Caffeic Acid Has Antiviral Activity against Ilhéus Virus In Vitro
Autor(a) principal: | |
---|---|
Data de Publicação: | 2023 |
Outros Autores: | , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.3390/v15020494 http://hdl.handle.net/11449/248450 |
Resumo: | Ilhéus virus (ILHV) is a neglected mosquito-borne flavivirus. ILHV infection may lead to Ilhéus fever, an emerging febrile disease like dengue fever with the potential to evolve into a severe neurological disease characterized by meningoencephalitis; no specific treatments are available for this disease. This study assessed the antiviral properties of caffeic acid, an abundant component of plant-based food products that is also compatible with the socioeconomic limitations associated with this neglected infectious disease. The in vitro activity of caffeic acid on ILHV replication was investigated in Vero and A549 cell lines using plaque assays, quantitative RT-PCR, and immunofluorescence assays. We observed that 500 µM caffeic acid was virucidal against ILHV. Molecular docking indicated that caffeic acid might interact with an allosteric binding site on the envelope protein. |
id |
UNSP_ae3b04f111cb4eed550a7d1eb5642339 |
---|---|
oai_identifier_str |
oai:repositorio.unesp.br:11449/248450 |
network_acronym_str |
UNSP |
network_name_str |
Repositório Institucional da UNESP |
repository_id_str |
2946 |
spelling |
Caffeic Acid Has Antiviral Activity against Ilhéus Virus In Vitroantiviral activitycaffeic acidIlhéus virusin silico analysisinhibitionIlhéus virus (ILHV) is a neglected mosquito-borne flavivirus. ILHV infection may lead to Ilhéus fever, an emerging febrile disease like dengue fever with the potential to evolve into a severe neurological disease characterized by meningoencephalitis; no specific treatments are available for this disease. This study assessed the antiviral properties of caffeic acid, an abundant component of plant-based food products that is also compatible with the socioeconomic limitations associated with this neglected infectious disease. The in vitro activity of caffeic acid on ILHV replication was investigated in Vero and A549 cell lines using plaque assays, quantitative RT-PCR, and immunofluorescence assays. We observed that 500 µM caffeic acid was virucidal against ILHV. Molecular docking indicated that caffeic acid might interact with an allosteric binding site on the envelope protein.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Center for Information TechnologyCenter for Scientific ReviewNational Institutes of HealthOffice of Extramural Research, National Institutes of HealthOffice of Research Infrastructure Programs, National Institutes of HealthLaboratório de Pesquisas em Virologia Departamento de Doenças Dermatológicas Infecciosas e Parasitárias Faculdade de Medicina de São José do Rio Preto, SPBrazilian Biosciences National Laboratory Centro Nacional de Pesquisa em Energia e Materiais (CNPEM), SPLaboratório de Estudos Genômicos Departamento de Biologia Instituto de Biociências Letras e Ciências Exatas Universidade Estadual Paulista, SPFaceres Medical School, SPDepartamento de Biofísica e Farmacologia Universidade Federal do Rio Grande do Norte, RNUnidade Especial de Ciências Exatas Universidade Federal de Jataí, GOLaboratório de Marcadores Moleculares e Bioinformática Departamento de Biologia Molecular Faculdade de Medicina de São José do Rio Preto, SPDepartment of Pathology The University of Texas Medical BranchLaboratório de Estudos Genômicos Departamento de Biologia Instituto de Biociências Letras e Ciências Exatas Universidade Estadual Paulista, SPFAPESP: 2013/21719-3Center for Information Technology: U01AI151807Center for Scientific Review: U01AI151807National Institutes of Health: U01AI151807Office of Extramural Research, National Institutes of Health: U01AI151807Office of Research Infrastructure Programs, National Institutes of Health: U01AI151807Faculdade de Medicina de São José do Rio PretoCentro Nacional de Pesquisa em Energia e Materiais (CNPEM)Universidade Estadual Paulista (UNESP)Faceres Medical SchoolUniversidade Federal do Rio Grande do NorteUniversidade Federal de JataíThe University of Texas Medical BranchSaivish, Marielena VogelPacca, Carolina Colombelli [UNESP]da Costa, Vivaldo Gomes [UNESP]de Lima Menezes, Gabrielada Silva, Roosevelt AlvesNebo, Lilianeda Silva, Gislaine Celestino Dutrade Aguiar Milhim, Bruno Henrique Gonçalvesda Silva Teixeira, IgorHenrique, TiagoMistrão, Natalia Franco BuenoHernandes, Victor MirandaZini, Nathaliade Carvalho, Ana CarolinaFontoura, Marina AlvesRahal, Paula [UNESP]Sacchetto, LíviaMarques, Rafael EliasNogueira, Maurício Lacerda2023-07-29T13:44:24Z2023-07-29T13:44:24Z2023-02-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.3390/v15020494Viruses, v. 15, n. 2, 2023.1999-4915http://hdl.handle.net/11449/24845010.3390/v150204942-s2.0-85149254337Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengVirusesinfo:eu-repo/semantics/openAccess2023-07-29T13:44:24Zoai:repositorio.unesp.br:11449/248450Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-07-29T13:44:24Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Caffeic Acid Has Antiviral Activity against Ilhéus Virus In Vitro |
title |
Caffeic Acid Has Antiviral Activity against Ilhéus Virus In Vitro |
spellingShingle |
Caffeic Acid Has Antiviral Activity against Ilhéus Virus In Vitro Saivish, Marielena Vogel antiviral activity caffeic acid Ilhéus virus in silico analysis inhibition |
title_short |
Caffeic Acid Has Antiviral Activity against Ilhéus Virus In Vitro |
title_full |
Caffeic Acid Has Antiviral Activity against Ilhéus Virus In Vitro |
title_fullStr |
Caffeic Acid Has Antiviral Activity against Ilhéus Virus In Vitro |
title_full_unstemmed |
Caffeic Acid Has Antiviral Activity against Ilhéus Virus In Vitro |
title_sort |
Caffeic Acid Has Antiviral Activity against Ilhéus Virus In Vitro |
author |
Saivish, Marielena Vogel |
author_facet |
Saivish, Marielena Vogel Pacca, Carolina Colombelli [UNESP] da Costa, Vivaldo Gomes [UNESP] de Lima Menezes, Gabriela da Silva, Roosevelt Alves Nebo, Liliane da Silva, Gislaine Celestino Dutra de Aguiar Milhim, Bruno Henrique Gonçalves da Silva Teixeira, Igor Henrique, Tiago Mistrão, Natalia Franco Bueno Hernandes, Victor Miranda Zini, Nathalia de Carvalho, Ana Carolina Fontoura, Marina Alves Rahal, Paula [UNESP] Sacchetto, Lívia Marques, Rafael Elias Nogueira, Maurício Lacerda |
author_role |
author |
author2 |
Pacca, Carolina Colombelli [UNESP] da Costa, Vivaldo Gomes [UNESP] de Lima Menezes, Gabriela da Silva, Roosevelt Alves Nebo, Liliane da Silva, Gislaine Celestino Dutra de Aguiar Milhim, Bruno Henrique Gonçalves da Silva Teixeira, Igor Henrique, Tiago Mistrão, Natalia Franco Bueno Hernandes, Victor Miranda Zini, Nathalia de Carvalho, Ana Carolina Fontoura, Marina Alves Rahal, Paula [UNESP] Sacchetto, Lívia Marques, Rafael Elias Nogueira, Maurício Lacerda |
author2_role |
author author author author author author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Faculdade de Medicina de São José do Rio Preto Centro Nacional de Pesquisa em Energia e Materiais (CNPEM) Universidade Estadual Paulista (UNESP) Faceres Medical School Universidade Federal do Rio Grande do Norte Universidade Federal de Jataí The University of Texas Medical Branch |
dc.contributor.author.fl_str_mv |
Saivish, Marielena Vogel Pacca, Carolina Colombelli [UNESP] da Costa, Vivaldo Gomes [UNESP] de Lima Menezes, Gabriela da Silva, Roosevelt Alves Nebo, Liliane da Silva, Gislaine Celestino Dutra de Aguiar Milhim, Bruno Henrique Gonçalves da Silva Teixeira, Igor Henrique, Tiago Mistrão, Natalia Franco Bueno Hernandes, Victor Miranda Zini, Nathalia de Carvalho, Ana Carolina Fontoura, Marina Alves Rahal, Paula [UNESP] Sacchetto, Lívia Marques, Rafael Elias Nogueira, Maurício Lacerda |
dc.subject.por.fl_str_mv |
antiviral activity caffeic acid Ilhéus virus in silico analysis inhibition |
topic |
antiviral activity caffeic acid Ilhéus virus in silico analysis inhibition |
description |
Ilhéus virus (ILHV) is a neglected mosquito-borne flavivirus. ILHV infection may lead to Ilhéus fever, an emerging febrile disease like dengue fever with the potential to evolve into a severe neurological disease characterized by meningoencephalitis; no specific treatments are available for this disease. This study assessed the antiviral properties of caffeic acid, an abundant component of plant-based food products that is also compatible with the socioeconomic limitations associated with this neglected infectious disease. The in vitro activity of caffeic acid on ILHV replication was investigated in Vero and A549 cell lines using plaque assays, quantitative RT-PCR, and immunofluorescence assays. We observed that 500 µM caffeic acid was virucidal against ILHV. Molecular docking indicated that caffeic acid might interact with an allosteric binding site on the envelope protein. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-07-29T13:44:24Z 2023-07-29T13:44:24Z 2023-02-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.3390/v15020494 Viruses, v. 15, n. 2, 2023. 1999-4915 http://hdl.handle.net/11449/248450 10.3390/v15020494 2-s2.0-85149254337 |
url |
http://dx.doi.org/10.3390/v15020494 http://hdl.handle.net/11449/248450 |
identifier_str_mv |
Viruses, v. 15, n. 2, 2023. 1999-4915 10.3390/v15020494 2-s2.0-85149254337 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Viruses |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1803046491627978752 |