and pubertal males. There was a prolongation on the estrous and proestrus phases in females from E but the estrous cycle duration did not change between groups. Ovary and uterus weight were reduced in pubertal and adult females from E group. Reduced epididymis and seminal vesicle weight, increased sperm abnormalities, decrease in the daily sperm production and accelerated epididymal transit time were observed in E males. The high maternal and paternal ethanol use on postpuberty impairs the parameters of ethanol-naive offspring inducing alteration on development and reproduction. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-06-25T11:10:55Z 2021-06-25T11:10:55Z 2021-02-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1530/REP-20-0316 Reproduction, v. 161, n. 2, p. 195-204, 2021. 1741-7899 1470-1626 http://hdl.handle.net/11449/208364 10.1530/REP-20-0316 2-s2.0-85100280142 |
url |
http://dx.doi.org/10.1530/REP-20-0316 http://hdl.handle.net/11449/208364 |
identifier_str_mv |
Reproduction, v. 161, n. 2, p. 195-204, 2021. 1741-7899 1470-1626 10.1530/REP-20-0316 2-s2.0-85100280142 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Reproduction |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
195-204 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129101343490048 |