Chemical Composition and Trypanocidal Activity of the Essential Oils from Hedychium coronarium J. Koenig (Zingiberaceae)

• Autor(a) principal: Rodrigues, Danilo Fernando [UNESP]
• Data de Publicação: 2013
• Outros Autores: Arenas Velásquez, Angela María [UNESP], Cavaleiro, Carlos, Salgueiro, Lígia, Martins, Gilmárcio Zimmermann [UNESP], Magalhães, Nathália Oliveira [UNESP], Martins, Maria Bernadete GonÇalves [UNESP], Cicarelli, Regina Maria Barretto [UNESP], Moreira, Raquel Regina Duarte [UNESP]
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://www.hindawi.com/journals/isrn/2013/639275/; http://hdl.handle.net/11449/123640
• topic: chemical composition of essential oils; trypanocidal activity; Trypanosoma brucei

The composition of the essential oils (EO) from leaves and rhizomes of Hedychium coronarium was analyzed both by gas chromatography and gas chromatography-mass spectroscopy. Thirty and thirty-nine compounds were identified, respectively, in the oils from leaves and rhizomes, representing 88% and 86.1% of the whole compositions. Caryophyllene oxide is the major component in rhizomes while 1,8-cineole predominates in leaves oil. Essential oils and major components were tested for trypanocidal activity using procyclic forms of Trypanosoma brucei (427 and 29-13 strains). The cytotoxicity index (CI50), using the MTT colorimetric method, showed that essential oils and 1,8-cineole were inactive (>100 μg·mL−1. Nevertheless, caryophyllene oxide revealed a remarkable activity against both T. brucei strains (CI50 = 65.77 μg·mL−1 and 24.53 μg·mL−1, resp.), and the synergism between caryophyllene oxide plus pentamidine (1 : 1, v/v) highly increased the trypanocidal activity (<1.0 μg·mL−1).